Does the Type of Dietary Fat Affect Mortality and Heart Disease in Individuals with Type 2 Diabetes?
BACKGROUND AND PURPOSE:
Cardiovascular disease is the leading cause of death in adults with diabetes
Current guidelines recommend that patients with diabetes limit their intake of saturated fatty acids, trans fats, and cholesterol, and consume more omega-3s
Recommendations based on general population with limited data from individuals with type 2 diabetes
Jiao et al. (BMJ, 2019) sought to determine the association between dietary fatty acids, CVD mortality, and total mortality among patients with type 2 diabetes
Prospective, longitudinal cohort study
Participants: Patients with type 2 diabetes
Females: Nurses’ Health Study (1980-2014)
Males: Health Professionals Follow-Up Study (1986-2014)
Dietary fat intake assessed using validated food frequency questionnaires
Updated every 2 to 4 years
11,264 participants included in the 2 cohorts
Mortality risk was calculated using hazard ratio (HRs) across quarters of PUFA intake (multivariate analysis model)
HR ratios for mortality trended down with increasing polyunsaturated fatty acids (PUFA) intake for both CVD mortality (P for trend=0.03) and total mortality (P for trend<0.001)
Inverse associations with total mortality were also observed for intakes of total PUFAs, marine n-3 PUFAs, and linoleic acid
Monounsaturated fatty acids of animal, but not plant, origin associated with a higher total mortality
Theoretical models: Substituting PUFAs for other fats (same calories) demonstrated that replacing 2% of energy from saturated fatty acids with total PUFAs or linoleic acid was associated with lower CVD mortality
Total PUFAs: 13% lower CVD mortality (HR 0.87, 95% CI, 0.77 to 0.99)
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This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.
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presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
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