When started at 14–28 weeks of pregnancy, all three ART regimens studied in this trial led to high rates of virological suppression
…the results of this trial showed that the efficacy and safety of dolutegravir-containing ART regimens observed in non-pregnant adults are also evident when started in pregnancy
These findings affirm the WHO recommendation to use dolutegravir in all populations, including in pregnant women, and suggest that dolutegravir, emtricitabine, and tenofovir alafenamide fumarate might be preferred
Efficacy and safety of dolutegravir with emtricitabine and tenofovir alafenamide fumarate or tenofovir disoproxil fumarate, and efavirenz, emtricitabine, and tenofovir disoproxil fumarate HIV antiretroviral therapy regimens started in pregnancy (IMPAACT 2010/VESTED): a multicentre, open-label, randomised, controlled, phase 3 trial
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