Thank you to Professor Jim Thornton, professor of Obstetrics and Gynaecology in Nottingham, author and NHS consultant, for permission to post his primary source research and case report updates here.
THE RISK OF DYING FROM COVID-19 IN PREGNANCY: Professor Thornton has provided a ‘must-read’ analysis of the estimated pregnancy mortality rate that can be attributed to infection with SARS-CoV-2. You can find his post here.
DISAMBIGUATION: In addition to a running list of all the primary scientific reports, Professor Thornton also has a ‘must-read’ post where he sorts out “the various hospitals and universities where reported cases of Covid-19 in pregnancy were treated…[this] needs to be done because some authors have submitted the same manuscripts to multiple journals, included previously reported cases in new case series without making this clear, or reported different aspects of the same cases in multiple papers.” You can find his post on this disambiguation here.
REGISTRIES: Professor Thornton also provides a list of “Covid-19 & pregnancy” registries, as well as of some regional groups who have reported data here.
All material is copied with permission; use of the first person refers to Dr Thornton.
You can follow Dr Thornton on Twitter.
This is not a source for advice on COVID-19. Neither professional nor lay. For that, in the US, CDC advice is here and NIH research updates here. In the UK, visit the government website here, or the RCOG here.
Nor is this a place to report cases. The US registry is here . UK cases should be reported to the UK Obstetric Surveillance System (UKOSS) (click here) via each NHS Trust’s local UKOSS reporter. Early pregnancy cases, including miscarriages & ectopic pregnancies, should also be reported there. There also is an international registry here.
However, some of the primary sources are confusing, in that hospitals overlap and pre-prints appear before full publication. There must be a risk of double counting. Below are links to, & brief notes on, the primary scientific reports in English on Covid-19 in pregnancy and childhood. They are in, roughly, reverse order. Click here for running totals from Jim Thornton’s Ripe-tomato blog
Studies 713 and 714 added.
Study 714 – 65 cases from Israel
From eight hospitals, so likely overlap with other Israeli studies (click here or study). Compared with 86 vaccinated pregnant women -see vaccine source 39. Citation: Beharier O, Plitman Mayo R, Raz T, Nahum Sacks K, Schreiber L, Suissa-Cohen Y, Chen R, Gomez-Tolub R, Hadar E, Gabbay-Benziv R, Jaffe Moshkovich Y, Biron-Shental T, Shechter-Maor G, Farladansky-Gershnabel S, Yitzhak Sela H, Benyamini-Raischer H, Sela ND, Goldman-Wohl D, Shulman Z, Many A, Barr H, Yagel S, Neeman M, Kovo M. Efficient maternal to neonatal transfer of antibodies against SARS-CoV-2 and BNT162b2 mRNA COVID-19 vaccine. J Clin Invest. 2021 May 20:150319. doi: 10.1172/JCI150319. Epub ahead of print. PMID: 34014840.
Study 713 – 68 cases from Bangladesh
These women were treated at Dhaka Medical College Hospital from March 15, to August 15, 2020 (click here or study). Two mothers died. This hospital, which disambiguates as Dhaka Medical College and Hospital grid.413674.3, has not previously reported cases. Citation: S. K. Jakaria Been Sayeed, Md. Mujibur Rahman, A. K. M. Humayon Kabir, Md. Moniruzzaman, Reaz Mahmud, Mohammad Abdullah Yusuf, Sabrina Rahman. Clinical, Laboratory Characteristics and Pregnancy Outcome of COVID-19 Patients Admitted in the Largest COVID Dedicated Hospital of Bangladesh. American Journal of Internal Medicine. Vol. 9, No. 1, 2021, pp. 11-16. doi: 10.11648/j.ajim.20210901.12 Cautionary note – American Journal of Internal Medicine is not on PubMed, but is listed as a predatory journal on Beall’s list. The publisher Science Publishing Group has an address in New York City but is actually based in Pakistan (click here).
Studies 710 to 712 added.
Study 712 – 1,347 cases from Spain
Collected by the 78 centers of the Spanish Obstetric Emergency Group between 26 February and 5 November 2020 (click here or study). Includes both the second wave in Spain, and a control group of unaffected women. Likely overlap with many other reports from Spain. Citation: Cruz Melguizo S, de la Cruz Conty ML, Carmona Payán P, Abascal-Saiz A, Pintando Recarte P, González Rodríguez L, Cuenca Marín C, Martínez Varea A, Oreja Cuesta AB, Rodríguez PP, Fernández Buhigas I, Rodríguez Gallego MV, Fernández Alonso AM, López Pérez R, Broullón Molanes JR, Encinas Pardilla MB, Ramírez Gómez M, Gimeno Gimeno MJ, Sánchez Muñoz A, Martínez-Pérez O, On Behalf Of The Spanish Obstetric Emergency Group S O E G. Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study. Viruses. 2021 May 7;13(5):853. doi: 10.3390/v13050853. PMID: 34067086; PMCID: PMC8151603. [important]
Study 711 – five cases from Indonesia
From Cipto Mangunkusumo General Hospital, Jakarta, and treated with remdesivir (click here or study). This hospital has not previously reported cases. Citation: Saroyo YB, Rumondang A, Febriana IS, Harzif AK, Irwinda R. Remdesivir Treatment for COVID 19 in Pregnant Patients with Moderate to Severe Symptoms: Serial Case Report. Infect Dis Rep. 2021 May 17;13(2):437-443. doi: 10.3390/idr13020042. PMID: 34067822; PMCID: PMC8162322.
Study 710 – 14 cases from Turkey
From Gungoren Hospital, Istanbul, which has not previously reported cases (click here or study). Citation: Yaman A, Kandemir I, Varkal MA. Infants infected with SARS-CoV-2 and newborns born to mother diagnosed with COVID-19: clinical experience. Ir J Med Sci. 2021 Jun 1:1–6. doi: 10.1007/s11845-021-02662-8. Epub ahead of print. PMID: 34075529; PMCID: PMC8169398.
Studies 708 and 709 added.
Study 709 – 64 cases from Italy
From Sacco Hospital and Buzzi Hospital in Milan, and at San Gerardo Hospital in Monza between March and August 2020 (click here or study). The cases are likely included in the various Lomabardy series. Citation: Chiara Tasca, Roberta Simona Rossi, Silvia Corti, Gaia Maria Anelli, Valeria Savasi, Federica Brunetti, Manuela Cardellicchio, Emilio Caselli, Cristina Tonello, Patrizia Vergani, Manuela Nebuloni, Irene Cetin, Placental pathology in COVID-19 affected pregnant women: A prospective case-control study. Placenta, Volume 110, 2021, Pages 9-15, ISSN 0143-4004, .
Study 708 – 55 cases from Israel
These first and second trimester cases were treated at Sheba Medical Center, Tel-Hashomer, between March 2020 and February 2021 (click here or study). Possible overlap with studies 330 and 449. Citation: Rosen H, Bart Y, Zlatkin R, Ben-Sira L, Ben Bashat D, Amit S, Cohen C, Regev-Yochay G, Yinon Y. Fetal and Perinatal Outcome Following First and Second Trimester COVID-19 Infection: Evidence from a Prospective Cohort Study. J Clin Med. 2021 May 16;10(10):2152. doi: 10.3390/jcm10102152. PMID: 34065646; PMCID: PMC8156528.
Studies 706 and 707 added.
Study 707 – 120 cases from Palestine
Collected by the Palestine Ministry of Health (click here or study). One mother died. The first reported cases from Palestine. Citation: Maraqa B, Al-Shakhra K, Alawneh M, Jallad R, Alkaila M. Demographic factors associated with COVID-19-related death in Palestine. Public Health Pract (Oxf). 2021 Nov;2:100145. doi: 10.1016/j.puhip.2021.100145. Epub 2021 May 18. PMID: 34027510; PMCID: PMC8129786.
Study 706 – 288 cases from Saudi Arabia
From King Fahad Medical City, Al-Yammamah, and Imam Abdulrahman Al-Faisal hospitals in Riyadh between March and November 2020 (click here or study). One mother and four babies died. This series likely includes cases in studies 554 and 608. Citation: Al-Matary A, Almatari F, Al-Matary M, AlDhaefi A, Alqahtani MHS, Alhulaimi EA, AlOtaiby S, Almehiny K, John LS, Alanazi FS, Azad A, Aldandan FK. Clinical outcomes of maternal and neonate with COVID-19 infection – Multicenter study in Saudi Arabia. J Infect Public Health. 2021 Apr 20;14(6):702-708. doi: 10.1016/j.jiph.2021.03.013. Epub ahead of print. PMID: 34020209; PMCID: PMC8056848.
Study 705 added.
Study 705 – 28 pregnant women in Recovery immune plasma trial
Tewnty eight pregnant women participated in the UK Recovery convalescent plasms trial (click here or study). Their group allocation was not reported. Citation: RECOVERY Collaborative Group. Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomized controlled, open-label, platform trial. Lancet. 2021 May 14:S0140-6736(21)00897-7. doi: 10.1016/S0140-6736(21)00897-7. Epub ahead of print. PMID: 34000257; PMCID: PMC8121538.
Study 704 added.
Study 704 – 52 cases from Japan
A web-survey of 624 hospitals in Japan identified 52 newborns born to mothers with confirmed SARS-CoV-2 infection (click here). One newborn tested positive. Citation: Morioka I, Toishi S, Kusaka T, Wada K, Mizuno K; committee of neonatal medicine in Japan Pediatric Society. Medical care of newborns born to mothers with confirmed or suspected severe acute respiratory syndrome coronavirus 2 infections in Japan. Pediatr Int. 2021 May 27. doi: 10.1111/ped.14855. Epub ahead of print. PMID: 34041810.
Studies 702 and 703 added.
Study 703 – 198 cases from Spain
From author affiliations collected by 11 pathology departments in Barcelona (click here or study). Probably overlap with studies 140, 185, 191, 235, 413, 417, 607, 635, and 695. Citation: Garrido-Pontnou, M., Navarro, A., Camacho, J. et al. Diffuse trophoblast damage is the hallmark of SARS-CoV-2-associated fetal demise. Mod Pathol (2021).
Study 702 – 7,950 cases from USA
Collected by the SET-NET consortium (click here or study). Citation: Romeo R Galang, Suzanne M Newton, Kate R Woodworth, Isabel Griffin, Titilope Oduyebo, Christina L Sancken, Emily O’Malley Olsen, Kathryn Aveni, Heather Wingate, Hanna Shephard, Chris Fussman, Zahra S Alaali, Kristin Silcox, Samantha Siebman, Umme-Aiman Halai, Camille Delgado Lopez, Mamie Lush, Ayomide Sokale, Jerusha Barton, Ifrah Chaudhary, Paul H Patrick, Levi Schlosser, Bethany Reynolds, Nicole Gaarenstroom, Sarah Chicchelly, Jennifer S Read, Leah de Wilde, Deborah Mbotha, Eduardo Azziz-Baumgartner, Aron J Hall, Van T Tong, Sascha Ellington, Suzanne M Gilboa, CDC COVID-19 Response Pregnancy and Infant Linked Outcomes Team, Risk factors for illness severity among pregnant women with confirmed SARS-CoV-2 infection – Surveillance for Emerging Threats to Mothers and Babies Network, 22 state, local, and territorial health departments, March 29, 2020 -March 5, 2021, Clinical Infectious Diseases, 2021;, ciab43.
Study 701 added.
Study 701 – 3,527 cases from UK
3,527 women who gave birth between 29th May 2020 and 31st 29 January 2021, and had a positive SARS-Cov-2 test, were compared with 338,553 women giving birth without (click here or study). They were identified using Hospital Episode Statistics, and will therefore overlap with UKOSS and most other UK reports over this time period. Citation: Ipek GUROL-URGANCI, Jennifer E. JARDINE, Fran CARROLL, Tim DRAYCOTT, George DUNN, Alissa FREMEAUX, Tina HARRIS, Jane HAWDON, Edward MORRIS, Patrick MULLER, Lara WAITE, Kirstin WEBSTER, Jan VAN DER MEULEN, Asma KHALIL. Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection at the time of birth in England: national cohort study. American Journal of Obstetrics and Gynecology,
2021. ISSN 0002-9378. [important]
Study 700 added.
Study 700 – 73 cases from USA
From MedStar Washington Hospital Center, Washington, District of Columbia. (click here). Citation: Chornock R, Iqbal SN, Wang T, Kodama S, Kawakita T, Fries M. Incidence of Hypertensive Disorders of Pregnancy in Women with COVID-19. Am J Perinatol. 2021 May 3. doi: 10.1055/s-0041-1727167. Epub ahead of print. PMID: 33940651.
Studies 697 to 699 added. Study 533 updated.
Study 699 – 20 cases from China
From Tongji Hospital in Wuhan between January 19 to April 20, 2020 (click here or study). Likely previously reported many times. Citation: Chen G, Liao Q, Ai J, Yang B, Bai H, Chen J, Liu F, Cao Y, Liu H and Li K (2021) Immune Response to COVID-19 During Pregnancy. Front. Immunol. 12:675476. doi: 10.3389/fimmu.2021.675476
Study 698 – 8,248 cases from Brazil
From the Brazilian official severe acute respiratory syndrome (SARS) surveillance system (click here or study). 803 mothers died. Likely overlap with studies 66, 138, 194, 201, 203, 248, 249 and 309. Citation: Maíra L S Takemoto, Marcos Nakamura-Pereira, Mariane O Menezes, Leila Katz, Roxana Knobel, Melania M R Amorim, Carla B Andreucci. Higher case fatality rate among obstetric patients with COVID-19 in the second year of pandemic in Brazil: do new genetic variants play a role? medRxiv 2021.05.06.21256651.
Study 697 – 145 cases from USA
Treated in a public healthcare system, in Santa Clara County, California from April 15, 2020 to March 31, 2021 (click here or study). Citation: Song D, Prahl M, Gaw SL, et al. Passive and active immunity in infants born to mothers with SARS-CoV-2 infection during pregnancy: Prospective cohort study. Preprint. medRxiv. 2021;2021.05.01.21255871. Published 2021 May 3. doi:10.1101/2021.05.01.21255871
Studies 693 to 696 added.
Study 696 – case report from USA
From Cedars‐Sinai Medical Center, Los Angeles, California (click here or study). Citation: Rushakoff JA, Polyak A, Caron J, et al. A case of a pregnant patient with COVID‐19 infection treated with emergency c‐section and extracorporeal membrane oxygenation. J Card Surg. 2021;1‐4.
Study 695 – two cases from Belgium
From author affiliations probably treated at Ghent University Hospital which has not previously reorted cases (click here or study). Citation: Libbrecht S, Van Cleemput J, Vandekerckhove L, Colman S, Padalko E, Verhasselt B, Van de Vijver K, Dendooven A, Dehaene I, Van Dorpe J. A rare but devastating cause of twin loss in a near-term pregnancy highlighting the features of severe SARS-CoV-2 placentitis. Histopathology. 2021 May 13. doi: 10.1111/his.14402. Epub ahead of print. PMID: 33982813.
Study 694 – 60 cases from Spain
This MedRxiv preprint describes lack of virus and presence of antibodies in breast milk (click here or study). Participants were recruited from 7 health centers from Valencia, Barcelona, Granada, and Zaragoza from April to December 2020 Citation: Christine Bauerl, Walter Randazzo, Gloria Sanchez, Marta Selma-Royo, Elia Garcia-Verdevio, Laura Martinez-Rodriguez, Anna Parra-Llorca, Carles Lerin, Victoria Fumado, Francesca Crovetto, Fatima Crispi, Francisco Jose Perez-Cano, Gerardo Rodriguez, Gema Ruiz-Redondo, Cristina Campoy, Cecilia Martinez-Costa, Maria Carmen Collado. SARS-CoV-2 RNA and antibody detection in human milk from a prospective multicenter study in Spain. medRxiv 2021.05.06.21256766.
Study 693 – 1,062 cases from USA
Cases and controls collected from the Premier Healthcare Database, an all-payer data repository that captures 20% of U.S. hospitalizations (click here). Citation: Pineles BL, Goodman KE, Pineles L, O’Hara LM, Nadimpalli G, Magder LS, Baghdadi JD, Parchem JG, Harris AD. In-Hospital Mortality in a Cohort of Hospitalized Pregnant and Nonpregnant Patients With COVID-19. Ann Intern Med. 2021 May 11. doi: 10.7326/M21-0974. Epub ahead of print. PMID: 33971101.
Study 692 added.
Study 692 – case report from the Netherlands
From Amsterdam Medical Centre (AMC) (click here or study). Citation: van Amesfoort JE, Werter DE, Painter RC, Hermans FJR. Severe metabolic ketoacidosis as a primary manifestation of SARS-CoV-2 infection in non-diabetic pregnancy. BMJ Case Rep. 2021 Apr 19;14(4):e241745. doi: 10.1136/bcr-2021-241745. PMID: 33875510.
Studies 690 and 691 added.
Study 691 – 2,824 cases from Canada
The 3rd report from the CanCovid registry includes cases up to 31 December 2020 (click study). 1,880 cases reported in detail. Overlap with studies 510 and 690. Citation: Deborah Money. CANADIAN SURVEILLANCE OF COVID-19 IN PREGNANCY: EPIDEMIOLOGY, MATERNAL AND INFANT OUTCOMES Report #3: Released February 25, 2021. School of Population & Public Health, University of British Colombia
Study 690 – 1,940 cases from Canada
The 2nd report from the CanCovid registry includes cases up to 30 November 2020 (click here or study). 1,271 cases repoted in detail. Overlap with study 510. Citation: Deborah Money. CANADIAN SURVEILLANCE OF COVID-19 IN PREGNANCY: EPIDEMIOLOGY, MATERNAL AND INFANT OUTCOMES Report #2: Released January 15, 2021. School of Population & Public Health, University of British Colombia
Study 689 added.
Study 689 – no hospital-acquired maternal infection in New York
Of 72 SARS-CoV-2 negative pregnant women admitted to New York Presbyterian Hospital/Columbia University Irving Medical Center between November 23, 2020 to March 3, 2021, none retested positive during their admission (click here or study). Citation: Zork NM, Markan A, Sheen J-J, AUBEY J, Saiman L, Goffman D, Serial Surveillance for SARS-CoV-2 in hospitalized antepartum women, American Journal of Obstetrics and Gynecology (2021).
Study 688 added.
Study 688 – 2,286 cases from Sweden
Collected from the National Swedish Pregnancy Register between March 11, 2020, and January 31, 2021 (click here or study). Baby outcomes compared with babies of all SARS-CoV-2 negative mothers, and with a matched control group. Probable overlap with studies 20, 88, 259b, 282, 298, 523, 588, 610 and 636. Citation: Norman M, Navér L, Söderling J, et al. Association of Maternal SARS-CoV-2 Infection in Pregnancy With Neonatal Outcomes. JAMA. Published online April 29, 2021. doi:10.1001/jama.2021.5775 [important]
Studies 686 & 687 added.
Study 687 – case report from Japan
From Toho University Omori Medical Center, Tokyo, which has not previously reported cases (click here or study). Citation: Ito A, Hayata E, Nakata M, Shigeta T, Nakamura Y, Kishi K, Yoda H, Morita M. Rapid recovery achieved by intensive therapy after preterm cesarean section for worsening COVID-19-induced acute respiratory failure: A case report and literature review. Case Rep Womens Health. 2021 Apr;30:e00315. doi: 10.1016/j.crwh.2021.e00315. Epub 2021 Apr 18. PMID: 33898274; PMCID: PMC8053357.
Study 686 – 105 cases from Spain
Collected from hospitals participating in the GESNEO-COVID cohort between 15 March & 31 July 2020 (click here or study). The hospitals include General Universitario Gregorio Marañón; Hospital Universitario Infanta Sofía; Hospital La Fe; Hospital Materno Infantil de Badajoz; Complejo Hospitalario de Navarra; Hospital Universitario de Albacete; Hospital Universitario Infanta Elena; Hospital Parc Taulí ; Hospital Universitario HM Montepríncipe; Hospital General de Albace; Complejo Hospitalario de Navarra; Hospital Universitario Infanta Leonor; Hospital San Pedro de Alcántara; Complejo Hospitalario de Santiago, and Hospital 12 de Octubre. Only the last appears to have previously reported cases. However that hospital in Madrid has reported cases in studies 151, 165, 196, 205, 458, 470, 583 and 635. Citation: Carrasco I, Muñoz-Chapuli M, Vigil-Vázquez S, Aguilera-Alonso D, Hernández C, Sánchez-Sánchez C, Oliver C, Riaza M, Pareja M, Sanz O, Pérez-Seoane B, López J, Márquez E, Domínguez-Rodríguez S, Hernanz-Lobo A, De León-Luis JA, Sánchez-Luna M, Navarro ML. SARS-COV-2 infection in pregnant women and newborns in a Spanish cohort (GESNEO-COVID) during the first wave. BMC Pregnancy Childbirth. 2021 Apr 26;21(1):326. doi: 10.1186/s12884-021-03784-8. PMID: 33902483.
Studies 684 & 685 added, 610 updated, & numbering from 650 corrected.
Study 685 – 240 cases from Mexico
Cared for at Instituto Nacional de Perinatologı´a Isidro Espinosa de los Reyes, (INPer), in Mexico City, between April 22 and May 25, 2020 (click here or study). This hospital has not previously reported cases although they likely overlap with other multicentre Mexican series. Citation: Cardona-Pérez JA, Villegas-Mota I, Helguera-Repetto AC, Acevedo-Gallegos S, Rodríguez-Bosch M, Aguinaga-Ríos M, Coronado-Zarco I, León-Juárez M, Aguilar-Ayala D, Valdespino-Vázquez MY, Moreno-Verduzco ER, Rivera MA, Valencia-Contreras C, Gómez-Sousa ML, Solis-Paredes M, Frías-Madrid B, Velasco-Téllez C, Rodriguez-Aldama JC, Avila-Sosa V, Galván-Contreras R, Figueroa-Damian R, Cortés-Bonilla M, Estrada-Gutierrez G, Espino-Y-Sosa S, Irles C. Prevalence, clinical features, and outcomes of SARS-CoV-2 infection in pregnant women with or without mild/moderate symptoms: Results from universal screening in a tertiary care center in Mexico City, Mexico. PLoS One. 2021 Apr 22;16(4):e0249584. doi: 10.1371/journal.pone.0249584. PMID: 33886590.
Study 684 – 250 cases from USA
255 neonates born to 250 mothers with Covid-19 between March 1 and July 31, 2020 (click here or study). Cared for at 11 hospitals in Massachusetts (Baystate; Beth Israel Deaconess; Beverly; Brigham & Women’s; Boston Medical Center; Cambridge Health Alliance; Massachusetts General; Newton-Wellesley; Tufts Children’s; UMass Memorial; Winchester). Probable overlap with studies 142, 231, 257, 262, 387, 488, 490, 519, 531, 550, 571, 577, 589, 591 and 606. Citation: Angelidou A, Sullivan K, Melvin PR, Shui JE, Goldfarb IT, Bartolome R, Chaudhary N, Vaidya R, Culic I, Singh R, Yanni D, Patrizi S, Hudak ML, Parker MG, Belfort MB. Association of Maternal Perinatal SARS-CoV-2 Infection With Neonatal Outcomes During the COVID-19 Pandemic in Massachusetts. JAMA Netw Open. 2021 Apr 1;4(4):e217523. doi: 10.1001/jamanetworkopen.2021.7523. PMID: 33890989.
Study 683 added.
Study 683 – 706 cases & 1,424 controls from the Intergrowth-21 consortium
For each case, two control pregnancies were selected (click here or study). Collected from 43 institutions in 18 countries. Although some institutions had previously reported cases, the authors “excluded women/neonates from the final analysis if their data were already published in any comparative study with women without COVID-19 diagnosis”, and list the overlapping papers. These are studies 92, 102, 140, 144, 150, 161, 232, 246, 252 and 488. Citation: Villar J, Ariff S, Gunier RB, et al. Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection: The INTERCOVID Multinational Cohort Study. JAMA Pediatr. Published online April 22, 2021. doi:10.1001/jamapediatrics.2021.1050 [important]
Study 682 added.
Study 682 – case report from Germany
A pregnant woman with Covid-19 deteriorated post-partum and required ventilation and ECMO (click here). From author affiliations she was cared for at Vivantes Klinikum im Friedrichshain in Berlin, which has not previously reported cases. Citation: Maier JT, Zickler D, Metz M, Jebens A, Jarchau U, Fischer J, Kimmel V, Prueter E, Hellmeyer L. Peripartum Covid-19 Pneumonia with Severe ARDS – A Case Report. Z Geburtshilfe Neonatol. 2021 Apr;225(2):183-187. doi: 10.1055/a-1365-9262. Epub 2021 Apr 19. PMID: 33873231.
Studies 676 to 681 added.
Study 681 – 72 cases from USA
Cared from at Boston Medical Center, Massachusetts (click here). Probable overlap with studies 292 and 490. Citation: Sabharwal V, Bartolome R, Hassan SA, Levesque BM, Camelo IY, Wachman EM, Figueira M, Yarrington CD, Cooper ER, Barnett ED, Parker MG. Mother-Infant Dyads with COVID-19 at an Urban, Safety-Net Hospital: Clinical Manifestations and Birth Outcomes. Am J Perinatol. 2021 Apr 14. doi: 10.1055/s-0041-1726429. Epub ahead of print. PMID: 33853145.
Study 680 – case report from USA
Cared for at University of California, Los Angeles (click here). Citation: Mok T, Contreras D, Chmait RH, Goldstein J, Pluym ID, Tabsh K, Aldrovandi G, Afshar Y. Complicated Monochorionic-Diamniotic Twins in a Pregnant Woman with COVID-19 in the Second Trimester. Am J Perinatol. 2021 Apr 14. doi: 10.1055/s-0041-1726428. Epub ahead of print. PMID: 33853148.
Study 679 – 56 cases from USA
Cared from at Kings County Hospital Center in New York, which has not previously reported cases (click here or study). Citation: Liu C, Andrusier M, Silver M, Applewhite L, Clare CA. Effect of SARS-CoV-2 Infection on Pregnancy Outcomes in an Inner-City Black Patient Population. J Community Health. 2021 Apr 15:1–7. doi: 10.1007/s10900-021-00988-z. Epub ahead of print. PMID: 33855649; PMCID: PMC8046575.
Study 678 – 34 patients from Turkey
Cared for at Kartal Training and Research Hospital, Istanbul, which has not previously reported cases (click here or study). Citation: Ozer KB, Sakin O, Koyuncu K, Cimenoglu B, Demirhan R. Comparison of Laboratory and Radiological Findings of Pregnant and Non-Pregnant Women with Covid-19. Rev Bras Ginecol Obstet. 2021 Mar;43(3):200-206. doi: 10.1055/s-0041-1726054. Epub 2021 Apr 15. PMID: 33860503.
Study 677 – 1,609 cases from USA
The Cerner COVID-19 De-Identified Data Cohort was used to compare pregnant women with Covid, with non-pregnant affected women aged 18-44 (click here or study). Although pregnant women were more likely to be hospitalised, they were no more likely to need invasive ventilation or die. They were cared for in 62 US hospitals with which Cerner had a data use agreement. Citation: Qeadan F, Mensah NA, Tingey B, Stanford JB. The risk of clinical complications and death among pregnant women with COVID-19 in the Cerner COVID-19 cohort: a retrospective analysis. BMC Pregnancy Childbirth. 2021 Apr 16;21(1):305. doi: 10.1186/s12884-021-03772-y. PMID: 33863292.
Study 676 – 18 cases from Ireland
Cared for at Rotunda Hospital, Dublin (click here). Probable overlap with studies 284, 300 and 596. Citation: Alaya F, Worrall AP, O’toole F, Doyle J, Duffy RM, Geary MP. Health-related quality of life and quality of care in pregnant and postnatal women during the COVID-19 pandemic: A cohort study. Int J Gynaecol Obstet. 2021 Apr 16. doi: 10.1002/ijgo.13711. Epub ahead of print. PMID: 33864252.
Studies 674 and 675 added.
Study 675 – 38 severe cases in UK
7/34 ECMO referrals of women aged 16-49 to the Royal Brompton Hospital in London in the first wave, were pregnant or post-partum, compared with 31/62 in the second wave (click here or study). This hospital has not previously reported cases, but there will be overlap with the various UKOSS and ICNARC reports. Citation: Suraj Kadiwar, Jonathan J Smith, Stephane Ledot, Mark Johnson, Paolo Bianchi, Natasha Singh, Claudia Montanaro, Michael Gatzoulis, Nishel Shah, Emem-Fong Ukor, Were pregnant women more affected by COVID-19 in the second wave of the pandemic?, The Lancet, 2021, ISSN 0140-673
Study 674 – 525 first wave cases from Italy
ollected by the Italian Obstetric Surveillance System (ITOSS) registry between 25 February and 31 July 2020 (click here or study). Likely overlap with study 536 and other Italian series. Citation: Donati, S.; Corsi, E.; Salvatore, M.A.; Maraschini, A.; Bonassisa, S.; Casucci, P.; Cataneo, I.; Cetin, I.; D’Aloja, P.; Dardanoni, G.; De Ambrosi, E.; Ferrazzi, E.; Fieni, S.; Franchi, M.P.; Gargantini, G.; Iurlaro, E.; Leo, L.; Liberati, M.; Livio, S.; Locci, M.; Marozio, L.; Martini, C.; Maso, G.; Mecacci, F.; Meloni, A.; Mignuoli, A.D.; Patanè, L.; Pellegrini, E.; Perotti, F.; Perrone, E.; Prefumo, F.; Ramenghi, L.; Rusciani, R.; Savasi, V.; Schettini, S.C.A.; Simeone, D.; Simeone, S.; Spinillo, A.; Steinkasserer, M.; Tateo, S.; Ternelli, G.; Tironi, R.; Trojano, V.; Vergani, P.; Zullino, S.; on behalf of the ItOSS COVID-19 Working Group. Childbirth Care among SARS-CoV-2 Positive Women in Italy. Int. J. Environ. Res. Public Health 2021, 18, 4244.
Study 673 added.
Study 673 – 75 cases from USA
The placentas were compared with those from 75 control pregnancies (click here or study). From author affiliations the patients had been cared for at Columbia University Irving Medical Center, New York. Citation: Debelenko L, Katsyv I, Chong AM, Peruyero L, Szabolcs M, Uhlemann AC. Trophoblast damage with acute and chronic intervillositis: disruption of the placental barrier by severe acute respiratory syndrome coronavirus 2. Hum Pathol. 2021 Mar;109:69-79. doi: 10.1016/j.humpath.2020.12.004. Epub 2020 Dec 13. PMID: 33321162; PMCID: PMC7733682.
Studies 671 and 672 added.
Study 672 – 50 cases from USA
From Loma Linda University Medical Center which has not previously reported cases (click here or study). Citation: Ruofan Yao, Courtney B Martin , Victoria S Haase , Beverly C Tse , Ms Melissa Nishino , Ciprian Gheorghe , Kevin Balli , Initial clinical characteristics of gravid SARS-CoV-2 positive patients and the risk of progression to severe COVID-19 disease, American Journal of Obstetrics & Gynecology MFM (2021).
Study 671 – 29 cases from Spain
From University Hospital La Paz, Madrid (click here or study). Probable overlap with study 196. Citation: Blasco Santana L, Miraval Wong E, Álvarez-Troncoso J, Sánchez García L, Bartha JL, Regojo-Zapata RM. Maternal and perinatal outcomes and placental pathologic examination of 29 SARS-CoV-2 infected patients in the third trimester of gestation. J Obstet Gynaecol Res. 2021 Apr 5. doi: 10.1111/jog.14784. Epub ahead of print. PMID: 33821521.
Studies 668 to 670 added.
Study 670 – 110 cases from Iran
Collected between March and October 2020 from multiple hospitals in Tehran (click here). Five women died. Citation: Vizheh M, Muhidin S, Aghajani F, Maleki Z, Bagheri F, Hosamirudsari H, Aleyasin A, Tehranian A. Characteristics and outcomes of COVID-19 pneumonia in pregnancy compared with infected nonpregnant women. Int J Gynaecol Obstet. 2021 Apr 8. doi: 10.1002/ijgo.13697. Epub ahead of print. PMID: 33829492.
