Do Neuraminidase Inhibitors Used for Flu Impact Neonatal Outcomes?
Neuraminidase inhibitors are antiviral drugs commonly used for the flu such as Oseltamivir (Tamiflu) or Zanamivir (Relenza). This study by Graner et al. (BMJ, 2017) aimed to explore any relationship associated with neuraminidase inhibitors and adverse neonatal outcomes, such as low birth weight, preterm birth, low Agpar score, stillbirth, neonatal mortality or morbidity, and congenital malformations.
Observational Cohort Study and Meta-Analysis
5,824 women who had taken neuraminidase inhibitors during pregnancy and 692,232 women who had not were surveyed along with their infants. Infants who had been exposed to neuraminidase inhibitors in utero did not have increased rates of any of the adverse neonatal outcomes or congenital malformations even when medication was taken in the first trimester. These findings are aligned with previous studies that likewise did not find an association between this class of drugs and adverse neonatal outcomes.
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