Percentage of spontaneous abortions (defined using ICD9/10 code)
PGA users: 3881 | Controls: 3881
Pregnancies in PGA cohort: 261
Spontaneous abortion: 10% (n=26)
Pregnancies in control group: 801
Spontaneous abortion: 7% (n=56)
Similar risk factors for spontaneous abortions including
Age | Preeclampsia | Mood disorders | Use of other drugs
Spontaneous abortions among PGA users: 10% (n=26)
Within 90 days of the pregnancy code and had an overlapping prescription for a PGA: 4.6% (n=12)
Within age group of 40 to 45 years: 41.7%
There was no significant difference in spontaneous abortions among PGA users and non-users
PGA users: 10%
Increased risk 2.4% (95% CI, −0.7 to 5.4); P=0.17
There does not seem to be an increased risk of spontaneous abortion with topical PGA use during pregnancy
Limitation: Study based on coding which may be inaccurate
The authors state
The results of this case-series study suggest there is no association between use of PGAs and risk of spontaneous abortions. Given the nature of this study design and potential for unmeasured confounding factors, these results might be explored further in future epidemiologic studies that can better control for potential confounding variables and more accurately ascertain spontaneous abortions through perinatal databases
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