ProMisE Study: Genetic Basis for Classifying Endometrial Cancer
This study by Talhouk et al. (Cancer, 2017) aimed to validate a new approach to diagnose and classify endometrial cancer (EC) using genetic information instead of morphology, which remains prone to diagnostic irreproducibility.
Retrospective validation trial
319 EC samples were analyzed using immunohistochemistry and sequencing in order to classify different types of tumors. Their technique, Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE) combines mutation and protein expression analyses. When compared to current risk-stratification systems (the European Society of Medical Oncology [ESMO]), the ProMisE system proved to be better at discriminating potential outcomes in endometrial cancer.
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