1206 patients | 1217 specimens tested for SARS-CoV-2 and other respiratory pathogens
Positive for SARS-CoV-2: 9.5% (116 specimens)
Positive for another respiratory pathogen: 26.1% (318 specimens)
There was no difference in the rate of infection with non-SARS-CoV-2 pathogens between specimens positive and negative for SARS-CoV-2
COVID positive and positive for ≥1 additional pathogen: 20.7%
COVID negative but positive for ≥1 additional pathogen: 26.7%
Difference 6.0% (95% CI, –2.3% to 14.3%)
There was no difference in SARS-CoV-2 infection rates between specimens positive or negative for non–SARS-CoV-2 pathogens
≥1 non–SARS-CoV-2 pathogen positive and COVID positive: 7.5%
≥1 non–SARS-CoV-2 pathogen negative and COVID positive: 10.2%
Difference 2.7% (95% CI, –1.0% to 6.4%)
Most common co-infections
Respiratory syncytial virus: 5.2%
Non–SARS-CoV-2 Coronaviridae: 4.3%
Patients with co-infections did not differ significantly in age from those COVID positive only
COVID positive with co-infection (mean age): 46.9 years
COVID positive only (mean age): 51.5 years
Difference 4.2-years (95% CI, –4.8 to 13.2)
Co-infection rates in patients with COVID-19 are likely higher than originally reported
The authors caution against assuming a patient doesn’t have COVID due to the presence of another respiratory pathogen and further state
…these results suggest that routine testing for non–SARS-CoV-2 respiratory pathogens during the COVID-19 pandemic is unlikely to provide clinical benefit unless a positive result would change disease management (eg, neuraminidase inhibitors for influenza in appropriate patients)
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