Study 669 – 1,454 cases from USA
From the Society for Obstetric Anesthesia and Perinatology (SOAP) COVID-19 Registry (click here). Collected from March 19-May 31, 2020 from 14 centres which, from author affiliations, probably include Brigham and Women’s Hospital, Boston; Weill Cornell, New York; Massachusetts General Hospital, Boston; University of California at San Francisco; Langone Health, New York, Stanford University School of Medicine, Emory School of Medicine, Atlanta, Icahn School of Medicine at Mount Sinai, New York; Mayo Clinic, Rochester; University of Maryland School of Medicine, Baltimore; Washington University School of Medicine, St. Louis; MGH-North Shore Medical Center, Danvers; Columbia University College of Physicians and Surgeons, New York. Citation: Katz D, Bateman BT, Kjaer K, Turner DP, Spence NZ, Habib AS, George RB, Toledano RD, Grant G, Madden HE, Butwick AJ, Lynde G, Minehart RD, Beilin Y, Houle TT, Sharpe EE, Kodali B, Bharadwaj S, Farber MK, Palanisamy A, Prabhu M, Gonzales NY, Landau R, Leffert L. The Society for Obstetric Anesthesia and Perinatology (SOAP) COVID-19 Registry: An analysis of outcomes among pregnant women delivering during the initial SARS-CoV-2 outbreak in the United States. Anesth Analg. 2021 Apr 8. doi: 10.1213/ANE.0000000000005592. Epub ahead of print. PMID: 33830956.
Study 668 – two cases from Chile
Two patients with severe Covid-19 were pregnant in this series of patients cared for in the Regional Hospital in Los Ríos (click here or study). Both were in the 2nd trimester. One was delivered by Caesarean at 28 weeks. This hospital has not previously reported cases. Citation: Olivares F, Muñoz D, Fica A, Delama I, Alvarez I, Navarrete M, Blackburn E, Garrido P, Wenger R, Grandjean J. Clinical features of 47 patients infected with COVID-19 admitted to a Regional Reference Center. Rev Med Chil. 2020 Nov;148(11):1577-1588. doi: 10.4067/S0034-98872020001101577. PMID: 33844763.
Studies 662-667 added.
Study 667 – 5,479 cases from UK
This paper was prepared by the ISARIC4C Consortium, UK Obstetric Surveillance System (UKOSS) and COVID-19 Clinical Information Network (CO-CIN) for the UK Scientific Advisory Group for Emergencies (SAGE). It includes pregnant women with Covid from the whole of the UK. It is available as a pdf (click here or study) and as a set of powerpoint slides (click here or study). Citation: Marian Knight, Rema Ramakrishnan, Kathryn Bunch, Nicola Vousden, Jennifer J Kurinczuk, Sarah Dunn, Lisa Norman, Aisling Barry, Ewen Harrison, Annemarie Docherty, Calum Semple. Females in Hospital with SARS-CoV-2 infection, the association with pregnancy and pregnancy outcomes: A UKOSS/ISARIC/CO-CIN investigation. Report presented 25 March 2021. Published 9 April 2021 Accessed 12 April 2021 [important]
Study 666 – 165 cases from Brazil
The patients were cared for in three different unnamed hospitals in São Paulo (click here or study). They may overlap with cases in studies 201, 213 and 426. Citation: Kiappe OP, Santos da Cruz NF, Rosa PAC, Arrais L, Bueno de Moraes NS. Ocular Assessments of a Series of Newborns Gestationally Exposed to Maternal COVID-19 Infection. JAMA Ophthalmol. Published online April 07, 2021. doi:10.1001/jamaophthalmol.2021.1088
Study 665 – 567 cases from Iran
Eight women died (click here or study). They were all cared for at Forghani Hospital in Qom. If this is the same as Nekouei-Hedayati-Forghani Hospital in the same city, some may have been reported in study 555. Neither hospital disambiguates on GRID.ac. Citation: Samadi, P., Alipour, Z., Ghaedrahmati, M. and Ahangari, R. (2021), The severity of COVID‐19 among pregnant women and the risk of adverse maternal outcomes. International Journal of Gynecology & Obstetrics. Accepted Author Manuscript.
Study 664 – case report from Iran
Cared for at Firoozgar Hospital, Tehran (click here or study). The patient died, so may be included in study 345. Citation: Goudarzi, S, Firouzabadi, FD, Mahmoudzadeh, F, Aminimoghaddam, S. Pulmonary embolism in pregnancy with COVID‐19 infection: A case report. Clin Case Rep. 2021; 00: 1– 5.
Study 663 – 68 cases from USA
This BioRxiv preprint reports a detailed study of placental immunology (click here or study). The hospitals caring for the patients are not reported, but from the last author affiliation might be Massachusetts General Hospital in Boston. Citation: Evan A Bordt, Lydia L Shook, Caroline Atyeo, Krista M Pullen, Rose M De Guzman, Marie-Charlotte Meinsohn, Maeva Chauvin, Stephanie Fischinger, Laura J. Yockey, Kaitlyn James, Rosiane Lima, Lael M Yonker, Alessio Fasano, Sara Brigida, Lisa M Bebell, Drucilla J Roberts, David Pépin, Jun R Huh, Staci D Bilbo, Jonathan Z Li, Anjali Kaimal, Danny Schust, Kathryn J Gray, Douglas Lauffenburger, Galit Alter, Andrea G Edlow. Sexually dimorphic placental responses to maternal SARS-CoV-2 infection bioRxiv 2021.03.29.437516.
Study 662 – 13 cases from China
Collected from centres outside Wuhan (click here or study). Some or all have probably been reported previously. Citation: Yangli Liu , Haihong Chen , Weiping Tan , Yukun Kuang , Kejing Tang , Yifeng Luo , Yubiao Guo , Clinical characteristics and outcome of SARS-CoV-2 infection during pregnancy, Journal of Infection (2021).
Studies 658-661 added.
Study 661 – 246 cases from Spain
Collected from the 45 hospitals of the Spanish Obstetric Emergency group (click here or study). Likely overlap with studies 264b, 548 and 589 as well as other reports from Spain. Citation: Martinez-Perez O, Prats Rodriguez P, Muner Hernandez M, Encinas Pardilla MB, Perez Perez N, Vila Hernandez MR, Villalba Yarza A, Nieto Velasco O, Del Barrio Fernandez PG, Forcen Acebal L, Orizales Lago CM, Martinez Varea A, Muñoz Abellana B, Suarez Arana M, Fuentes Ricoy L, Martinez Diago C, Janeiro Freire MJ, Alférez Alvarez-Mallo M, Casanova Pedraz C, Alomar Mateu O, Lesmes Heredia C, Wizner de Alva JC, Bernardo Vega R, Macia Badia M, Alvarez Colomo C, Sanchez Muñoz A, Pratcorona Alicart L, Alonso Saiz R, Lopez Rodriguez M, Del Carmen Barbancho Lopez M, Meca Casbas MR, Vaquerizo Ruiz O, Moran Antolin E, Nuñez Valera MJ, Fernandez Fernandez C, Tubau Navarra A, Cano Garcia AM, Baena Luque C, Soldevilla Perez S, Gastaca Abasolo I, Adanez Garcia J, Teulon Gonzalez M, Puertas Prieto A, Ostos Serna R, Del Pilar Guadix Martin M, Catalina Coello M, Ferriols Perez E, Caño Aguilar A, De la Cruz Conty ML, Sainz Bueno JA; Spanish Obstetric Emergency Group. The association between SARS-CoV-2 infection and preterm delivery: a prospective study with a multivariable analysis. BMC Pregnancy Childbirth. 2021 Apr 1;21(1):273. doi: 10.1186/s12884-021-03742-4. PMID: 33794829; PMCID: PMC8016158.
Study 660 – 22 cases from USA
From Johns Hopkins Hospital, Baltimore, which has not previously reported cases (click here or study). Citation: Sherer ML, Lei J, Creisher P, Jang M, Reddy R, Voegtline K, Olson S, Littlefield K, Park HS, Ursin RL, Ganesan A, Boyer T, Elsayed N, Brown DM, Walch SN, Antar AAR, Manabe YC, Jones-Beatty K, Christopher Golden W, Satin AJ, Sheffield JS, Pekosz A, Klein SL, Burd I. Pregnancy alters IL-1β expression and anti-viral antibody responses during SARS-CoV-2 infection. Am J Obstet Gynecol. 2021 Mar 30:S0002-9378(21)00208-8. doi: 10.1016/j.ajog.2021.03.028. Epub ahead of print. PMID: 33798476; PMCID: PMC8008823.
Study 659 – case report from Italy
A woman with Covid-19 and twins cared for at the Institute for Maternal and Child Health “IRCCS Burlo Garofolo”, Trieste (click here or study). This hospital has not previously reported cases. Citation: Trombetta A, Comar M, Tommasini A, Canton M, Campisciano G, Zanotta N, Cason C, Maso G, Risso FM. SARS-CoV-2 Infection and Inflammatory Response in a Twin Pregnancy. Int J Environ Res Public Health. 2021 Mar 17;18(6):3075. doi: 10.3390/ijerph18063075. PMID: 33802696; PMCID: PMC8002573.
Study 658 – 30 cases from Italy
From Policlinico Umberto I Hospital, Sapienza University of Rome (click here or study). This hospital appears to have only reported one previous case in study 448. Citation: Porpora MG, Merlino L, Masciullo L, D’Alisa R, Brandolino G, Galli C, De Luca C, Pecorini F, Fonsi GB, Mingoli A, Franchi C, Oliva A, Manganaro L, Mastroianni CM, Piccioni MG. Does Lung Ultrasound Have a Role in the Clinical Management of Pregnant Women with SARS COV2 Infection? Int J Environ Res Public Health. 2021 Mar 9;18(5):2762. doi: 10.3390/ijerph18052762. PMID: 33803223; PMCID: PMC7967479.
Studies 654-657 added.
Study 657 – case report from Iran
Neurosurgical complications from Covid-19 in pregnancy are described (click here or Saberi case rep). From author affiliations the patient was cared for, and delivered by Caesarean, in Imam Khomeini hospital, Tehran, which has not previously reported cases. Citation: Saberi H, et al, Acute presentation of third ventricular cavernous malformation following COVID-19 infection in a pregnant woman: A case report, Neurochirurgie.
Study 656 – case report from Japan
From author affiliations the patient who required ventilation, but recovered was probably cared for at University of the Ryukyus Hospital, Okinawa, which has not previously reported cases (click here or Chinen case rep). Citation: Y. Chinen, Y. Kinjyo, K. Mekaru, et al., Critical respiratory failure in pregnancy complicated with COVID-19: A case report, Case Reports in Women’s Health (2018),
Study 655 – 45 cases from Canada
From author affiliations the women were cared for at McGill University Health Centre, and Jewish General Hospital Montreal (click here or Trahan Montreal). Citation: Marie-Julie Trahan, Isabelle Malhame, Patrick O’Farrell, Cristina Mitric, Jade Desilets, Marie-Pier Bastrash, Amira El-Messidi, Haim A. Abenhaim, Obstetrical and Newborn Outcomes among Patients with SARS-CoV-2 during Pregnancy, Journal of Obstetrics and Gynaecology Canada (2021).
Study 654 – 458 cases from Chile
From Hospital San Jose, Santiago, 8 April – 30 August 2020 (click here or Haye Chile). One mother died. A different hospital Study 486, which has not previously reported cases. Citation: Maria Teresa Haye, Giorgia Cartes, Jorge Gutiérrez, Paz Ahumada, Bernardo Krause, Mario Merialdi & Rogelio Gonzalez (2021): Maternal and perinatal outcomes in pregnant women with confirmed severe and mild COVID-19 at one large maternity hospital in Chile, The Journal of Maternal-Fetal & Neonatal Medicine.
Studies 652 and 653 added.
Study 653 – 64 cases from Egypt
This MedRxiv preprint includes 64 pregnant women, of whom three died (click here or paper). Citation: Noha Asem, Mohamed Hassany, Khaled Taema, Hossam Masoud, Gehan Elassal, Ehab Kamal, Wagdy Amin, Akram Abdelbary, Amin Abdel Baki, Samy Zaky, Ahmad Abdalmohsen, Hamdy Ibrahim, Mohamed Elnady, Ahmed Mohamed, Ehab Atteia, Hala Zaid. Demographic and clinical features associated with in-hospital mortality in Egyptian COVID-19 patients: A retrospective cohort study. medRxiv 2021.03.22.21253577.
Study 652 – 708 cases from Norway
This MedRxiv preprint includes 708 pregnant women with a positive test from the Norwegian National Population Registry between March 1st, 2020 and February 28th, 2021 (click here or paper). Citation: Maria C. Magnus, Laura Oakley, Håkon K. Gjessing, Olof Stephansson, Hilde M. Engjom, Ferenc Macsali, Petur B. Juliusson, Anne-Marie Nybo Andersen, Siri E. Håberg. Pregnancy and risk of COVID-19. medRxiv 2021.03.22.21254090.
Study 651 added.
Study 651 – two cases in two US fertility clinics
Both asymptomatic (click here or PIIS0002937821001599). Six other women, out of 339 showed evidence of past infection. The clinics were Utah Fertility Center, Utah, and Boston IVF, Massachussetts. Citation: FOULK R, SAKKAS D, KAYALI R, VALBUENA D, SIMON C, CUZZI J, SARSCoV-2 immunity, infective and naïve incidence in fertility clinics after lockdown, American Journal of Obstetrics and Gynecology (2021).
Studies 648 to 650 added.
Study 650 – 132 cases from India
Cared for between 15th May and 15th November 2020, at Tata Main Hospital, Jamshedpur, which has not previously reported cases (click here or cureus-0013-00000013184). Citation: Singh V, Choudhary A, Datta MR, Ray A. Maternal and Neonatal Outcomes of COVID-19 in Pregnancy: A Single-Centre Observational Study. Cureus. 2021 Feb 6;13(2):e13184. doi: 10.7759/cureus.13184. PMID: 33717728; PMCID: PMC7943051.
Study 649 – Case report from USA
The authors are affiliated with the Medical College of Wisconsin, Milwaukee, Wisconsin (click here or e240385.full). The clinical details differ from the case in study 563. Citation: Roddy JT, Collier WS, Kurman JS. Prone positioning for severe ARDS in a postpartum COVID-19 patient following caesarean section. BMJ Case Rep. 2021 Mar 16;14(3):e240385. doi: 10.1136/bcr-2020-240385. PMID: 33727296.
Study 648 – one case from UK
From 7 May to 6 June 2020, 1/465 asymptomatic pregnant women from The Rosie Hospital in Cambridge tested positive (click here or s12884-021-03653-4). The Rosie has not previously reported cases. Citation: Xu R, Pauley TA, Missfelder-Lobos H, Haddon RJ, Gupta RK, Chong HP. Samba II PCR testing for COVID-19 in pregnant women: a retrospective cohort study and literature review. BMC Pregnancy Childbirth. 2021 Mar 17;21(1):212. doi: 10.1186/s12884-021-03653-4. PMID: 33731037.
Study 647 added.
Study 647 – 36 cases from UK
This MedRxiv preprint from ICNARC, QResearch, and the COVID-19 testing (PHE) database, reports 36 pregnant or recently pregnant women in critical care with Covid-19, between 1 November 2020 and 27 January 2021, of whom 25 were infected with the variant of concern (VOC) B.1.1.7 (click here or 2021.03.11.21253364v1.full). Citation: Martina Patone, Karen Thomas, Rob Hatch, Pui San Tan, Carol Coupland, Weiqi Liao, Paul Mouncey, David Harrison, Kathryn Rowan, Peter Horby, Peter Watkinson, Julia Hippisley-Cox Analysis of severe outcomes associated with the SARS-CoV-2 Variant of Concern 202012/01 in England using ICNARC Case Mix Programme and QResearch databases. medRxiv 2021.03.11.21253364.
Study 646 added.
Study 646 – Case report from UK
Cared for at East and North Hertfordshire NHS Trust, Stevenage, in April 2020 (click here or e238055.full). Likely included in studies 533, 539 and perhaps others. Citation: Reindorf M, Newman J, Ingle T. BMJ Case Rep 2021;14:e238055. doi:10.1136/bcr-2020-238055
Studies 642 to 645 added. Study 541, English version added
Study 645 – case report from Brazil
From author affiliations she was probably cared for at the Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, which has not previously reported cases (click here or fmed-08-624166). Citation JAK B, Zanirati G, Rodrigues FVF, et al. Case Report: Placental Maternal Vascular Malperfusion Affecting Late Fetal Development and Multiorgan Infection Caused by SARS-CoV-2 in Patient With PAI-1 4G/5G Polymorphism. Front Med (Lausanne). 2021;8:624166. Published 2021 Feb 17. doi:10.3389/fmed.2021.624166
Study 644 – 17 serologically positive cases from Italy
It is not clear which Turin hospital cared for these patients (click here or diagnostics-11-00398). They may therefore overlap with those in studies 79, 167, 195, 247 and 615. Citation: Cosma S, Carosso AR, Borella F, Cusato J, Bovetti M, Bevilacqua F, Carosso M, Gervasoni F, Sciarrone A, Marozio L, Revelli A, Rolfo A, Filippini C, Ghisetti V, Di Perri G, Benedetto C. Prenatal Biochemical and Ultrasound Markers in COVID-19 Pregnant Patients: A Prospective Case-Control Study. Diagnostics (Basel). 2021 Feb 26;11(3):398. doi: 10.3390/diagnostics11030398. PMID: 33652805.
Study 643 – case report from US
Cared for at McGovern Medical School, University of Texas Health Science Center, Houston (click here or cureus-0013-00000012990). May be included in study 267b. Citation: Moses ML, Kazzi NG, Lee L. Severe Thrombocytopenia in a Pregnant Patient with Asymptomatic COVID-19 Infection: A Case Report. Cureus. 2021 Jan 29;13(1):e12990. doi: 10.7759/cureus.12990. PMID: 33654642; PMCID: PMC7916745.
Study 642 – 142 cases from USA
Cared for at New York Presbyterian, Brooklyn Methodist Hospital between March and August 2020 (click here or Zhang JMFM Feb 28 14767058.2021). Probably included in a number of New York series. Citation: Peilin Zhang, Taryn Heyman, Marisa Greechan, Beata Dygulska, Farah Al Sayyed, Pramod Narula & Sanford Lederman (2021) Maternal, neonatal and placental characteristics of SARS-CoV-2 positive mothers, The Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2021.1892637
Study 641 added.
Study 641 – 50 cases from Italy
From Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, so likely included in the various series from there and Lombardy (click here or jog.14729). Citation: D’Ambrosi F, Iurlaro E, Tassis B, Di Maso M, Erra R, Cetera GE, Cesano N, Di Martino D, Ossola MW, Ferrazzi EM. Sociodemographic characteristics of pregnant women tested positive for COVID-19 admitted to a referral center in Northern Italy during lockdown period. J Obstet Gynaecol Res. 2021 Mar 1. doi: 10.1111/jog.14729. Epub ahead of print. PMID: 33650278.
Study 640 added.
Study 640 – 54 cases from Turkey
54 pregnant women with Covid-19 cared for in Ankara City Hospital between August 1 and October 1, 2020 (click here). Likely overlap with studies 203, 223, 399, 512, 569 and 604. Citation: Ayhan SG, Tanacan A, Atalay A, Sinaci S, Tokalioglu EO, Sahin D, Tekin OM. Assessment of fetal Doppler parameters in pregnant women with COVID-19 infection: a prospective case-control study. J Perinat Med. 2021 Mar 3. doi: 10.1515/jpm-2020-0512. Epub ahead of print. PMID: 33660492.
Studies 638 and 639 added.
Study 639 – 5,963 cases from USA
This MedRxiv preprint includes pregnant women testing positive for SARS-CoV-2 identified through the Surveillance for Emerging Threats to Mothers and Babies Network (SET-NET) between March 29, and January 8, 2021 (click here or 2021.02.27.21252169v1.full). They likely overlap with those in study 338. Citation: Romeo R. Galang, Suzanne M. Newton, Kate R. Woodworth, Isabel Griffin, Titilope Oduyebo, Christina L. Sancken, Emily O’Malley Olsen, Kathy Aveni, Heather Wingate, Hanna Shephard, Chris Fussman, Zahra S. Alaali, Samantha Siebman, Umme-Aiman Halai, Camille Delgado Lopez, Jerusha Barton, Mamie Lush, Paul H. Patrick, Levi Schlosser, Ayomide Sokale, Ifrah Chaudhary, Bethany Reynolds, Similoluwa Sowunmi, Nicole Gaarenstroom, Jennifer S. Read, Sarah Chicchelly, Leah de Wilde, Eduardo Azziz-Baumgartner, Aron J. Hall, Van T. Tong, Sascha Ellington, Suzanne M. Gilboa Risk factors for illness severity among pregnant women with confirmed SARS-CoV-2 infection – Surveillance for Emerging Threats to Mothers and Babies Network, 20 state, local, and territorial health departments, March 29, 2020 -January 8, 2021 CDC COVID-19 Response Pregnancy and Infant Linked Outcomes Team medRxiv 2021.02.27.21252169;
Study 638 – 83 cases from USA
From Barnes-Jewish Hospital in St. Louis, Missouri between June 1, and November 30, 2020 (click here or Rosenbloom AJOG PIIS0002937821001502). They likely overlap with cases in studies 69, 259, 290 and possibly 579. Citation: Rosenbloom JI, Raghuraman N, Carter EB, Kelly JC, COVID-19 Infection and Hypertensive Disorders of Pregnancy, American Journal of Obstetrics and Gynecology (2021).
Studies 636 and 637 added.
Study 637 – case report from USA
The hospital is not named, but the authors are affiliated with the Whole Family Health Center, Vero Beach, Florida, which has not previously reported cases (click here or 1-s2.0-S2214911221000059-main). Citation: Poisson TM, Pierone G Jr. Placental pathology and fetal demise at 35 weeks of gestation in a woman with SARS-CoV-2 infection: A case report. Case Rep Womens Health. 2021 Apr;30:e00289. doi: 10.1016/j.crwh.2021.e00289. Epub 2021 Jan 28. PMID: 33527073; PMCID: PMC7840395.
Study 636 – case report from Sweden
Probably included in study 610 (click here or Zaigham case BJOG in press). Although cared for at either Lund or Malmo hospitals clinical details differ from cases in studies 259b and 588. Citation: Zaigham M, Holmberg A, Karlberg ML, Lindsjö OK, Jokubkiene L, Sandblom J, Strand AS, Andersson O, Hansson SR, Nord DG, Tannenberg P. Intrauterine vertical SARS-CoV-2 infection: a case confirming transplacental transmission followed by divergence of the viral genome. BJOG. 2021 Feb 27. doi: 10.1111/1471-0528.16682. Epub ahead of print. PMID: 33638908.
Study 635 added.
Study 635 – 12 cases from Spain
From author affiliations they were cared for at Vall d’Hebron Hospital, Barcelona, and Hospital Universitario “12 de Octubre”, Madrid, between 1 March and 31 April 2020 (click here ). They probably overlap with cases in studies 151, 165, 185, 205, 413, 417, 458, 470 and 583. Citation: Jiménez-Lozano I, Caro-Teller JM, Fernández-Hidalgo N, Miarons M, Frick MA, Batllori Badia E, Serrano B, Parramon-Teixidó CJ, Camba-Longueira F, Moral-Pumarega MT, San Juan-Garrido R, Cabañas Poy MJ, Suy A, Gorgas Torner MQ. Safety of tocilizumab in COVID-19 pregnant women and their newborn: A retrospective study. J Clin Pharm Ther. 2021 Feb 26. doi: 10.1111/jcpt.13394. Epub ahead of print. PMID: 33638257.
Studies 628 to 634 added.
Study 634 – 13 cases from Spain
These 13 pregnant women with Covid-19 were cared for at five public hospitals in Valencia (Hospital Universitario de La Ribera, Hospital Lluis Alcanyis, Hospital de Ontinyent, Hospital General de Valencia and Hospital Universitari i Politècnic La Fe), none of which have previously reported cases (click here or 1-s2.0-S1130862121000334-main). They may of course be included in Spanish or international registries. Spanish, with English abstract. Citation: R. Vila-Candel, D. Mena-Tudela, A. Gómez-Seguí et al., Manejo del parto, el puerperio y la lactancia en mujeres positivas para SARS-CoV-2. Estudio multicéntrico en la Comunidad Valenciana, Enfermería Clínica,
Study 633 – 58 cases from USA
These pregnant women with Covid-19 were cared for at the University of Iowa Hospitals and Clinics, which have not previously reported cases (click here or Steffen Iowa AJP s-0041-1723938). However the woman reported in study 537 is probably also in this series. Citation: Steffen HA, Swartz SR, Jackson JB, Kenne KA, Ten Eyck PP, Merryman AS, Castaneda CN, Marsden K, Maxwell T, Merrill AE, Krasowski MD, Rysavy MB. SARS-CoV-2 Infection during Pregnancy in a Rural Midwest All-delivery Cohort and Associated Maternal and Neonatal Outcomes. Am J Perinatol. 2021 Feb 21. doi: 10.1055/s-0041-1723938. Epub ahead of print. PMID: 33611783.
Study 632 – 583 cases from Mexico
This report (click here or excli2021-3413) of 395,343 patients with COVID-19 in 688 medical units in Mexico City between February 24 and September 14, 2020, includes 583 pregnant women, of whom 10 died. See supplementary tables 3, 8 and 15 for pregnancy data excli2021-3413_supplementary_information. They likely overlap with cases reported in studies 271, 340, 425, 475, 513 and 518. Citation: Mancilla-Galindo, J., García-Méndez, J. Óscar, Marquéz-Sánchez, J., Reyes-Casarrubias, R. E. ., Aguirre-Aguilar, E., Rocha-González, H. I., & Kammar-García, A. (2021). All-cause mortality among patients treated with repurposed antivirals and antibiotics for COVID-19 in Mexico City: A real-world observational study. EXCLI Journal, 20, 199-222.
Study 631 – case report from China
Cared for in March 2020 in Peking (Beijing) University Third Hospital grid.411642.4 (click here or JCTH-9-133). This hospital has not previously reported cases and does not seem to be included in the various non-Wuhan China series. Citation: Li QY, An ZY, Li C, et al. Chronic Active Hepatitis B with COVID-19 in Pregnancy: A Case Report. J Clin Transl Hepatol. 2021;9(1):133-135. doi:10.14218/JCTH.2020.00085
Study 630 – 81 cases from Turkey
55/81 with chest X ray or CT are reported (click here or JTGGA-0-0-En). From author affiliations they were cared for in Sancaktepe Şehit Prof. Dr. İlhan Varank Training and Research Hospital, and Marmara University Faculty of Medicine, both in Istanbul. The cases may therefore overlap with those in studies 146, 210, 244 and 286. Citation: Kuzan TY, Murzoğlu Altıntoprak K, Çiftçi HÖ, Kuzan BN, Yassa M, Tuğ N, Çimşit NÇ. Clinical and radiologic characteristics of symptomatic pregnant women with COVID-19 pneumonia. J Turk Ger Gynecol Assoc. 2021 Feb 26. doi: 10.4274/jtgga.galenos.2021.2020.0215. Epub ahead of print. PMID: 33631874.
Study 629 – 45 cases from USA
Of these 45 cases from Einstein Medical Center Philadelphia, three re-tested positive more than 90 days later (click here or 1-s2.0-S2589933321000264-main). Probably includes the case reported in study 320. Citation: Emily Dubelbeiss, Michael Silverberg, Chase White, David Jaspan, Christopher Haines, Jay Goldberg, Repeat positive SARS-CoV-2 (COVID-19) testing e 90 days apart in pregnant women., American Journal of Obstetrics & Gynecology MFM (2021).
Study 628 – 887 cases from WAPM
These cases collected from 76 centers in 25 countries, and diagnosed between 04 April & 28 October 2020 overlap with those in studies 278 and 415 and other studies (click here or 1-s2.0-S2589933321000240-main). The centres can be inferred from author affilations, but case numbers by centre are not reported. Citation: Francesco D’Antonio, Cihat Sen, Daniele DI Mascio, et al. Maternal and perinatal outcomes in high vs low risk-pregnancies affected by SARS-COV-2 infection (Phase-2): The WAPM (World Association of Perinatal Medicine) working group on COVID-19, American Journal of Obstetrics & Gynecology MFM (2021),
Study 539 (UK PanCovid & US AAP SONPM registries) updated.
Studies 619 to 627 added.
Study 627 – 49 cases from Italy
From Università di Roma Tor Vergata, from September to November 2020 (click here or aogs.14130). Citation: Rizzo, G., Mappa, I., Maqina, P., Bitsadze, V., Khizroeva, J., Makatsarya, A. and D’Antonio, F. (2021), Effect of SARS‐CoV‐2 infection during the second half of pregnancy on fetal growth and hemodynamics: a prospective study. Acta Obstetricia et Gynecologica Scandinavica. Accepted Author Manuscript. https://doi.org/10.1111/aogs.14130 [case series & controls, 2nd wave]
Study 626 – 247 cases from Germany
Collected from 65 hospitals participating in the CRONOS registry between 3 April and 1 October 2020 (click here or CRONOS). 14 women were treated in ITU. No maternal deaths were reported, although 32 women have not yet recovered. Of 189 completed pregnancies, there were 4 terminations, 2 stillbirths and 183 livebirths. Four neonates were infected but all recovered. Although German cases were included in studies 127 and 278 this is the first substantive rport from Germany. Citation: Pecks U, Kuschel B, Mense L, Oppelt P, Rüdiger M, on behalf of the CRONOS network: Pregnancy and SARS-CoV-2 infection in Germany—the CRONOS registry. Dtsch Arztebl Int 2020; 117: 841–2. DOI: 10.3238/arztebl.2020.0841 [important]
Study 625 – case report from USA
From MedStar Washington Hospital Center, Washington DC (click here or 10-1055-s-0040-1721672). The clinical details differ from those in study 21 from the same hospital. Citation: Mokhtari NB, Drassinower D, Orr LA, Cobb NK, Mims OL Jr, Landy HJ. Expectant Management of Severe COVID-19 Pneumonia in Late Preterm Pregnancy and Subsequent Cholecystitis: Lessons Learned. AJP Rep. 2021;11(1):e29-e33. doi:10.1055/s-0040-1721672
Study 624 – 4 cases from India
Of four pregnant women with Covid-19 in pregnancy treated in Bundelkhand Medical College Hospital, Sagar City, one died (click here or jog.14696). This hospital has not previously reported cases. Citation: Rawat, S.K., Saad, T., Jindal, A. and Vyas, A.K. (2021), Coronavirus disease 2019 in pregnancy: Case report on maternal death in Sagar City of Central India. J. Obstet. Gynaecol. Res.
Study 623 – Case report from Japan
From Kyoto Prefectural University of Medicine, which as not previously reported cases (click here or jog.14701). Citation: Waratani, M., Ito, F., Tanaka, Y., Mabuchi, A., Mori, T. and Kitawaki, J. (2021), Severe coronavirus disease pneumonia in a pregnant woman at 25 weeks’ gestation: A case report. J. Obstet. Gynaecol. Res.
Study 622 – Case report from Iran
From Arash Hospital, Tehran University of Medical Sciences, Tehran (click here or Rabiei JMCR). The clinical features and hospital suggest these are the same triplets as previously reported in studies 250 and 409. Citation: Rabiei, M., Soori, T., Abiri, A. et al. Maternal and fetal effects of COVID-19 virus on a complicated triplet pregnancy: a case report. J Med Case Reports 15, 87 (2021).
Study 621 – Case report from Turkey
From Konya Education and Research Hospital, Konya, which has not previously reported cases (click here or Gunduz). Citation: GUNDUZ, Zahide Betül. Venous sinus thrombosis during COVID-19 infection in pregnancy: a case report. Sao Paulo Med. J. [online]. In press. [cited 2021-02-21], pp.-. Available from: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802021005005202&lng=en&nrm=iso>. Epub Feb 15, 2021. ISSN 1806-9460.
Study 620 – 17 cases from Brazil
Of 360 women aged <20 with Covid-19 in Pernambuco, from March 12 to June 19, 2020, 17 were pregnant or in the puerperium (click here or [14761645 The American Journal of Tropical Medicine and Hygiene] Clinical Characteristics and Mortality Profile of COVID-19 Patients Aged less than 20 years Old in Pernambuco – Brazil). None died. Citation: Sena GR, Lima TPF, Vidal SA, Duarte MDCMB, Bezerra PGM, Fonseca Lima EJ, Braga C, Andrade LB, Lins MM, Torres LC, Lima JTO, Mello MJG. Clinical Characteristics and Mortality Profile of COVID-19 Patients Aged less than 20 years Old in Pernambuco – Brazil. Am J Trop Med Hyg. 2021 Feb 18: tpmd201368. doi: 10.4269/ajtmh.20-1368. Epub ahead of print. PMID: 33606669.
