RCT Results: Which COVID-19 Vaccines Can be Used for Boosters?
BACKGROUND AND PURPOSE:
Munro et al. (The Lancet, 2021) investigated the reactogenicity and immunogenicity of seven different COVID-19 vaccines as a third dose after two doses of ChAdOx1 nCov-19 (Oxford–AstraZeneca) or BNT162b2 (Pfizer–BioNtech)
Multicenter, randomized, controlled phase 2 trial
>30 years of age
No history of laboratory confirmed SARS-CoV-2 infection
Time from primary dosing
≥70 days post two doses of AstraZeneca or
≥84 days post two doses of Pfizer
Three groups (A, B, and C) across 18 sites
Within each group, participants were assigned an experimental vaccine as a third dose, or a control
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Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information
presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
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