This activity is intended for healthcare providers delivering care to women and their families.
After completing this activity, the participant should be better able to:
1. Describe the results from the Qui et al. (JAMA Pediatrics, 2020) study that looked at epidural exposure during labor and association with autism spectrum disorders
2. Discuss the limitations of this study
Estimated time to complete activity: 0.25 hours
Postgraduate Institute for Medicine (PIM) requires faculty, planners, and others in control of educational content to disclose all their financial relationships with ineligible companies. All identified conflicts of interest (COI) are thoroughly vetted and mitigated according to PIM policy. PIM is committed to providing its learners with high quality accredited continuing education activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.
The PIM planners and others have nothing to disclose. The OBG Project planners and others have nothing to disclose.
Faculty: Ashley Comfort, MD, has a financial interest in Pfizer and has no other conflicts of interest to disclose.
Planners and Managers: The PIM planners and managers, Trace Hutchison, PharmD, Samantha Mattiucci, PharmD, CHCP, Judi Smelker-Mitchek, MBA, MSN, RN, and Jan Schultz, MSN, RN, CHCP have nothing to disclose.
Fees for participating and receiving CME credit for this activity are as posted on The ObG Project website. During the period from 3/31/2022 through 3/31/2024, participants must read the learning objectives and faculty disclosures and study the educational activity.
If you wish to receive acknowledgment for completing this activity, please complete the test and evaluation. Upon registering and successfully completing the test with a score of 100% and the activity evaluation, your certificate will be made available immediately.
In support of improving patient care, this activity has been planned and implemented by the Postgraduate Institute for Medicine and The ObG Project. Postgraduate Institute for Medicine is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Postgraduate Institute for Medicine designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
The maximum number of hours awarded for this Continuing Nursing Education activity is 0.25 contact hours.
Designated for 0.1 contact hours of pharmacotherapy credit for Advance Practice Registered Nurses.Read Disclaimer & Fine Print
ACOG, MFM, Society for Obstetric Anesthesia and Perinatology, American Society for Anesthesiologists and the Society of Pediatric Anesthesia have released a joint statement in response to a retrospective study (Qui et al. JAMA Pediatrics, 2020) that suggests an association between epidural anesthesia and autism. The joint statement states that this study “…does not provide credible scientific evidence that labor epidurals for pain relief cause autism.”
…our findings should be interpreted with caution given the wide varieties of LEA practice and cannot be interpreted as a demonstration of a causal link between LEA exposure and subsequent development of ASD
Joint Statement by Professional Societies
…if anything, epidurals improve maternal and neonatal outcomes
…five medical societies that represent more than 100,000 physicians want to assure the public that an association between a mother’s use of epidural analgesia during childbirth, and her infant’s risk of developing autism does not imply causation
Millions of women worldwide benefit from epidural pain relief every year and give birth without any complications to mother or baby
Royal College of Anaesthetists
…one of the surprising aspects of this study is lack of data about pregnancy and delivery complications which are known to increase the risk of autism
Such complications as prolonged duration of labour, fetal distress, fetal malposition and assisted vaginal delivery are also known to be associated with an increased request rate for epidurals. It is possible therefore that birth complications are actually the hidden factor linking epidurals and autism
Association Between Epidural Analgesia During Labor and Risk of Autism Spectrum Disorders in Offspring (Qui et al. JAMA Pediatrics, 2020)
Joint Statement of the Society for Obstetric Anesthesia and Perinatology, American Society of Anesthesiologists, Society for Pediatric Anesthesia, American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine: Labor epidurals do not cause autism; Safe for mothers and infants, say anesthesiology, obstetrics, and pediatric medical societies
Position Statement from the Canadian Anesthesiologists’ Society (CAS), the Society for Obstetrics and Gynecology of Canada (SOGC), and the Canadian
Paediatric Society (CPS): Lack of evidence that epidural pain relief during labour causes autism spectrum disorder
Royal College of Anaesthetists: No evidence that labour epidurals cause autism
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This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information
presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
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