Study 619 – 240 cases from USA
From Washington state (click here or Lokken AJOG Feb 21). These appear to be the same cases as in study 573. Citation: LOKKEN EM, TAYLOR GG, HUEBNER EM, VANDERHOEVEN J, HENDRICKSON S, COLER B, SHENG JS, WALKER CL, MCCARTNEY SA, KRETZER NM, RESNICK R, KACHIKIS A, BARNHART N, SCHULTE V, BERGAM B, K K, ALBRIGHT C, LARIOS V, KELLEY L, LARIOS V, EMHOFF S, RAH J, RETZLAFF K, THOMAS C, PAEK BW, HSU RJ, ERICKSON A, CHANG A, MITCHELL T, HWANG JK, GOURLEY R, ERICKSON S, DELANEY S, KLINE CR, ARCHABALD K, BLAIN M, LACOURSE SM, ADAMS WALDORF KM, Higher SARS-CoV-2 Infection Rate in Pregnant Patients, American Journal of Obstetrics and Gynecology (2021).
Studies 615 to 618 added.
Study 618 – 350 cases from India
From Government Medical College Kannur, Pariyaram, in Kerala, which has not previously reported cases (click here or 13224_2021_Article_1436). Two mothers were admitted to ITU, one of whom was ventilated. Of 221 babies 32 tested positive. Citation: Ajith S, Reshmi VP, Nambiar S, Naser A, Athulya B. Prevalence and Risk Factors of Neonatal Covid-19 Infection: A Single-Centre Observational Study. J Obstet Gynaecol India. 2021 Feb 4:1-4. doi: 10.1007/s13224-021-01436-7. Epub ahead of print. PMID: 33564217; PMCID: PMC7861010.
Study 617 – Case report from Indonesia
A woman with Covid-19 delivered twins at 32 weeks by Caesarean (click here or main (3)). One twin had an ileal perforation. Mother and babies were cared for at Dr. Soetomo General Hospital, Surabaya, which has not previously reported cases. Citation: Harahap A, Harianto A, Etika R, Utomo MT, Angelika D, Handayani KD, Arif Sampurna MT. Spontaneous Ileum Perforation in a premature twin with Coronavirus-19 positive mother. J Pediatr Surg Case Rep. 2021 Feb 4:101807. doi: 10.1016/j.epsc.2021.101807. Epub ahead of print. PMID: 33564621; PMCID: PMC7860962.
Study 616 – 91 cases from USA
From the University of Texas Medical Branch Galveston, Texas which has not previously reported cases (click here). Citation: Berry M, Wang A, Clark SM, Harirah HM, Jain S, Olson GL, Pacheco LD, Saade GR, Saad AF. Clinical Stratification of Pregnant COVID-19 Patients based on Severity: A Single Academic Center Experience. Am J Perinatol. 2021 Feb 6. doi: 10.1055/s-0041-1723761. Epub ahead of print. PMID: 33548937.
Study 615 – 17 patients with antibodies from Italy
These pregnant women were probably cared for at S. Anna Hospital, Turin (click here or 1 s20 S0165037821000152 main). They may therefore overlap with studies 79, 167, 195 and 247. Citation: Stefano Cosma, Andrea Roberto Carosso, Silvia Corcione, Jessica Cusato, Fulvio Borella, Miriam Antonucci, Luca Marozio, Alberto Revelli, Mario Preti, Valeria Ghisetti, Giovanni Di Perri, Chiara Benedetto. Longitudinal analysis of antibody response following SARS-CoV-2 infection in pregnancy: From the first trimester to delivery. Journal of Reproductive Immunology, Volume 144, 2021, 103285, ISSN 0165-0378, https://doi.org/10.1016/j.jri.2021.103285.
Studies 611 to 614 added.
Study 614 – serum screening in Jamaica
From University Hospital of the West Indies, in Kingston, during September-November 2020 (click here or Chisolm preprint). Citation: Te’Anne Chisolm, Jerome P Walker, Ynolde Leys, Tiffany R Butterfield, Candice Medley, Tamara K Thompson, Glendee Reynolds-Campbell, Willem H Mulder, Michelle Campbell Mitchell, Joshua J Anzinger. SARS-CoV-2 Seroprevalence Among Antenatal Clinic Attendees in Kingston, Jamaica, September-November 2020. medRxiv 2021.02.08.21251367.
Study 613 – serum screening in Kenya
From Kenyatta National Hospital in Nairobi between 30th July and 25th August (click here or 2021.02.05.21250735v1.full). Citation: R. Lucinde, D. Mugo, C. Bottomley, R Aziza, J. Gitonga, H. Karanja, J. Nyagwange, J. Tuju, P. Wanjiku, E. Nzomo, E. Kamuri, K. Thuranira, S. Agunda, G. Nyutu, A. Etyang, I. M. O. Adetifa, E. Kagucia, S. Uyoga, M. Otiende, E. Otieno, L. Ndwiga, C. N. Agoti, R. Aman, M. Mwangangi, P. Amoth, K. Kasera, A. Nyaguara, W. Ng’ang’a, L. B. Ochola, E. Barasa, P. Bejon, B. Tsofa, L. I. Ochola-Oyier, G. M. Warimwe, A. Agweyu, J. A. G. Scott, K. E. Gallagher. Sero-surveillance for IgG to SARS-CoV-2 at antenatal care clinics in two Kenyan referral hospitals. medRxiv 2021.02.05.21250735.
Study 612 – 14 cases from Spain
Interim report of a planned follow-up study (click here or MOACC-19 study 2020.08.20.20178657v2.full). Citation: Javier Llorca, Carolina Lechosa-Muñiz, Pilar Gortázar, María Fernández-Ortiz, Yolanda Jubete, María J. Cabero, the MOACC-19 group, Jéssica Alonso-Molero, Bárbara Arozamena, Laura Conde-Gil, Elsa Cornejo del Río, Rocío Cuesta-González, Trinidad Dierssen-Sotos, Pelayo Frank de Zulueta, Inés Gómez-Acebo, Coral Llano-Ruiz, Lorena Lasarte-Oria, Sonia López-Gómez, Sonia Mateo-Sota, Victoria Orallo, Rosa Pardo, Daniel Pérez González, María Sáez de Adana Herrero. Cohort profile: COVID-19 in a cohort of pregnant women and their descendants, the MOACC-19 study. medRxiv 2020.08.20.20178657.
Study 611 – ISARIC again
Among 240,149 patients admitted to hospital with covid-19 in the UK, 1,502/17,850 women of childbearing age, were reported as being pregnant Click here or 2020 07 17 20155218v6 full). Citation: Martina Escher, Matthew Hall, J Kenneth Baillie, Joaquin Baruch, Lucille Blumberg, Gail Carson, Barbara Wanjiru Citarella, Emmanuelle Dankwa, Annemarie B Docherty, Murray Dryden, Christl Donnelly, Jake Dunning, Christophe Fraser, Hayley Hardwick, Ewen M Harrison, Karl Holden, Waasila Jassat, Christiana Kartsonaki, Kalynn Kennon, James Lee, Kenneth McLean, Caroline Mudara, Peter JM Openshaw, Daniel R Plotkin, Mark Pritchard, Amanda Rojek, Clark D Russell, Malcolm Gracie Semple, Louise Sigfrid, Susan Smith, Jia Wei, Peter Horby, Piero L Olliaro, Laura Merson. ISARIC COVID-19 Clinical Data Report: 10 February 2021 medRxiv 2020.07.17.20155218.
Study 610 added.
Study 610 – 214 cases from Scandinavia
These cases were collected by the Nordic Obstetric Surveillance Study (NOSS) collaboration countries, Denmark, Finland, Iceland, Norway, Sweden, (click here or 2021.02.05.21250672v1.full). They probably include cases from studies 20, 88, 256, 259b, 278, 282, 298, 299, 341, 523 and 588. Citation: Hilde Engjom, Anna JM Aabakke, Kari Klungsøyr, Teresia Svanvik, Outi Äyräs, Eva Jonasdottir, Lars Thurn, Elin Jones, Karin Pettersson, Lill Trine Nyfløt, Iqbal Al-Zirqi, Siri Vangen, Pétur B. Júlíusson, Karin Källén, Mika Gissler, Lone Krebs. COVID-19 in pregnancy – characteristics and outcomes of pregnant women admitted to hospital because of SARS-CoV-2 infection in the Nordic countries. medRxiv 2021.02.05.21250672; doi:
Studies 608 and 609 added.
Study 609 – 1,291 cases from USA
These pregnant women with a positive SARS-CoV-2 test result were cared for in 33 National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network hospitals between March 1 and July 31, 2020 (click here or METZ Disease Severity and Perinatal Outcomes of 121 (1)). The hospitals, listed here, include many which have previously reported cases. Citation: Metz, Torri D. MD, MS; Clifton, Rebecca G. PhD; Hughes, Brenna L. MD; Sandoval, Grecio MA; Saade, George R. MD; Grobman, William A. MD, MBA; Manuck, Tracy A. MD, MS; Miodovnik, Menachem MD; Sowles, Amber BSN, RN; Clark, Kelly BSN, RN; Gyamfi-Bannerman, Cynthia MD, MS; Mendez-Figueroa, Hector MD; Sehdev, Harish M. MD; Rouse, Dwight J. MD; Tita, Alan T.N. MD, PhD; Bailit, Jennifer MD, MPH; Costantine, Maged M. MD; Simhan, Hyagriv N. MD; Macones, George A. MD; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network Disease Severity and Perinatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 (COVID-19), Obstetrics & Gynecology: February 8, 2021 – Volume Latest Articles – Issue – 10.1097/AOG.0000000000004339 doi: 10.1097/AOG.0000000000004339
Study 608 – Case report from Saudi Arabia
From King Saud Medical City, Riyadh (click here or ccr3.3913). None of the newborns reported in study 554 from the same centre tested positive. Citation: Huseynova, RA, A. Bin Mahmoud, L, Huseynov, O, et al. A neonate born to an infected COVID‐19 mother was tested positive just 24 hours after its birth. Clin Case Rep. 2021; 00: 1– 4.
Studies 606 and 607 added.
Study 607 – 317 cases from Spain
Pregnant women with anti SARS-CoV-2 &/or a positive RT-PCR, from three hospitals (Sant Joan de Déu, Hospital Clinic Barcelona, and Hospital de Sant Pau) in Barcelona (click here or CROVETTO ciab104 (1)). The details and hospitals suggest overlap with study 235. Citation: Francesca Crovetto, Fàtima Crispi, Elisa Llurba, Rosalia Pascal, Marta Larroya, Cristina Trilla, Marta Camacho, Carmen Medina, Carlota Dobaño, Maria Dolores Gomez-Roig, Francesc Figueras, Eduard Gratacos, KidsCorona Pregnancy COVID-19 group, Impact of SARS-CoV-2 Infection on Pregnancy Outcomes: A Population-Based Study, Clinical Infectious Diseases, 2021; ciab104.
Study 606 – IgG & IgA in breast milk from 18 cases in USA
The hospitals from which women were recruited is not stated. but from the ethics approvals included centres in Idaho, the University of Rochester Medical Center, New York, and Brigham & Women’s Hospital, Boston, Massachusetts (click here or mBio 2021 Pace e03192 20.full). Citation: Pace RM, Williams JE, Järvinen KM, Belfort MB, Pace CDW, Lackey KA, Gogel AC, Nguyen-Contant P, Kanagaiah P, Fitzgerald T, Ferri R, Young B, Rosen-Carole C, Diaz N, Meehan CL, Caffé B, Sangster MY, Topham D, McGuire MA, Seppo A, McGuire MK. 2021. Characterization of SARS-CoV-2 RNA, antibodies, and neutralizing capacity in milk produced by women with COVID-19. mBio 12:e03192-20.
Studies 603 to 605 added.
Study 605 – Case report from Qatar
From the Women’s Wellness and Research Center, Hamad Medical Corporation, Doha, which also reported the case in study 577 (click here or ccr3.3886). However the clinical details differ. Citation: Khatib MY, Olagundoye VO, Elshafei MS, El Khatib FM, Mohamed AS, Nashwan AJ. Management considerations for a critically ill 26-gestational week patient with COVID-19: A case report. Clin Case Rep. 2021;00:1–4.
Study 604 – 39 cases from Turkey
Cared for at Ankara City Hospital (click here). Likely overlap with studies 203, 227, 244, 399, 444, 512, & 569. Citation: Erol Koç, Esin Merve, Fındık, Rahime Bedir, Akkaya, Hatice, Karadağ, Işılay, Tokalıoğlu, Eda Özden and Tekin, Özlem Moraloğlu. “Comparison of hematological parameters and perinatal outcomes between COVID-19 pregnancies and healthy pregnancy cohort” Journal of Perinatal Medicine, vol. 49, no. 2, 2021, pp. 141-147.
Study 603 – 35 cases from Austria
Cared for at Clinik Ottakring, in Vienna, which has not previously reported cases (click here). Citation: Hall, Mirijam, Endress, David, Hölbfer, Susanne and Maier, Barbara. “SARS-CoV-2 in pregnancy: maternal and perinatal outcome data of 34 pregnant women hospitalised between May and October 2020” Journal of Perinatal Medicine, vol. 49, no. 2, 2021, pp. 138-140.
Studies 599 to 602 added.
Study 602 – case report from United Arab Emirates
A woman contracted Covid-19 at 26 weeks gestation and required ventilation and five days of ECMO therapy (click here or Tambawala e240823.full). She recovered and the pregnancy is continuing. Cared for at Dubai Hospital, which has not previously reported cases. Citation: Tambawala ZY, Hakim ZT, Hamza LK, et al. Successful management of severe acute respiratory distress syndrome due to COVID-19 with extracorporeal membrane oxygenation during mid-trimester of pregnancy. BMJ Case Reports CP 2021;14:e240823.
Study 601 – 34 cases from USA
Cared for at Hutzel Women’s Hospital, Detroit, Michigan, between March 11, 2020, and July 31, 2020 (click here or 10-1055-s-0040-1721673). This hospital has not previously reported cases. Citation: Jani S, Jacques SM, Qureshi F, et al. Clinical Characteristics of Mother-Infant Dyad and Placental Pathology in COVID-19 Cases in Predominantly African American Population. AJP Rep. 2021;11(1):e15-e20. doi:10.1055/s-0040-1721673
Study 600 – 171 cases from USA
Of 171 pregnant women hospitalised with Covid-19, 21 were admitted to ICU and 3 died (click here or 2021.01.29.21250788v1.full). They were cared for at the University of California affiliated hospitals of Davis, Irvine, Los Angeles, San Diego, and San Francisco, so likely overlap with study 323. Citation: Miriam Nuño, Yury García, Ganesh Rajasekar, Diego Pinheiro, Alec J. Schmidt. COVID-19 Hospitalizations in Five California Hospitals. medRxiv 2021.01.29.21250788.
Study 599 – 116 seropositive women and 12 RT-PCR positive in USA
Of 708 pregnant women cared for at the Mount Sinai and Mount Sinai West hospitals in New York, from April 20, 2020 and delivered by 15 August, 116 were seropositive, and 12 RT-PCR positive (click here or 2021 02 01 21250943v1 full (1)). They likely overlap with studies 86, 119,131, 135, 160, 240, 412, 455, & 457. Citation: Nina M. Molenaar, Anna-Sophie Rommel, Lotje de Witte, Siobhan M. Dolan, Whitney Lieb, Erona Ibroci, Sophie Ohrn, Jezelle Lynch, Christina Capuano, Daniel Stadlbauer, Florian Krammer, Lauren B. Zapata, Rachel I. Brody, Rhoda S. Sperling, Omara Afzal, Mr Roy Missall, Amy Balbierz, Teresa Janevic, Joanne Stone, Elizabeth A. Howell, Veerle Bergink. Seroprevalence of SARS-CoV-2 during pregnancy and associated outcomes: results from an ongoing prospective cohort study, New York City. medRxiv 2021.02.01.21250943.
Study 598 added.
Study 598 – 100 mothers, 101 babies from USA
From New York–Presbyterian’s Morgan Stanley Children’s Hospital and Allen Hospital from March 13 to April 24, 2020 (click here or jamapediatrics dumitriu 2020 oi 200070 1611604165.97231 (1)). Both hospitals are affiliated with Columbia University Irving Medical Center. The authors note that they include 14 previously reported cases in study 27. There may also be overlap with studies 14, 41, 95, 96, 136, 160, 216, 230, 234, 261, and 276. Citation: Dumitriu D, Emeruwa UN, Hanft E, et al. Outcomes of Neonates Born to Mothers With Severe Acute Respiratory Syndrome Coronavirus 2 Infection at a Large Medical Center in New York City. JAMA Pediatr. 2021;175(2):157–167. doi:10.1001/jamapediatrics.2020.4298
Studies 592 to 597 added. Study 3 withdrawal noted.
Studies 593 to 597 – SMFM 2021 posters
Posters presented at the Society for Maternal Fetal Medicine virtual conference, 25 to 30 January, 2021 (SMFM 2021). Study 593– 52 patients from McGill University Medical Centre and the Jewish Genereal Hospital, Montreal, Quebec, Canade . Study 594 – 10 cases from University of Toledo, Ohio, USA . Study 595 – 29 cases from University of New Mexico Hospital, Albuquerque, New Mexico, USA . Study 596 – 11 cases from The Rotunda Hospital, Dublin, Ireland . Study 597 – 15 cases (two deaths) from the University of Mississippi Medical Center, Jackson, Mississippi, USA . Citations to the AJOG abstracts to be added.
Study 592 – Case report from Italy
From Santo Stefano Hospital, Prato (click here or jmv.26609). The clinical features suggest this is case 2 in study 367. Citation: Cavaliere AF, Marchi L, Aquilini D, Brunelli T, Vasarri PL. Passive immunity in newborn from SARS-CoV-2-infected mother. J Med Virol. 2020 Oct 19. doi: 10.1002/jmv.26609. Epub ahead of print. PMID: 33073377.
Study 589 to 591 added.
Study 591 – antibody transfer in 22 mother infant dyads from USA
SARS-CoV-2-specific antibody transfer is reduced compared to influenza- and pertussis-specific antibodies, and cord titers and functional activity is lower than in maternal plasma, in 22 maternal: cord dyads from SARS-CoV-2 positive mothers in third trimester (click here or PIIS0092867420317499). From Boston Massachussetts. Citation: Atyeo C, Pullen KM, Bordt EA, Fischinger S, Burke J, Michell A, Slein MD, Loos C, Shook LL, Boatin AA, Yockey LJ, Pepin D, Meinsohn MC, Nguyen NMP, Chauvin M, Roberts D, Goldfarb IT, Matute JD, James KE, Yonker LM, Bebell LM, Kaimal AJ, Gray KJ, Lauffenburger D, Edlow AG, Alter G. Compromised SARS-CoV-2-specific placental antibody transfer. Cell. 2020 Dec 23:S0092-8674(20)31749-9. doi: 10.1016/j.cell.2020.12.027. Epub ahead of print. PMID: 33476549; PMCID: PMC7755577.
Study 590 – antibody levels in 83 mother/infant dyads from USA
Anti-SARS-CoV-2 IgG crosses the placenta (click here or jamapediatrics flannery 2021 oi 210002 1611680224.61476). From Pennsylvania Hospital in Philadelphia, so may overlap with studies 65, 175, 202, 221, 350, 359 and 496. Citation: Flannery DD, Gouma S, Dhudasia MB, et al. Assessment of Maternal and Neonatal Cord Blood SARS-CoV-2 Antibodies and Placental Transfer Ratios. JAMA Pediatr. Published online January 29, 2021. doi:10.1001/jamapediatrics.2021.0038
Study 589 – 1,150 cases from Spain
No association between past flu & Tdap vaccination status, and severity of SARS-CoV-2 in pregnancy (click here or vaccines-09-00031). From the 78 Spanish Obstetric Emergency Group hospitals. Citation: de la Cruz Conty ML, Encinas Pardilla MB, Garcia Sanchez M, Gonzalez Rodriguez L, Muner-Hernando ML, Royuela Vicente A, Pintado Recarte P, Martinez Varea A, Martinez Diago C, Cruz Melguizo S, Martinez-Perez O, On Behalf Of The Spanish Obstetric Emergency Group. Impact of Recommended Maternal Vaccination Programs on the Clinical Presentation of SARS-CoV-2 Infection: A Prospective Observational Study. Vaccines (Basel). 2021 Jan 8;9(1):31. doi: 10.3390/vaccines9010031. PMID: 33429912; PMCID: PMC7826802.
Studies 582 to 588 added.
Study 588 – Case report from Sweden
From either Lund or Malmo (click here or main (13)). The clinical details differ from study 259b. Citation: Kolkova Z, Bjurström MF, Länsberg JK, Svedas E, Hamer MA, Hansson SR, Herbst A, Zaigham M. Obstetric and intensive-care strategies in a high-risk pregnancy with critical respiratory failure due to COVID-19: A case report. Case Rep Womens Health. 2020 Jul 8;27:e00240. doi: 10.1016/j.crwh.2020.e00240. PMID: 32714844; PMCID: PMC7340590.
Study 587 – 0/67 tested pregnant women from South Africa
From Kalafong Provincial Tertiary Hospital in Atteridgeville, Pretoria. Abstract only (click here). Citation: N. Mopane F. Molokoane M. Mojela L. Seopela L.C. Snyman. First results of universal SARS-CoV-2 virus testing of asymptomatic pregnant patients presenting for antenatal care at the Kalafong Provincial Tertiary Hospital. Obstetrics and Gynaecology Forum Vol. 30, No. 2 Jan 2020
Study 586 – Case report from France
From Service de Gynécologie-Obstétrique, Centre Fédératif de Pelvi-Périnéologie, CHU de Nantes, Nantes (click here or main (12)). Citation: Smati S, Mahot P, Bourdiol A, Ploteau S, Hadjadj S, Cariou B. Euglycaemic ketoacidosis during gestational diabetes with concomitant COVID-19 infection. Diabetes Metab. 2020 Jul 29:S1262-3636(20)30100-2. doi: 10.1016/j.diabet.2020.07.008. Epub ahead of print. PMID: 32738403; PMCID: PMC7387919.
Study 585 – Case report from India
From Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, Maharashtra (click here or 2838 Article Text 7183 1 10 20200818 (1)). Citation: Priyanka Singh, Neema Acharya, & Neha Verma. (2020). Experience of managing covid-19 suspected case in labour in a green zone district tertiary care hospital. International Journal of Research in Pharmaceutical Sciences, 11(SPL1), 500-505.
Study 584 – case report from Iran
From Imam Ali Hospital, Alborz University of Medical Sciences, Karaj (click here or main (11)). Citation: Motlagh AJ, Esmaelzadeh Saeieh S, Parhigar O, Salehi L. An asthmatic pregnant woman with COVID-19: A case report study. Respir Med Case Rep. 2020;31:101296. doi: 10.1016/j.rmcr.2020.101296. Epub 2020 Nov 19. PMID: 33240787; PMCID: PMC7676370.
Study 583 – case report from Spain
From Hospital Universitario 12 de Octubre, Madrid (click here or main (10)). Citation: López Pérez V, Cora Vicente J, Echevarría Granados C, Salcedo Vázquez ML, Estol F, Tebar Cuesta MY. Postpartum consciousness disturbance: can covid-19 cause posterior reversible encephalopathy syndrome? Rev Esp Anestesiol Reanim. 2020 Nov;67(9):511-515. English, Spanish. doi: 10.1016/j.redar.2020.06.008. Epub 2020 Jul 14. PMID: 33036761; PMCID: PMC7359790.
Study 582 – Case report from India
From Dr. RML Hospital, New Delhi, which has not previously reported cases (click here or fmaa094). Citation: Bandyopadhyay T, Sharma A, Kumari P, Maria A, Choudhary R. Possible Early Vertical Transmission of COVID-19 from an Infected Pregnant Female to Her Neonate: A Case Report. J Trop Pediatr. 2020 Nov 22:fmaa094. doi: 10.1093/tropej/fmaa094. Epub ahead of print. PMID: 33221859; PMCID: PMC7717437.
Studies 574 to 581 added.
Study 581 – Placental analysis of 39 cases from USA
From Yale New Haven Hospital so probably overlap with studies 132, 155 and 314 (click here or 2021.01.25.21250452v1.full). Citation: Alice Lu-Culligan, Arun R. Chavan, Pavithra Vijayakumar, Lina Irshaid, Edward M. Courchaine, Kristin M. Milano, Zhonghua Tang, Scott D. Pope, Eric Song, Chantal B.F. Vogels, William J. Lu-Culligan, Katherine H. Campbell, Arnau Casanovas-Massana, Santos Bermejo, Jessica M. Toothaker, Hannah J. Lee, Feimei Liu, Wade Schulz, John Fournier, M. Catherine Muenker, Adam J. Moore, Yale IMPACT Team, Liza Konnikova, Karla M. Neugebauer, Aaron Ring, Nathan D. Grubaugh, Albert I. Ko, Raffaella Morotti, Seth Guller, Harvey J. Kliman, Akiko Iwasaki, Shelli F. Farhadian. SARS-CoV-2 infection in pregnancy is associated with robust inflammatory response at the maternal-fetal interface. medRxiv 2021.01.25.21250452.
Study 580 – 2,126 cases from Brazil
From the Brazilian Ministry of Health, “severe acute respiratory syndrome” tracking database (click here or 2021.01.22.21250346v1.full). For pregnancies see table 1. Likely overlap with studies 66, 138, 182, 194, 201, 213, 248, 249, 278, 309, 358, 426, 552, and 565. Citation: Eduardo Pietre, Gabriel P Amorim, Maria F F Bittencourt, Marcelo Ribeiro-Alves, Mariana Acquarone Prevalent comorbidities among young and underprivileged: Death portrait of COVID-19 among 235 555 hospitalized patients in Brazil. medRxiv 2021.01.22.21250346.
Study 579 – 22 cases from USA
The authors are from Washington University in St. Louis, Missouri (click here or 1 s2.0 S2589933321000148 main). If the unnamed hospital was Barnes Jewish these cases may overlap with studies 69, 259 and 290. Citation: Megan C. OAKES MD , Annessa S. KERNBERG MD , Ebony B. CARTER MD MPH , Megan E. FOELLER MD , Arvind PALANISAMY MD FRCA , Nandini RAGHURAMAN MD MS , Jeannie C. KELLY MD MS , Pregnancy as a risk factor for severe coronavirus 2019 (COVID-19) disease using standardized clinical criteria, American Journal of Obstetrics & Gynecology MFM (2021).
Study 578 – serology of 88 cases from USA
From New York-Presbyterian Hospital, Weill Cornell, so probably overlapping with many previous studies (click here or 1 s2.0 S0002937821000533 main). Citation: Kubiak JM, Murphy EA, Yee J, Cagino K, Friedlander RL, Glynn SM, Matthews KC, Jurkiewicz M, Sukhu AC, Zhao Z, Prabhu M, Riley L, Yang YJ, SARS-CoV-2 serology levels in pregnant women and their neonates., American Journal of Obstetrics and Gynecology (2021).
Study 577 – Case report from Qatar
From Women’s Wellness and Research Center, Hamad Medical Corporation, Doha, which has not previously reported cases (click here or ccr3.3485). Probably included in studies 364 and 407. Citation: Yaqoub, S, Ahmad, S, Mansouri, Z, et al. Management of life‐threatening acute respiratory syndrome and severe pneumonia secondary to COVID‐19 in pregnancy: A case report and literature review. Clin Case Rep. 2021; 9: 137– 143.
Study 576 – 9 ECMO cases from USA & Italy
From Houston, Iowa, New York, Boston and Bergamo. Abstract only (click here). Citation: Barrantes JH, Ortoleva J, O’Neil ER, Suarez EE, Beth Larson S, Rali AS, Agerstrand C, Grazioli L, Chatterjee S, Anders M. Successful Treatment of Pregnant and Postpartum Women With Severe COVID-19 Associated Acute Respiratory Distress Syndrome With Extracorporeal Membrane Oxygenation. ASAIO J. 2021 Feb 1;67(2):132-136. doi: 10.1097/MAT.0000000000001357. PMID: 33229971.
Study 575 – 66 cases from Russia
Cared for at the National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation in Moscow which has not previously reported cases (click here or IJMF_0_1850683). Possible inclusion in study 278. Citation: Shmakov RG, Prikhodko A, Polushkina E, Shmakova E, Pyregov A, Bychenko V, Priputnevich TV, Dolgushin GO, Yarotskaya E, Pekarev O, Bolibok N, Degtyarev D, Sukhikh GT. Clinical course of novel COVID-19 infection in pregnant women. J Matern Fetal Neonatal Med. 2020 Nov 29:1-7. doi: 10.1080/14767058.2020.1850683. Epub ahead of print. PMID: 33249969; PMCID: PMC7711745.
Study 574 – Case report from Italy
From University Hospital, Modena, so probably included in studies 64, 117 and 252 (click here or R09Y9999N00A20113005). Citation: Sileo FG, Tramontano AL, Leone C, Meacci M, Gennari W, Ternelli G, La Marca A, Lugli L, Berardi A, Facchinetti F, Bertucci E. Pregnant woman infected by Coronavirus Disease (COVID-19) and calcifications of the fetal bowel and gallbladder: a case report. Minerva Ginecol. 2020 Nov 30. doi: 10.23736/S0026-4784.20.04717-6. Epub ahead of print. PMID: 33249821.
Studies 570 to 573 added.
Study 573 – 240 cases from USA
From 35 sites in Washington State (click here or 1-s2.0-S0002937821000338-main). These cases overlap with those in studies 83, 102, 139 and 389. Citation: Lokken EM, Huebner EM, Taylor GG, Hendrickson S, Vanderhoeven J,Kachikis A, Coler B, Walker CL, Sheng JS, al-Haddad BJS, McCartney SA, Kretzer NM, Resnick R,Barnhart N, Schulte V, Bergam B, Ma KK, Albright C, Larios V, Kelley L, Larios V, Emhoff S, Rah J,Retzlaff K, Thomas C, Paek BW, Hsu RJ, Erickson A, Chang A, Mitchell T, Hwang JK, Erickson S,Delaney S, Archabald K, Kline CR, LaCourse SM, Adams Waldorf KM, For the Washington StateCOVID-19 in Pregnancy Collaborative, Disease Severity, Pregnancy Outcomes and Maternal Deaths among Pregnant Patients with SARS-CoV-2 Infection in Washington State, American Journal ofObstetrics and Gynecology (2021).
Study 572 – Case report from Romania
From ‘Dr Carol Davila’ Central Military Emergency University Hospital, Bucharest, which has not previously reported cases (click here or etm 21 1 9524 PDF). Citation: Florea AA, Sirbu CA, Ghinescu MC, Plesa CF, Sirbu AM, Mitrica M and Ionita‑Radu F: SARS‑CoV‑2, multiple sclerosis, and focal deficit in a postpartum woman: A case report. Exp Ther Med 21: 92, 2021
Study 571 – serological testing in Spain
From Madrid (click here or pone.0243029). Overlap with study 458. Citation: Villalaı´n C, HerraizI, Luczkowiak J, Pe´rezRivilla A, Folgueira MD, Mejı´a I, et al. (2020) Seroprevalence analysis of SARS-CoV-2 in pregnant women along the first pandemic outbreak and perinatal outcome. PLoS ONE 15(11): e0243029.
Study 570 – 1,120 cases from USA
Abstract reporting 1,129 pregnant cases from Los Angeles county (click here or 1 s2.0 S0027968420302765 main). Of those who have given birth no neonates tested positive. Citation: L. Khadijah Lang, Covid-19 Maternal-Neonate Vertical Transmission Rates in Los Angeles County, Journal of the National Medical Association, Volume 112, Issue 5, Supplement, 2020, Pages S36-S37, ISSN 0027-9684.
Studies 567 to 569 added.
