Do More Pregnancies Increase Risk of Atrial Fibrillation?
Increased number of pregnancies is associated with cardiovascular disease (CVD) risk. This study by Wong et al. (Circulation, 2017) sought to elucidate the relationship between parity and risk of atrial fibrillation (AF).
Prospective Cohort Study
The study was based on a previous Randomized Controlled Trial (RCT) that looked at aspirin to prevent CVD and colon cancer in generally healthy women who were ≥ 45 years of age. 34,639 who had agreed to participate in a follow up prospective cohort study and who met criteria were surveyed and provided annual updates of their obstetric and medical histories. The study found parity increased the risk of AF in a linear fashion even after adjustment of confounders.
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