RCT Results: Does Dexamethasone Prevent Neonatal Adverse Outcomes in Low-Resource Settings?
BACKGROUND AND PURPOSE:
WHO ACTION Trial Collaborators (Lancet eClinicalMedicine, 2022) assessed the safety and efficacy of dexamethasone when given to women at risk of late preterm birth in hospitals in low-resource countries
Double-blind, randomized trial
4 hospitals in India (December 2017 to May 2020)
Pregnant women at risk of preterm birth between 34w0d and 36w0d
Birth planned or expected in the next 48 hours
Dexamethasone IM 6 mg injection every 12 hours with a maximum of four doses or until hospital discharge or birth (whichever came first)
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Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
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presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
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