Early-Onset Menopause – Increased Risk of Cardiovascular Disease?
This study by Muka et al. (JAMA Cardiology, 2016) sought to determine if women who experienced early-onset menopause (younger than 45 years of age) had a higher risk of cardiovascular disease (CVD) and all-cause mortality.
Systematic Review and Meta-Analysis
32 studies that included 310,329 women were analyzed. This meta-analysis found that women who were younger than 45 years of age at onset of menopause had a higher risk for coronary heart disease (CHD), CVD mortality, and overall mortality than woman who were 45 or older at the onset of menopause. The authors also analyzed women who were between 50 and 54 years at onset of menopause. Compared to women under 50 years of age, this cohort had a decreased risk of fatal CHD but no affect was found with respect to stroke.
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