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#Grand Rounds

How Common is SARS-CoV-2 Reinfection among Healthcare Workers with Antibodies?

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BACKGROUND AND PURPOSE:

  • Lumley et al. (NEJM, 2020) assessed the incidence of positive SARS-CoV-2 tests and symptomatic COVID-19 infections in health care workers who were seropositive for SARS-CoV-2 antibodies

METHODS:

  • Cohort study
  • Setting
    • Oxford University Hospitals in the UK
  • Participants
    • Seropositive and seronegative healthcare workers
  • Study design
    • Asymptomatic healthcare staff: Invited to participate in voluntary PCR testing every 2 weeks and serologic testing every 2 months (beginning April 23, 2020)
    • Follow-up: 31 weeks
    • Primary outcomes were analyzed according to antibody status | Calculations adjusted for age, reported gender, and changes in incidence over time
  • Primary outcome
    • PCR-positive SARS-CoV-2 test results
    • New symptomatic infections

RESULTS:

  • 12,541 healthcare workers (HCWs)
    • Baseline negative antibody results: 11,364 HCWs
    • Baseline positive antibody results: 1265 HCWs
  • Seronegative HCWs with a positive PCR test
    • Total: 223 HCWs (1.09 per 10,000 days at risk)
      • Asymptomatic at screening: 100 HCWs
      • Symptomatic at screening: 123 HCWs
  • Seropositive HCWs with a positive PCR test
    • Total: 2 HCWs (0.13 per 10,000 days at risk)
      • Both were asymptomatic when tested
    • Adjusted incidence rate ratio 0.11 (95% CI, 0.03 to 0.44; P=0.002)
    • There were no symptomatic infections in HCWs with antibodies

CONCLUSION:

  • SARS-CoV-2 reinfections in healthcare workers with antibodies were rare in the 31 weeks of follow-up
  • The authors state

No symptomatic infections and only two PCR-positive results in asymptomatic health care workers were seen in those with anti-spike antibodies, which suggests that previous infection resulting in antibodies to SARS-CoV-2 is associated with protection from reinfection for most people for at least 6 months.

Learn More – Primary Sources:

Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers

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Related ObG Topics:

SARS-CoV-2 Antibody Testing Among NYC Healthcare Personnel: How Many are Seropositive?
CDC Update: COVID-19 Infection Rate Among Healthcare Workers
How Long Does It Take for COVID-19 Patients to Develop Antibodies?

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