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COVID-19 Clinical Features

COVID-19 Vaccination Does Not Decrease Sperm Counts

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BACKGROUND AND PURPOSE:

  • COVID-19 vaccine hesitancy can be due to concerns about the negative impact of vaccines on fertility
  • Gonzales et al. (JAMA, 2021) assessed sperm parameters before and after mRNA vaccine administration

METHODS:

  • Prospective study
  • Participants
    • Individuals aged 18 to 50 years
    • Scheduled for mRNA COVID-19 vaccination with no underlying fertility issues
    • Exclusion: Men with a positive COVID-19 test result within 90 days
  • Exposures
    • mRNA COVID-19 vaccination
  • Study design
    • Recruited men provided semen samples at two time points
      • Prior to vaccination (after 2 to 7 days of abstinence)
      • ~70 days after the second dose of vaccination
    • Semen analyses were performed per WHO guidelines and included
      • Semen volume
      • Sperm concentration
      • Sperm motility
      • Total motile sperm count (TMSC)
    • Wilcoxon rank sum test was used to compare pre- and postvaccination semen parameters

RESULTS:

  • 45 men
    • Median (IQR) age: 28 (25 to 31) years
    • Received Pfizer: 46.7%
    • Received Moderna: 53.3%
  • Baseline sperm count values
    • Median sperm concentration: 26 million/mL (IQR, 19.5 to 34)
    • TMSC: 36 million (IQR, 18 to 51)
  • After the second vaccine dose, the median sperm counts increased
    • Sperm concentration: 30 million/mL (IQR, 21.5 to 40.5); P=0.02
    • TMSC: 44 million (IQR, 27.5 to 98); P=0.001
  • Semen volume and sperm motility also significantly increased
  • No men became azoospermic after vaccination

CONCLUSION:

  • Healthy men who received COVID-19 mRNA vaccines did not experience decreases in any sperm parameter
  • Magnitude of increase in sperm count values was within normal variation
  • The authors state

Because the vaccines contain mRNA and not the live virus, it is unlikely that the vaccine would affect sperm parameters

Learn More – Primary Sources:

Sperm Parameters Before and After COVID-19 mRNA Vaccination

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Related ObG Topics:

More Evidence that Fertility is Unaffected by COVID-19 Vaccination
Do Menstrual Cycle Changes Occur Following SARS-CoV-2 Infection?
Is There Any Evidence of a Link Between COVID-19 Vaccines and Spontaneous Abortion?

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