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COVID-19 Testing

What is the SARS-CoV-2 Re-Infection Rate in the General Population?

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BACKGROUND AND PURPOSE:

  • Qureshi et al. (Clinical Infectious Diseases, 2021) determined the rate of SARS-CoV-2 re-infection, associated factors, and the mortality rate in patients with previous SARS-CoV-2 infection

METHODS:

  • Cohort study
  • Population
    • Presence of SARS-CoV-2 infection
    • Patients who received serial tests between December 2019 and November 2020
  • Study design
    • Definitions
      • Re-infection: 2 positive tests separated by an interval of >90 days after resolution of first infection
      • Resolution of infection: ≥2 consecutive negative tests
    • Logistic regression used to analyze covariates, including demographic and clinical characteristics

RESULTS:

  • 9,119 patients
  • Re-infection rate
    • 0.7% (95% CI, 0.5 to 0.9%); n=63
  • Mean period between two positive tests
    • 116 (SD 21) days
  • Factors associated with re-infection
    • Asthma
      • Odds ratio (OR) 1.9 (95% CI, 1.1 to 3.2)
    • Nicotine dependence/tobacco use
      • OR 2.7 (95% CI, 1.6 to 4.5)
  • Compared to the primary infection, these patients’ re-infections had a lower rate of
    • Pneumonia
    • Heart failure
    • Acute kidney injury
  • Mortality rate
    • 3.2% (2 deaths)

CONCLUSION:

  • In this large cohort of patients with a previous SARS-CoV-2 infection, re-infection occurred at low rate (0.7%)
  • The secondary infection was associated with milder disease, though there was associated mortality
  • The authors state

Our observations strongly suggest that survivors from SARS-CoV-2 infection must not relax compliance with proven interventions in prevention of SARS-CoV-2 transmission such as social distancing and universal face mask use 

Learn More – Primary Sources:

Re-infection with SARS-CoV-2 in Patients Undergoing Serial Laboratory Testing

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Related ObG Topics:

Does SARS-CoV-2 Infection Provide Protection Against Reinfection?
How Common is SARS-CoV-2 Reinfection among Healthcare Workers with Antibodies?
SARS-CoV-2 Antibody Levels in Healthcare Personnel Decreased Over 60 Days

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