• About Us
    • Contact Us
    • Login
    • ObGFirst
  • COVID-19
  • Alerts
  • OB
  • 2T US Atlas
  • The Genome
  • GYN
    • GYN
    • Sexual Health
  • Primary Care
  • Your Practice
  • GrandRounds
  • My Bookshelf
  • Now@ObG
  • Media
About Us Contact Us Login ObGFirst
  • COVID-19
  • Alerts
  • OB
  • 2T US Atlas
  • The Genome
  • GYN
    • GYN
    • Sexual Health
  • Primary Care
  • Your Practice
  • GrandRounds
  • My Bookshelf
  • Now@ObG
  • Media
Grand Rounds

Is the Impact of a High Potassium Diet on Cardiovascular Health Sex-Specific?

image_pdfFavoriteLoadingFavorite

BACKGROUND AND PURPOSE:

  • Potassium intake is associated with lower BP and lower risk for cardiovascular disease (CVD)
  • Wouda et al. (European Heart Journal, 2022) analyzed whether the associations between daily potassium consumption and BP and CVD differ between men and women

METHODS:

  • Secondary analysis of a prospective, population-based cohort study
    • European Prospective Investigation into Cancer (EPIC-Norfolk)
  • Participants
    • Adults in the UK
    • 40 to 79 years
  • Exposures
    • 24-hour excretion of sodium and potassium, reflecting intake
  • Study design
    • Sodium and potassium intake was estimated from sodium and potassium concentration in spot urine samples using a validated formula
    • Linear regression and Cox proportional hazards model stratified by sex used to explore the association between potassium intake and the primary outcomes
  • Primary outcomes
    • Systolic BP (SBP)
    • CVD events (defined as hospitalization or death due to CVD)

RESULTS:

  • 11,267 men | 13,696 women
    • Median follow-up: 19.5 years
  • After adjusting for confounders, there was an interaction by sex for the association between potassium intake and SBP (P<0.001)
    • In women, but not in men, the inverse relationship between potassium intake and SBP was stronger in those within the highest tertile of sodium intake compared with those within the lowest tertile of sodium intake
  • In both women and men, higher potassium intake was associated with a lower risk of CVD events
    • The hazard ratio (HR) associated with higher potassium intake was lower in women than in men (P=0.033 for interaction by sex)
      • Men, highest vs. lowest potassium intake tertile
        • HR 0.93 (95% CI, 0.87 to 1.00)
      • Women
        • HR 0.89 (95% CI, 0.83 to 0.95)

CONCLUSION:

  • The association between replete potassium intake and BP and CVD is sex-specific
  • Women particularly benefit from a higher potassium intake in regard to blood pressure
  • The authors state

In conclusion, we demonstrate that the association between daily potassium intake, SBP, and CVD events is sex specific

In women, the association between potassium intake and SBP was modified by sodium intake

Considering the natriuretic effects of potassium, these findings seem consistent with increased sodium sensitivity of BP in women 

Learn More – Primary Sources:

Sex-specific associations between potassium intake, blood pressure, and cardiovascular outcomes: the EPIC-Norfolk study

Want to stay on top of key guidelines and research papers?

ObGFirst® – Try It Free! »

image_pdfFavoriteLoadingFavorite
< Previous
All Grand Rounds Posts
Next >

Related ObG Topics:

Potassium and Sodium Intake: Do the WHO Recommendations Have it Right?
RCT Results: Is the Mediterranean Diet or a Low-Fat Diet Better for Secondary Prevention of Cardiovascular Disease?
Cochrane Review: Do Omega-3 Fatty Acids Reduce Cardiovascular Disease? 

Sections

  • COVID-19
  • Alerts
  • OB
  • GYN
    • GYN
    • Sexual Health
  • 2T US Atlas
  • The Genome
  • Primary Care
  • Your Practice
  • Grand Rounds
  • My Bookshelf
  • Now@ObG
  • Media

Are you an
ObG Insider?

Get specially curated clinical summaries delivered to your inbox every week for free

  • Site Map/
  • © ObG Project/
  • Terms and Conditions/
  • Privacy/
  • Contact Us/
© ObG Project
SSL Certificate


  • Already an ObGFirst Member?
    Welcome back

    Log In

    Want to sign up?
    Get guideline notifications
    CME Included

    Sign Up

Download Your ObG App
HERE!

Sign In

Lost your password?

Sign Up for ObGFirst and Stay Ahead

  • - Professional guideline notifications
  • - Daily summary of a clinically relevant
    research paper
  • - Includes 1 hour of CME every month

ObGFirst Free Trial

Already a Member of ObGFirst®?

Please log in to ObGFirst to access the 2T US Atlas

Password Trouble?

Not an ObGFirst® Member Yet?

  • - Access 2T US Atlas
  • - Guideline notifications
  • - Daily research paper summaries
  • - And lots more!
ObGFirst Free Trial

Media - Internet

Computer System Requirements

OBG Project CME requires a modern web browser (Internet Explorer 10+, Mozilla Firefox, Apple Safari, Google Chrome, Microsoft Edge). Certain educational activities may require additional software to view multimedia, presentation, or printable versions of their content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Flash, Apple QuickTime, Adobe Acrobat, Microsoft PowerPoint, Windows Media Player, or Real Networks Real One Player.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information
presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Jointly provided by

NOT ENOUGH CME HOURS

It appears you don't have enough CME Hours to take this Post-Test. Feel free to buy additional CME hours or upgrade your current CME subscription plan

Subscribe

JOIN OBGFIRST AND GET CME/CE CREDITS

One of the benefits of an ObGFirst subscription is the ability to earn CME/CE credits from the ObG entries you read. Tap the button to learn more about ObGFirst

Learn More
Leaving ObG Website

You are now leaving the ObG website and on your way to PRIORITY at UCSF, an independent website. Therefore, we are not responsible for the content or availability of this site