The NOVEL (Nonavalent Prophylactic HPV Vaccine (Gardasil 9) After Local Conservative, NCT03979014) trial, an ongoing, large, appropriately powered randomised controlled trial, is expected to report results and give further insight on the effect of Gardasil 9 on persistent incident, recurrent, and prevalent HPV infections and cost effectiveness
If the study reports benefit, the results could be applicable to women with multifocal disease, other diseases related to HPV infection, and individuals with a diagnosis of malignancies related to HPV infection
Role of human papillomavirus (HPV) vaccination on HPV infection and recurrence of HPV related disease after local surgical treatment: systematic review and meta-analysis
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