What is the Seroprevalence of SARS-CoV2-2 Antibodies in Patients on Labor and Delivery?
BACKGROUND AND PURPOSE:
Haizler-Cohen et al. (AJOG, 2020) report on the seroprevalence of antibodies against SARS-CoV-2 in women admitted for labor and delivery
Seven hospitals in New York State (May 27 to July 24, 2020)
Women admitted to labor and delivery (L&D) who had their blood drawn for SARS-CoV-2 IgG antibodies
IgG titers were reported as either positive, negative, or equivocal
False positive rate of antibody test: 0.2%
Secondary to cross-reactivity with cytomegalovirus, Epstein-Barr virus and systemic lupus erythematosus
False negative rate unknown
May be secondary to testing before seroconversion or waning antibody levels over time
All women admitted to L&D also underwent universal RT-PCR testing for SARS-CoV-2
1671 women included in the study
18.9% of these women were also positive via RT-PCR testing
In this cohort of pregnant women, 16.1% had antibodies against SARS-CoV-2
This is likely a reflection of high prevalence of the virus in New York State
The authors conclude
Universal testing on L&D represents a unique opportunity to continuously study 105 exposure to SARS-CoV-2 in the population
Further research is necessary to determine the antibody response to SARS116 CoV-2 in pregnant women, its accuracy and its significance for the management of 117 seropositive pregnant women and their fetuses
OBG Project CME requires a modern web browser (Internet Explorer 10+, Mozilla Firefox, Apple Safari, Google Chrome, Microsoft Edge). Certain educational activities may require additional software to view multimedia, presentation, or printable versions of their content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Flash, Apple QuickTime, Adobe Acrobat, Microsoft PowerPoint, Windows Media Player, or Real Networks Real One Player.
Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information
presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
Jointly provided by
NOT ENOUGH CME HOURS
It appears you don't have enough CME Hours to take this Post-Test. Feel free to buy additional CME hours or upgrade your current CME subscription plan