Pregnancy Outcomes in Women with Budd-Chiari Syndrome
BACKGROUND AND PURPOSE:
Budd-Chiari syndrome (obstruction of the hepatic venous outflow caused by thrombosis of the hepatic veins or proximal IVC) and portal vein thrombosis are unusual manifestations of venous thromboembolism
Wiegers et al. (BJOG, 2021) evaluated current practice and outcomes of pregnancy in women with Budd-Chiari syndrome and/or portal vein thrombosis
Multicenter retrospective cohort study
Women who conceived in the study period after a diagnosis of Budd-Chiari syndrome and/or portal vein thrombosis
Live birth rate
Maternal, neonatal, and obstetric complications
45 women | 76 pregnancies
Budd-Chiari syndrome: 12 women
Portal vein thrombosis: 33 women
Presence of underlying prothrombotic disorders: 51%
Received low-molecular-weight heparin during pregnancy: 84%
Women with a previous diagnosis of Budd-Chiari syndrome experienced a high percentage of live births at term
There were also fewer than expected major maternal or neonatal morbidities
However, a multidisciplinary approach with individualized care is still required to optimize outcomes
The authors conclude
The high number of term live births and lower than expected rate of pregnancy-related maternal and foetal morbidity in our small cohort indicate that there is no absolute contra-indication for pregnancy in patients with Budd-Chiari syndrome and/or portal vein thrombosis
OBG Project CME requires a modern web browser (Internet Explorer 10+, Mozilla Firefox, Apple Safari, Google Chrome, Microsoft Edge). Certain educational activities may require additional software to view multimedia, presentation, or printable versions of their content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Flash, Apple QuickTime, Adobe Acrobat, Microsoft PowerPoint, Windows Media Player, or Real Networks Real One Player.
Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information
presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
Jointly provided by
NOT ENOUGH CME HOURS
It appears you don't have enough CME Hours to take this Post-Test. Feel free to buy additional CME hours or upgrade your current CME subscription plan