There were no significant differences identified for the following
Types of wound complications
Readmission or office or emergency department visits
Antibiotics prescribed for wound complications
Patient scar assessment scores of pain, stiffness, and irregularity
Tissue adhesive performed slightly better in regard to itchiness of scar and overall scar satisfaction
Based on above data at interim analysis, using conditional power analysis
Probability of showing a benefit with tissue adhesive was extremely low (6.2%)
Study was halted due to futility
Authors suggest that the reason tissue adhesive may work better to prevent infection in non-OB cases is that while it may be effective against skin microbes, it may not work as well against microorganisms arising from the genital tract
Limitations include the fact that the trial was unmasked and the incidence of wound complication was lower than anticipated (7.7% vs 10%)
Tissue adhesive with 2-octyl cyanoacrylate is unlikely to reduce risk of wound complications when used to close a cesarean Pfannenstiel incision
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