• About Us
    • Contact Us
    • Login
    • ObGFirst
  • Alerts
  • OB
  • 2T US Atlas
  • The Genome
  • GYN
    • GYN
    • Sexual Health
  • Primary Care
  • Your Practice
  • GrandRounds
  • My Bookshelf
  • COVID-19
About Us Contact Us Login ObGFirst
  • Alerts
  • OB
  • 2T US Atlas
  • The Genome
  • GYN
    • GYN
    • Sexual Health
  • Primary Care
  • Your Practice
  • GrandRounds
  • My Bookshelf
  • COVID-19
Grand Rounds

Postpartum Hemorrhage in Patients with von Willebrand Disease

image_pdfFavoriteLoadingFavorite

BACKGROUND AND PURPOSE:

  • Kazi et al. (Journal of Obstetrics and Gynaecology Canada, 2022) determined the rate and etiology of PPH in women with von Willebrand disease (VWD)

METHODS:

  • Retrospective cohort study
  • Population
    • Pregnancies with VWD that ended in live birth
  • Primary outcomes
    • PPH: Rates | Etiology | Timing

RESULTS:

  • 63 women | 80 pregnancies
    • Median age 32.9 (range, 19 to 43) years
    • Nulliparous: 41.3%
  • VWD type (see ‘Learn More – Primary Sources’ below for more detail on types)
    • Type 1: 82.5%
    • Type 2 (unclear subtype): 5.0%
    • Type 2A: 3.8%
    • Type 2B: 3.8%
    • Type 2M: 2.5%
  • Pregnancies that
    • Received prophylactic hemostatic treatment prior to delivery: 46.3%
    • Delivered vaginally: 74%
    • Received epidural anesthesia: 88%
  • VWF levels above 1.00 IU/mL: 71.3%
  • PPH complications
    • Primary PPH: 5.2% of pregnancies
    • Delayed postpartum bleeding: 6.3%
    • Uterine atony: 2 pregnancies
    • Placenta previa: 1 pregnancy

CONCLUSION:

  • Rates of primary and delayed PPH are lower than previously described for women with VWD and are similar to those in the general population
  • Uterine etiologies for primary PPH should be considered for women with VWD, similar to the assessments performed for women without VWD, to ensure hemostasis
  • The authors state

The etiologies of primary PPH were predominantly secondary to obstetric etiologies, whereas delayed PPH appeared to be unrelated to uterine pathology, suggesting the need for ongoing vigilance postpartum, particularly for women with type 1 VWD, who may not be expected to have ongoing bleeding

Learn More – Primary Sources:

Postpartum Hemorrhage in Women with von Willebrand Disease: Consider Other Etiologies

Want to stay on top of key guidelines and research papers?

ObGFirst® – Try It Free! »

image_pdfFavoriteLoadingFavorite
< Previous
All Grand Rounds Posts
Next >

Related ObG Topics:

Are We Meeting the ACOG Screening Guidelines for Von Willebrand Disease in Adolescents with Menorrhagia?
Is Heavy Menstrual Bleeding a Sign of a Bleeding Disorder in Adolescents?
Phase 3 Study: Gene-Therapy Treatment Reduces Bleeding in Patients with Hemophilia A

Sections

  • Alerts
  • OB
  • GYN
    • GYN
    • Sexual Health
  • 2T US Atlas
  • The Genome
  • Primary Care
  • Your Practice
  • Grand Rounds
  • My Bookshelf
  • COVID-19

Are you an
ObG Insider?

Get specially curated clinical summaries delivered to your inbox every week for free

  • Site Map/
  • © ObG Project/
  • Terms and Conditions/
  • Privacy/
  • Contact Us/
© ObG Project
SSL Certificate


  • Already an ObGFirst Member?
    Welcome back

    Log In

    Want to sign up?
    Get guideline notifications
    CME Included

    Sign Up

Sign In

Lost your password?

Sign Up for ObGFirst and Stay Ahead

  • - Professional guideline notifications
  • - Daily summary of a clinically relevant
    research paper
  • - Includes 1 hour of CME every month

ObGFirst Free Trial

Already a Member of ObGFirst®?

Please log in to ObGFirst to access the 2T US Atlas

Password Trouble?

Not an ObGFirst® Member Yet?

  • - Access 2T US Atlas
  • - Guideline notifications
  • - Daily research paper summaries
  • - And lots more!
ObGFirst Free Trial

Media - Internet

Computer System Requirements

OBG Project CME requires a modern web browser (Internet Explorer 10+, Mozilla Firefox, Apple Safari, Google Chrome, Microsoft Edge). Certain educational activities may require additional software to view multimedia, presentation, or printable versions of their content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Flash, Apple QuickTime, Adobe Acrobat, Microsoft PowerPoint, Windows Media Player, or Real Networks Real One Player.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information
presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Jointly provided by

NOT ENOUGH CME HOURS

It appears you don't have enough CME Hours to take this Post-Test. Feel free to buy additional CME hours or upgrade your current CME subscription plan

Subscribe

JOIN OBGFIRST AND GET CME/CE CREDITS

One of the benefits of an ObGFirst subscription is the ability to earn CME/CE credits from the ObG entries you read. Tap the button to learn more about ObGFirst

Learn More
Leaving ObG Website

You are now leaving the ObG website and on your way to PRIORITY at UCSF, an independent website. Therefore, we are not responsible for the content or availability of this site