Fewer pregnancy losses: RR 0.69 (95% CI, 0.50 to 0.95)
Increased live births: RR 1.33 (95% CI, 1.08 to 1.64)
Delayed postconception initiation of low-dose aspirin therapy led to a reduction in the estimated effects especially for pregnancy loss
6 weeks after conception: RR 0.70 (95% CI, 0.47 to 1.04)
10 weeks after conception: RR 0.93 (95% CI, 0.65 to 1.33)
Live birth: Effects were greater if treatment initiated before conception and continued throughout pregnancy vs starting aspirin >6 weeks
Effects were obtained if participants adhered at a minimum of 4 days per week
In this study based on the EAGeR RCT, women with 1 to 2 previous losses who were adherent in their use of low dose aspirin for at least 4 days per week had an increase in live births greater than 30% vs placebo in subsequent pregnancy
In addition, the authors conclude
Our study is the first to our knowledge to shed light on the optimal timing of LDA therapy, suggesting maximum benefits by initiating treatment before and early in pregnancy
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