• About Us
    • Contact Us
    • Login
    • ObGFirst
  • COVID-19
  • Alerts
  • OB
  • 2T US Atlas
  • The Genome
  • GYN
    • GYN
    • Sexual Health
  • Primary Care
  • Your Practice
  • #GrandRounds
  • My Bookshelf
  • Now@ObG
  • Media
About Us Contact Us Login ObGFirst
  • COVID-19
  • Alerts
  • OB
  • 2T US Atlas
  • The Genome
  • GYN
    • 0 CME Hours
    • GYN
    • Sexual Health
  • Primary Care
  • Your Practice
  • #GrandRounds
  • My Bookshelf
  • Now@ObG
  • Media
#Grand Rounds

Is HBV Infection A Risk Factor for Developing Gestational Diabetes?

image_pdfFavoriteLoadingFavorite

BACKGROUND AND PURPOSE:

  • Evidence is conflicting as to whether chronic hepatitis B virus infection (HBV) may be associated with gestational diabetes mellitus (GDM)
    • Results have tended to show a positive relationship in populations more prone to GDM (e.g. Chinese, and Asian ethnicity)
  • Giles et al. (BJOG, 2020) sought to ascertain if GDM was more common in women with chronic HBV in a non-Asian population

METHODS:

  • Cross-sectional study
  • Participants
    • All singleton births in Victoria, Australia between 2009 and 2017
  • Study design and data analysis
    • Regression analysis was used to determine whether GDM is more common in women with HBV than in women without HBV
    • Results were adjusted to account for other GDM risk factors (i.e. maternal BMI, region of birth, maternal age, smoking and parity)
  • Primary outcome
    • Risk for GDM diagnosis in women with and without chronic HBV infection
    • Risks comparing women with chronic HBV Asian country of birth vs Australian born

RESULTS:

  • 670,944 patients included
    • GDM: 8.2%
    • Hepatitis B: 0.5%
  • The highest incidence of GDM was in women with HBV and BMI >40: 37.1%
  • Rate of GDM was higher in women with HBV (14.3%) vs without HBV (8.1%); P <0.001
  • Region of origin: HBV infection
    • Was associated with an increased incidence of GDM in women from low prevalence HBV regions (e.g. Southern and Eastern Europe) 
    • Not associated with increased incidence of GDM in women born in high prevalence regions (e.g. Southern, Central and Southeast Asia)
  • Incidence risk ratio (RR) for GDM for women with chronic HBV
    • (Unadjusted) RR: 1.75 (95% CI, 1.6 to 1.9)
    • Adjusted RR: 1.2 (95% CI, 1.1 to 1.3)

CONCLUSION:

  • HBV infection appears to be a risk factor for developing GDM
    • This association remained after adjustment for known GDM risk factors
  • The underlying mechanism is not well understood
    • One hypothesis is related to viral replication leading to increased insulin resistance due to elevated cytokine levels
  • The authors suggest that based on these findings

…women with HBV and a high BMI should have early screening, and interventions currently considered to be best practice, such as healthy diet, weight control and exercise, should be encouraged

Learn More – Primary Sources:

Chronic hepatitis B infection and the risk of gestational diabetes: a cross-sectional study

Now You Can Get ObG Clinical Research Summaries Direct to Your Phone, with ObGFirst

Try it Free  »

image_pdfFavoriteLoadingFavorite
< Previous
All #Grand Rounds Posts
Next >

Related ObG Topics:

What is the Effect of Hepatitis C on Fertility and Pregnancy Outcomes?
Are Travel Vaccines Safe During Pregnancy?
Screening for Sexually Transmitted Diseases – Who, When and How Often?

Sections

  • COVID-19
  • Alerts
  • OB
  • GYN
    • GYN
    • Sexual Health
  • 2T US Atlas
  • The Genome
  • Primary Care
  • Your Practice
  • #Grand Rounds
  • My Bookshelf
  • Now@ObG
  • Media

ObG Library

  • Hysteroscopy
  • Fertility
  • Site Map/
  • © ObG Project/
  • Terms and Conditions/
  • Privacy/
  • Contact Us/
© ObG Project
SSL Certificate


  • Already an ObGFirst Member?
    Welcome back

    Log In

    Want to sign up?
    Get guideline notifications
    CME Included

    Sign Up

Get Guideline Alerts Direct to Your Phone
Try ObGFirst Free!

Sign In

Lost your password?

Sign Up for ObGFirst and Stay Ahead

  • - Professional guideline notifications
  • - Daily summary of a clinically relevant
    research paper
  • - Includes 1 hour of CME every month

ObGFirst Free Trial

Log In to ObG First

Please log in to access OBGFirst and the 2T Ultrasound Atlas

Password Trouble?

Sign Up for ObGFirst

  • - Access 2T US Atlas
  • - Guideline notifications
  • - Daily research paper summaries
  • - And lots more!

ObG First Free Trial

Media - Internet

Computer System Requirements

OBG Project CME requires a modern web browser (Internet Explorer 10+, Mozilla Firefox, Apple Safari, Google Chrome, Microsoft Edge). Certain educational activities may require additional software to view multimedia, presentation, or printable versions of their content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Flash, Apple QuickTime, Adobe Acrobat, Microsoft PowerPoint, Windows Media Player, or Real Networks Real One Player.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information
presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Jointly provided by

NOT ENOUGH CME HOURS

It appears you don't have enough CME Hours to take this Post-Test. Feel free to buy additional CME hours or upgrade your current CME subscription plan

Subscribe

JOIN OBGFIRST AND GET CME/CE CREDITS

One of the benefits of an ObGFirst subscription is the ability to earn CME/CE credits from the ObG entries you read. Tap the button to learn more about ObGFirst

Learn More
Leaving ObG Website

You are now leaving the ObG website and on your way to PRIORITY at UCSF, an independent website. Therefore, we are not responsible for the content or availability of this site