Screening, data extraction and quality assessment conducted by 2 independent reviewers
1,027,918 total deliveries
21 studies | 428 pregnancies with vasa previa
Included studies were at low risk of bias
Vasa previa incidence
0.46 cases per 1000 deliveries
Prevalence of risk factors in vasa previa cases
61.5% (95% CI, 53.0% to 70.0%)
Velamentous cord insertion
52.2% (95% CI, 39.6% to 64.7%)
Bilobed or succenturiate lobed placenta
33.3% (95% CI, 20.9% to 45.7%)
Use of IVF
26.4% (95% CI, 16.0% to 36.8%)
8.92% (95% CI, 5.33% to 12.5%)
Vasa previa is relatively rare, with 0.46 cases out of every 1000 pregnancies
The authors suggest that while targeted risk factor strategies may be appropriate (e.g. all women undergoing IVF)
The high prevalence of known risk factors in cases of vasa previa identified in our study makes it difficult not to offer screening for vasa previa at the time of midtrimester anatomy ultrasound scan, which is routinely performed in most high-resource countries
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