Does pH-Balanced Vaginal Gel Improve Dyspareunia in Breast Cancer Survivors?
BACKGROUND AND PURPOSE:
Dyspareunia and sexual dysfunction often occur in breast cancer survivors following adjuvant therapy
Vaginal gels can be used as treatment for dyspareunia
This study by Kim et al. (Obstetrics & Gynecology, 2017) sought to determine if pH-balanced vaginal gel using allayed the symptoms of dyspareunia in breast cancer survivors who were premenopausal at the time of diagnosis
Randomized Controlled Trial
Breast cancer survivors, who were diagnosed when they were premenopausal, and who experienced dyspareunia, were included in the study
69 women were randomized to receive pH-balanced gel containing lactic acid
67 women were randomized to receive a lactate-free placebo gel
The gel was applied 3 times weekly before bed, as well as before intercourse, for eight weeks
Both groups demonstrated the following benefits although there were no differences between groups
Significant decrease in pain during intercourse
Significant improvement in overall Female Sexual Function Index score
Improvement in sexual dysfunction
In the pH-balanced group but not the placebo group:
Vaginal pH (indicator strip) decreased slightly (median from 6.5 to 5.5; P<.01)
Vaginal maturation index (sum of percentages of superficial cells, intermediate cells, and parabasal cells on smear) increased slightly (from 46.0 to 48.5; P<.01).
Neither group experienced severe adverse events
pH-balanced vaginal gel is no better than a placebo gel for improving sexual function and dyspareunia in breast cancer survivors who were premenopausal at time of diagnosis
OBG Project CME requires a modern web browser (Internet Explorer 10+, Mozilla Firefox, Apple Safari, Google Chrome, Microsoft Edge). Certain educational activities may require additional software to view multimedia, presentation, or printable versions of their content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Flash, Apple QuickTime, Adobe Acrobat, Microsoft PowerPoint, Windows Media Player, or Real Networks Real One Player.
Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information
presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
Jointly provided by
NOT ENOUGH CME HOURS
It appears you don't have enough CME Hours to take this Post-Test. Feel free to buy additional CME hours or upgrade your current CME subscription plan