Study 569 – 39 cases from Turkey
Cared for at Ankara City Hospital so probably overlap with studies 203, 223, 244, 399, 444 and 512 (click here or [16193997t). Citation: Erol Koç, E. M., Fındık, R. B., Akkaya, H., Karadağ, I., Tokalıoğlu, E. Ö., & Tekin, Ö. M. (2020). Comparison of hematological parameters and perinatal outcomes between COVID-19 pregnancies and healthy pregnancy cohort, Journal of Perinatal Medicine (published online ahead of print 2020), 000010151520200403.
Study 568 – Case report from USA
Conference poster from Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY which has not previously reported cases (click here). Citation: Wander Praneet, He Qiu, Ceena Chandrabos, David Bernstein, Sanjaya Satapathy. P2162 (S2415). – COVID-19 Infection Presenting as Acute Hepatitis in a 22-Week Pregnant Woman. American Journal of Gastroenterology. Conference: 2020 Annual Scientific Meeting of the American College of Gastroenterology, ACG 2020. 115 (SUPPL) (pp S1282), 2020. Date of Publication: October 2020. AN: 633658549
Study 567 – Case report from USA
Cared for at Loyola University Medical Center, Chicago, Illinois, which has not previously reported cases (click here or S2301 COVID 19 and Ulcerative Colitis in Pregnancy.2301). Citation: Lewine, Eliza MD1; Trieu, Judy MD, MPH2; Asamoah, Nikiya MD2; Venu, Mukund MD, FACG2; Naik, Amar MD2 S2301 COVID-19 and Ulcerative Colitis in Pregnancy, The American Journal of Gastroenterology: October 2020 – Volume 115 – Issue – p S1217 doi: 10.14309/01.ajg.0000711252.28660.fc
Studies 550 to 566 added.
Study 566 – Two cases from Bangladesh
One pregnant woman with Covid-19 survived. The other died (click here or JSAFOG-12-258). They were both cared for at Chittagong Medical College Hospital, Chattogram, which has not previously reported cases. Citation: Rashid F, Shahnaz S, Sharmin R, et al. Pregnancy with COVID-19: Weal and Woe. J South Asian Feder Obst Gynae 2020;12(4):258–260.
Study 565 – Case report from Brazil
Cared for at Fundação Hospital de Clínicas Gaspar Vianna, Belém, Pará state, which has not previously reported cases (click here or en_1678-4170-abc-115-05-0936). Citation: HOLANDA, Lucianna Serfaty de et al. Infecção por COVID-19 em Gestante Cardiopata. Arq. Bras. Cardiol. [online]. 2020, vol.115, n.5 [cited 2021-01-26], pp.936-938. Available from: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2020001300936&lng=en&nrm=iso>. Epub Dec 07, 2020. ISSN 1678-4170.
Study 564 – Case report from Iran
Cared for at Urmia University of Medical Sciences, Urmia, which has not previously reported cases (click here or archcid-15-5-104394). Citation: Zarrintan A, Boeoofeh B , Rabieipour M , Mohammadi A, Khademvatani K, et al. Pulmonary Thromboembolism in a Pregnant Patient with Severe COVID19: A Novel Case Report and Review of Literature, Arch Clin Infect Dis. 2020 ; 15(5):e104394. doi: 10.5812/archcid.104394.
Study 563 – Case report from USA
From School of Medicine and Public Health, University of Wisconsin, Madison, which has not previously reported cases (click here or 1-s2.0-S221491122030103X main). Citation: Jennifer Jacobson, Kathleen Antony, Michael Beninati, William Alward, Kara K. Hoppe, Use of dexamethasone, remdesivir, convalescent plasma and prone positioning in the treatment of severe COVID-19 infection in pregnancy: A case report, Case Reports in Women’s Health, Volume 29, 2021, e00273, ISSN 2214-9112.
Study 562 – Case report from India
From Lokmanya Tilak Muncipal General Hospital, Mumbai (click here or JSAFOG-12-243) so probably included in study 245. Citation: Mevada SA, Mehendale MA, Nayak AH, et al. Cardiomyopathy in Pregnancy with COVID-19: An Enigma. J South Asian Feder Obst Gynae 2020;12(4):243–244
Study 561- Case report from USA
A mother with Covid-19 gave birth to a baby with an ischaemic upper limb (click here or [21928959–Case Reports in Perinatal Medicine] Neonate born with ischemic limb to a COVID-19 positive mother management and review of literature). The baby was cared for at Zucker School of Medicine at Hofstra, Northwell, New York. Citation: Perveen, S., Millington, K. A., Acharya, S., Grag, A., & Boyar, V. (2021). Neonate born with ischemic limb to a COVID-19 positive mother: management and review of literature, Case Reports in Perinatal Medicine, 10(1), 20200086.
Study 560 – 25 cases from France
Cared for at Cochin Hospital (Port-Royal Maternity) Paris (click here or 1 s2.0 S2468784720304177 main). Probably included in studies 150, 161 and 239. Citation: Tsatsaris V, Mariaggi AA, Launay O, Couffignal C, Rousseau J, Ancel PY, Marcault E, Ville Y, Cordier AG, Vivanti A, Carrara J, Luton D, Dommergues M, Borie C, Kayem G, Alessandrini V, Lecomte L, Meritet JF, Leruez-Ville M, Goffinet F, Dubois C, Picone O, Vauloup Fellous C. SARS-COV-2 IgG antibody response in pregnant women at delivery. J Gynecol Obstet Hum Reprod. 2020 Dec 10;50(7):102041. doi: 10.1016/j.jogoh.2020.102041. Epub ahead of print. PMID: 33310133.
Study 559 – 22 cases from China
Cared for at Tongji hospital, Wuhan (click here or 1-s2.0-S0924857920304805-main (1)). Previously reported many times. Citation: He Z, Fang Y, Zuo Q, Huang X, Lei Y, Ren X, Liu D. Vertical transmission and kidney damage in newborns whose mothers had coronavirus disease 2019 during pregnancy. Int J Antimicrob Agents. 2020 Dec 9:106260. doi: 10.1016/j.ijantimicag.2020.106260. Epub ahead of print. PMID: 33309765.
Study 558 – 19 cases from Uzbekistan
Abstract only (click here). Cared for in Kagan maternity hospital in Bukhara which has not previously reported cases. Citation: GULCHEKHRA A, IKHTIYAROVA, NIGORA K. DUSTOVA, MAVLYUDA A. KHASANOVA, GULRUKH S. SULEYMANOVA, SALIM S. DAVLATOV. Pathomorphological changes of the placenta in pregnant women infected with coronavirus covid-19 International Journal of Pharmaceutical Research ; 13(1):1935-1942, 2021.
Study 557 – case report from Kyrgyzstan
Cared for at City Maternity Hospital No. 2, 225 Moskva Street, Bishkek-720010, which has not previously reported cases (click here or 341 Article Text 592 1 10 20210107). Citation: Zhumabekova A, Tagaev T, Yethindra V, Zhumabaeva S, Ysabaeva D, Imankulova B. A case report of a pregnant woman with coronavirus disease 2019 (COVID-19) and her live-born infant. Biomedicine [Internet]. 2021Jan.1 [cited 2021Jan.26];40(4):551-3. Available from: https://biomedicineonline.org/index.php/home/article/view/341
Study 556 – case report from Iran
Cared for at Vasei Hospital, Sabzevar University of Medical Sciences, Sabzevar, which has not previously reported cases (click here or Tanaffos-19-152). Citation: Pourdowlat G, Mikaeilvand A, Eftekhariyazdi M, Nematshahi M, Ebrahimi M, Kazemzadeh A. Prone-Position Ventilation in a Pregnant Woman with Severe COVID-19 Infection Associated with Acute Respiratory Distress Syndrome. Tanaffos. 2020;19(2):152-155.
Study 555 – 56 cases from Iran
Cared for at Nekouei-Hedayati-Forqani Hospital in Qom which has not previously reported cases (click here or 32025 Article Text 134703 5 10 20210108 (2)). Citation: Mirzaie M, Shafie H, Heidarifar R, Yousefi MS, Yousefi MS. Relationship between ABO Blood Group Type and COVID-19 Outcome in Pregnant Women. J Cell Mol Anesth [Internet]. 2020Sep.23 [cited 2021Jan.26];5(4):282-3.
Study 554 – 4 cases from Saudi Arabia
Cared for at King Saud University Medical City, Riyadh which has not previously reported cases (click here or JEGH-10-3-214). Citation: Barry M, AlMohaya A, AlHijji A, Akkielah L, AlRajhi A, Almajid F, Alsharidi A, Al-Shahrani FS, Alotaibi NH, Alanazi A, Ghonem L, Alhetheel A, Alsubaie S, Memish ZA. Clinical Characteristics and Outcome of Hospitalized COVID-19 Patients in a MERS-CoV Endemic Area. J Epidemiol Glob Health. 2020 Sep;10(3):214-221. doi: 10.2991/jegh.k.200806.002. PMID: 32954712; PMCID: PMC7509106.
Study 553 – 29 cases from USA
Screened at University of Illinois at Chicago which has not previously reported cases (click here or 10 1055 s 0040 1721416). Citation: Buhimschi CS, Elam GL, Locher SR, Norris-Stojak D, Aldasoqi H, Stephenson MD, Buhimschi IA. Prevalence and Neighborhood Geomapping of COVID-19 in an Underserved Chicago Pregnant Population. AJP Rep. 2020 Oct;10(4):e413-e416. doi: 10.1055/s-0040-1721416. Epub 2020 Dec 3. PMID: 33294287; PMCID: PMC7714615.
Study 552 – Case report from Brazil
Cared for at Hospital Universitário da Universidade Federal do Maranhão, São Luis, MA. which has not previously reported cases (click 1806 9282 ramb 66 12 1621). Citation: PESSOA, Fabrício Silva et al. Probable vertical transmission identified within six hours of life. Rev. Assoc. Med. Bras. [online]. 2020, vol.66, n.12 [cited 2021-01-26], pp.1621-1624. Available from: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302020001201621&lng=en&nrm=iso>. Epub Dec 16, 2020. ISSN 1806-9282. https://doi.org/10.1590/1806-92126.96.36.1991.
Study 551 – Case report from USA
A maternal death from Covid-19 treated at St. Joseph’s University Medical Center, Paterson, New Jersey, which has not previously reported cases (click here or amjcaserep 21 e926591). Citation: Patel P, Kulkarni S, Guerrero M, Persaud C, Zuberi J, Rebein B. Emergency Cesarean Section at 38 Weeks of Gestation with COVID-19 Pneumonia: A Case Report. Am J Case Rep. 2020 Dec 19;21:e926591. doi: 10.12659/AJCR.926591. PMID: 33339814; PMCID: PMC7755590.
Study 550 – 67 cases from USA
From Massachussetts General Hospital, Boston (click here or ofaa524). Overlap with studies 142, 231, 262, 519, 531. Citation: M D Soffer, L L Shook, K James, M R Sawyer, A Ciaranello, R Mahrouk, S N Bernstein, A A Boatin, A G Edlow, C York-Best, A J Kaimal, I T Goldfarb, Protocol-Driven Intensive Outpatient Management of Pregnant Patients With Symptomatic Coronavirus Disease 2019, Open Forum Infectious Diseases, Volume 7, Issue 11, November 2020, ofaa524.
Studies 547 to 549 added.
Study 549 – 32 cases from UK
These 32 women with Covid-19 in pregnancy were cared for at Newham University Hospital in London which has not previously reported cases (click here or 1753495 20985403). One woman died. They are included in the UKOSS reports. Citation: Milln J, Heard S, Gunganah K, Velauthar L, Saeed F. Clinical characteristics and pregnancy outcomes of women diagnosed with SARS-CoV-2 in London’s most ethnically diverse borough: A cross-sectional study. Obstetric Medicine. January 2021. doi:10.1177/1753495X20985403
Study 548 – 279 cases from Spain
Of 279 women with SARS-Cov-2 cared for in the 42 hospitals of the Spanish Obstetric Emergency Group, 174 were asymptomatic, and are reported in this paper (click here or Cruz-Lemini viruses-13-00112). They likely overlap with many of the previous studies from Spain. Citation: Cruz-Lemini, M.; Ferriols Perez, E.; de la Cruz Conty, M.L.; Caño Aguilar, A.; Encinas Pardilla, M.B.; Prats Rodríguez, P.; Muner Hernando, M.; Forcen Acebal, L.; Pintado Recarte, P.; Medina Mallen, M.d.C.; et al. Obstetric Outcomes of SARS-CoV-2 Infection in Asymptomatic Pregnant Women. Viruses 2021, 13, 112.
Study 547 – 879 cases from India
This paper from Nair Hospital, Mumbai reports on five pregnant women with Covid-19 (out of 879 treated in that hospital) who also had heart disease (click here or Tilve India EJOG in press). They probably overlap with those in studies 225, 283 & 520, but the clinical details suggest no overlap with studies 369 & 501. Citation: Tilve A, Mahajan NN, Pandey A, Jnanananda B, Gadekar S, Mahale SD, Gajbhiye RK, Impact of COVID-19 on pregnant women with Rheumatic heart disease or Peripartum cardiomyopathy, European Journal of Obstetrics and amp; Gynecology and Reproductive Biology (2021).
Studies 545 and 546 added.
Study 546 – 55,154 cases from the US
The CDC tracking data up to Jan 11th 2021 includes 55,154 pregnant women with Covid-19, of whom 66 (0.12%) had died (click here). Citation: Centres for Disease Control. Weekly COVID-19 Pregnancy Data updated January 11 2021, Accessed 19 Jan 2021.
Study 545 – 3,928 cases from the Netherlands
January 6 update of NETHOSS registry includes 3,928 women with Covid-19 in pregnancy and further details (click here). 26 women were treated in ITU, 10 ventilated and one woman died. There is also a graph showing the first and second waves. Available here. Accessed 19 Jan 2021.
Study 544 added.
Study 544 – 6,380 cases from US
Among these 6,380 women with Covid-19, 86 required ventilation and nine died (click here or jamainternal jering 2021 ld 200094 1610581352.25094). They were identified from a multi-hospital database covering about 20% of the United States, so will overlap with other series. Citation: Jering KS, Claggett BL, Cunningham JW, et al. Clinical Characteristics and Outcomes of Hospitalized Women Giving Birth With and Without COVID-19. JAMA Intern Med. Published online January 15, 2021. doi:10.1001/jamainternmed.2020.9241
Study 543 added.
Study 543 – Case report from Ireland
A woman contracted COVID-19 at 36 weeks and was delivered by Caesarean (click here or 1-s2.0-S0143400421000205-main). Placental histology is described in detail. Mother and baby recovered. She was cared for at Cork University Maternity Hospital, which has not previously reported cases. Citation: Linehan L, O’Donoghue K, Dineen S, White J, Higgins JR, Fitzgerald B, SARS-CoV-2 Placentitis: An uncommon complication of maternal COVID-19, Placenta, https://doi.org/10.1016/j.placenta.2021.01.012.
Studies 540 to 542 added.
Study 542 – 112 cases in ICU in UK
The 8 January ICNARC report includes 69 currently and 43 recently pregnant women in ICU with Covid-19 since 1 September 2020 (available here or ICNARC COVID-19 Report 2021-01-08.pdf). 12 and 13 women respectively were ventilated. Citation: Intensive Care National Audit & Research Centre. ICNARC report on COVID-19 in critcal care: England, Wales and Northern Ireland 8 January 2021 Accessed 14 January 2021. https://www.icnarc.org/Our-Audit/Audits/Cmp/Reports
Study 541 – 73 cases from Spain
73 women with Covid-19 gave birth to 79 babies (click here or S1695403320305233). [Spanish. English abstract] No babies tested positive. From author affiliations they were probably cared for at Hospital General Universitario Gregorio Marañón, Madrid, so probably overlap with cases in studies 151 and 381. Citation: Gonzalo Solís-García, Ana Gutiérrez-Vélez, Isabel Pescador Chamorro, Elena Zamora-Flores, Sara Vigil-Vázquez, Elena Rodríguez-Corrales, Manuel Sánchez-Luna, Epidemiología, manejo y riesgo de transmisión de SARS-CoV-2 en una cohorte de hijos de madres afectas de COVID-19, Anales de Pediatría, 2020, ISSN 1695-4033, . (http://www.sciencedirect.com/science/article/pii/S1695403320305233)
Study 540 – 9 cases from Israel
Of 1,326 asymptomatic pregnant women tested, 9 were positive for SARS-CoV-2 (click here or PIIS0002937821000259). No clinical details. From author affiliations they were probably cared for at Hadassah-Hebrew University Medical Center, Jerusalem, so may overlap with cases in study 330. Citation: Rottenstreich A, Zarbiv G, Kabiri D, Benenson S, Oster Y, Porat S, Sompolinsky Y, Reubinoff B, Rapid antigen detection testing for universal screening for SARS-CoV-2 in women admitted for delivery, American Journal of Obstetrics and Gynecology (2021).
Studies 536 to 539 added.
Study 539 -1,606 cases from UK and 2,398 from USA
This Medxiv preprint describes 1,606 cases collected by the UK PanCovid registry and 2,398 fromthe US American Academy of Pediatrics Section on Neonatal Perinatal Medicine (AAP SONPM) National Perinatal COVID-19 Registry (click here or 2021.01.06.21249325v1.full). They likely overlap with other UK and US registries and reports. Citation: Edward Mullins, Mark Hudak, Jay Banerjee, Trace Getzlaff, Julia Townson, Kimberly Barnette, Rebecca Playle, Tom Bourne, PAN-COVID-investigators, National Perinatal COVID-19 Registry Study Group, Christoph Lees Pregnancy and neonatal outcomes of COVID-19, co-reporting of common outcomes from the PAN-COVID and AAP SONPM registry. medRxiv 2021.01.06.21249325.
(23 Feb Update. Preprint in J Ultrasound Obstet Gynecol (click here or uog.23619). Cases reported from the AAP SONPM registry now 2,399. Two figures and four tables, referenced within, but missing from the MedRxiv preprint added. Citation: Mullins, E., Hudak, M.L., Banerjee, J., Getzlaff, T., Townson, J., Barnette, K., Playle, R., Bourne, T., Lees, C. on behalf of PAN‐COVID investigators and the National Perinatal COVID‐19 Registry Study Group (2021), Pregnancy and neonatal outcomes of COVID‐19: co‐reporting of common outcomes from PAN‐COVID and AAP SONPM registries. Ultrasound Obstet Gynecol. Accepted Author Manuscript. )
Study 538 – Case report from Iran
A woman who had recently delivered from a pregnancy complicated by pre-eclampsia contracted Covid-19 four days post-partum (click here or 1-s2.0-S2210778920301367-main). Despite intensive care and ventilation, she died on May 28th. She was cared for in Iranshahr University of Medical Sciences, Baluchestan, which has not previously reported cases. Citation: Fatemeh Azarkish, Firouzeh Sheikhi, Zohreh Mirkazehi, Saeed Kalkali, Paria Bameni Moghadam, Mahya Zahirniya, Preeclampsia and the crucial postpartum period for Covid-19 infected mothers: A case report, Pregnancy Hypertension, Volume 23, 2021, Pages 136-139, ISSN 2210-7789, https://doi.org/10.1016/j.preghy.2020.10.012.
Study 537 – Case report of ECMO from USA
A woman with Covid-19 at 23 weeks gestation was treated with ECMO, and recovered (click here or mark ECMO pzaa189). From author affiliations she was likely treated at the University of Iowa Heart and Vascular Center, which has not previously reported pregnancy cases. However she may be included in study 535. Citation: Alex Mark, Jennifer P Crumley, Kristina L Rudolph, Kevin Doerschug, Anna Krupp, Maintaining Mobility in a Patient Who Is Pregnant and Has COVID-19 Requiring Extracorporeal Membrane Oxygenation: A Case Report, Physical Therapy, , pzaa189.
Study 536 – 534 cases from Italy
This report, in Italian, includes 534 cases of Covid-19 in pregnancy, reported to the ITOSS registry between February 25th and July 10th 2020 (click here or itOSS 081-087_ART-Corsi (002)). There will be overlap with study 246. Citation: Edoardo Corsi, Alice Maraschini, Enrica Perrone, Michele Antonio Salvatore, Paola D’Aloja, Serena Donati, Gruppo di lavoro ItOSS COVID-194. La preparedness dell’Italian obstetric surveillance system in occasione della pandemia da SARS-CoV-2: aspetti metodologici di uno studio di popolazione. (The preparedness of the Italian obstetric surveillance system in the response to the emergency of the SARS-CoV-2 pandemic: methodological aspects of a population-based study) Epidemiol Prev 2020; 44 (5-6) Suppl 2:81-87. doi: 10.19191/EP20.5-6.S2.089
Study 535 added.
Study 535 – 22 pregnant women treated with ECMO
This series of people with Covid-19 treated with ECMO between Jan 16 and May 1, 2020, from 213 hospitals in 36 countries, includes 22 pregnant women (click here or PIIS0140673620320080). No separate outcome data. Citation: Barbaro, Ryan P, Alexander, Peta et al. Extracorporeal membrane oxygenation support in COVID-19: an international cohort study of the Extracorporeal Life Support Organization registry The Lancet, Volume 396, Issue 10257, 1071 – 1078.
Study 534 added.
Study 534 – 145 cases from Italy
Of 145 pregnant women with SARS-CoV-2 infection, 116 were symptomatic (click here or DiGuardo2021 Article PoorMaternalNeonatalOutcomesIn). Seven mothers and nine neonates died. They were cared for in two unnamed tertiary referral hospitals between March and July 2020. The authors are affiliated with one hospital in Calabria, in the south, two in Catania, Sicily and one in Vicenza in the North East. Ethics approval was from another hospital in Sicily. Assuming the two hospitals are in Sicily, these cases have probably not been reported. None of the author affiliations were with Palermo, study 355. Citation: Di Guardo F, Di Grazia FM, Di Gregorio LM, Zambrotta E, Carrara G, Gulino FA, Tuscano A, Palumbo M. Poor maternal-neonatal outcomes in pregnant patients with confirmed SARS-Cov-2 infection: analysis of 145 cases. Arch Gynecol Obstet. 2021 Jan 3:1–6. doi: 10.1007/s00404-020-05909-4. Epub ahead of print. PMID: 33389111; PMCID: PMC7778712.
Study 533 added.
Study 533 – 1,148 cases from UK
This Medxiv preprint describes 1,148 pregnant women with SARS-CoV-2, 722 with symptoms. who were admitted to hospital (click here or UKOSS Preprint (002)). Of 640 completed pregnancies, there were 16 pregnancy losses before 24 weeks, 5 stillbirths and 2 neonatal deaths. Eight mothers died. Collected from all 194 consultant-led obstetric units in the United Kingdom between 1st March and 31st August 2020, they therefore overlap with those reported in study 92. Citation: Nicola Vousden, Kathryn Bunch, Edward Morris, Nigel Simpson, Christopher Gale, Patrick O’Brien, Maria Quigley, Peter Brocklehurst, Jennifer J Kurinczuk, Marian Knight. The incidence, characteristics and outcomes of pregnant women hospitalized with symptomatic and asymptomatic SARS-CoV-2 infection in the UK from March to September 2020: a national cohort study using the UK Obstetric Surveillance System (UKOSS). medRxiv 2021.01.04.21249195.
[important] Update 16 May. Peer review published (click here or study) Citation: Vousden N, Bunch K, Morris E, Simpson N, Gale C, O’Brien P, et al. (2021) The incidence, characteristics and outcomes of pregnant women hospitalized with symptomatic and asymptomatic SARS-CoV-2 infection in the UK from March to September 2020: A national cohort study using the UK Obstetric Surveillance System (UKOSS). PLoS ONE 16(5): e0251123.
Studies 529 to 532 added.
Study 532 – zero pregnancy cases in a city in Japan
All 1475 pregnant women and 1343 partners tested for COVID-19 by PCR in saliva in all 12 maternity facilities in Himeji city between May 29 and September 5, 2020 were negative (click here or jog.14591). Over the same period 74 non-pregnant patients had Covid-19 in the same city. Citation: Okamura S, Akamatsu N, Kitajima T, Nakabayashi K, Fukumoto S, Katayama T, Mizutani Y, Kiyomoto H, Yamada H. Screening of COVID-19 polymerase chain reaction tests using saliva for pregnant women and their partners in Himeji city. J Obstet Gynaecol Res. 2020 Dec 22. doi: 10.1111/jog.14591. Epub ahead of print. PMID: 33354868.
Study 531 – 68 cases from USA
This preprint includes 68 pregnant women with suspected or confirmed COVID-19 (click here or 2907ed6a c4cd 4147 b0bd a5c41c5afec6). They were recruited through social media. Authors are mostly affilated with Harvard Medical School or Massachusetts General Hospital. Citation: Mayopoulos G, Ein-Dor T, Li K, Chan S, Dekel S. Giving birth under hospital visitor restrictions: Heightened acute stress in childbirth in COVID-19 positive women. Res Sq [Preprint]. 2020 Dec 9:rs.3.rs-112882. doi: 10.21203/rs.3.rs-112882/v1. PMID: 33330856; PMCID: PMC7743075.
Study 530 – 70 cases from Iran
Of 70 pregnant women with COVID-19 hospitalized from early March to late April 2020, two mothers died (click here or aim 23 856). 15/32 births were premature but no other baby outcomes are reported. The patients were cared for in various unnamed hospitals in Guilan province. Author affiliations suggest that these included Al-Zahra Hospital, in Rasht, which has not previously reported cases. Shared authors suggest the maternal deaths may overlap with those reported in study 67. Citation: Kazemi Aski S, Sharami SH, Hosseinzadeh F, Hesni E, Dalil Heirati SF, Ghalandari M, Mousavi A. Risk Factors, Clinical Symptoms, Laboratory Findings and Imaging of Pregnant Women Infected with COVID-19 in North of Iran. Arch Iran Med. 2020 Dec 1;23(12):856-863. doi: 10.34172/aim.2020.114. PMID: 33356344.
Study 529 – Case report from the Netherlands
A woman with Covid-19 was delivered by Caesarean at 31 weeks (click here or piaa153). There was evidence of SARS-CoV-2 in the placenta and the baby developed complications of both prematurity and birth asphyxia. However the baby tested negative. They were cared for in Erasmus University Medical Center, Rotterdam, which has not previously reported cases. The case was probably included in the NETHOSS registry. Citation: Schoenmakers S, Snijder P, Verdijk RM, Kuiken T, Kamphuis SSM, Koopman LP, Krasemann TB, Rousian M, Broekhuizen M, Steegers EAP, Koopmans MPG, Fraaij PLA, Reiss IKM. Severe Acute Respiratory Syndrome Coronavirus 2 Placental Infection and Inflammation Leading to Fetal Distress and Neonatal Multi-Organ Failure in an Asymptomatic Woman. J Pediatric Infect Dis Soc. 2020 Dec 26:piaa153. doi: 10.1093/jpids/piaa153. Epub ahead of print. PMID: 33367801.
Studies 525-528 added.
Study 528 – 16 cases from Singapore
16 pregnant women with COVID-19 cared for in 4 hospitals (abstract only click here). Citation: Mattar CN, Kalimuddin S, Sadarangani SP, Tagore S, Thain S, Thoon KC, Hong EY, Kanneganti A, Ku CW, Chan GM, Lee KZ, Yap JJ, Tan SS, Yan B, Young BE, Lye DC, Anderson DE, Yang L, Su LL, Somani J, Tan LK, Choolani MA, Chan JK. Pregnancy Outcomes in COVID-19: A Prospective Cohort Study in Singapore. Ann Acad Med Singap. 2020 Nov;49(11):857-869. PMID: 33381779.
Study 527 – 114 cases from Peru
114 pregnant women positive for SARS-CoV-2, between April 15 and May 10, 2020, who delivered in the National Perinatal Maternal Institute, Lima, which has not previously reported cases (English abstractonly click here). Three newborns died. Citation: Dávila-Aliaga C, Espínola-Sánchez M, Mendoza-Ibáñez E, Guevara-Ríos E, Torres-Marcos E, Hinojosa-Pérez R, Espinoza-Vivas Y, Álvarez-Carrasco R, Velásquez-Vásquez C, Meza-Santibáñez L, Gonzales-Carrillo O, Arango-Ochante P, Racchumí-Vela A, Saldaña-Díaz C. Resultados perinatales y serológicos en neonatos de gestantes seropositivas para SARS-CoV-2: estudio transversal descriptivo [Perinatal outcomes and serological results in neonates of pregnant women seropositive to SARS-CoV-2: A cross-sectional descriptive study]. Medwave. 2020 Dec 21;20(11):e8084. Spanish. doi: 10.5867/medwave.2020.11.8084. PMID: 33382393.
Study 526 – 35 pregnant women from Switzerland
There were 35 pregnant women in this preprint hospital registry study up to August 31st, 2020 (click here or 2020.12.10.20246884v2.full). One went to ICU. No mothers died. No baby outcomes were reported. They were cared for 20 hospitals listed in the paper, and may overlap with cases in studies 72, 310 & 427. Citation: Amaury Thiabaud, Anne Iten, Carlo Balmelli, Laurence Senn, Nicolas Troillet, Andreas Widmer, Domenica Flury, Peter W. Schreiber, Miriam Vázquez, Lauro Damonti, Michael Buettcher, Danielle Vuichard-Gysin, Christoph Kuhm, Alexia Cusini, Thomas Riedel, Yvonne Nussbaumer, Roman Gaudenz, Ulrich Heininger, Christoph Berger, Franziska Zucol, Sara Bernhard-Stirnemann, Natascia Corti, Petra Zimmermann, Anita Uka, Anita Niederer-Loher, Céline Gardiol, Maroussia Roelens, Olivia Keiser. SARS-CoV-2/COVID-19 hospitalised patients in Switzerland: a prospective cohort profile. medRxiv 2020.12.10.20246884.
Study 525 – 41 cases from Canada
Of 41 pregnant women testing positive for SARS-CoV-2, 30 had symptoms (click here or montreal). Two women required ventilation. There were no maternal deaths. No baby outcomes were reported. They were cared for in the Jewish General Hospital in Montreal, Quebec, which has not previously reported cases. Citation: Trahan, Marie-Julie et al.Screening and Testing Pregnant Patients for SARS-CoV-2: First-Wave Experience of a Designated COVID-19 Hospitalization Centre in Montreal J Obstet Gynaecol Can 2020;36(00):1−5.
Study 254 added.
Study 524 – 30 cases from Reus
13 pregnant and 17 postpartum women with Covid-19 in this series collected between 15th March and 15th October (click here or 2020.12.10.20246959v2.full). The authors suggest that pregnancy infection was more common in the second wave. Citation: Simona Iftimie, Ana F. López-Azcona, Immaculada Vallverdú, Salvador Hernàndez-Flix, Gabriel de Febrer, Sandra Parra, Anna Hernández-Aguilera, Francesc Riu, Jorge Joven, Jordi Camps, Antoni Castro, REUSCOVID Study Group. First and second waves of coronavirus disease-19: A comparative study in hospitalized patients in Reus, Spain. medRxiv 2020.12.10.20246959.
Study 523 added.
Study 523 – seropositivity in pregnancy in Sweden
This preprint reports that about 15% of randomly sampled asymptomatic pregnant women from the Stockholm area had antibodies to SARS-CoV-2 by December 2020 (click here or 2020.12.24.20248821v1.full). 96% at levels that would be expected to confer immunity. Citation: Xaquin Castro Dopico, Sandra Muschiol, Murray Christian, Leo Hanke, Daniel J. Sheward, Nastasiya F. Grinberg, Gordana Bogdanovic, Gerald M. Mcinerney, Tobias Allander, Chris Wallace, Ben Murrell, Jan Albert, Gunilla B. Karlsson Hedestam. Seropositivity in blood donors and pregnant women during 9-months of SARS-CoV-2 transmission in Stockholm, Sweden. medRxiv 2020.12.24.20248821.
Studies 521 & 522 added. Citation for study 313 updated.
Study 522 – Pancreatitis in a pregnant woman with Covid-19
A woman with severe Covid-19 at 33 weeks gestation also developed pancreatitis (click here or Acute Pancreatitis in a Pregnant Patient With.75). She went into preterm labour and delivered vaginally. Both mother and baby recovered. From author affiliations she was cared for at the Mayo Clinic, Rochester, Minnesota. USA, which has not previously reported cases. Citation: Narang K, Szymanski LM, Kane SV, Rose CH. Acute Pancreatitis in a Pregnant Patient With Coronavirus Disease 2019 (COVID-19). Obstet Gynecol. 2020 Dec 22;Publish Ahead of Print. doi: 10.1097/AOG.0000000000004287. Epub ahead of print. PMID: 33355431.
