Ospemifene is an oral medication that is indicated for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause.
Topical estrogen is considered a first line therapy for post-menopausal atrophy. However, there are situations where some women in consultation with their provider may choose not to use local estrogen. According to the FDA, there is insufficient data to use ospemifene in women with breast cancer. While there do not appear to be any cases of ospemifene causing endometrial cancer, a potential risk for this particular malignancy is mentioned in a boxed warning, and surveillance for any signs of endometrial hyperplasia such as irregular uterine bleeding is recommended.
Menopausal Symptoms and Their Management
FDA: Osphena (ospemifene) prescribing information
Effects of ospemifene on bone parameters including clinical biomarkers in postmenopausal women
Ospemifene: A Novel Oral Therapy for Vulvovaginal Atrophy of Menopause
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