RCT Results: Does Molnupiravir Help Prevent COVID-19 Related Hospitalizations and Deaths?
BACKGROUND AND PURPOSE:
Butler et al. (The Lancet, 2022) determined whether the addition of molnupiravir to usual care reduced hospital admission and deaths associated with COVID-19 in vaccinated patients at increased risk of poor COVID-19 outcomes
Prospective multicenter, open-label randomized controlled trial (UK based PANORAMIC trial)
≥50 years or ≥18 years with relevant comorbidities
Confirmed COVID-19 for ≤5 days upon recruitment
800 mg molnupiravir twice daily for 5 days plus usual care
Usual care only
Randomization was 1:1
Age (<50 years vs ≥50 years)
Vaccination status (yes vs no)
COVID-19 outcomes were tracked via a self-completed online daily diary for 28 days
All-cause hospitalization or death within 28 days of randomization
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Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
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presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
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