Study 521 – 57 cases from India
Between May 5, and June 5, 2020, 348 pregnant women were tested and 57 positive for SARS-CoV-2 at Safdarjung Hospital, New Delhi (click here or PIIS170121632030829X). Three women died. Five babies tested positive but survived. Two test negative babies died. Likely overlap with study 441. Citation: Sumitra Bachani, Renu Arora, Anjali Dabral, Sheeba Marwah, Pratima Anand, K. Sravani Reddy, Nitesh Gupta, Balwinder Singh, Clinical Profile, Viral Load, MaternalFetal Outcomes of Pregnancy With COVID-19: 4-Week Retrospective, Tertiary Care Single-Centre Descriptive Study J Obstet Gynaecol Can 2020;000(000):1−9.
Study 520 added.
Study 520 – 879 cases from India
This series from Nair Hospital, Mumbai included 879 women with Covid-19 seen between April 4 and September 10, 2020 (click here or ijgo.13508). They likely overlap with cases reported in studies 225, 283, 369 and 501. Citation: Mahajan, N.N., Ansari, M., Gaikwad, C., Jadhav, P., Tirkey, D., Pophalkar, M.P., Bhurke, A.V., Modi, D.N., Mahale, S.D. and Gajbhiye, R.K. (2020), Impact of SARS‐CoV‐2 on multiple gestation pregnancy. Int J Gynecol Obstet.
Studies 518 and 519 added.
Study 519 – 127 cases from USA
A detailed analysis of viraemia, and placental transfer of virus and antibodies, in 127 pregnant women with SARS-CoV-2 (click here or edlow 2020 oi 200960 1607964328.94511). They were cared for in Massachusetts General, Brigham and Women’s Hospital, and Beth Israel Deaconess Medical Center, in Boston, Massachusetts between April 2 & June 13, 2020, and likely overlap with those in studies 129, 142, 231 and 232. Citation: Edlow AG, Li JZ, Collier AY, et al. Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic. JAMA Netw Open. 2020;3(12):e2030455. doi:10.1001/jamanetworkopen.2020.30455
Study 518 – 7,028 cases from Mexico
7,028 pregnant with COVID-19 identified through the Mexican Public Health Network between February 1st and October 27th (click on Martinez Portilla AJOG). 93 (1.3%) women died. They had been cared for 475 unnamed monitoring hospitals. A further analysis of the series reported in study 513, with additional cases. Citation: Martinez Portilla RJ, Smith ER, He S, Torres JT, Espino-Y-Sosa S, Solis-Paredes JM, Poon LC, Young pregnant women are also at an increased risk of mortality and severe illness due to COVID-19: Analysis of the Mexican National Surveillance Program, American Journal of Obstetrics and Gynecology (2021).
Study 517 added.
Study 517 – 47 screen positives in US
Of 126 women screened on admission in labour to Elmhurst Hospital, between March 29 and April 22, 45 tested positive for SARS-CoV-2 (click here or pone.0238409). They likely overlap with those in studies 160 and 236. Citation: Maru S, Patil U, Carroll-Bennett R, Baum A, Bohn-Hemmerdinger T, Ditchik A, et al. (2020) Universal screening for SARS-CoV-2 infection among pregnant women at Elmhurst Hospital Center, Queens, New York. PLoS ONE 15(12): e0238409. https://doi.org/10.1371/journal. pone.0238409
Studies 513 to 516 added.
Study 516 – 22 cases from China
22 neonates born to women with Covid-19 and admitted to Tongji Hospital, Wuhan, from January 1 to April 1, 2020 (click here or 1 s2.0 S0924857920304805 main). These cases have likely been reported before. Citation: Zheng He, Yinian Fang, Qin Zuo, Xiaoxing Huang, Yongfang Lei, Xiuhua Ren, Dong Liu, Vertical transmission and kidney damage in newborns from coronavirus disease 2019 infection pregnant mother, International Journal of Antimicrobial Agents (2020).
Study 515 – 90 cases from Iran
45 symptomatic and 45 asymptomatic women with SARS-CoV-2 were compared (click here or Pregnancy outcomes among symptomatic and asymptomatic women infected with COVID 19 in the west of Iran a case control study). They were cared for in various hospitals of Hamadan Province, and therefore likely overlap with study 375. Citation: Ensiyeh Jenabi , Saeid Bashirian , Salman Khazaei , Seyedeh Zahra Masoumi , Samereh Ghelichkhani , Firoozeh Goodarzi & Mohammad Mirzaei (2020): Pregnancy outcomes among symptomatic and asymptomatic women infected with COVID-19 in the west of Iran: a case-control study, The Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2020.1861599
Study 514 – 9 cases from Iran
A woman with Covid-19 gave birth at 37 weeks (click here or aaem-9-e5). The baby tested positive. The babies of 8 other affected women in the same hospital tested negative. They were cared for at Mahdiyeh Hospital, Shahid Beheshti University of Medical Sciences, Tehran, which has not previously reported cases. Citation: Parsa Y, Shokri N, Jahedbozorgan T, Naeiji Z, Zadehmodares S, Moridi A. Possible Vertical Transmission of COVID-19 to the Newborn; a Case Report: Vertical Transmission and The Coronavirus . Arch Acad Emerg Med [Internet]. 2020Nov.15 [cited 2020Dec.19];9(1):e5.
Study 513 – 5,183 cases in Mexico
5,183 pregnant women with Covid-19 identified through the National Data Registry of Mexico from February 1st, to October 28th, 2020 (click here or uog.23575). 77(1·5%) mothers died. They had been cared for in 475 unnamed monitoring hospitals, located in all 32 states. Citation: Martinez‐Portilla, R.J., Sotiriadis, A., Chatzakis, C., Torres‐Torres, J., Espino y Sosa, S., Sandoval‐Mandujano, K., Castro‐Bernabe, D.A., Medina‐Jimenez, V., Monarrez‐Martin, J.C., Figueras, F. and Poon, L.C. (2020), Pregnant women with SARS‐CoV‐2 infection are at higher risk of death and severe pneumonia: propensity score‐matched analysis of a nationwide prospective cohort study (COV19Mx). Ultrasound Obstet Gynecol. Accepted Author Manuscript.
Studies 511 (belatedly) and 512 added.
Study 512 – 60 cases from Turkey
60 pregnant women with Covid-19 (click here or jmv.26725). Cared for in Ankara City Hospital between 26 June and 27 August 2020. Probably overlapping with studies 31, 203, 223, 244, 399 & 444. Citation: Erol, S.A., Tanacan, A., Anuk, A.T., Tokalioglu, E.O., Biriken, D., Keskin, H.L., Tekin, O.M., Yazihan, N. and Sahin, D. (2020), Evaluation of Maternal Serum Afamin and Vitamin E Levels in Pregnant Women with COVID‐19 and Its Association with Composite Adverse Perinatal Outcomes. J Med Virol. Accepted Author Manuscript.
Study 511 – 9 cases from China
We were originally unable to source this early paper despite it being cited in a number of early reports (click here or 1007 9408 23 0004s). Patients were treated in the People’s Hospital of Wuhan University from January 22 to February 1, 2020, and therefore likely reported many times elsewhere. In Chinese. Citation: Lei Di, Wang Chen, Li Chunyan, et al. Clinical analysis of 9 cases of pregnancy with new coronavirus pneumonia[J]. Chinese Journal of Perinatal Medicine, 2020,23 (03): 225-231. DOI: 10.3760/cma. j.cn113903-20200216-00117
Study 510 added.
Study 510 – 1,584 cases in Canada
The first report of the Canadian Covid in pregnancy registry CanCovid (click here or CANCOVID Preg report 1 BC AB ON data 02DEC2020). As of November 23rd, 2020, 1,584 pregnant women with SARS-CoV-2 had been reported in Canada. 430 are reported here in detail. Eight were admitted to ITU. Nos. of events which affected <6 women are not reported. Citation: Deborah Money. CANADIAN SURVEILLANCE OF COVID-19 IN PREGNANCY: EPIDEMIOLOGY, MATERNAL AND INFANT OUTCOMES Report #1: Released December 2nd, 2020 School of Population & Public Health, University of British Colombia
Study 509 added.
Study 509 – Case in China
A woman with Covid-19 at 36 weeks was delivered by Caesarean on 24 January (click here or PIIS0007091220301318). She was cared for at Wuhan Red Cross Hospital grid.507948.7, which has not previously reported cases. Citation: Xia H, Zhao S, Wu Z, Luo H, Zhou C, Chen X. Emergency Caesarean delivery in a patient with confirmed COVID-19 under spinal anaesthesia. Br J Anaesth. 2020 May;124(5):e216-e218. doi: 10.1016/j.bja.2020.02.016. Epub 2020 Mar 17. PMID: 32192711; PMCID: PMC7118662.
Studies 501 to 508 added.
Study 508 – Case from Shiraz, Iran
A woman with Covid-19 was delivered by Caesarean section at term and suffered a post-partum pulmonary embolus (click here or 20-1383). She was cared for at Shiraz University of Medical Sciences, Shiraz, Iran, which has not previously reported cases. Citation: Khodamoradi Z, Boogar SS, Shirazi FKH, Kouhi P. COVID-19 and Acute Pulmonary Embolism in Postpartum Patient. Emerg Infect Dis. 2020;26(8):1937-1939. doi:10.3201/eid2608.201383
Study 507 – 71 cases in New Jersey, USA
71 pregnant women with Covid-19 and their babies (click here or s-0040-1713416) were cared for in Morristown Medical Center, and at Overlook Medical Center in New Jersey, USA, and therefore may overlap with those reported in study 159. Citation: Griffin I, Benarba F, Peters C, Oyelese Y, Murphy T, Contreras D, Gagliardo C, Nwaobasi-Iwuh E, DiPentima MC, Schenkman A. The Impact of COVID-19 Infection on Labor and Delivery, Newborn Nursery, and Neonatal Intensive Care Unit: Prospective Observational Data from a Single Hospital System. Am J Perinatol. 2020 Aug;37(10):1022-1030. doi: 10.1055/s-0040-1713416. Epub 2020 Jun 13. PMID: 32534458; PMCID: PMC7416206.
Study 506 – 37 cases from New York
37 pregnant women with Covid-19 were cared for at Flushing Hospital Medical Centre or Jamaica Hospital Medical Centre in New York, between March 20, and April 30, 2020 (click here or IDOG2020-8460672). Neither hospital has previously reported cases. Citation: Sindy C. Moreno, Justin To, Hajoon Chun, Ivan M. Ngai, “Vertical Transmission of COVID-19 to the Neonate”, Infectious Diseases in Obstetrics and Gynecology, vol. 2020, Article ID 8460672, 5 pages, 2020.
Study 505 – Case report from New York
A woman with clinical Covid-19 (PCR negative but antibody positive) at 26 weeks gestation required 23 days ventilation (click here or CRIOG2020-8891787). She delivered vaginally at 39 weeks. The baby was healthy. From author affiliations she was cared for at New York Presbyterian-Brooklyn Methodist Hospital, so may be included in study 230 and possibly other studies from the NY Presbyterian network. Citation: Farah Alsayyed, Victoria Hastings, Sanford Lederman, “Expectant Management of a Critically Ill Pregnant Patient with COVID-19 with Good Maternal and Neonatal Outcomes”, Case Reports in Obstetrics and Gynecology, vol. 2020, Article ID 8891787, 6 pages, 2020.
Study 504 – Four mothers, five babies from Rome, Italy
Four women with Covid-19 had five babies who became infected (click here or olivini ItJ Ped 2020). From author affiliations the babies were cared for at Bambino Gesù Children’s Hospital – IRCCS, Rome, Italy. The paper has no OB authors so it is not clear which maternity hospital cared for the mothers. However, it is possible that some of them were included in studies 76, 78 and 464. Citation: Olivini, N., Calò Carducci, F.I., Santilli, V. et al. A neonatal cluster of novel coronavirus disease 2019: clinical management and considerations. Ital J Pediatr 46, 180 (2020).
Study 503 – “Rooming in” in Lombardy
Of 61 mothers with Covid-19, and 62 neonates “roomed in”, only one baby got infected (click here or jamapediatrics ronchi 2020 oi 200078 1605627156.62602). They were cared for at 6
COVID-19 maternity centers, located in Lombardy, Northern Italy, between March 19 & May 2, 2020, and therefore probably overlap with those reported in the other Lombardy series. Citation: Ronchi A, Pietrasanta C, Zavattoni M, et al. Evaluation of Rooming-in Practice for Neonates Born to Mothers With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Italy. JAMA Pediatr. Published online December 07, 2020. doi:10.1001/jamapediatrics.2020.5086
Study 502 – ICNARC 2nd wave, UK
The UK Intensive Care National Audit & Research Centre (ICNARC) is now reporting patients with Covid on ICU separately for the periods before and after 1 September 2020 (click here or ICNARC COVID-19 Report 2020-12-11), For the period after 1 September, 13 currently pregnant and 12 recently pregnant women with Covid-19, had been admitted to ITU, of whom 8 and 10 respectively had been ventilated.
Study 501 – Case from Mumbai
A woman contracted Covid-19 at 30 weeks and developed delirium (click here or 1-s2.0-S1876201820306262-main). She recovered but the baby died. Three cases of postpartum psychosis in women with Covid from the same hospital are mentioned. The hospital is Nair Hospital, Mumbai, so these cases may be included in studies 225, 283 & 369. Citation: Mahajan NN, Gajbhiye RK, Pednekar RR, Pophalkar MP, Kesarwani SN, Bhurke AV, Mahale SD, Delirium in a pregnant woman with SARS-CoV-2 infection in India, Asian Journal of Psychiatry (2020).
Studies 499 and 500 added.
Study 500 – 7 cases from Hubei
Seven pregnant women with Covid-19 (click here or 12098 2020 Article 3372). They were cared for in 5 provincial hospitals, namely Renmin Hospital of Wuhan University (n = 2) grid.412632.0, Huangshi Maternal and Child Health Hospital (n = 2) does not disambiguate, Jingzhou Maternal and Child Health Hospital (n = 1) grid.507996.4, Jingmen First Renmin Hospital (n = 1) does not disambiguate, and Zaoyang First Renmin Hospital (n = 1) which does not disambiguate. It is likely that the various Renmin hospital cases have been reported elsewhere. The Jingzhou case may not have been reported before. Citation: Nawsherwan, Khan S, Nabi G, Fan C, Wang S. Impact of COVID-19 Pneumonia on Neonatal Birth Outcomes. Indian J Pediatr. 2020;87(8):645-646. doi:10.1007/s12098-020-03372-2
Study 499 – 19 cases from Tongji Hospital, Wuhan, China
17 mothers with Covid-19 and their babies (click here or 11684 2020 Article 772). They were cared for in Tongji Hospital and therefore likely included in many previous reports. Citation: Liu W, Wang J, Li W, Zhou Z, Liu S, Rong Z. Clinical characteristics of 19 neonates born to mothers with COVID-19. Front Med. 2020;14(2):193-198. doi:10.1007/s11684-020-0772-y
Studies 493 to 498 added.
Study 498 – Case from Hangzhou, China
A 30-year-old woman with Covid-19 at 35-weeks was delivered by caesarean and became depressed and anxious after her baby was isolated (click here or JZUSB21-0394). From author affiliations she was cared for at the First Affiliated Hospital, Zhejiang University School of Medicine, grid.452661.2, Hangzhou, China, and may therefore the same case as in studies 4 and 9. Citation: Huang JW, Zhou XY, Lu SJ, et al. Dialectical behavior therapy-based psychological intervention for woman in late pregnancy and early postpartum suffering from COVID-19: a case report. J Zhejiang Univ Sci B. 2020;21(5):394-399. doi:10.1631/jzus.B2010012
Study 497 – case from Shaanxi, China
A woman contracted Covid-19 at 36 weeks (click here or 540 2020 Article 2796). She delivered by Caesarean at 37 weeks. Both mother and baby recovered. From author affiliatons she was cared for at the Second Affiliated Hospital of Xi’an Jiaotong University, grid.452672.0. Xi’an, Shaanxi China, which has not previously reported cases. Citation: Du Y, Wang L, Wu G, Lei X, Li W, Lv J. Anesthesia and protection in an emergency cesarean section for pregnant woman infected with a novel coronavirus: case report and literature review. J Anesth. 2020;34(4):613-618. doi:10.1007/s00540-020-02796-6
Study 496 – Case from Pennsylvania, USA
A woman contracted Covid-19 and vulvovaginitis at 31 weeks (click here or s-0040-1713665). From author affiliations she was treated at the Hospital of the University of Pennsylvania, Philadelphia, so might be included in studies 86, 175, 302 & 350. Citation: Rubin ES, Sansone SA, Hirshberg A, Clement EG, Srinivas SK. Detection of COVID-19 in a Vulvar Lesion. Am J Perinatol. 2020 Sep;37(11):1183-1184. doi: 10.1055/s-0040-1713665. Epub 2020 Jul 2. PMID: 32615620; PMCID: PMC7516389.
Study 495 – 17 self-reported cases from Belgium
17 out of 6,470 self-selected pregnant or breastfeeding women completing an internet survey, reported testing positive for SARS-CoV-2 (click here or ijerph-17-06766 (1)). Citation: Ceulemans M, Verbakel JY, Van Calsteren K, Eerdekens A, Allegaert K, Foulon V. SARS-CoV-2 Infections and Impact of the COVID-19 Pandemic in Pregnancy and Breastfeeding: Results from an Observational Study in Primary Care in Belgium. Int J Environ Res Public Health. 2020 Sep 17;17(18):6766. doi: 10.3390/ijerph17186766. PMID: 32957434; PMCID: PMC7559009.
Study 494 – Case from Umbria, Italy
A woman with Covid-19 at 32 weeks gestation (click here or Lettera Indraccolo). The pregnancy outcome was not reported. She was cared for at “Alto Tevere”, Hospital of Città di Castello, Umbria, Italy, which has not previously reported cases. Citation: Indraccolo U. A pregnant woman and the SARS-CoV-2 infection: how are barriers easily crossed? Recenti Prog Med. 2020 Apr;111(4):259-260. doi: 10.1701/3347.33190. PMID: 32319449.
Study 493 – Patient treated with ECMO from Zhongshan, China
One of four patients treated with convalescent plasma was pregnant (click here or PIIS0012369220305717). She was aged 31, 35 weeks gestion, delivered by caesarean and following treatment with ECMO recovered. The baby died. She was initially treated at Xiaolan People’s Hospital of Zhongshan, and later transferred to the Second People’s Hospital of Zhongshan, neither of which disambiguates on GRID.ac but which must be the same as Zhongshan People’s Hospital grid.476868.3. This appears to be the sixth report of this woman, (studies 3, 57, 81, 192 & 433) Citation: Zhang B, Liu S, Tan T, Huang W, Dong Y, Chen L, Chen Q, Zhang L, Zhong Q, Zhang X, Zou Y, Zhang S. Treatment With Convalescent Plasma for Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Chest. 2020 Jul;158(1):e9-e13. doi: 10.1016/j.chest.2020.03.039. Epub 2020 Mar 31. PMID: 32243945; PMCID: PMC7195335.
Studies 491 and 492 added.
Study 492 – 4 cases from Jordan
Four pregnant women with mild Covid-19 (click here or ijgo.13240). They were cared for in the King Abdullah University Hospital, Irbid, Jordan, so may overlap with cases in studies 153, 435 & 463. Citation: Alsharaydeh I, Rawashdeh H, Saadeh N, Obeidat B, Obeidat N. Challenges and solutions for maternity and gynecology services during the COVID-19 crisis in Jordan. Int J Gynaecol Obstet. 2020 Aug;150(2):159-162. doi: 10.1002/ijgo.13240. Epub 2020 Jun 17. PMID: 32470178.
Study 491 – Abortion case in New York
An asymptomatic woman with sickle cell disease undergoing abortion by D&E at 15 weeks developed post-operative pneumonia and tested positive for SARS-CoV-2 (click here or PIIS0010782420301530). From author affiliations she was cared for at Columbia University Irving Medical Center, New York, previous reports from which (studies 14, 27, 136, & 271) have not included pregnancy termination cases. Citation: Fang NZ, Castaño PM, Davis A. A hospital-based COVID-19 abortion case in the early phase of the pandemic. Contraception. 2020;102(2):137-138. doi:10.1016/j.contraception.2020.05.005
Studies 478 to 490 added.
Study 490 – Case report from Boston, Massachusetts, USA
A woman with Covid-19 was delivered by Caesarean at 35 weeks (click here or acc-14-e01303). She was cared for at Boston Medical Center, Boston, Massachusetts, so might be included in study 292. Citation: Norris MC, Kalustian A, Salavati S. Epidural Blood Patch for Postdural Puncture Headache in a Patient With Coronavirus Disease 2019: A Case Report. A&A Practice. 2020 Aug;14(10):e01303. DOI: 10.1213/xaa.0000000000001303.
Study 489 – Case report from Chongqing, China
A woman contracted Covid-19 at 35 weeks and was delivered by Caesarean (click here or BMJ-37-226). She recovered. From author affiliations she was cared for at Chongqing Three Gorges Central Hospital, grid.477128.f Chongqing, China. Other features also suggest this and study 252 describe the same woman. Citation: Liao X, Yang H, Kong J, Yang H. Chest CT Findings in a Pregnant Patient with 2019 Novel Coronavirus Disease. Balkan Med J. 2020;37(4):226-228. doi:10.4274/balkanmedj.galenos.2020.2020.3.89
Study 488 – 20 SARS-CoV-2 cases detected by screening in Massachussetts, USA
Four hospitals associated with Mass General Brigham Health tested 757 women admitted in labour between April 18th & May 5th. 20 were positive for SARS-CoV-2 (click here or S0899823X2000255Xa). This organization has not previously reported cases. Citation: Goldfarb IT, Diouf K, Barth WH, et al. Universal SARS-CoV-2 testing on admission to the labor and delivery unit: Low prevalence among asymptomatic obstetric patients. Infect Control Hosp Epidemiol. 2020;41(9):1095-1096. doi:10.1017/ice.2020.255
Study 487 – 5 cases in Virgina, USA
There were 79/1,811 SARS-CoV-2 positive tests between April 27, and May 18, in a big hospital. Five were in pregnant women (click on S0899823X2000358Xa). The hospital is unnamed, but probably affiliated with Virginia Commonwealth University, Richmond, Virginia. Citation:: Sastry SR, et al. (2020). Universal screening for the SARS-CoV-2 virus on hospital admission in an area with low COVID-19 prevalence. Infection Control & Hospital Epidemiology.
Study 486 – 37 cases from Santiago, Chile
37/583 pregnant women had a positive test for SARS CoV-2 (click here or journal.pone.0239887). Two women required ventilation. None died. Two babies tested positive. One baby, who tested negative, died. The study was conducted in Clınica Davila, Santiago, Chile, which has not previously reported cases. Citation: Dı´az-Corvillo´n P, Mo¨nckeberg M, Barros A, Illanes SE, Soldati A, Nien J-K, et al. (2020) Routine screening for SARS CoV-2 in unselected pregnant women at delivery. PLoS ONE 15(9): e0239887.
Study 485 – 3 cases from Jaén, Spain
Three pregnant women with Covid-19 (click here or main (9) In Spanish). From author affiliations cared for at Hospital Universitario Materno-Infantil de Jaén, Jaén, Espana so may overlap with study 158. Citation: Hijona Elósegui JJ, Carballo García AL, Fernández Risquez AC. New evidences that discard the possible vertical transmission of SARS-CoV-2 during pregnancy. Nuevas evidencias que descartan la posible transmisión vertical del SARS-CoV-2 durante la gestación. Med Clin (Barc). 2020;155(7):313-314. doi:10.1016/j.medcli.2020.05.021
Study 484 – Case report from Milan, Italy
A pregnant woman with Covid-19 also had a pulmonary embolus (click here or PIIS0049384820301389). She was cared for in Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy, so probably included in the Lombardy series. Citation: Martinelli I, Ferrazzi E, Ciavarella A, Erra R, Iurlaro E, Ossola M, Lombardi A, Blasi F, Mosca F, Peyvandi F. Pulmonary embolism in a young pregnant woman with COVID-19. Thromb Res. 2020 Jul;191:36-37. doi: 10.1016/j.thromres.2020.04.022. Epub 2020 Apr 20. PMID: 32371163; PMCID: PMC7169886.
Study 483 – 21 cases from Brescia, Italy
21 women with Covid-19 during pregnancy (click here or R02Y2020N11A1248). From author affiliations cared for at Spedali civili of Brescia, Brescia, Italy, so likely included in the various Lombardy series. Citation: Giannini A, Mantovani A, Vezzoli C, Franchini D, Finazzi P. Lung ultrasound for pregnant women admitted to ICU for COVID-19 pneumonia. Minerva Anestesiol. 2020 Nov;86(11):1248-1249. doi: 10.23736/S0375-9393.20.14726-6. Epub 2020 May 29. PMID: 32486608.
Study 482 – Case from Bahgdad, Iraq
A pregnant woman with Covid-19 at 28 weeks went into preterm labour and delivered at 30 weeks (click here or AsianPacJReprod000 415713 113251). The baby was not infected. From author affiliations she was cared for at Al-Kadhemia Teaching Hospital, Baghdad, Iraq. This is the first report from Iraq. Citation: Al-Kuraishy, H., Al-Maiahy, T., Al-Gareeb, A., Musa, R., & Ali, Z. (2020). COVID-19 pneumonia in an Iraqi pregnant woman with preterm delivery. Asian Pacific Journal of Reproduction, 9(3).
Study 481 – Puerperal skin manifestations of Covid-19
A woman with Covid-19 developed a skin rash 7 days post partum (click here or ijd.14919). She was cared for at San Raffaele Hospital, Milan, Italy, so may have been included in the various Lombardy series. Citation: Paolino, G., Canti, V., Mercuri, S.R., Rovere Querini, P., Candiani, M. and Pasi, F. (2020), Diffuse cutaneous manifestation in a new mother with COVID‐19 (SARS‐Cov‐2). Int J Dermatol, 59: 874-875.
Study 480 – Puerperal case in USA
A woman with puerperal Covid-19 (click here or 10-1055-s-0040-1712926). From author affiliations she was cared for at University of Alabama at Birmingham, Alabama, which has not previously reported cases. Citation: Sinkey RG, Rajapreyar I, Robbins LS, et al. Heart Failure with Preserved Ejection Fraction in a Postpartum Patient with Superimposed Preeclampsia and COVID-19. AJP Rep. 2020;10(2):e165-e168. doi:10.1055/s-0040-1712926
Study 479 – Patient in the Netherlands
A pregnant woman with systemic lupus erythematosus, using long-term corticosteroids, contracted Covid-19 (click here or bcr-2020-235581). She gave birth normally and the baby was unaffected. She was cared for at Reinier de Graaf Gasthuis, Delft, which has not previously reported cases. Citation: Grimminck K, Santegoets LAM, Siemens FC, et al. BMJ Case Rep 2020;13:e235581. doi:10.1136/bcr-2020-235581
Study 478 – Case report from Caracas, Venezuela
A woman tested postive for SARS-CoV-2 during the pregnancy, and had mild symptoms, but had recovered by the time she was delivered by Caesarean on March 31st (click here or main (8)). The baby tested negative. The birth hospital is not named. Citation: Forero-Peña DA, Rodríguez MI, Flora-Noda DM, et al. The first pregnant woman with COVID-19 in Venezuela: Pre-symptomatic transmission. Travel Med Infect Dis. 2020;36:101805. doi:10.1016/j.tmaid.2020.101805
Studies 464 to 475 added.
Study 475 – 308 cases from Mexico
Using open data from the Mexican Ministry of Health up to May 17th, 7/308 pregnant women with Covid-19 had died (click here or ijgo.13250). This report will overlap with study 340. Citation: Lumbreras‐Marquez, M.I., Campos‐Zamora, M., Lizaola‐Diaz de Leon, H. and Farber, M.K. (2020), Maternal mortality from COVID‐19 in Mexico. Int Obstet, 150: 266-67.
Study 474 – 12 cases from Turkey
No SARS-CoV-2 was detected in vaginal fluid of 12 pregnant women with COVID-19 (click here or SARS CoV-2 is not present in the vaginal fluid of pregnant women with COVID-19(1)). All had mild symptoms and none needed critical care. From author affiliations they were cared for at Sakarya Training and Research Hospital, Sakarya, Turkey, which has not previously reported cases. Citation: Mehmet Musa Aslan , Hilal Uslu Yuvacı , Osman Köse , Hande Toptan , Nermin Akdemir , Mehmet Köroğlu , Arif Serhan Cevrioğlu & Selçuk Özden (2020): SARS-CoV-2 is not present in the vaginal fluid of pregnant women with COVID-19, The Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2020.1793318
Study 473 – Thrombocytopaenia & mild Covid-19
Three pregnant women with mild Covid-19 also had thrombocytopaenia (click here or main (7)). From author affiliations they cared for at Antoine-Beclere Hospital, Paris, so may overlap with studies 217 and 326. Citation: Le Gouez A, Vivanti AJ, Benhamou D, Desconclois C, Mercier FJ. Thrombocytopenia in pregnant patients with mild COVID-19. Int J Obstet Anesth. 2020;44:13-15. doi:10.1016/j.ijoa.2020.05.010
Study 472 – 16 cases from Wuhan, China
These 16 pregnant women with COVID‐19 up until February 16, 2020 in Wuhan Union Hospital (click here or ijgo.13236) have probably been reported before. Citation: Zeng Y, Lin L, Yan Q, Wei W, Xiang Yang B, Huang R, He F, Chen D. Update on clinical outcomes of women with COVID-19 during pregnancy. Int J Gynaecol Obstet. 2020 Aug;150(2):264-266. doi: 10.1002/ijgo.13236. Epub 2020 Jun 9. PMID: 32438521.
Study 471 – 12 cases from Wuhan, China
12 pregnant women with Covid-19 (click here or 1-s2.0-S0890623820302677-main). They were cared for at Renmin Hospital of Wuhan University grid.412632.0 and the near hospitals in Wuhan City, Hubei Province, China. They have therefore probably already been reported. Citation: Cuifang Fan, No obviously adverse pregnancy complications and outcomes of the recovered pregnant women from COVID-19. Letter. Reproductive Toxicology
Study 470 – Screening in Madrid, Spain
86 seropositive pregnant women were detected out of 759 tested between February 28th and May 10th (click here or pone.0243029). The hospital was Hospital Universitario 12 de Octubre, so they may overlap with those in studies 205 and 458. Citation: Villalaı´n C, Herraiz I, Luczkowiak J, Pe´rez-Rivilla A, Folgueira MD, Mejı´a I, et al. (2020) Seroprevalence analysis of SARS-CoV-2 in pregnant women along the first pandemic outbreak and perinatal outcome. PLoS ONE 15(11): e0243029.
Study 469 – Case report from Istanbul, Turkey
An asymptomatic woman with SARS-CoV-2 delivered by Caesarean (click here or jog.14584). Cared for at Umraniye Training and Research Hospital Emergency Obstetrics Clinic, Istanbul, Turkey which has not previously reported cases. Citation: Palalioglu, R.M., Mahammadaliyeva, A., Erbiyik, H.I. and Muhcu, M. (2020), COVID‐19 in third trimester may not be as scary as you think, it can be innocent: Evaluating vertical transmission from a COVID‐19 positive asymptomatic pregnant woman with early membrane rupture. J. Obstet. Gynaecol. Res.
Study 468 – 4 patients from Toronto, Canada
Four pregnant patients with SARS-CoV-2 were identified by screening (click here or birt.12520). It’s not possible to determine from author affiliations which centre in Toronto, Canada, cared for them, so some may have been included in studies 48 and 103. Citation: Mei‐Dan, E, Satkunaratnam, A, Cahan, T, Leung, M, Katz, K, Aviram, A. Questionnaire‐based vs universal PCR testing for SARS‐CoV‐2 in women admitted for delivery. Birth. 2020; 00: 1– 8.
Study 467 – 137 cases from West French Guiana
Of 137 pregnant women with SARS-CoV-2 infection, 3 required ITU admission but none died (click on hcini ejog). There were 3 terminations and 7 stillbirths. Four babies were infected. Patients were cared for at West French Guiana Hospital Center (Centre Hospitalier de l’Ouest Guyanais), which has not previously reported cases. Citation: Hcini N, Maamri F, Picone O, Carod J-Francois, Lambert V, Mathieu M, Carles G, Pomar L, Maternal, fetal and neonatal outcomes of large series of SARS-CoV-2 positive pregnancies in peripartum period: a single-center prospective comparative study, European Journal of Obstetrics and amp; Gynecology and Reproductive Biology (2020).
