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Grand Rounds

Your Anemia Screening Test Fits in Your Pocket

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BACKGROUND AND PURPOSE:

  • Telehealth devices continue to improve, but are not yet able to replace invasive blood tests
  • Mannino et al. (Nature Communications, 2018) introduced a completely non-invasive, on-demand smartphone app that can estimate hemoglobin levels

METHODS:

  • App design that estimates hemoglobin levels by analyzing color and metadata of fingernail bed smartphone photos
    • Individual takes a picture of her fingernail beds
    • App prompts individual to tap regions of interest (individual nailbeds)
    • App algorithm analyzes the color of the nailbed to determine hemoglobin estimate
  • Anemia: Defined as hemoglobin levels <12.5 g dL

RESULTS:

  • Compared with ‘gold standard’ CBC, app detects anemia with an
    • Accuracy: ±2.4 g dL
    • Sensitivity: 97% (95% CI, 89–100%) s
  • With personalized calibration (to eliminate error due to subject-to-subject variability
    • Accuracy: ±0.92 g dL

CONCLUSION:

  • The app is viable to serve as a non-invasive anemia screening tool
  • Data can be transmitted and is device-agnostic
  • Authors conclude that the app can be used to monitor patients with chronic anemia

Learn More – Primary Sources:

Smartphone app for non-invasive detection of anemia using only patient-sourced photos


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