Does Inositol Prevent GDM in Women with a Family History?
This study by Farren et al. (Diabetes Care, 2017) aimed to determine if inositol combined with myo-inositol and D-Chiro-inositol prevents gestational diabetes mellitus (GDM) in women with a family history of diabetes.
Randomized Controlled Trial (RCT)
240 pregnant women with a family history of diabetes were randomized to receive either a combination of 1,100 mg myo-inositol, 27.6 g D-Chiro inositol, and 400 mcg folic acid (treatment arm, n=120) or 400 mcg of folic acid (control arm, n=120). Treatment began at the first antenatal visit and an oral glucose tolerance test was performed between 24 and 28 weeks’ gestation. No statistically significant difference in rates of GDM were found between the two groups (23.3% in the treatment arm vs. 18.3% in the control arm), where P=0.34. The authors concluded that beginning inositol in early pregnancy did not prevent GDM in women with a family history of diabetes.
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