Is there any Link between Maternal Vaccinations and Infant Hospitalizations or Death? 6 Month Infant Follow-up
BACKGROUND AND PURPOSE:
Safety data for influenza and Tdap vaccines are reassuring for pregnancy complications
Birth outcomes have also been evaluated and are likewise encouraging, but limited beyond the immediate neonatal period
Sukumaran et al. (Pediatrics 2018) assessed whether maternal vaccinations have any impact on the risk of infant hospitalization or death in the first 6 months of life
Case control study
Data derived from Vaccine Safety Datalink (VSD) is a collaboration between the Centers for Disease Control and Prevention and 8 integrated health care systems with vaccination and health care data on ∼10 million persons per year
Singleton, live birth pregnancies
Patients and controls were matched 1:1
Exposure group: Influenza and Tdap vaccine in pregnancy
Infant hospitalizations and mortality in the first 6 months of life
Odds ratio (OR) calculated for maternal exposure
413,034 live births
25,222 infants were hospitalized
157 infants died in the first 6 months of life
There was no association between infant hospitalization and maternal immunization
Influenza: Adjusted OR 1.00; 95% CI, 0.96–1.04
Tdap: Adjusted OR 0.94; 95% CI: 0.88–1.01
There was no found association between infant mortality and maternal immunization
Influenza: Adjusted OR 0.96; 95% CI, 0.54–1.69
Tdap: Adjusted OR 0.44; 95% CI, 0.17–1.13
Maternal vaccinations for influenza or Tdap were not significantly associated with higher risk for infant hospitalization or mortality
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This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.
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