Study 466 – Case report from Manhasset, New York
A woman with Covid-19 required ventilation (click here or Coronavirus Disease 2019 COVID 19 Related.74). She survived. From author affiliations she was cared for in North Shore University Hospital, Manhasset, NY, USA which means she might be included in study 179. Citation: Gulersen, Moti MD, MSc; Staszewski, Cara MD; Grayver, Evelina MD; Tam Tam, Hima MD; Gottesman, Eric MD; Isseroff, Donnie MD; Rochelson, Burton MD; Bonanno, Clarissa MD Coronavirus Disease 2019 (COVID-19)–Related Multisystem Inflammatory Syndrome in a Pregnant Woman, Obstetrics & Gynecology: December 3, 2020 – Volume Latest Articles – Issue – 10.1097/AOG.0000000000004256 doi: 10.1097/AOG.0000000000004256
Study 465 – Case report from Wuhan
A woman with Covid-19 at 34 weeks cared for at Renmin Hospital of Wuhan University (click here or ijgo.13232). Probably included in a multiple previous studies. Citation: Yu, Y., Fan, C., Bian, J. and YinShen, (2020), Severe COVID‐19 in a pregnant patient admitted to hospital in Wuhan. Int J Gynecol Obstet, 150: 262-263.
Study 464 – Lung ultrasound in 4 cases
Four women with Covid-19 underwent lung ultrasound (click here or uog.22055). From author affiliations they were cared for at Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy, and may overlap with those in studies 76 and 78. Citation: Buonsenso, D., Raffaelli, F., Tamburrini, E., Biasucci, D.G., Salvi, S., Smargiassi, A., Inchingolo, R., Scambia, G., Lanzone, A., Testa, A.C. and Moro, F. (2020), Clinical role of lung ultrasound for diagnosis and monitoring of COVID‐19 pneumonia in pregnant women. Ultrasound Obstet Gynecol, 56: 106-109.
Studies 452-463 added.
Study 463 – Case report from Irbid, Jordan
A woman with Covid-19 (click on 925512) was treated at King Abdullah University Hospital Irbid, Jordan, on March 28, 2020. She may therefore have been reported in studies 153 and 435. Citation: Bani Hani D.A. et al.: Successful anesthetic management in cesarean section for Pregnant Woman with COVID-19. Am J Case Rep, 2020; 21: e925512
Study 462 – Normal birth in Perugia, Italy
A woman tested positive at 40 weeks gestation (click here or mjhid-12-1-e2020033). She gave birth normally. The baby tested negative. From author affiliations she gave birth at Santa Maria della Misericordia Hospital, Perugia, Italy which has not previously reported cases. Citation: De Socio G.V., Malincarne L., Arena S., Troiani S., Benedetti S., Camilloni B., Epicoco G., Mencacci A., Francisci D. Delivery in asymptomatic italian woman with SARS-CoV-2 infection. Mediterr J Hematol Infect Dis 2020, 12(1): e2020033.
Study 461 – Maternal death in Tehran, Iran
A woman contracted Covid-19 at 23 weeks with twins (click here or 29688-Article Text-117866-1-10-20200408). She died with the twins undelivered. She was cared for at Imam Hossein
Medical and Educational Center, Shahid Beheshti University of Medical Sciences, Tehran, which has not previously reported cases. Citation: Shojaei S, Kouchek M, Miri MM, Salarian S, Sistanizad M, Ariana S, et al. Twin pregnant woman with COVID-19: a case report. J Cell Mol Anesth. 2020;5(1):43-6
Study 460 – Severe case from Cuneo, Italy
A woman with Covid-19 at 27 weeks required 15 days ventilation (click here or sv-YX051401). She recovered and the baby remained undelivered. She was cared for in Azienda Ospedaliera Santa Croce e Carle, Cuneo, Italy, which has not previously reported cases. Citation: Luigi Barile, Martina Cerrano, Alessandro Locatelli, Andrea Puppo, Anna F. Signorile, Nicoletta Barzaghi. Prone Ventilation in a 27 Week Pregnant Woman with COVID-19 Severe ARDS. Signa Vitae. 2020. 16(1);199-202.
Study 459 – 6 cases from Guangzhou, Guangdong, China
6 pregnant women with Covid-19 (click here or PIIS0163445320302929). Three required ITU admission and ventilation, and one ECMO. They all survived. The patients were cared for in the First Affiliated Hospital of Jinan University grid.412601.0, Guangzhou, Guangdong. This suggests possible overlap with studies 3, 57 and 81, all of which also reported a pregnant woman treated with ECMO. Citation: Huang, Wenhui et al. Unfavorable outcomes in pregnant patients with COVID-19.Journal of Infection, Volume 81, Issue 2, e99 – e101
Study 458 – two cases from Madrid
2/203 women screened on admission in labour at Hospital Universitario 12 de Octubre in Madrid, tested positive (click here or [16193997 – Journal of Perinatal Medicine] Universal screening for SARS-CoV-2 before labor admission during Covid-19 pandemic in Madrid). Citation: Herraiz, I., Folgueira, D., Villalaín, C., Forcén, L., Delgado, R., & Galindo, A. (2020). Universal screening for SARS-CoV-2 before labor admission during Covid-19 pandemic in Madrid, Journal of Perinatal Medicine, 48(9), 981-984.
Study 457 – 94 cases in New York
94 confirmed or suspected cases of Covid-19 in pregnancy (click here or s00401712529). From author affiliations they were cared for at Icahn School of Medicine at Mount Sinai, New York, New York, USA, so overlap with studies 86, 119, 131 and 455 is likely. Citation: Fox NS, Melka S. COVID-19 in Pregnant Women: Case Series from One Large New York City Obstetrical Practice. Am J Perinatol. 2020 Aug;37(10):1002-1004. doi: 10.1055/s-0040-1712529. Epub 2020 May 21. PMID: 32438425; PMCID: PMC7416214.
Study 456 – 9 cases from Senegal
Nine pregnant women with Covid-19 from March 2 to May 15, were identified (click here or 58). They all recovered. This is the first report from Senegal. Citation: Abdoul Aziz Diouf et al. Clinical characteristics and outcomes of COVID-19 infection in nine pregnant women: a report from a sub-Saharan African country, Senegal. Pan African Medical Journal. 2020;35(2):58. [doi: 10.11604/pamj.supp.2020.35.2.23736]
Study 455 – Case report from New York
A woman with Covid-19 at 30 weeks improved after Caesarean delivery (click here or e236290.full). From author affiliations she was cared for at Icahn School of Medicine at Mount Sinai, New York, New York, USA, so she might be included in studies 86, 119, and 131. Citation: Oliva M, Hsu K, Alsamarai S, et al. Clinical improvement of severe COVID-19 pneumonia in a pregnant patient after cesarean delivery. BMJ Case Reports CP 2020;13:e236290.
Study 454 – Follow up of four patients in Study 6
The four women who were undelivered at the time of reporting study 6 recovered, but their pregnancy outcomes are still not reported (Click here or ajr.20.23247). Citation: Lin Li, Dehan Liu, and Lian Yang. Follow-Up Information About the Four Pregnant Patients With Coronavirus Disease (COVID-19) Pneumonia Who Were Still in the Hospital at the End of Our Study. American Journal of Roentgenology 2020 215:1, W17-W18
Study 453 – Lung ultrasound in 2 pregnant women with Covid-19
The lung ultrasound appearances of two pregnant women with Covid-19 (click here or jum.15419). From author affiliations, they were cared for in Hospital General Universitario de Alicante, which has not previously reported cases. Citation: Gil‐Rodrigo, A., Llorens‐Soriano, P. and Ramos‐Rincón, J.‐M. (2020), Ultrasound in Pregnant Women With Suspected COVID‐19 Infection. J Ultrasound Med.
Study 452 – Maternal death in Turkey
Studies 438 to 451 added.
Study 451 – 24 cases, 3 severe, from London, UK
Of 24 pregnant or immediately post-partum patients with COVID-19, three required prolonged admission to ICU (click here or 1751143720947547). They were cared for at Chelsea and Westminster NHS Foundation Trust in London, which has not previously reported cases. However, they were probably included in study 92. The three ICU cases were probably included in the various ICNARC reports. Citation: Morton S, Lamont H, Silvey N, et al. Adult intensive care unit admissions with severe COVID-19 infection following emergency Caesarean section deliveries: A case series. Journal of the Intensive Care Society. August 2020. doi:10.1177/1751143720947547
Study 450 – case report from Wuhan
This woman with Covid-19 who delivered in Maternal and Child Health Hospital of Hubei Province on April 5, 2020 (click here or medi-99-e21335) must have been included in many of the Wuhan series.. Citation: Peng J, Li R, Yin H, et al. A case report of a pregnant woman infected with coronavirus disease 2019 pneumonia. Medicine (Baltimore). 2020;99(30):e21335. doi:10.1097/MD.0000000000021335
Study 449 – 11 cases from Israel
11 pregnant women with SARS-CoV-2 infection cared for at Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel (click here or Mohr-Sasson2020 Article LaboratoryCharacteristicsOfPre). They may overlap with cases in studies 278 and 330. Citation: Mohr-Sasson A, Chayo J, Bart Y, Meyer R, Sivan E, Mazaki-Tovi S, Yinon Y. Laboratory characteristics of pregnant compared to non-pregnant women infected with SARS-CoV-2. Arch Gynecol Obstet. 2020 Sep;302(3):629-634. doi: 10.1007/s00404-020-05655-7. Epub 2020 Jun 22. PMID: 32572616; PMCID: PMC7307945.
Study 448 – a case with polymorphic eruption of pregnancy
A woman who tested positive for SARS-CoV-2 at 39 weeks developed polymorphic eruption of pregnancy 10 days after giving birth (click here or dth.14117). The hospital is not named but from author affiliations is affiliated with Sapienza University of Rome. Citation: Proietti I, Bernardini N, Tolino E, Mambrin A, Balduzzi V, Marchesiello A, Michelini S, Skroza N, Potenza C. Polymorphic eruption of pregnancy as a possible COVID-19 manifestation. Dermatol Ther. 2020 Aug 1:e14117. doi: 10.1111/dth.14117. Epub ahead of print. PMID: 32737915; PMCID: PMC7436318.
Study 447 – 29 cases from Wuhan, China
29 women with Covid-19 delivered 30 babies (one set of twins) between January 30 and March 10 (click here or journal.pmed.1003195 (1)). They were cared for in Renmin Hospital, Wuhan University, grid.412793.a and Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology grid.412793.a. They likely overlap with many previous reports from Wuhan. Citation: Wu YT, Liu J, Xu JJ, Chen YF, Yang W, Chen Y, Li C, Wang Y, Liu H, Zhang C, Jiang L, Qian ZX, Kawai A, Mol BW, Dennis CL, Xiong GP, Cheng BH, Yang J, Huang HF. Neonatal outcome in 29 pregnant women with COVID-19: A retrospective study in Wuhan, China. PLoS Med. 2020 Jul 28;17(7):e1003195. doi: 10.1371/journal.pmed.1003195. PMID: 32722722; PMCID: PMC7386573.
Study 446 – A woman treated with ECMO in London, UK
A woman with severe Covid-19 was delivered by Caesarean at 39 weeks and required ventilation and ECMO (click here or demirjian2020). The baby tested positive and had clinical disease. Both eventually recovered. The birth took place at North Middlesex University Hospital NHS Trust, so although not cited, this is also case 1 in study 93. Citation: Demirjian A, Singh C, Tebruegge M, Herbert R, Draz N, Mirfenderesky M, Jones V, Hinstridge P, Seneviratne R, Myers R, Ellis J, Miah S, Meadows CI, Kenny J, Alonso A, Handforth J, Perkins S, Butler M, Blackburn F, Douthwaite S, Pillay D, Chand M, Zambon M. Probable Vertical Transmission of SARS-CoV-2 Infection. Pediatr Infect Dis J. 2020 Sep;39(9):e257-e260. doi: 10.1097/INF.0000000000002821. PMID: 32658096.
Study 445 – Miscarriage in Islamambad, Pakistan
A woman with Covid-19 miscarried at 11 weeks (click here or PIIS0163445320305879). She recovered. It is not possible to deduce which hospital cared for her from author affiliations. However, this is the first report from Islamabad. Citation: Rana MS, Usman M, Alam MM, Khalid A, Ikram A, Salman M, Zaidi SSZ, Faryal R, Qadir M, Umair M, Roohullah, Sufian MM. First trimester miscarriage in a pregnant woman infected with COVID-19 in Pakistan. J Infect. 2020 Sep 5:S0163-4453(20)30587-9. doi: 10.1016/j.jinf.2020.09.002. Epub ahead of print. PMID: 32896525.
Study 444 – SARS-CoV-2 detected in breast milk
A breast milk sample from an asymptomatic woman who tested positive for SARS-CoV-2 at birth also tested positive (click here or firstname.lastname@example.org). The neonate tested negative and remained well. She was cared for Ankara City Hospital, Ankara, Turkey. The case may have been included in studies 95, 203 and 244. Citation: Bastug A, Hanifehnezhad A, Tayman C, Ozkul A, Ozbay O, Kazancioglu S, Bodur H. Virolactia in an Asymptomatic Mother with COVID-19. Breastfeed Med. 2020 Aug;15(8):488-491. doi: 10.1089/bfm.2020.0161. Epub 2020 Jul 1. PMID: 32614251.
Study 443 – No SARS-CoV-2 detected in colostrum
Seven women with SARS-CoV-2 positive tests at delivery gave samples of colostrum, which all tested negative (click here or bfm.2020.0183). From author affiliations, the hospital was Puerta de Hierro-Majadahonda University Hospital, Madrid, Spain, so they likely overlap with cases in studies 125, 151, 177, and 196. Citation: Marín Gabriel MÁ, Malalana Martínez AM, Marín Martínez ME, Anel Pedroche J. Negative Transmission of SARS-CoV-2 to Hand-Expressed Colostrum from SARS-CoV-2-Positive Mothers. Breastfeed Med. 2020 Aug;15(8):492-494. doi: 10.1089/bfm.2020.0183. Epub 2020 Jul 9. PMID: 32644841.
Study 442 – 30 cases from Wuhan
30 pregnant women with Covid-19 treated in th Central Hospital of Wuhan grid.440160.7, China, from December 8, 2019 to April 1, 2020 are reported (click here or ijgo.13265). They overlap with those in study 39 and many other Wuhan series. Citation: Wang Z, Wang Z, Xiong G. Clinical characteristics and laboratory results of pregnant women with COVID-19 in Wuhan, China. Int J Gynaecol Obstet. 2020 Sep;150(3):312-317. doi: 10.1002/ijgo.13265. Epub 2020 Jul 3. PMID: 32510581; PMCID: PMC7496890.
Study 441 – 69 cases from New Delhi, India
69 women with SARS-CoV-2 had one abortion and four stillbirths (click here or Anand2020 Article ClinicalProfileViralLoadManage). Of 65 live births, 7 neonates tested positive. There were two neonatal deaths both of whom tested negative. Two mothers died. From author affiliations, they were cared for at Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India, which has not previously reported cases. Citation: Anand P, Yadav A, Debata P, Bachani S, Gupta N, Gera R. Clinical profile, viral load, management and outcome of neonates born to COVID 19 positive mothers: a tertiary care centre experience from India. Eur J Pediatr. 2020 Sep 10:1–13. doi: 10.1007/s00431-020-03800-7. Epub ahead of print. PMID: 32910210; PMCID: PMC7482055.
Study 440 – Maternal and obstetrician deaths in Nigeria
This predominantly opinion piece mentions a mother who died of Covid-19 in Lagos StateUniversity Teaching Hospital, who has not been reported elsewhere (click here or ijgo.13325). The article also refers to a newspaper report of an obstetrician who died of Covid-19 having been infected in his private clinic (added as report 274 here). Citation: Ijarotimi OA, Ubom AE, Olofinbiyi BA, Kuye-Kuku T, Orji EO, Ikimalo JI. COVID-19 and obstetric practice: A critical review of the Nigerian situation. Int J Gynaecol Obstet. 2020 Jul 22. doi: 10.1002/ijgo.13325. Epub ahead of print. PMID: 32698245.
Study 439 – One case from Hunan province in China
One pregnant woman in this series from Hunan province (click here or ijmsv17p2187). No further details. Hunan province is adjacent to Hubei province which contains the City of Wuhan. The authors are affiliated with hospitals in Changsha, Chenzhou, Loudi, and Yiyang, all cities in Hunan. No previous cases have been reported from Hunan province. Citation: Tao PY, Leng L, Liu K, Zhou RH, Hu YC, Wu SJ, Xiao YD, Liu J. Determination of risk factors for predicting the onset of symptoms in asymptomatic COVID-19 infected patients. Int J Med Sci. 2020 Aug 6;17(14):2187-2193. doi: 10.7150/ijms.47576. PMID: 32922180; PMCID: PMC7484673.
Study 438 – Maternal death in Uşak, Turkey
A 22-year-old woman died from Covid-19 at 32 weeks (click here or 42399 2020 Article 508). The baby, delivered by Caesarean, tested negative and survived. The mother had been treated with extra-corporal cytokine hemo-adsorption therapy to remove inflammatory cytokines from the circulation. From author affiliations she was cared for in Uşak Training and Research Hospital, Uşak, Turkey, which has not previously reported cases. Citation: Karabulut Keklik ES, Dal H, Bozok Ş. Cytokine Hemoadsorption in the Management of a Pregnant Woman with COVID-19 Pneumonia: Case Report [published online ahead of print, 2020 Sep 16]. SN Compr Clin Med. 2020;1-5. doi:10.1007/s42399-020-00508-5
Studies 434 to 437 added.
Study 437 – Case report from Chicago
A woman with Covid-19 at 34 weeks was delivered by emergency Caesarean for an abnormal CTG trace (click here or e625.full). The baby tested negative. From author affiliations the hospital was part of the NorthShore University Health System, Evanston, Illinois, USA, which has not previously reported cases. Citation: Suresh SC, MacGregor CA, Ouyang DW. Urgent Cesarean Delivery Following Nonstress Test in a Patient with COVID-19 and Pregestational Diabetes. Neoreviews. 2020 Sep;21(9):e625-e630. doi: 10.1542/neo.21-9-e625. PMID: 32873658.
Study 436 – Case report from Korea
On March 6, 2020, a 28-year old woman with Covid-19 gave birth to a girl by Caesarean in Daegu Fatima Hospital at 37 weeks (click here or cep 2020 00850). This is probably the same patient as reported in study 22. Citation: Lee EK, Kim WD, Lee DW, Lee SA. Management of the first newborn delivered by a mother with COVID-19 in South Korea. Clin Exp Pediatr. 2020;63(9):373-375. doi:10.3345/cep.2020.00850
Study 435 – 2 patients delivered in a burns unit in Jordan
Two women with mild Covid-19 (but no burns) were delivered by caesarean section in a burns facility (click here or Altal 2020_Article Preparing The Burns Unit To Accommo). Neither baby was infected. All recovered. The hospital was King Abdullah University Hospital in Irbid, Jordan, which may also be where the patient in study 153 delivered. The clinical features suggest that one of these cases is also that case. Citation: Altal O, Bani Hani D, Aleshawi A, Alhowary AA, Obeidat B, Bani-Ata M. Preparing the Burns Unit to Accommodate Vaginal Delivery and Cesarean Section for Pregnant Women with COVID-19: A Successful Experience from Jordan. Adv Ther. 2020 Oct;37(10):4049-4053. doi: 10.1007/s12325-020-01457-0. Epub 2020 Aug 27. PMID: 32852673; PMCID: PMC7450677.
Study 434 – 242 women and 248 babies from Spain
This series from the Spanish Neo-COVID-19 Research Group seems to describe the same patients as those reported in study 390 (click here or Maternal, Perinatal and Neonatal Outcomes With.2). There is also probably overlap with those in study 264b. Citation: Marín Gabriel MA, Reyne Vergeli M, Caserío Carbonero S, Sole L, Carrizosa Molina T, Rivero Calle I, Cuadrado Pérez I, Álvarez Fernández B, Forti Buratti A, Fernández-Cañadas Morillo A; Neo-COVID-19 Research Group. Maternal, Perinatal and Neonatal Outcomes With COVID-19: A Multicenter Study of 242 Pregnancies and Their 248 Infant Newborns During Their First Month of Life. Pediatr Infect Dis J. 2020 Dec;39(12):e393-e397. doi: 10.1097/INF.0000000000002902. PMID: 32947599.
Studies 428 to 433 added.
Study 433 – pregnant woman with Covid-19 recovering after ECMO in Zhongshan, China
A woman with Covid-19 at 35 weeks was ventilated, delivered by Caesarean, and treated with ECMO (click PIIS0147956320303599). She survived. The baby outcome is not reported in the present paper. She was cared for in Zhongshan People’s Hospital grid.476868.3, Zhongshan, China. It seems likely that this is the same case as reported in studies 3, 57, 81 and 192. In those papers the baby is reported to have died. The present paper cites none of those papers. Citation: Hou, Liusheng et al. First successful treatment of a COVID-19 pregnant woman with severe ARDS by combining early mechanical ventilation and ECMO. Heart & Lung: The Journal of Cardiopulmonary and Acute Care, Volume 0, Issue 0
Study 432 – case report from Pakistan
A woman with Covid-19 was delivered by Caesarean (click here or JPAM Vol 14 Issue2 p 1121-1123 (1)). The baby tested negative. Both recovered. She was cared for in Aziz Bhatti Shaheed Teaching Hospital in Gujrat, Pakistan which has not previously reported cases. Citation: Tarar SH, Atta H, Khalid M, et al. A Case Report of Pregnant Lady having COVID-19 Delivered via Cesarean Section in Tertiary Care Hospital in Pakistan. J Pure Appl Microbiol. 2020;14(2):1121-1123. doi: 10.22207/JPAM.14.2.06
Study 431 – Case report from Prayagraj, Uttar Pradesh, India
An asymptomatic woman who tested positive for SARS-CoV-2 was delivered by Caesarean at 38 weeks (click here or fmaa048). The asymptomatic baby was isolated and artificially fed, but tested positive at 48 hours. From author affiliations the hospital was S.N. Children Hospital, Prayagraj, Uttar Pradesh, India, which has not previously reported cases. Citation: Singh MV, Shrivastava A, Maurya M, Tripathi A, Sachan R, Siddiqui SA. Vertical Transmission of SARS-CoV-2 from an Asymptomatic Pregnant Woman in India. J Trop Pediatr. 2020 Sep 25:fmaa048. doi: 10.1093/tropej/fmaa048. Epub ahead of print. PMID: 32974677.
Study 430 – Screening in Genoa, Italy
Of 333 pregnant women screened in four hospitals of Genoa, Italy from April 1 to April 30, only one symptomatic patient (0.3%) and six asymptomatic ones (1.8%) tested positive (click here or JMV-9999-na). The hospitals were San Martino, G. Gaslini, Galliera and Villa Scassi – ASL3 Hospital, none of which have previously reported cases. Citation: Massarotti C, Adriano M, Cagnacci A, et al. Asymptomatic SARS-CoV-2 infections in pregnant patients in an Italian city during the complete lockdown [published online ahead of print, 2020 Aug 25]. J Med Virol. 2020;10.1002/jmv.26458. doi:10.1002/jmv.26458
Study 429 – Ovarian vein thrombosis and COVID‑19
A 26-year-old woman with Covid-19 at 8 weeks gestation also developed a right ovarian vein thrombosis (click here or Mohammadi2020 Article Ovarian Vein Thrombosis After Coro). The pregnancy outcome was not reported. She was cared for at Besat Hospital in Sanandaj, Iran, which has not previously reported cases. Citation: Mohammadi S, Abouzaripour M, Hesam Shariati N, Hesam Shariati MB. Ovarian vein thrombosis after coronavirus disease (COVID-19) infection in a pregnant woman: case report. J Thromb Thrombolysis. 2020 Oct;50(3):604-607. doi: 10.1007/s11239-020-02177-6. PMID: 32514763; PMCID: PMC7278233.
Study 428 – Postnatal case from Bari, Italy
A 34-year-old pregnant woman gave birth on 9 August at the “Mater Dei” hospital, Bari, Apulia region, Italy, which has not previously reported cases (click here or main (6)). Both mother and baby contracted Covid-19 postnatally. Citation: Lenoci G, Galante D, Ceci E, et al. Sars-CoV-2 isolation from a 10-day-old newborn in Italy: A case report. IDCases. 2020;22:e00960. doi:10.1016/j.idcr.2020.e00960
Studies 419 to 427 added.
Study 427 – 5 placentas from SARS-CoV-2 pregnancies
Five placentas from pregnancies positive for SARS-CoV-2 are described (click here or 511324). From author affiliations the pregnancies had been cared for at University Hospital Basel, Basel, Switzerland, which has not previously reported cases. Citation: Menter T, Mertz KD, Jiang S, Chen H, Monod C, Tzankov A, Waldvogel S, Schulzke SM, Hösli I, Bruder E. Placental Pathology Findings during and after SARS-CoV-2 Infection: Features of Villitis and Malperfusion. Pathobiology. 2020 Sep 18:1-9. doi: 10.1159/000511324. Epub ahead of print. PMID: 32950981; PMCID: PMC7573905.
Study 426 – Pregnancy, Covid-19 & sickle cell disease in Brazil
A pregnant woman with sickle cell disease contracted Covid-19 at 28 weeks gestation (click here or 2531 1379 htct 42 03 0212). She recovered and the pregnancy is ongoing. From author affiliations she was cared for in Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, which has not previously reported cases. Citation: JUSTINO, Caio Cesar et al. COVID-19 as a trigger of acute chest syndrome in a pregnant woman with sickle cell anemia. Hematol., Transfus. Cell Ther. [online]. 2020, vol.42, n.3 [cited 2020-12-02], pp.212-214. Available from: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2531-13792020000300212&lng=en&nrm=iso>. Epub Sep 18, 2020. ISSN 2531-1387.
Study 425 – Pregnant health care workers with Covid in Mexico
Of 11,226 health-care workers with Covid-19 living in Mexico city, 38 (0.34%) were pregnant, compared with 49/23,869 (0.21%) of HCWs without Covid-19 (click here or ciaa1487). Citation: Antonio-Villa NE, Bello-Chavolla OY, Vargas-Vázquez A, Fermín-Martínez CA, Márquez-Salinas A, Bahena-López JP. Health-care workers with COVID-19 living in Mexico City: clinical characterization and related outcomes. Clin Infect Dis. 2020 Sep 28:ciaa1487. doi: 10.1093/cid/ciaa1487. Epub ahead of print. PMID: 32986819; PMCID: PMC7543362.
Study 424 – Screening in Belgium
Of 221 pregnant women tested on admission to the obstetric ward, 10 (4.5%) were positive, of whom 4 had symptoms (click here or [16193997 – Journal of Perinatal Medicine] Testing of patients and coronavirus disease 2019 (COVID-19) infection before scheduled deliveries (1)). The hospital was Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium. The cases may therefore overlap with those in studies 100 and 278, but likely not with those in studies 193 and 217. Citation: Yombi JC, De Greef J, Bernard P, Belkhir L. Testing of patients and coronavirus disease 2019 (COVID-19) infection before scheduled deliveries. J Perinat Med. 2020 Nov 26;48(9):995-996. doi: 10.1515/jpm-2020-0444. PMID: 32990649.
Study 423 – 111 cases from Wuhan, China
31 pregnant women admitted to Renmin Hospital of Wuhan University grid.412632.0 from January 15 to February 23 were compared with 80 non-pregnant women (click here or ofaa294). The cases may overlap with those in studies 6a, 10, 12, 36, 37, 40, 80, 183, 220 and 294. Citation: Biheng Cheng, Tao Jiang, Lu Zhang, Ruheng Hu, Jinhua Tian, Yan Jiang, Bo Huang, Jun Li, Min Wei, Jing Yang, Shengxiang Ren, Gaohua Wang, Clinical Characteristics of Pregnant Women With Coronavirus Disease 2019 in Wuhan, China, Open Forum Infectious Diseases, Volume 7, Issue 8, August 2020, ofaa294.
Study 422 – Two mid-trimester cases from Wuhan, China
Two women contracted Covid-19 in the mid-trimester (click here or No evidence for vertical transmission of SARS CoV 2 in two neonates with mothers infected in the second trimester). The babies were unaffected. They were cared for in Wuhan No.1 Hospital grid.410609.a which appears to be separate from other Wuhan hospitals which have reported cases. Citation: Jing-yi Tang, Wen-qi Song, Hao Xu & Na Wang (2020) No evidence for vertical transmission of SARS-CoV-2 in two neonates with mothers infected in the second trimester, Infectious Diseases, 52:12, 913-916, DOI: 10.1080/23744235.2020.1798499
Study 421 – case report from Lima, Peru
An asymptomatic pregnant woman with SARS-CoV-2 antibodies, but PCR negative, delivered vaginally (click here or en 2304 5132 rgo 66 02 00008). From author affiliations the hospital was Delgado Clinic – AUNA, Lima, Peru, which has not previously reported cases. Citation: Campodónico Olcese L, Paredes Salas JR, Campodónico Olcese D, Chang Vargas C, Acuña Barrueto L, Marchena Arias J. Management of eutocic delivery in a patient with COVID-19 in Lima, Peru. Rev Peru Ginecol Obstet: 2020;66(2).
Study 420 – 65 cases in Colombia
Of 946 pregnant women surveyed, between April 13 and May 18, in seven cities in Colombia, 65 had symptoms of Covid-19, 10 had required hospitalisation and 5 had tested positive. (click here or ijgo.13348). Citation: Parra‐Saavedra, M., Villa‐Villa, I., Pérez‐Olivo, J., Guzman‐Polania, L., Galvis‐Centurion, P., Cumplido‐Romero, Á., Santacruz‐Vargas, D., Rivera‐Moreno, E., Molina‐Giraldo, S., Guillen‐Burgos, H., Navarro, E., Flórez‐Lozano, K., Barrero‐Ortega, A., Sanz‐Cortes, M. and Miranda, J. (2020), Attitudes and collateral psychological effects of COVID‐19 in pregnant women in Colombia. Int J Gynecol Obstet, 151: 203-208.
Study 419 – 31 cases from Pakistan
From 29th March to 9th May, 31/303 pregnant women tested positive for SARS-CoV-2 on admission in labour, of whom 29 had symptoms (click here or ANN_20_03_17). They were cared for in the Government Maternity Hospital, Gujrat, the Basic Health Unit, Fatehpur, Shaikh Zayed Hospital Lahore and DUHS Hospital Karachi, which have not previously reported cases.Citation: Ullah R, Memon FS, Anjum S. The alarming rate of COVID-19 among pregnant women in Pakistan. Anaesth. pain intensive care 2020;24(4):471-472. DOI: 10.35975/apic.v24i4.1325
Studies 406 to 418 added.
Study 418 – 86 cases from USA
Of 1,989 pregnant women screened for SARS-CoV-2, 86 (4.3%) tested positive (click here or An initiative to evaluate the safety of maternal bonding in patients with SARS CoV 2 infection). Rooming in, breastfeeding and neonatal infection are reported. The hospital was the University of Maryland School of Medicine, Baltimore. Apart from the single case in study 269 these are the first cases reported from that hospital. Citation: Liviu Cojocaru, Sarah Crimmins, Sripriya Sundararajan, Katherine Goetzinger, Emad Elsamadicy, Allison Lankford, Ozhan M. Turan & Sifa Turan (2020) An initiative to evaluate the safety of maternal bonding in patients with SARS-CoV-2 infection, The Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2020.1828335.
Study 417 – 8 pregnant women in ITU, Spain
Among 3,033 patients critically ill with Covid-19 in Vall dHebron University Hospital in Barcelona were eight pregnant women treated in intensive care (click here or 1-s2.0-S0213005X2030272X-main). All eight survived. They probably overlap with those in studies 140, 185 and 413. Citation: Ferrer R, Báguena M, Balcells J, Bañeras J, Biarnes A, de Nadal M, Gracia RM, Martinez J, Nuvials X, Riera J, Roca O, Ruiz-Rodriguez JC. Planning for the assistance of critically ill patients in a Pandemic Situation: The experience of Vall d’Hebron University Hospital. Enferm Infecc Microbiol Clin. 2020 Sep 8:S0213-005X(20)30272-X. English, Spanish. doi: 10.1016/j.eimc.2020.08.007. Epub ahead of print. PMID: 33010961.
