Natural History of CIN2 Lesions: Informing Practice Decisions
BACKGROUND AND PURPOSE:
CIN2 or higher on colposcopy guided biopsy is the cut-off point for treatment
Tainio et al. (BMJ, 2018) estimated the regression, persistence, and progression of untreated cervical intraepithelial neoplasia grade 2 (CIN2) lesions managed conservatively as well as compliance with follow-up protocols
Systematic review and meta-analysis
Studies reported on outcomes of histologically confirmed CIN2 in non-pregnant women, managed conservatively for ≥3 months
Primary outcomes at 3, 6, 12 , 24, 36, and 60 months
Rates of regression
Progression of CIN2
36 studies were included, totaling 3160 women
16 prospective cohorts
13 retrospective cohorts
50% of studies were at low risk of bias
Rate of non-compliance (at 6 to 24 months of follow-up) in prospective studies was approximately 10%
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Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.
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presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
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