Does Vitamin D Supplementation in Pregnancy Reduce the Risk of Enamel Defects in Children?
BACKGROUND AND PURPOSE:
Nørrisgaard et al. (JAMA Pediatrics, 2019) investigated whether vitamin D supplementation during the third trimester of pregnancy is associated with a lower risk of enamel defects and caries in offspring
Post hoc analysis of a double-blind, single-center RCT
The clinical trial was the Copenhagen Prospective Studies on Asthma in Childhood 2010 cohort (COPSAC2010)
Women recruited at 24 weeks gestation
Offspring dental exam at 6 years
Intervention (from 24 weeks GA to 1 week postpartum)
Vitamin D group: High-dose vitamin D3 (2400 IU/d)
Control group: matching placebo tablets
All women received 400 IU/d of vitamin D3 as part of standard care and therefore final comparison was 2800 IU/d vs 400 IU/d
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Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.
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presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
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