2021 Updated Cochrane Review: Does Calcium Supplementation Reduce Blood Pressure?
BACKGROUND AND PURPOSE:
Several studies have found a link between increased calcium levels and reduced blood pressure
In this update to a 2015 review, Cormick et al. (Cochrane Database of Systematic Reviews, 2021) assessed the efficacy and safety of calcium supplementation versus placebo/control for reducing blood pressure in normotensive people and for the prevention of primary hypertension
Update to a systematic review and meta-analysis
Randomized and quasi-randomized controlled trials
Studies that included normotensive people and provided dietary calcium interventions such as
Supplementation (pills, tablets or sprinkle powder)
GRADE criteria used to assess the certainty of evidence
Hypertension: BP ≥140/90 mmHg)
Blood pressure measures
20 trials (18 in meta-analysis) | 3512 participants (3140 in meta-analysis)
New trials included in update: 4
Calcium interventions had a significant reduction effect on systolic and diastolic blood pressure
Mean difference (MD) ‐1.37 mmHg (95% CI, ‐2.08 to ‐0.66)
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Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information
presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
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