• About Us
    • Contact Us
    • Login
    • ObGFirst
  • COVID-19
  • Alerts
  • OB
  • 2T US Atlas
  • The Genome
  • GYN
    • GYN
    • Sexual Health
  • Primary Care
  • Your Practice
  • GrandRounds
  • My Bookshelf
  • Now@ObG
  • Media
About Us Contact Us Login ObGFirst
  • COVID-19
  • Alerts
  • OB
  • 2T US Atlas
  • The Genome
  • GYN
    • GYN
    • Sexual Health
  • Primary Care
  • Your Practice
  • GrandRounds
  • My Bookshelf
  • Now@ObG
  • Media
Grand Rounds

Is Preterm Birth More Common in Women with Endometriosis? 

image_pdfFavoriteLoadingFavorite

BACKGROUND AND PURPOSE: 

  • Whether endometriosis is associated with worse pregnancy outcomes is still unclear 
  • Marcellin et al. (JAMA Network Open, 2022) evaluated the association between the presence of endometriosis and preterm birth

METHODS: 

  • Multicenter, prospective cohort study 
    • 7 academic units in France  
  • Participants 
    • Singleton pregnancies  
    • Follow-up <22 weeks’ gestation  
    • Neonates delivered ≥22 weeks’ 
  • Exposures 
    • Endometriosis: Documented history with 3 possible phenotypes 
      • Isolated superficial peritoneal endometriosis (SUP) 
      • Ovarian endometrioma (OMA; potentially associated with SUP) 
      • Deep endometriosis (DE; potentially associated with SUP and OMA) 
    • Control: No clinical endometriosis symptoms  
  • Study design 
    • Association between endometriosis and the primary outcome was assessed through univariate and multivariate logistic regression analyses 
    • Adjusted for preterm risk factors 
      • Maternal age | BMI before pregnancy | Country of birth | Parity | Previous cesarean delivery | History of myomectomy and hysteroscopy, and preterm birth 
    • The same analysis was performed according to the 3 endometriosis phenotypes  
  • Primary outcome 
    • Preterm birth between 22w0d and 36w6d 

RESULTS: 

  • 1351 study participants 
    • Mean (SD) age 32.9 (5.0) years 
    • Endometriosis diagnosis: 470 participants 
      • SUP: 10.2% 
      • OMA: 17.7% 
      • DE: 72.1% 
  • There was no difference in the rate of preterm birth between groups 
    • Endometriosis: 7.2% 
    • Control: 6.0% 
    • P=0.38 
  • After adjustment, endometriosis was still not associated with preterm birth 
    • aOR 1.07 (95% CI, 0.64 to 1.77) 
  • Results were comparable across different disease phenotypes (P=0.84) 
    • SUP: 6.2% preterm birth  
    • OMA: 7.2% preterm birth 
    • DE: 7.4% preterm birth 

CONCLUSION: 

  • In this cohort, there was no association between endometriosis and incidence of preterm birth 
  • Endometriosis phenotype did not modify this finding 
  • The authors state 

Pregnant women with endometriosis should not be considered to have an exceptionally high risk for preterm birth; thus, monitoring their pregnancy beyond the normal protocols or changing management strategies may not be warranted 

Learn More – Primary Sources: 

Association Between Endometriosis Phenotype and Preterm Birth in France 

image_pdfFavoriteLoadingFavorite
< Previous
All Grand Rounds Posts
Next >

Sections

  • COVID-19
  • Alerts
  • OB
  • GYN
    • GYN
    • Sexual Health
  • 2T US Atlas
  • The Genome
  • Primary Care
  • Your Practice
  • Grand Rounds
  • My Bookshelf
  • Now@ObG
  • Media

Are you an
ObG Insider?

Get specially curated clinical summaries delivered to your inbox every week for free

  • Site Map/
  • © ObG Project/
  • Terms and Conditions/
  • Privacy/
  • Contact Us/
© ObG Project
SSL Certificate


  • Already an ObGFirst Member?
    Welcome back

    Log In

    Want to sign up?
    Get guideline notifications
    CME Included

    Sign Up

Get Guideline Alerts Direct to Your Phone
Try ObGFirst Free!

Sign In

Lost your password?

Sign Up for ObGFirst and Stay Ahead

  • - Professional guideline notifications
  • - Daily summary of a clinically relevant
    research paper
  • - Includes 1 hour of CME every month

ObGFirst Free Trial

Already a Member of ObGFirst®?

Please log in to ObGFirst to access the 2T US Atlas

Password Trouble?

Not an ObGFirst® Member Yet?

  • - Access 2T US Atlas
  • - Guideline notifications
  • - Daily research paper summaries
  • - And lots more!
ObGFirst Free Trial

Media - Internet

Computer System Requirements

OBG Project CME requires a modern web browser (Internet Explorer 10+, Mozilla Firefox, Apple Safari, Google Chrome, Microsoft Edge). Certain educational activities may require additional software to view multimedia, presentation, or printable versions of their content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Flash, Apple QuickTime, Adobe Acrobat, Microsoft PowerPoint, Windows Media Player, or Real Networks Real One Player.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information
presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Jointly provided by

NOT ENOUGH CME HOURS

It appears you don't have enough CME Hours to take this Post-Test. Feel free to buy additional CME hours or upgrade your current CME subscription plan

Subscribe

JOIN OBGFIRST AND GET CME/CE CREDITS

One of the benefits of an ObGFirst subscription is the ability to earn CME/CE credits from the ObG entries you read. Tap the button to learn more about ObGFirst

Learn More
Leaving ObG Website

You are now leaving the ObG website and on your way to PRIORITY at UCSF, an independent website. Therefore, we are not responsible for the content or availability of this site