Study 416 – Mother & newborn with Covid-19 from Mexico
A woman with severe Covid-19 at term required ventilation, and delivered a baby by Caesarean, who tested positive and had a clinical diagnosis of Covid-19 (click here or PIIS1201971220306846). Both mother and baby recovered. Both were treated at Hospital de Ginecología y Obstetricia, Instituto Materno Infantil del Estado de México, Toluca, which appears to be different from other hospitals reporting cases from that city in study 396, and has therefore probably not been previously reported. Citation: Hinojosa-Velasco A, de Oca PVB, García-Sosa LE, Mendoza-Durán JG, Pérez-Méndez MJ, Dávila-González E, Ramírez-Hernández DG, García-Mena J, Zárate-Segura P, Reyes-Ruiz JM, Bastida-González F. A case report of newborn infant with severe COVID-19 in Mexico: Detection of SARS-CoV-2 in human breast milk and stool. Int J Infect Dis. 2020 Nov;100:21-24. doi: 10.1016/j.ijid.2020.08.055. Epub 2020 Aug 27. PMID: 32860950; PMCID: PMC7449937.
Study 415 -388 pregnancies collected by WAPM
388 singleton pregnancies positive for Covid-19 from 73 centers in 22 countries collected by the World Association of Perinatal Medicine (click here or [16193997 Journal of Perinatal Medicine] Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19) secondary analysis of the WAPM study on COVID-19). These cases were also reported in studies 278 and 307. The centres are listed but not the number of cases per centre. Citation: Di Mascio D, Sen C, Saccone G, Galindo A, Grünebaum A, Yoshimatsu J, Stanojevic M, Kurjak A, Chervenak F. Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19. J Perinat Med. 2020 Nov 26;48(9):950-958. doi: 10.1515/jpm-2020-0355. PMID: 32975205.
Study 414 – Low rate of symptomatic disease at birth
17/3,923 (0.43%) of pregnant women admitted to labor and delivery units in Kaiser Permanente Southern California (KPSC) hospitals between April 6 and May 11, who underwent SARSCoV-2 testing were positive (click here or s-0040-1714060). None had symptoms, although one woman developed a headache attributed to COVID-19 3 days postpartum. All babies tested negative. This is the first report from the Kaiser Permanante network. Citation: Fassett MJ, Lurvey LD, Yasumura L, Nguyen M, Colli JJ, Volodarskiy M, Gullett JC, Braun D, Fong A, Trivedi N, Bruxvoort K, Chiu V, Getahun D. Universal SARS-Cov-2 Screening in Women Admitted for Delivery in a Large Managed Care Organization. Am J Perinatol. 2020 Sep;37(11):1110-1114. doi: 10.1055/s-0040-1714060. Epub 2020 Jul 3. PMID: 32620022; PMCID: PMC7516390.
Study 413 – Two cases from Spain
Two women with severe Covid-19 requiring ventilation, one with twins, gave birth prematurely (click here or PIIS1875957220301455). All three babies tested negative and had an uneventful course. They were cared for in Vall d’Hebron University Hospital in Barcelona, so may overlap with studies 140, 185 and 196, as well as other Spanish registry studies. Citation: Fernandez-Garcia C, Montaner-Ramon A, Hernandez-Perez S, Camba-Longueira F, Ribes-Bautista C, Frick MA, Castillo-Salinas F. Severe COVID-19 during pregnancy and the subsequent premature delivery. Pediatr Neonatol. 2020 Sep 19:S1875-9572(20)30145-5. doi: 10.1016/j.pedneo.2020.09.005. Epub ahead of print. PMID: 33039313; PMCID: PMC7501516.
Study 412 – Abnormal bleeding at Caesarean in USA
A woman had abnormal bleeding at Caesarean, and subsequently tested positive for SARS-CoV-2 (click here or s12884-020-03140-2). From author affiliations she was cared for at Icahn School of Medicine at Mount Sinai West, New York, so might be included in studies 86, 119, and 131. Citation: Kinsey, K.E., Ganz, E., Khalil, S. et al. Intraoperative coagulopathy during cesarean section as an unsuspected initial presentation of COVID-19: a case report. BMC Pregnancy Childbirth 20, 481 (2020).
Study 411 – Eclampsia and Covid-19
A woman with eclampsia and cortical blindness at term who also tested positive for SARS-CoV-2 (click here or s12884-020-03275-2). She recovered. The baby outcome is not reported. She was cared for in the University Complex Hospital of Leon, Leon, which has not previously reported cases, but was included in other multicentre reports from Spain. Citation: Garcia Rodriguez A, Marcos Contreras S, Fernandez Manovel SM, Marcos Vidal JM, Diez Buron F, Fernandez Fernandez C, Riveira Gonzalez MDC. SARS-COV-2 infection during pregnancy, a risk factor for eclampsia or neurological manifestations of COVID-19? Case report. BMC Pregnancy Childbirth. 2020 Oct 6;20(1):587. doi: 10.1186/s12884-020-03275-2. PMID: 33023500; PMCID: PMC7538036.
Study 410 – Covid in a pregnant man with cystic fibrosis
A transgender man (genetically female, identifying as male) with cystic fibrosis contracted Covid-19 at 39 weeks gestation (click here or PIIS246804512030050X). The baby tested negative. From author affiliations the patient was cared for in Sunshine Coast University Hospital, Queensland, Australia which has not previously reported cases. The case is likely to be the same as news report 220 (click here). Citation: Walczak A, Wilks K, Shakhovskoy R, Baird T, Schlebusch S, Taylor C, Reid D, Choong K. COVID-19 in a complex obstetric patient with cystic fibrosis. Infect Dis Health. 2020 Nov;25(4):239-241. doi: 10.1016/j.idh.2020.07.002. Epub 2020 Jul 23. PMID: 32763024; PMCID: PMC7379287.
Study 409 – Triplets from Tehran, Iran
A woman with IVF triplets contracted Covid-19 and was delivered by Caesarean at 30 weeks (click here or IJN Volume 11 Issue 3 Pages 120-122). She survived. The triplets all tested negative but two died of complications of prematurity. They were cared for in Arash Hospital, Tehran and appear to be the same triplets as case 5 in study 250. Citation: Farsi Z, Taheriderakhsh N, Bassirnia M, Ahmadi L, Shiva M, Yousefzadegan S. Coronavirus Disease-2019 Infection in Neonates of an Infected Pregnant Mother with Triplets. 2020 Sep: 11(3). DOI: 10.22038/ijn.2020.49218.1856
Study 408 – Post partum cardiomyopathy and Covid-19
A woman had experienced fever, cough, and altered sense of taste and smell a week before giving birth normally March 21(click here or echo.14873). On April 22 she developed cardiomyopathy and tested postive for SARS-CoV-2. She recovered. She was cared for in Luigi Sacco University Hospital, Milan, Italy, but it is not clear if she was included in the various Lombardy series. Citation: De Vita, S, Ippolito, S, Caracciolo, MM, Barosi, A. Peripartum cardiomyopathy in a COVID-19-infected woman: differential diagnosis with acute myocarditis—A case report from a Hub Institution during the COVID-19 outbreak. Echocardiography. 2020; 37: 1673– 1677. https://doi.org/10.1111/echo.14873
Study 407 – 26 cases from Quatar
There were 26 pregnant women with Covid-19 in this series from Quatar (click here or s12879-020-05511-8). Two women miscarried, there were 10 live births and 14 pregnancies are ongoing. Some cases are probably included in study 364. Citation: Omrani, A.S., Almaslamani, M.A., Daghfal, J. et al. The first consecutive 5000 patients with Coronavirus Disease 2019 from Qatar; a nation-wide cohort study. BMC Infect Dis 20, 777 (2020). https://doi.org/10.1186/s12879-020-05511-8
Study 406 – 43 cases from Tongji Hospital, Wuhan, China
These 43 cases from Tongji Hospital, grid.412793.a Wuhan, China, have surely been reported many times already (click here or pdf). Citation: Wei L, Gao X, Chen S, Zeng W, Wu J, Lin X, Zhang H, Mwamaka Sharifu L, Chen L, Feng L, Wang S. Clinical Characteristics and Outcomes of Childbearing-Age Women With COVID-19 in Wuhan: Retrospective, Single-Center Study. J Med Internet Res. 2020 Aug 24;22(8):e19642. doi: 10.2196/19642. PMID: 32750000; PMCID: PMC7446716.
Studies 397 to 405 added.
Study 405 – 77 cases from New York
The placental histology of 77 COVID-19 pregnancies are reported (click here or 1-s2.0-S0002937820311947 main). The patients were delivered at NYU Winthrop Hospital so may have been included in studies 61 and 91. Citation: Patberg ET, Adams T, Rekawek P, Vahanian SA, Akerman M, Hernandez A, Rapkiewicz AV, Ragolia L, Sicuranza G, Chavez MR, Vintzileos AM, Khullar P. Coronavirus disease 2019 infection and placental histopathology in women delivering at term. Am J Obstet Gynecol. 2020 Oct 19:S0002-9378(20)31194-7. doi: 10.1016/j.ajog.2020.10.020. Epub ahead of print. PMID: 33091406; PMCID: PMC7571377.
Study 404 – Case report from New York
A woman contracted Covid-19 at 38 weeks (click here or 9796 Article Text 55170-2-10-20200902). She had altered liver enzymes but recovered. The baby was not infected. From author affiliations she was probably cared for in St. John’s Episcopal Hospital, Far Rockaway, New York, USA, which has not previously reported cases. Citation: Nkeih C, Sisti G, Schiattarella A. Elevated transaminases in a COVID-19 positive patient at term of gestation: a case report: Covid19 and pregnancy. Acta Bio Med [Internet]. 2020Sep.7 [cited 2020Nov.30];91(3):e2020002.
Study 402 – 9 cases from Nigeria
Nine pregnant women with COVID-19 gave birth at Lagos University Teaching Hospital (click here or ijgo.13436). Eight delivered by caesarean and there was one macerated stillbirth. This is the first series from this hospital although one case might be the same as in study 243. Citation: Banke‐Thomas, A., Makwe, C.C., Balogun, M., Afolabi, B.B., Alex‐Nwangwu, T.A. and Ameh, C.A. (2020), Utilization cost of maternity services for childbirth among pregnant women with coronavirus disease 2019 in Nigeria’s epicenter. Int J Gynecol Obstet. https://doi.org/10.1002/ijgo.13436
Study 401 – Six cases from Mexico city, Mexico
Six women with Covid-19 underwent caesarean (click here or 1-s2.0-S2049080120303939 main). Two were admitted to ICU but no mothers or babies died. They were cared for in the General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City, Mexico so might be included in study 340. Citation: Dra Mariel González-Calatayud, Dr Benito Vargas-Ábrego, Dra Gabriela E. Gutiérrez-Uvalle, Dra Sandra C. López-Romero, Dr Luis Gabriel González-Pérez, Dr José Alberto Carranco-Martínez, Dr Jed Raful-Zacarías-Ezzat, Dr Noé I. Gracida-Mancilla. Observational study of the suspected or confirmed cases of sars COV-2 infection needing emergency surgical intervention during the first months of the pandemic in a third level hospital: Case series, Annals of Medicine and Surgery, Volume 60, 2020, Pages 149-154, ISSN 2049-0801, https://doi.org/10.1016/j.amsu.2020.10.038.
Study 400 – Six patients from Milan, Italy
Six women with Covid-19 and diabetes are reported (click here or ijgo.13434). They were cared for in Institution Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy and therefore probably included in studies 64, 117, 163, 252, and 312. Citation: D’Ambrosi F, Rossi G, Soldavini CM, Maggi V, Cetera GE, Carbone IF, Di Martino D, Di Maso M, Ferrazzi E. Management of gestational diabetes in women with a concurrent Sars-Cov-2 infection, experience of a single center in Northern Italy. Int J Gynaecol Obstet. 2020 Oct 25. doi: 10.1002/ijgo.13434. Epub ahead of print. PMID: 33099770.
Study 399 – 95 cases from Ankara, Turkey
95 pregnant women with Covid-19 (click here or jmv.26631). They were cared for at Turkish Ministry of Health Ankara City Hospital between May 11, and August 30, 2020. They may have been included in studies 203, 223 and 244. Citation: Yazihan, N, Tanacan, A, Erol, SA, et al. Comparison of VEGF‐A values between pregnant women with COVID‐19 and healthy pregnancies and its association with composite adverse outcomes. J Med Virol. 2020; 1‐ 6. https://doi.org/10.1002/jmv.26631
Study 398 – Maternal death & twin pregnancy in Tehran, Iran
A woman who had conceived twins via IVF, contracted Covid-19 at 28 weeks (click here or 30428 Article Text 131298-6-10-20201031). Mother and both twins died. She was cared for in Shohada-e-Tajrish Hospital, Tehran, Iran, which has not previously reported cases, and the clinical details differ from those in studies 23 and 218. Citation: Azizi FarsaniH, BehnazF, TeymourianH, MohseniG.Termination of Pregnancy in a Twin Pregnant Patient with COVID-19.J Cell Mol Anesth.2020;5(3):206-8.
Study 397 – Case Report from Suzhou, China
A woman with Covid-19 gave birth in Suzhou, by Caesarean at 30 weeks (click here or 13274 Article Text 114670-1-10-20201006). The baby was not infected. This may be the same case as study 257b. Citation: Xiaotong Wang, Zhiqiang Zhou, Jianping Zhang, Fengfeng Zhu, Yongyan Tang, Xinghua Shen, A Case of 2019 Novel Coronavirus in a Pregnant Woman With Preterm Delivery, Clinical Infectious Diseases, Volume 71, Issue 15, 1 August 2020, Pages 844–846, https://doi.org/10.1093/cid/ciaa200
Studies 387 to 394 added.
Study 396 – 20 pregnant women with Covid-19 from Toluca, Mexico
Twenty pregnant or postnatal women with Covid-19 were treated at “Mónica Pretelini Sáenz” Maternal Perinatal Hospital, or “Dr. Nicolás San Juan” General Hospital, both in Toluca, Mexico (click here or 13274-Article Text-114670-1-10-20201006). Two mothers died, and of the 15 pregnancies which had ended there were three fetal loses due to: ectopic pregnancy, fetal death at 16 weeks of pregnancy and a postnatal death from prematurity complications. Neither of these hospitals has previously reported cases, although the maternal deaths may have been included in studies 66, 271 and 340. Citation: Meneses Calderón J, Figueroa Flores M del R, Paniagua Coria L, Briones Garduño JC, Meneses Figueroa J, Vargas Contretas MJ, de la Cruz Ávila L, Díaz Meza S, Ramírez Chacón R, Padmanabhan S, Mendieta Zerón H (2020) Nitazoxanide against COVID-19 in three explorative scenarios. J Infect Dev Ctries 14:982-986. doi: 10.3855/jidc.13274
Study 395 – 48 cases from Wuhan
Maternal and neonatal details reported (click here or 10-1055-s-0040-1716505). The babies were cared for in Tongji Hospital grid.412793.a and HuangShi [?Huazhong] Maternal and Child Healthcare Hospital grid.412793.a from January 17 to March 4, 2020 so the pregnancies have been reported before. Citation: Liu W, Cheng H, Wang J, et al. Clinical Analysis of Neonates Born to Mothers with or without COVID-19: A Retrospective Analysis of 48 Cases from Two Neonatal Intensive Care Units in Hubei Province. Am J Perinatol. 2020;37(13):1317-1323. doi:10.1055/s-0040-1716505
Study 394 – infarction of a pituitary tumour and Covid-19 in pregnancy
A woman with visual disturbance at 38 weeks tested positive for SARS-CoV-2 (click here or Chan2020 Article Pituitary Apoplexy Associated Wit). She delivered vaginally and the baby tested negative. Two weeks later a presumed infarcted pituitary tumour was removed. From author affliliations she was cared for at Cedars-Sinai Medical Center, Los Angeles, USA and therefore might be included in study 121. Citation: Chan, J.L., Gregory, K.D., Smithson, S.S. et al. Pituitary apoplexy associated with acute COVID-19 infection and pregnancy. Pituitary 23, 716–720 (2020). https://doi.org/10.1007/s11102-020-01080-w
Study 393 – zero cases in pregnancy in Lubliana, Slovenia
None of 202 pregnant women tested for SARS-CoV-2 in the Ljubljana Maternity Hospital between March 15 and May 16, 2020 were positive (click here, full text not available). Citation: Šterbenc, A., Premru Sršen, T., Lučovnik, M., Vidmar Šimic, M., Steblovnik, L., Fabjan Vodušek, V., Druškovič, M., Kavšek, G., Poljak, M., & Trojner Bregar, A. (2020). Usefulness of COVID-19 screen-and-test approach in pregnant women: an experience from a country with low COVID-19 burden, Journal of Perinatal Medicine (published online ahead of print 2020), 000010151520200368. doi: https://doi.org/10.1515/jpm-2020-0368
Study 392 – two cases from New Jersey, USA
Two babies born to women with moderately severe Covid-19 are reported (click here or 10-1055-s-0040-1715180). From author affiliations the patients were cared for at Rutgers University, Robert Wood Johnson Medical School, New Brunswick, New Jersey. The mothers may therefore have been included in studies 86 and 285. Citation: Reddy A, Engelhardt K, Jain D. Air Leak Syndrome in Two Very Preterm Infants Born to Mothers with Coronavirus Disease 2019: An Association or a Coincidence?. AJP Rep. 2020;10(3):e266-e269. doi:10.1055/s-0040-1715180
Study 391 – 23 cases from Chicago, USA
Of 23 pregnant women who tested positive for SARS-CoV-2, 13 had symptoms but none severe disease (click here or Dhuyvetter2020 Article_Coronavirus Disease 2019 In Pregna). They were cared for at John H Stroger Hospital in Chicago, Illinois which has not previously reported cases. Citation: Dhuyvetter, A., Cejtin, H.E., Adam, M. et al. Coronavirus Disease 2019 in Pregnancy: The Experience at an Urban Safety Net Hospital. J Community Health (2020). https://doi.org/10.1007/s10900-020-00940-7
Study 390 – 248 infants from Spain
Breastfeeding rates among 242 mothers with Covid-19 and 248 live newborn infants (click here or PIIS0301211520306400). The infants were born in 15 Spanish hospitals, who were members of
the Neo-COVID-19 research group, between 13 March and 31 May, and therefore probably overlap with those in studies 264b and 366. Citation: del Río R, Dip Pérez E, Marín Gabriel MÁ; the Neo-COVID-19 Research Group. Multi-centre study showed reduced compliance with the World Health Organization recommendations on exclusive breastfeeding during COVID-19. Acta Paediatr. 2020;00:1–2. https://doi.org/10.1111/apa.15642
Study 389 – Forceps birth in the ITU in Washington, USA
A woman with severe Covid-19 who had already required 5 days ventilation was induced and delivered vaginally by forceps at 33 weeks in the ITU (click here or Induction of Labor in an Intubated Patient With.15). The perineum was intact. The baby tested negative. The mother required a further 4 days ventilation but recovered. From author affiliations she was cared for at Legacy Salmon Creek Hospital, Vancouver, Washington, USA, which has not previosly reported cases. Citation: Slayton-Milam, Suzanne MD; Sheffels, Samantha BS; Chan, Dominic PharmD, BCPS (AQ-ID); Alkinj, Bashar MD Induction of Labor in an Intubated Patient With Coronavirus Disease 2019 (COVID-19), Obstetrics & Gynecology: November 2020 – Volume 136 – Issue 5 – p 962-964 doi: 10.1097/AOG.0000000000004044
Study 388 – case report from Los Angeles
A woman with severe Covid-19 at 22 weeks (click here or Tocilizumab and Remdesivir in a Pregnant Patient.25). She recovered and the pregnancy is ongoing. From author affiliations she was cared for at Cedars Sinai Medical Center, Los Angeles, California, and therefore might be included in study 121. Citation: Naqvi, Mariam MD; Zakowski, Phillip MD; Glucksman, Lindsey MD; Smithson, Sarah DO, MS; Burwick, Richard M. MD, MPH Tocilizumab and Remdesivir in a Pregnant Patient With Coronavirus Disease 2019 (COVID-19), Obstetrics & Gynecology: November 2020 – Volume 136 – Issue 5 – p 1025-1029 doi: 10.1097/AOG.0000000000004050
Study 387 – 22 cases from Massachusetts, USA
Outpatient care of 22 pregnant women with Covid-19 (click here or main (5)). They were cared for at Beth Israel Deaconess Medical Center so may have been included in studies 129 and 231. Citation: Reforma LG, Duffy C, Collier AY, et al. A multidisciplinary telemedicine model for management of coronavirus disease 2019 (COVID-19) in obstetrical patients. Am J Obstet Gynecol MFM. 2020;2(4):100180. doi:10.1016/j.ajogmf.2020.100180
Studies 379 to 386 added.
Study 386 – Case from Greece
A patient with mild Covid-19 at term gave birth by Caesarean (click here or JAnaesthClinPharmacol 365121-6656644 182926). The authors state this was the first case in Greece. From their affiliations the hospital was “Attikon” University Hospital, Athens. Citation: Batistaki C, Galarioti V, Vasiliadou S, Soulioti E, Kostopanagiotou G, Matsota P. Lessons learned from first case of Cesarean delivery in a COVID-19 positive parturient in Greek region. J Anaesthesiol Clin Pharmacol. 2020;36(Suppl 1):S121-S124. doi:10.4103/joacp.JOACP_157_20
Study 385 – Case from Patiala, India
A pregnant woman had mild Covid-19 at 37 weeks (click here or JAnaesthClinPharmacol 36577-6694834 183548). She was delivered by Caesarean under spinal anaesthesia. The baby tested negative. From author affiliations the hospital was Gian Sagar Medical College and Hospital, Banur, Patiala, India. Citation: Bajwa SJS, Gupta R, Wahi A, Goraya SPS. Exploring the unknown territories in the new normal world of COVID. J Anaesthesiol Clin Pharmacol. 2020;36(Suppl 1):S77-S80. doi:10.4103/joacp.JOACP_350_20
Study 384 – Seroconversion among maternity workers in London
In two London hospitals 29/200 (15%) of obstetric healthcare professionals seroconverted between 11 May 2020 and 5 June 2020 (click here or anae.15229). From author affiliations the hospitals were probably University College London Hospitals NHS Foundation Trust, and Northwick Park Hospital. Citation: Bampoe, S., Lucas, D.N., Neall, G., Sceales, P., Aggarwal, R., Caulfield, K., Siassakos, D. and Odor, P.M. (2020), A cross‐sectional study of immune seroconversion to SARS‐CoV‐2 in frontline maternity health professionals. Anaesthesia, 75: 1614-1619. https://doi.org/10.1111/anae.15229
Study 383 – Follow up of 138 cases from China
This important study reports three month follow-up of 72/138 pregnant women with Covid-19 collected by the National Epidemic Reporting System (NERS) in China (click here or s12916-020-01825-1). All 13 first trimester cases were aborted. In supplementary table 1 (click here or 12916 2020 1825 MOESM1 ESM) it appears that one of the 138 original mothers died; the first report of a maternal death from Covid-19 in China. The cases overlap with those in study 55 and other reports from China. Citation: Wang, Y., Chen, L., Wu, T. et al. Impact of Covid-19 in pregnancy on mother’s psychological status and infant’s neurobehavioral development: a longitudinal cohort study in China. BMC Med18, 347 (2020). https://doi.org/10.1186/s12916-020-01825-1
Study 382 – 64 cases from Turkey
Of 64 pregnant women with suspected Covid-19, 33 tested positive (click here or PCR positivity and D-dimer levels in pregnant women with COVID-19). Limited clinical information is presented, but one woman underwent thoracotomy. From author affiliation they were cared for in Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey, so some may have been included in study 244. Citation: K. Uzel, I. Lakhno. PCR positivity and D-dimer levels in pregnant women with COVID-19. Clin. Exp. Obstet. Gynecol. - ISSN: 0390-6663 XLVII, n. 5, 2020. doi: 10.31083/j.ceog.2020.05.2229
Study 381 – 111 patients with suspected COVID-19 in Madrid
In this paper 68 pregnant women who tested positive were compared with 43 who tested negative (click here or jcm-09-03552-v2). The negative group included nine women with both symptoms and radiological findings of pneumonia, one of whom later developed anti SARS-CoV-2 antibodies. The women were cared for in University Hospital Gregorio Marañón, Madrid , Spain. They probably overlap with those reported in study 151 and possibly 196. Citation: Cuñarro-López, Y.; Cano-Valderrama, Ó.; Pintado-Recarte, P.; Cueto-Hernández, I.; González-Garzón, B.; García-Tizón, S.; Bujan, J.; Asúnsolo, Á.; Ortega, M.A.; De León-Luis, J.A. Maternal and Perinatal Outcomes in Patients with Suspected COVID-19 and Their Relationship with a Negative RT-PCR Result. J. Clin. Med. 2020, 9, 3552.
Study 380 – 66 cases from Karachi, Pakistan
66 women who tested positive for SARS-CoV-2 in pregnancy between 27th April and 16th June 2020, were mostly asymptomatic (click here or Bulletin_pdf). No babies were infected. From author affililiations they were cared for at the Indus Hospital, Karachi, Pakistan, which has not previously reported cases. These may be the first reported cases from Pakistan. Citation: Khan M.A., Kumar V., Ali S.R. Vertical Transmission of Novel Coronavirus (COVID-19) from Mother to Newborn: Experience from a Maternity Unit, The Indus Hospital, Karachi. Journal of the College of Physicians and Surgeons–Pakistan : JCPSP. 30 (10) (pp 136), 2020. Date of Publication: 01 Oct 2020.
Study 379 – 34 cases from Union hospital, Wuhan, China
These 34 cases (click here or ofaa283) cared for in Union Hospital Wuhan (grid.412839.5) between January 15 & March 15, 2020, likely overlap with those in studies 2a, 2b, 2c, 5*, and 6). Citation: Xu S, Shao F, Bao B, et al. Clinical Manifestation and Neonatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. Open Forum Infect Dis. 2020;7(7):ofaa283. Published 2020 Jul 5. doi:10.1093/ofid/ofaa283
Studies 373 to 378 added.
Study 378 – Zero pregnancy cases in Fukui prefecture, Japan
805 pregnant women (half of all women giving birth in the region) were tested for SARS-CoV-2 in Fukui prefecture, Japan between April 24 to July 25, 2020 (click here or jog.14567). All tested negative, and later checking against case notifications of COVID‐19, revealed no missed cases. Fukui had a SARS-CoV-2 prevalence of 16.5/100.000 during this period. Citation: Orisaka, M., Kawamura, H. and Yoshida, Y. (2020), COVID‐19 testing of pregnant women in Japan. J. Obstet. Gynaecol. Res.. https://doi.org/10.1111/jog.14567
Study 377 – Co-infection with rhinovirus & SARS-CoV-2 in pregnancy
A woman was infected with both SARS-CoV-2 and Rhinovirus/Enterovirus at 31 weeks gestation (click here or 21928959 – Case Reports in Perinatal Medicine – A case report of co-infection with rhinovirus and SARS-CoV-2 in pregnancy). She had mild symptoms but recovered and the pregnancy is ongoing. The authors are affiliatated with Renaissance School of Medicine Stony Brook University, Stony Brook, New York, which has not previously reported cases. Citation: Heiselman, C. J., Iovino, N., & Herrera, K. M. (2020). A case report of co-infection with rhinovirus and SARS-CoV-2 in pregnancy, Case Reports in Perinatal Medicine, 9(1), 20200028. doi: https://doi.org/10.1515/crpm-2020-0028
Study 376 – Infected baby from New York
A woman contracted Covid-19 at 36 weeks and was delivered by Caesarean (click here or piaa109). The baby was asymptomatic but tested positive. The baby was born at Presbyterian Brooklyn Methodist Hospital in New York and therefore may be included in study 230. Citation: Ihab Alamar, Mohammad H Abu-Arja, Taryn Heyman, Drucilla J Roberts, Niyati Desai, Pramod Narula, Beata Dygulska, A Possible Case of Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a Newborn With Positive Placental In Situ Hybridization of SARS-CoV-2 RNA, Journal of the Pediatric Infectious Diseases Society, Volume 9, Issue 5, November 2020, Pages 636–639, https://doi.org/10.1093/jpids/piaa109
Study 375 – 50 cases from Iran
Of 50 pregnant women hospitalised with Covid-19 in Hamadan (alt. spelling Hamedan) Province in Iran, 2 mothers died, 7 babies were infected and 26 women remain undelivered (click here or jrhs-20-e00488). The hospitals are unnamed and cannot be guessed at from author affliliations. Hamadan province is remote from Tehran, Ilam, Tabriz, and Sari from which most Iranian reports of maternal disease have come. However, study 250 included some infected babies from Hamadan province, and the two maternal deaths may have been included in studies 23 and 67. Citation: Sattari M, Bashirian S, Masoumi SZ, Shayan A, Jenabi E, Ghelichkhani S, Ali Shirzadeh A, Jalili E, Alimohammadi S. Evaluating Clinical Course and Risk Factors of Infection and Demographic Characteristics of Pregnant Women with COVID-19 in Hamadan Province, West of Iran. J Res Health Sci. 2020; 20(3): e00488.
Study 374 – 44 advice calls to a teratology service in Italy
This report describes 44 advice calls to a teratology service in Bergamo in Lombardy concerning drug prescription to 16 pregnant or lactating women with suspected, and 28 with confirmed, Covid-19 (click here or [16193997 – Journal of Perinatal Medicine – Medications prescriptions in COVID-19 pregnant and lactating women – the Bergamo Teratology Information Service experience during COVID-19 outbreak in Italy). Citation: Giampreti, A., Eleftheriou, G., Gallo, M., Butera, R., Contessa, G., Faraoni, L., Sangiovanni, A., Negri, G., Falchi, G., & Bacis, G. (2020). Medications prescriptions in COVID-19 pregnant and lactating women: the Bergamo Teratology Information Service experience during COVID-19 outbreak in Italy, Journal of Perinatal Medicine, 48(9), 1001-1007. doi: https://doi.org/10.1515/jpm-2020-0339
Study 373 – Case report from Leiden, The Netherlands
A woman contracted severe Covid-19 at 23 weeks requiring prolonged ventilation and Caesarean delivery at 28 weeks (click here or main (2)). The mother survived. The baby suffered complications of prematurity but was not infected and survived. From author affiliations she was cared for at Leiden University Medical Center, Leiden, The Netherlands. Apart from NethOSS reports, the case has not been previously reported. The centre and clinical features differ from the case in study 263. Citation: du Fossé NA, Bronsgeest K, Arbous MS, et al. Detailed immune monitoring of a pregnant woman with critical Covid-19 [published online ahead of print, 2020 Oct 29]. J Reprod Immunol. 2020;143:103243. doi:10.1016/j.jri.2020.103243
Studies 368 to 372 added.
Study 372 – A case of thyroiditis following post-partum Covid-19 in Japan
A woman contracted Covid-19, 103 days after giving birth, and 33 days later was diagnosed with thyroiditis (click here or advpub_EJ20-0553). From author affililiations the thyroiditis was treated at Wakayama Medical University, Wakayama, Japan Citation: Mizuno S, Inaba H, Kobayashi KI, Kubo K, Ito S, Hirobata T, Inoue G, Akamizu T, Komiya N. A case of postpartum thyroiditis following SARS-CoV-2 infection. Endocr J. 2020 Nov 12. doi: 10.1507/endocrj.EJ20-0553. Epub ahead of print. PMID: 33177251.
