At four weeks post-infusion, a greater proportion of participants in the 500 mg dose group required a repeat infusion, compared to the higher dose group
500 mg group: 36%
100 mg group: 8%
Difference in proportions 0.283 (95% CI, 0.177 to 0.389)
The two doses were not equivalent within a 5% margin at any timepoint
Participants in the 500 mg group received twice the repeat infusion rate
500 mg group: 0.81
1000 mg group: 0.40
Rate ratio 2.05 (95% CI, 1.45 to 2.91)
For women with iron deficiency in pregnancy, a 1000 mg dose of intravenous ferric carboxymaltose in the second or third trimester was better at preventing the need for repeat infusions, compared to a 500 mg initial dose
The authors state
Administration of 1000 mg ferric carboxymaltose in pregnancy maintains iron stores and reduces the need for repeat infusions
A 500 mg dose requires ongoing monitoring to ensure adequate iron stores are reached and sustained
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