Can Azithromycin be Used as an Alternative to Erythromycin for PPROM?
BACKGROUND AND PURPOSE:
US PPROM recommendations (see ‘Related ObG
IV ampicillin [2 g every 6 hours] and
erythromycin [250 mg every 6 hours] for 48 hours followed by oral amoxicillin
[250 mg every 8 hours] and erythromycin base [333 mg every 8 hours] for an
additional 5 days (7 days total)
Azithromycin has the following benefits compared
Fewer side effects | Cheaper | Availability
Navathe et al. (AJOG, 2019) compared erythromycin
and azithromycin for PPROM
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Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information
presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
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