Compared with OCs, the following were associated with an increased risk of treatment escalation from topical acne medications to an oral tetracycline class antibiotic
HR 1.44 (95% CI, 1.00 to 2.06)
HR 1.34 (95% CI, 1.10 to 1.64)
The authors point out that absolute differences between contraceptive methods and incidence of clinical acne encounters were small (<1%)
Furthermore, the authors state that
…some of the observed associations in other studies between noncombined OC contraception classes and acne may be due to prior discontinuation of combined OCs before starting the noncombined OC contraception method, and that overall, large differences in the risk of acne between contraceptive classes are unlikely
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