Meta-analysis: Cerclage for Short Cervix but Without History of Preterm Birth
BACKGROUND AND PURPOSE:
Berghella et al. (Ultrasound in Obstetrics and Gynecology, 2017) have updated the previous individual patient-level data meta-analysis on the efficacy of cervical cerclage in the prevention of preterm birth (PTB) in asymptomatic singleton pregnancies with shortened cervical length (CL) and no previous history of PTB
Systematic review and meta-analysis of randomized controlled trials (RCTs)
Asymptomatic singleton pregnancies with
Short mid-trimester CL (< 25 mm) on transvaginal sonography
No prior history of spontaneous PTB
Meta-analysis of individual patient-level data was performed and merged into a master database
PTB< 35 weeks
PTB <37, <34, <23, <28 and 2<4 weeks
Gestational age delivery
Neonatal adverse outcomes (e.g., intraventricular hemorrhage, low birth weight, NICU stay and neonatal death)
419 asymptomatic singleton gestations were pooled from 5 RCTs and none received progesterone
224 (53.5%) cerclage (intervention group)
195 (46.5%) no cerclage (control)
No significant differences between groups were found in
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