Live birth rate was higher following fresh embryo transfer vs cryopreserved-thawed embryo transfer
Absolute difference 12.6% (95% CI, 11.7% to 13.5%)
Adjusted relative risk (aRR) 1.42 (95% CI, 1.39 to 1.46)
Clinical pregnancy rates were higher following fresh embryo transfer
Absolute difference 12.5% (95% CI, 11.6% to 13.4%)
aRR 1.34 (95% CI, 1.31 to 1.37)
Miscarriage rates were similar between the two groups
Absolute difference 0.2% (95% CI, −0.4% to 0.7%)
aRR 0.98 (95% CI, 0.91 to 1.07)
PGT-A did not impact outcomes
Compared to cryopreserved-thawed embryo transfer, fresh embryo transfer led to higher birth rates and clinical pregnancy rates among women undergoing assisted reproduction using freshly retrieved donor oocytes
Limitations of this study include missing data from the SART database and the potential for selection and confounding bias
The authors note that while reporting on obstetrical outcomes was beyond the scope of this study
Use of donor oocytes independently increases the risk of preeclampsia, and whether this is in part due to the type of uterine preparation needs to be elucidated in future studies
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