Povidone iodine was associated with a lower rate of
Infectious morbidity (P=0.01)
Povidone iodine: 3.0%
Urinary tract infection (P=0.03)
Povidone iodine: 1.1%
Emergency department visits (P=0.01)
Povidone iodine: 7.9%
With povidone iodine, there were also non-significant trends for
Lower rates of SSI (P=0.07)
Povidone iodine: 2.0%
Lower rates of reoperation (P=0.18)
Povidone iodine: 1.6%
In this propensity-matched analysis, povidone iodine for vaginal preparation before hysterectomy was associated with fewer infectious postoperative outcomes vs chlorhexidine
The absolute differences are sufficiently small (approximately 1%) that in the case of iodine allergy, chlorhexidine is an option
The authors state
In contrast to recent AAGL guidelines recommending the use of CHG for vaginal preparation, in this PSM analysis, we found that vaginal preparation with PI is more efficacious than CHG at reducing postoperative infectious morbidity and hospital utilization rates after hysterectomy
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