Is There a Causal Relationship Between HPV and Breast Cancer?
This study by Lawson et al. (Frontiers in Oncology, 2016) reviewed current data on the causality of HPV and breast cancer.
Expert Opinion Review
Human papilloma viruses (HPVs) are more frequent in breast cancers than benign breast and normal breast controls, and there is evidence to suggest that HPV could have a causal role in some breast cancers. This relationship is difficult to pin down because the HPV is very common, while HPV associated breast cancers are not. Furthermore, infection with HPV could precede development of cancer by years or decades. The authors also point out that unlike HPV-associated cervical cancer, rates of breast cancer are not increased among immunocompromised patients. Despite these reservations, there does appear to be a relationship between high-risk HPVs and breast cancer that may be indirect and may be causal in nature.
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