Evidence-Based. Clearly Delivered.
Evidence-Based. Clearly Delivered.
Bupropion for sexual dysfunction can be helpful when the patient’s concerns are arousal and orgasm. Bupropion is not indicated for sexual desire problems that do not include issues with arousal and orgasm.
Bupropion, a norepinephrine-dopamine reuptake inhibitor, is commonly used and has been approved for depression and smoking cessation. Following multiple studies, it is also used off-label for the treatment of HSDD. While dopamine is often associated with addiction and craving, it is also effective in aiding the access of pleasurable response. Data from studies in individuals who are not depressed indicate that the drug is useful in the setting of orgasmic dysfunction, separate from antidepressive properties it may have.
ISSWSH Expert Consensus Panel Review: Hypoactive Sexual Desire Disorder
Effect of Bupropion-SR on Orgasmic Dysfunction in Nondepressed Subjects: A Pilot Study
Disorders of Orgasm in Women: A Literature Review of Etiology and Current Treatments
Cochrane Review: Strategies for managing sexual dysfunction induced by antidepressant medication
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