• About Us
    • Contact Us
    • Login
    • ObGFirst
  • COVID-19
  • Alerts
  • OB
  • 2T US Atlas
  • The Genome
  • GYN
    • GYN
    • Sexual Health
  • Primary Care
  • Your Practice
  • GrandRounds
  • My Bookshelf
  • Now@ObG
  • Media
About Us Contact Us Login ObGFirst
  • COVID-19
  • Alerts
  • OB
  • 2T US Atlas
  • The Genome
  • GYN
    • GYN
    • Sexual Health
  • Primary Care
  • Your Practice
  • GrandRounds
  • My Bookshelf
  • Now@ObG
  • Media
COVID-19 Management

Do Unvaccinated Children Indirectly Benefit from Parents Vaccinated Against COVID-19?

image_pdfFavoriteLoadingFavorite

BACKGROUND AND PURPOSE:

  • Hayek et al. (Science, 2022) estimated the protection provided to children through parental vaccination with the Pfizer vaccine

METHODS:

  • Retrospective cohort study
  • Population
    • Households composed of two spouses
    • Both spouses within the 25 to 80 year range
    • Children under the minimal age of vaccine eligibility
  • Exposures
    • 0, 1 or 2 fully vaccinated parents
      • In the later period of this study, full vaccination included a booster
  • Study design
    • There were two study periods
      • Early: January 2021 through March 2021 (dominant strain Alpha, vaccination available to those 16 and older)
      • Late: July 2021 through September 2021 (dominant strain Delta, vaccination available to those 12 and older)
    • Vaccine effectiveness was defined as one minus the incidence rate ratio (VE=1-IRR) of one or two fully vaccinated parents vs no fully vaccinated parents
  • Primary outcomes
    • SARS-CoV-2 infection
    • Indirect vaccine effectiveness (VE)

RESULTS:

  • Population demographics
    • Early period
      • 400,733 unvaccinated children from 155,305 households who contributed 2,116,306 person-weeks of follow-up
    • Late period
      • 181,307 unvaccinated children from 76,621 households who contributed 1,089,191 person-weeks of follow-up
  • In the early period (Alpha dominant strain) vaccinated parents reduced the risk of infection in unvaccinated children
    • Single vaccinated parent: 26.0% reduced risk of infection
    • Two vaccinated parents: 71.7% reduced risk of infection
  • In the late period (Delta dominant strain), vaccinated parents still reduced the risk of infection for unvaccinated children
    • Single vaccinated parent:  20.8% reduced risk of infection
    • Two vaccinated parents: 58.1% reduced risk of infection

CONCLUSION:

  • Parental vaccination was shown to confer an indirect protection for unvaccinated children
  • The authors state

Indirect vaccine effects are mediated by two main mechanisms: First, by protecting potential contacts, vaccination reduces the likelihood that subjects will encounter an infectious individual

Second, vaccination may reduce the infectiousness of vaccinated individuals who do acquire the infection

Learn More – Primary Sources:

Indirect protection of children from SARS-CoV-2 infection through parental vaccination

Get Mobile-Friendly COVID-19 Research Summaries with ObGFirst

ObGFirst® – Try It Free! »

image_pdfFavoriteLoadingFavorite
< Previous
All COVID-19 Management Posts
Next >

Related ObG Topics:

COVID-19 Vaccination in Children Ages 5 to 11: Safety, Immunogenicity, and Efficacy Results
Real World COVID-19 Vaccine Effectiveness in Children 12 to 18 Years of Age
Does Living with Children Increase the Risk of SARS-CoV-2 Transmission and COVID-19 Hospitalization?

Sections

  • COVID-19
  • Alerts
  • OB
  • GYN
    • GYN
    • Sexual Health
  • 2T US Atlas
  • The Genome
  • Primary Care
  • Your Practice
  • Grand Rounds
  • My Bookshelf
  • Now@ObG
  • Media

Are you an
ObG Insider?

Get specially curated clinical summaries delivered to your inbox every week for free

  • Site Map/
  • © ObG Project/
  • Terms and Conditions/
  • Privacy/
  • Contact Us/
© ObG Project
SSL Certificate


  • Already an ObGFirst Member?
    Welcome back

    Log In

    Want to sign up?
    Get guideline notifications
    CME Included

    Sign Up

Get Guideline Alerts Direct to Your Phone
Try ObGFirst Free!

Sign In

Lost your password?

Sign Up for ObGFirst and Stay Ahead

  • - Professional guideline notifications
  • - Daily summary of a clinically relevant
    research paper
  • - Includes 1 hour of CME every month

ObGFirst Free Trial

Already a Member of ObGFirst®?

Please log in to ObGFirst to access the 2T US Atlas

Password Trouble?

Not an ObGFirst® Member Yet?

  • - Access 2T US Atlas
  • - Guideline notifications
  • - Daily research paper summaries
  • - And lots more!
ObGFirst Free Trial

Media - Internet

Computer System Requirements

OBG Project CME requires a modern web browser (Internet Explorer 10+, Mozilla Firefox, Apple Safari, Google Chrome, Microsoft Edge). Certain educational activities may require additional software to view multimedia, presentation, or printable versions of their content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Flash, Apple QuickTime, Adobe Acrobat, Microsoft PowerPoint, Windows Media Player, or Real Networks Real One Player.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information
presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Jointly provided by

NOT ENOUGH CME HOURS

It appears you don't have enough CME Hours to take this Post-Test. Feel free to buy additional CME hours or upgrade your current CME subscription plan

Subscribe

JOIN OBGFIRST AND GET CME/CE CREDITS

One of the benefits of an ObGFirst subscription is the ability to earn CME/CE credits from the ObG entries you read. Tap the button to learn more about ObGFirst

Learn More
Leaving ObG Website

You are now leaving the ObG website and on your way to PRIORITY at UCSF, an independent website. Therefore, we are not responsible for the content or availability of this site