In women without GDM there was an increased risk of cardiovascular disease found for the following groups vs ≤7.1 mmol/L on glucose challenge test (p=0.003)
Abnormal glucose result (≥7.8 mmol/L)
HR 1.94 (95% CI 1.29–2.92)
A result between 7.2 and 7.7 mmol/L
HR 1.65 (95% CI, 0.99–2.76)
The authors conclude that
The 1 hour post-challenge test glucose level is a continuous variable that was associated with future risk of cardiovascular disease in both the general obstetrical population and women without gestational diabetes
Development of type 2 diabetes would not explain these findings with such a short follow-up window
Rather, the challenge test likely reveals an underlying “high-risk cardiometabolic phenotype” early on
Glucose screening in pregnancy may identify future risk of CVD in women even without gestational diabetes
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