Vaccine effectiveness was similar in subgroups defined according to a
Age (<50 years or ≥50 years)
Race and ethnic group
Presence of underlying conditions
Level of patient contact
Evidence of waning vaccine effect assessed in 2 week intervals after receipt of second dose
Lower during weeks 9 through 14 than during weeks 3 through 8 after receipt of the second dose, but large overlapping CIs
During the study period, vaccine effectiveness in health care personnel for both the Pfizer and Moderna COVID-19 vaccines was high (~89% for Pfizer and ~96% for Moderna)
Vaccine effectiveness was similarly high for adults of different ages, races/ethnicities, and with underlying conditions
The authors state
In this population of health care personnel, vaccine effectiveness was similar among persons with underlying medical conditions or other risk factors for severe Covid-19, including pregnancy; in different subgroups of health care personnel defined according to job category; and in racial and ethnic groups that have been disproportionately affected by the pandemic
The long-term duration of protection and the effectiveness of these vaccines against emerging variants is unknown and should be monitored to indicate whether changes to vaccine composition or vaccine policy are needed
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