What are Reproductive Outcomes Among Cancer Survivors?
This study by Anderson et al. (JAMA Oncology, 2017) sought to determine if cancer diagnosis and treatment in adolescence and young adulthood (15-39 years of age) impairs reproductive outcomes for female cancer survivors.
Retrospective Cohort Study
2,598 live births born to adolescent and young adulthood (AYA) cancer survivors were compared to 1,299 randomly chosen births matched for maternal age and birth year. Outcomes compared included preterm birth, low birth weight, small-for-gestational age, C-sections, and low Apgar score (<7). AYA cancer survivors had significantly increased rates of preterm birth, low birth weight, and C-sections compared to the comparison cohort. These higher rates were most closely associated with intrapartum diagnoses. Cancers more highly associated with preterm birth and low birth weight included breast, gynecological cancers, and non-Hodgkin lymphoma. Rates of small for gestational age and low Apgar scores were not significantly different between the two groups. The authors suggest closer surveillance of AYA cancer survivors.
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