Study 371 – 40 cases in New York State and Connecticut, USA
Of 40 pregnant women with SARS-CoV-2 cared for in the Nuvance healthcare system, 3/4 had symptoms and 25 delivered (click here or full text not accessed). Of 20 neonates tested for SARS-CoV-2 all were negative. Nuvance maternity hospitals include Vassar Brothers, and Norwalk hospitals, neither of which have previously reported cases. Citation: Ogamba, I., Kliss, A., Rainville, N., Chuang, L., Panarelli, E., Petrini, J., & Zilberman, D. (2020). Initial review of pregnancy and neonatal outcomes of pregnant women with COVID-19 infection, Journal of Perinatal Medicine (published online ahead of print 2020), 000010151520200446. doi: https://doi.org/10.1515/jpm-2020-0446
Study 370 – A postnatal woman treated with ECMO in Japan
A woman with Covid-19 at 36 weeks gestation was delivered by Caesarean (click here or amjcaserep-21-e927521). The baby tested negative but the mother’s condition deteriorated, necessitating ventilation and later ECMO. She recovered. She was delivered in an unnamed general hospital in Tokyo, and from author affiliations the postnatal intensive care probably took place at Tokyo Medical and Dental University Hospital, Tokyo, Japan. These, and the clinical features, suggest she has not been included in previous series from Japan. Citation: Takayama W, Endo A, Yoshii J, et al. Severe COVID-19 Pneumonia in a 30-Year-Old Woman in the 36th Week of Pregnancy Treated with Postpartum Extracorporeal Membrane Oxygenation. Am J Case Rep. 2020;21:e927521. Published 2020 Oct 28. doi:10.12659/AJCR.927521
Study 369 – 3 pregnant women with Covid-19 & malaria, and one with dengue
All four survived although one of the women with malaria experienced an intrauterine fetal death at 24 weeks (click here or ijgo.13415). They were cared for in Nair hospital in Mumbai, India, so may have been included in studies 225 & 283. Citation: Mahajan, N.N., Kesarwani, S.N., Shinde, S.S., Nayak, A., Modi, D.N., Mahale, S.D. and Gajbhiye, R.K. (2020), Co‐infection of malaria and dengue in pregnant women with SARS‐CoV‐2. Int. J. Gynecol. Obstet., 151: 459-462. https://doi.org/10.1002/ijgo.13415
Study 368 – Covid-19 in a pregnant renal transplant recipient
A woman who was 30 weeks pregnant with a renal transplant contracted Covid-19 (click here or 40620_2020_Article_897). She recovered and gave birth normally at term. The baby was not tested. From author affiliations she was probably cared for at Queen Charlottes & Chelsea Hospital in London, which has not previously reported cases. Citation: Gleeson S, Noori M, Lightstone L, Webster P. Lesson for the clinical nephrologist: Kidney transplant, COVID-19 and pregnancy [published online ahead of print, 2020 Nov 12]. J Nephrol. 2020;1-3. doi:10.1007/s40620-020-00897-9
Studies 362 to 367 added.
Study 367 – Two cases from Prato, Italy
Santo Stefano Hospital in Prato, in Tuscany treated two cases of Covid-19 in pregnancy (click here or Cavaliere) and has not previously reported cases. Citation: A. F. Cavaliere, P. L. Vasarri, E. Scatena, A. Vidiri, M. S. Santicchia, I. Bordoni Vicini, M. Gardelli, F. Bressan, D. Matarrese, F. Perelli. SARS-CoV2 containment during pregnancy: single Center experience and the unique Chinese reality in Prato. Italian Journal of Gynæcology & Obstetrics September 2020 – Vol.32 – N. 3 – Quarterly – ISSN 2385 – 0868
Study 366 – 403 cases from Spain
These 403 cases of Covid-19 in pregnancy were divided into 231 with early cord clamping and 172 with delayed (click here or 1471-0528.16597). Two and 3 infants respectively tested positive. The cases were selected from the Spanish Registry of COVID-19 which collects cases from 100 Spanish hospitals. Citation: Mejía Jiménez, I., Salvador López, R., García Rosas, E., de la Torre, I.R., Montes García, J., de la Cruz Conty, M.L., Martínez Pérez, O. and (2020), Umbilical cord clamping and skin‐to‐skin contact in deliveries from women positive for SARS‐CoV‐2: a prospective observational study. BJOG: An International Journal of Obstetrics & Gynaecology. Accepted Author Manuscript. https://doi.org/10.1111/1471-0528.16597
Study 365 – 3 cases from Southampton, UK
Three pregnant women were included in this series from Southampton General Hospital, UK (click here or 1-s2.0-S0163445320306381-main). No further details are given. Citation: N.J. Brendish, S. Poole, V.V. Naidu et al., Clinical characteristics, symptoms and outcomes of 1054 adults presenting to hospital with suspected COVID-19: A comparison of patients with and without SARS-CoV-2 infection, Journal of Infection, https://doi.org/10.1016/j.jinf.2020.09.033
Study 364 – 678 cases from Qatar
There were 678 pregnant women testing positive for SARS-CoV-2 in this series (click here or main (1)). These are the first pregnant cases reported from Quatar. Citation: Ehab Hamed, Ahmed Sameer Alnuaimi, Mohamed Ahmed Syed, Mohamed Abd Elhamid , Saad Thamer Sedeeq , Bayan Alemrayat , Amina Ali Mohamed Muktar, AlAnoud Saleh AlFehaidi , Hamda Abdulla A/Qotba, Clinical characteristics of 51815 patients presenting with positive and negative SARS-CoV-2 swab results in primary health care settings, Journal of Infection (2020), doi: https://doi.org/10.1016/j.jinf.2020.11.014
Study 363 – A maternal death from Birmingham UK
A woman with Covid-19 in pregnancy was ventilated and transferred elsewhere for ECMO but died (click here). Full text not available, so it is not yet clear if the case has been reported elsewhere. Citation: Stout A, Crichton R, Tahmasebi F. Maternal death secondary to COVID-19 infection: A case report and review of the literature. Obstetric Medicine. November 2020. doi:10.1177/1753495X20970816
Study 362 – Case report
A case of severe COVID-19 pneumonia in a periviable pregnancy treated with concurrent combination of remdesivir, corticosteroids, and convalescent plasma therapy, leading to rapid maternal pulmonary improvement. Full text not yet obtained. Citation: Lam H., Lacasse A. Combination of remdesivir, corticosteroid, and convalescent plasma for severe COVID-19 in periviable pregnancy. Infectious Diseases in Clinical Practice. 28 (6) (pp e21-e23), 2020. Date of Publication: 01 Nov 2020.
Studies 359 to 361 added.
Study 361 – 252 cases from Texas
252 pregnant women who tested positive for SARS-CoV-2 were compared with 3122 who tested negative (click here or adhikari 2020 oi 200933 1605126584.8159). There was no difference in a primary composite outcome of birth <37 weeks, severe pre-eclampsia, or cesarean for abnormal fetal heart rate. There were no maternal deaths in either group. No babies died in the SARS-CoV-2 group. Women were cared for at Parkland Health and Hospital System, Dallas, Texas. Citation: Adhikari EH, Moreno W, Zofkie AC, et al. Pregnancy Outcomes Among Women With and Without Severe Acute Respiratory Syndrome Coronavirus 2 Infection. JAMA Netw Open. 2020;3(11):e2029256. doi:10.1001/jamanetworkopen.2020.29256
Study 360 – 21 cases from Israel
21 women with Covid-19 all gave birth to healthy babies, one of whom tested positive (click here or Lopian PedNeo). They were cared for in Mayanei Hayeshua Medical Center in Bnei Brak, Israel, which has not previously reported cases. Citation: Lopian M et al., Safety of vaginal delivery in women infected with COVID-19, Pediatrics and Neonatology.
Study 359 – 39 severe cases from New York & Philadelphia
In this case control study, 39 pregnant women with severe or critical Covid-19 were compared with 94 non-pregnant women (click here or DeBolt AJOG). Some or all of the pregnant women have probably been previously reported in studies 85, 86, 91, 98, 152, 160, 175 and 350. Citation: DeBolt CA, Bianco A, Limaye MA, Silverstein J, Penfield CA, Roman AS, Rosenberg HM, Ferrara L, Lambert C, Khoury R, Bernstein PS, Burd J, Berghella V, Kaplowitz E, Overbey JR, Stone J, Pregnant women with severe or critical COVID-19 have increased composite morbidity compared to non-pregnant matched controls, American Journal of Obstetrics and Gynecology (2020).
Studies 357 and 358 added.
Study 358 – A case from Brazil
A woman contracted severe Covid-19 at 27 weeks gestation, the fetus died in utero, was delivered by Caesarean section and tested positive (click here). The mother required ventilation but recovered. From author affiliations she was cared for in Hospital de Clínicas da Universidade Federal do Paraná, Parana, Brazil. Citation: Stonoga ETS, Lanzoni LA, Rebutini PZ, Olveira ALP, Chiste JA, Fugaça CA, et al. Intrauterine transmission of SARS-CoV-2. Emerg Infect Dis. 2021 Feb [date cited].
Study 357 – A case from Wenzhou, China
Among 67 cases of COVID-19 in Wenzhou, one was in a pregnant woman (click here or s12879-020-05528-z). No details are given of her, but all patients survived. They were cared for in Ruian People’s Hospital grid.452885.6 which has not previously reported cases. Citation: Hong, L., Ye, E., Sun, G. et al. Clinical and radiographic characteristics, management and short-term outcomes of patients with COVID-19 in Wenzhou, China. BMC Infect Dis 20, 841 (2020).
Studies 353 to 356 added.
Study 356 – 15 women from Italy
Among 15 pregnant women with SARS-CoV-2 none delivered infected infants (click here or fped-08-565522). They were cared for at City Hospital in Piacenza from late February through May 15, 2020. Although just outside Lombardy they have probably been reported in studies 32, 64 and 117. Citation: Biasucci G, Cannalire G, Raymond A, Capra ME, Benenati B, Vadacca G, Schiavo R, Pavesi C, Bonini R. Safe Perinatal Management of Neonates Born to SARS-CoV-2 Positive Mothers at the Epicenter of the Italian Epidemic. Front Pediatr. 2020 Oct 29;8:565522. doi: 10.3389/fped.2020.565522. PMID: 33194893; PMCID: PMC7658585.
Study 355 – Two cases from Northwestern China
Among 617 COVID-19 patients in Northwestern China, over 1,000km from Wuhan, two were pregnant, and one gave birth to a healthy baby at term. The outcome of the other was not reported. The exact location of neither was reported. Citation: Zhu J, Zhang Q, Jia C, et al. Epidemiological Characteristics and Clinical Outcomes of Coronavirus Disease Patients in Northwest China: High-Volume Research From Low Population Density Regions. Front Med (Lausanne). 2020;7:564250. Published 2020 Oct 30. doi:10.3389/fmed.2020.564250
Study 354 – First trimester case from Paris
A woman with an ivf pregnancy contracted Covid-19 at 7 weeks (click here or s12879-020-05551-0). Prior to the diagnosis she had been treated with estradiol, progesterone, corticosteroids, chloroquine, aspirin & heparin. Liver enzymes were raised. She recovered. The pregnancy was ongoing at the time of the report. From author affiliations she was cared for at Hôpital Privé de Parly 2, Le Chesnay, Paris, France. Citation: Lamazou, F., Oger, P., Dieli-crimi, R. et al. COVID-19 infection in first trimester of pregnancy marked by a liver cytolysis in a woman previously treated by hydroxychloroquine for repeated implantation failure: a case report. BMC Infect Dis 20, 845 (2020).
Study 353 – Anaphylaxis after convalescent plasma therapy
A woman with Covid-19 at 31 weeks gestation experienced an anaphylactic reaction after treatment with convalescent plasma (click here or 1-s2.0-S0012369220330798-main). She required delivery. Neither mode of birth nor outcome for mother or baby was reported. The hospital was unnamed and no author affiliations are given. Citation: ANAPHYLACTIC SHOCK IN A PREGNANT PATIENT WITH COVID-19 IN THE SETTING OF CONVALESCENT PLASMA TRANSFUSION. CHEST, Volume 158, Issue 4, A959
Study 352 added.
Study 352 – Infected stillbirth in Portugal
An asymptomatic woman gave birth to a hydropic stillborn fetus at 34 weeks (click here or PIIS0301211520307533). Both mother and fetus tested positive for SARS-CoV-2. From author affiliations she was cared for at Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal, which has not previously reported cases. Citation: Rodrigues ML, Gasparinho G, Sepulveda F, Matos T, Signs suggestive of congenital SARS-CoV-2 infection with intrauterine fetal death: a case report, European Journal of Obstetrics and amp; Gynecology and Reproductive Biology (2020).
Study 351 added.
Study 351 – SARS-CoV-2 seroprevalence in antenatal samples in Sydney, Australia
This anonymised seroprevalence study on samples collected between April & June 2020 in Sydney, Australia, included 560 samples from women undergoing antenatal screening. 0.79% were positive for SARS-CoV-2 IgG (click here or Gidding mja20.01971 – 11 November 2020_0). Citation: Heather F Gidding, Dorothy A Machalek, Alexandra J Hendry, Helen E Quinn, Kaitlyn Vette, Frank H Beard, Hannah Shilling, Rena Hirani, Iain B Gosbell, David O Irving, Linda Hueston, Marnie Downes, John B Carlin, Matthew NV O’Sullivan, Dominic E Dwyer, John M Kaldor and Kristine Macartney. Seroprevalence of SARS-CoV-2-specific antibodies in Sydney, Australia following the first epidemic wave in 2020 Med J Aust. Published online: 11 November 2020
Studies 349 and 350 added.
Study 350 – 8 pregnant women detected by screening in Philadelphia, USA
Of 318 pregnant women screened between April 13th & 26th, 2020, eight tested positive for Sars-CoV-2 (click here or Bender AJOG MFM main). The women were screened in the Hospital of the University of Pennsylvania and Pennsylvania Hospital, and may overlap with some reported in studies 65, 86, 175, and 202. Citation: Bender WR, Hirshberg A, Coutifaris P, et al. Universal testing for severe acute respiratory syndrome coronavirus 2 in 2 Philadelphia hospitals: carrier prevalence and symptom development over 2 weeks. Am J Obstet Gynecol MFM 2020;2:100226.
Study 349 – 66 babies with neonatal SARS-CoV-2 infection in UK
Of 66 neonates with confirmed SARS-CoV-2 infection, 28 (42%) had severe disease,16 (24%) were born preterm and one died of an unrelated cause (click here or Gale Lancet PIIS2352464220303424). However, only two babies (3%) were considered to have possible vertically acquired infection (SARS-CoV-2-positive sample within 12 h of birth where the mother was also positive). Citation: Gale, Chris et al. Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance. The Lancet Child & Adolescent Health, Volume 0, Issue 0
Study 342 (update of 203) and 343 to 348 added.
Study 348 – 33 patients from New York, USA
Of 33 women with Covid-19, two required ventilation and one died (click here or Curi AJOG MFM). The were two intrauterine fetal deaths. Patients were cared for at Lincoln Hospital Medical and Mental Health Center, South Bronx, which has not previously reported cases. Citation: Berenice Curi, Alexander Sabre, Israel Benjamin, Lisa Serventi, Dilfuza Nuritdinova. Coronavirus infection in a high-risk obstetrical population of the South Bronx, New York, American Journal of Obstetrics & Gynecology MFM, Volume 2, Issue 4, Supplement, 2020, 100203, ISSN 2589-9333.
Study 347 – Case report from Monterrey, Mexico
A woman contracted severe Covid-19 at 27 weeks (click here or ijgo.13467). She required four days ventilation and was also treated with enoxaparin, azithromycin, ceftaroline, lopinavir/ritonavir, methylprednisolone and convalescent plasma. She recovered and delivered a growth restricted baby (birth weight not reported) at 39 weeks. The hospital was San José Tec Salud which has not previously reported cases. However, she may be included in study 340. Citation: Magallanes‐Garza, G.I., Valdez‐Alatorre, C., Dávila‐González, D., Martínez‐Reséndez, M.F., Sánchez‐Salazar, S.S., Castilleja‐Leal, F. and Cardona‐Huerta, S. (2020), Rapid improvement of a critically ill obstetric patient with SARS‐CoV‐2 infection after administration of convalescent plasma. International Journal of Gynecology & Obstetrics. Accepted Author Manuscript.
Study 346 – 4 cases from Nancy, France
Two women with Covid-19 delivered infected babies (click here or hascoet fped-08-568979). Two others delivered uninfected babies. From author affiliations they were likely cared for at Maternite Regionale CHRU Nancy, France and therefore probably included in study 150. Citation: Hascoët Jean-Michel, Jellimann Jean-Marc, Hartard Cedric, Wittwer Apolline, Jeulin Hélène, Franck Patricia, Morel Olivier. Case Series of COVID-19 Asymptomatic Newborns With Possible Intrapartum Transmission of SARS-CoV-2. Frontiers in Pediatrics VOLUME=8. 2020. P 632. URL=https://www.frontiersin.org/article/10.3389/fped.2020.568979. DOI=10.3389/fped.2020.568979
Study 345 – 15 maternal deaths from Covid-19 in Tehran, Iran
Of 32 women who tested positive at Firoozgar General Hospital, Tehran, 15 died (click here or Moghadam ijgo.13461). Although this hospital has not previously reported cases, overlap with cases in studies 23, 67 & 218 cannot be excluded. Citation: Moghadam, S.A., Dini, P., Nassiri, S., Motavaselian, M., Hajibaba, M. and Sohrabi, M. (2020), Clinical features of pregnant women in Iran who died due to COVID‐19. Int J Gynecol Obstet. Accepted Author Manuscript.
Study 344 – Case report from Pennsylvania, USA
A woman with Covid-10 was delivered by Caesarean on 3 April (click here or 2050313×20945536). She and the baby were fine. The patient was treated in Lehigh Valley Hospital, Stroudsburg, Pennsylvania, which has not previously reported cases. Citation: Krupa Daniel, Kiran Goli, Anita Sargent. Repeat cesarean section in a COVID-19 positive mother in the United States. SAGE Open Medical Case Reports Volume 8: 1–3. 2020. DOI: 10.1177/2050313X20945536
Study 343 – 32 cases from Jodhpur, India
32 women with Covid-19 during prepgnany were seen over 5 months from April to August 2020 (click here or ijgo.13457). Few details given. The paper is largely concerned with indirect effects of the pandemic. Citation: Goyal, M., Singh, P., Singh, K., Shekhar, S., Agrawal, N. and Misra, S. (2020), The effect of the COVID‐19 pandemic on maternal health due to delay in seeking health care: Experience from a tertiary center. International Journal of Gynecology & Obstetrics. Accepted Author Manuscript.
Study 342 – an update of study 203 from Turkey
The 100 cases in study 203 have been expanded to 533 cases (click here or ijgo.13460). Two women died. There were 131 births and all neonatwes tested negative. Citation: Sahin, D., Tanacan, A., Erol, S.A., Anuk, A.T., Yetiskin, F.D., Keskin, H.L., Ozcan, N., Ozgu‐Erdinc, A.S., Eyi, E.G., Yucel, A., Tayman, C., Unlu, S., Dinc, B., Sari, E., Surel, A.A. and Moraloglu, O.T. (2020), Updated experience of a tertiary pandemic center on 533 pregnant women with COVID‐19 infection: A prospective cohort study from Turkey. Int J Gynecol Obstet. Accepted Author Manuscript.
Studies 340 and 341 added.
Study 341 – 18 pregnant women with antibodies from Copenhagen, Denmark
18/1019 (1.8%) women with stored first trimester serum taken for Down’s screening at Copenhagen University Hospital Hvidovre between Feb 17 & Apr 23 2020, had SARS-CoV-2 antibodies (click here or deaa311). Half had had symptoms. None were hospitalised. One miscarried. Of 36 women who miscarried before Down’s screening, none had antibodies. The positive antibody women may overlap with those in study 299. Citation: la Cour Freiesleben N, Egerup P, Vauvert Römmelmayer Hviid K, Rosenbek Severinsen E, Kolte AM, Westergaard D, Fich Olsen L, Prætorius L, Zedeler A, Hellerung Christiansen AM, Reinhardt Nielsen J, Bang D, Berntsen S, Ollé-López J, Ingham A, Bello-Rodríguez J, Marie Storm D, Ethelberg-Findsen J, Hoffmann ER, Wilken-Jensen C, Stener Jørgensen F, Westh H, Løvendahl Jørgensen H, Nielsen HS. SARS-CoV-2 in first trimester pregnancy: a cohort study. Hum Reprod. 2020 Nov 4:deaa311. doi: 10.1093/humrep/deaa311. Epub ahead of print. PMID: 33145598.
Study 340 – 448 cases from Mexico
448 women in the open national database of COVID-19 from the Ministry of Health of Mexico between February 28 & May 25, 2020, were pregnant (click here or jogh-10-020512). 137 were hospitalised, 14 admitted to ICU, 7 ventilated and 10 died. Some cases may overlap with those in studies 66 & 271. Citation: Ríos-Silva M, Murillo-Zamora E, Mendoza-Cano O, Trujillo X, Huerta M. COVID-19 mortality among pregnant women in Mexico: A retrospective cohort study. J Glob Health. 2020 Dec;10(2):020512. doi: 10.7189/jogh.10.020512. PMID: 33110595; PMCID: PMC7567444.
Study 339 added.
Study 339 – 65 cases from Wuhan, China
Using the Maternal and Child Health Information Management System of Wuhan, 65 women with Covid-19 delivering between Jan 13 & March 18 were identified and compared with 11,013 women without, or not tested for, Covid-19 (click here or s12916-020-01798-1). The paper was first submitted on 14 May. Despite six revisions the authors fail to make clear, and the referees & editors failed to notice, that most, if not all, of these cases will have been included in studies 1, 2, 6a, 8, 10, 11, 12, 13, 15, 34, 36, 39, 54, 55, 57, 59, 73, 75, 80, 108, 179, 183, 211, 220, 262b, 268, 280, 294, 305, & 329. Citation: Yang, R., Mei, H., Zheng, T. et al. Pregnant women with COVID-19 and risk of adverse birth outcomes and maternal-fetal vertical transmission: a population-based cohort study in Wuhan, China. BMC Med 18, 330 (2020).
Studies 336 to 338 added.
Study 338 – birth outcomes among 4,442 pregnancies from the US
5,252 women with laboratory-confirmed SARS-CoV-2 infection were reported from 16 jurisdictions within the Surveillance for Emerging Threats to Mothers and Babies Network (SET-NET), during March 29–October 14, 2020 (click here or mm6944e2-H). 309 pregnancies were presumed ongoing, and 501 had missing outcomes. Among 4,442 women with known pregnancy outcomes there were 3,912 live births with known gestational age, 12.9% were preterm (<37 weeks). Among 4,527 babies (incl. 79 twins and one set of triplets) 12 (0.3%) pregnancies miscarried before 20 weeks and there was 20 stillbirths (0.4%) after 20 weeks. Among 610 infants with reported SARS-CoV-2 test results, 16 were positive. Citation: Woodworth KR, Olsen EO, Neelam V, et al. Birth and Infant Outcomes Following Laboratory-Confirmed SARS-CoV-2 Infection in Pregnancy — SET-NET, 16 Jurisdictions, March 29–October 14, 2020. MMWR Morb Mortal Wkly Rep. ePub: 2 November 2020.
Study 337 – 30,415 maternal outcomes from the US
Compared with nonpregnant women of the same age, pregnant women were more frequently admitted to ICU (10.5 versus 3.9 per 1,000 cases), ventilated (2.9 versus 1.1 per 1,000 cases), treated with ECMO (0.7 versus 0.3 per 1,000 cases) (click here or mm6944e3-H). 34/23,434 (1.5 per 1,000) symptomatic pregnant women died, compared with 447/386,028 (1.2 per 1,000) nonpregnant women. Citation: Zambrano LD, Ellington S, Strid P, et al. Update: Characteristics of Symptomatic Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status — United States, January 22–October 3, 2020. MMWR Morb Mortal Wkly Rep. ePub: 2 November 2020.
Study 336 – 5 women from Tel Aviv, Israel
Vaginal swabs were tested from 35 women, aged 21-93 years with Covid-19 (click here or 1471-0528.16556). Two were positive. Five of the tested women were in the 3rd trimester of pregnancy, but none of them had a postive vaginal swab. From author affilitions the women were cared for in Lis Maternity Hospital, Tel Aviv, Israel, and may therefore be included in study 330. Citation: Schwartz, A., Yogev, Y., Zilberman, A., Alpern, S., Many, A., Yousovich, R. and Gamzu, R. (2020), Detection of SARS‐CoV‐2 in vaginal swabs of women with acute SARS‐CoV‐2 infection: a prospective study. BJOG: An International Journal of Obstetrics & Gynaecology. Accepted Author Manuscript.
Studies 329 to 335 added.
Study 335 – Case report from Palermo, Italy
A woman with Covid-19 at 27 weeks required mechanical ventilation for over 4 weeks, latterly via tracheostomy, and was delivered by Caesarean section at 30 weeks (click here or ccr3.3426). She survived. The baby tested negative and survived. Both were cared for at Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy which has not previously reported cases. Citation: Donzelli, M, Ippolito, M, Catalisano, G, et al. Prone positioning and convalescent plasma therapy in a critically ill pregnant woman with COVID‐19. Clin Case Rep. 2020; 00: 1– 7.
Study 334 – seroprevalaence among pregnant women around Oxford, UK
53/1000 (5.3%) of antenatal blood samples, in the Oxford region, between 14 April and 15 June 2020 were positive for SARS-CoV-2 IgG (click here or Lumley eurosurv-25-42-4). Citation: Lumley Sheila F , Eyre David W , McNaughton Anna L , Howarth Alison , Hoosdally Sarah , Hatch Stephanie B , Kavanagh James , Chau Kevin K , Downs Louise O , Cox Stuart , Dunn Laura , Justice Anita , Wareing Susan , Dingle Kate , Rudkin Justine , Auckland Kathryn , Fyfe Alexander , Bolton Jai , Paton Robert , Mentzer Alexander J, Jeffery Katie , Andersson Monique I , James Tim , Peto Tim E A , Marsden Brian D , Screaton Gavin , Cornall Richard J , Klenerman Paul , Ebner Daniel , Stuart David I , Crook Derrick W , Stoesser Nicole , Kennedy Stephen H , Thompson Craig , Gupta Sunetra , Matthews Philippa C ORCID icon. SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020. Euro Surveill. 2020;25(42):pii=2001721.
Study 333 – 250 cases from Lombardy, Italy
In this updated series from Lombardy, of 250 pregnant women with either asymptomatic, non-severe, or severe SARS-CoV-2 up to June 18, 2020, nine were admitted to ICU but there were no maternal deaths (click here or ijgo.13435). Some cases were included in studies 32, 64, 114, 180, 188, 197 & 252. Citation: Di Martino, D., Chiaffarino, F., Patanè, L., Prefumo, F., Vergani, P., Ornaghi, S., Savasi, V., Spinillo, A., Cromi, A., D’Ambrosi, F., Tassis, B., Iurlaro, E., Parazzini, F. and Ferrazzi, E. (2020), Assessing risk factors for severe forms of COVID‐19 in a pregnant population: A clinical series from Lombardy, Italy. Int J Gynecol Obstet. Accepted Author Manuscript.
Study 332 – Case report from Granada, West Indies
A woman with Covid-19 gave birth to an infected neonate (click here or Majachani AMCaseRep 925766). The mother had a past history of HIV infection. Both recovered. From author affiliations the unnamed hospital was probably St. George’s University General Hospital, which has not previously reported cases. Citation: Nicole Majachani, Jean Luc M. Francois, Ashen K. Fernando, Jamshed Zuberi. A Case of a Newborn Baby Girl Infected with SARS-CoV-2 Due to Transplacental Viral Transmission. Am J Case Rep 2020; 21:e925766 DOI: 10.12659/AJCR.925766. Available online: 2020-09-17
Study 331 – 180 cases from New York
Of these 180 women with Covid-19 in pregnancy, 7 required intensive care (click here or Janssen AJOG MFM). Three babies tested positive but none had illness consistent with COVID-19. The patients were probably cared for in the Northwell system hospitals, so some have probably been reported in studies 162, 179, 289 & 315. Citation: Janssen O, Thompson M, Milburn S, Green R, Wagner B, Bianco A, Stroustrup A, The Impact of Perinatal SARS-CoV2 Infection During the Peripartum Period, American Journal of Obstetrics & Gynecology MFM (2020).
Study 330 – 52 cases from 7 hospitals in Israel
Of 52 women with Covid-19 in pregnancy, one was critically ill, but no babies were infected (click Rottenstreich2020 Article Vaginal Delivery In SARS-CoV-2-in). The seven hospitals are unnamed, but from author affiliations probably include Hadassah-Hebrew University Medical Center, Jerusalem: Sheba Medical Center, Tel-Aviv University, Tel-Hashomer; Mayenei Hayeshua Medical Center, Tel-Aviv University, Ramat Gan; Lis Maternity Hospital, Tel-Aviv; Meir Medical Center, Tel-Aviv University, Kfar Saba; and Ziv Medical Center, Safed. None of these hospitals have reported cases. Citation: Rottenstreich, A., Tsur, A., Braverman, N. et al. Vaginal delivery in SARS-CoV-2-infected pregnant women in Israel: a multicenter prospective analysis. Arch Gynecol Obstet (2020).
Study 329 – 60 cases from Wuhan, China
These cases (click here or fcimb-10-560899) delivered between January 24 & March 14, 2020 in the Maternity and Child Health Hospital in Wuhan, Hubei province have probabaly been reported many times. The MCH hospital in Wuhan is part of Huazhong University of Science and Technology Hospital grid.488485.d. Studies 8, 17, 30, 38, 54, 55 & 262b. Citation: Sun G, Zhang Y, Liao Q and Cheng Y (2020) Blood Test Results of Pregnant COVID-19 Patients: An Updated Case-Control Study. Front. Cell. Infect. Microbiol. 10:560899. doi: 10.3389/fcimb.2020.560899
Study 328 added.
Study 328 – 154 cases from the Dominican Republic
Of 154 women with Covid-19, 15 developed cardiac injury (click here or Mercedes AJOG PIIS0002937820312060). Two died. The hospital is “an obstetric tertiary level hospital in Santo Domingo”. However none of the authors, including those from the Dominican Republic, report an affiliation from that city, which contains more than one large maternity hospital. Citation: Mercedes BR, Serwat A, Naffaa L, Ramirez N, Khalid F, Steward SB, Caro Feliz OG, Kassab M, Karout L, New-Onset myocardial injury in COVID-19 Pregnant Patients: A Case Series of 15 Patients, American Journal of Obstetrics and Gynecology (2020).
Study 327 added.
Study 327 – 40 cases of neonatal SARS-CoV-2 in Spain
A National Registry supported by the Spanish Society of Neonatology identified 40 neonates who tested positive for SARS-CoV-2 between 3 April & 18 May 2020 (click here or fped-08-580584) Citation: Fernández Colomer Belén, Sánchez-Luna Manuel, de Alba Romero Concepción, Alarcón Ana, Baña Souto Ana, Camba Longueira Fátima, Cernada María, Galve Pradell Zenaida, González López María, López Herrera M. Cruz, Ribes Bautista Carmen, Sánchez García Laura, Zamora Flores Elena, Pellicer Adelina, Alonso Díaz Clara, Herraiz Perea Cristina, Romero Ramírez Dolores Sabina, de las Cuevas Terán Isabel, Pescador Chamorro Isabel, Fernández Trisac José Luis, Arruza Gómez Luis, Cardo Fernández Luis Miguel, García García Mª Jesús, Nicolás López Marta, Hortelano López Miryam, Riaza Gómez Mónica, Hernández González Natalio, González Sánchez Raquel, Zambudio Sert Sílvia, Larrosa Capacés Susana, Matías del Pozo Vanesa. Neonatal Infection Due to SARS-CoV-2: An Epidemiological Study in Spain. Frontiers in Pediatrics. VOL 8. 2020. p 670. DOI 10.3389/fped.2020.580584
Study 326 added.
Study 326 – Seroprevalence in Paris, France
Of women admitted to the delivery room at Antoine Be´clère Hospital maternity ward from 4th to 31st May, 20/249 (8%) were SARS-CoV-2 IgG positive (click here: journal.pone.0240782). 1/190 tested for nasopharyngeal SARS-CoV-2 RT-PCR was positive. She was asymptomatic and her baby tested negative. The period covered the final week of, and first three weeks post, lockdown. Citation: Mattern J, Vauloup-Fellous C, Zakaria H, Benachi A, Carrara J, Letourneau A, et al. (2020) Post lockdown COVID-19 seroprevalence and circulation at the time of delivery, France. PLoS ONE 15(10): e0240782.
Studies 319 to 325 added.
Study 325 – Screening in Porto, Portugal
Full text not yet available. 11/184 (6.0%) of pregnant women screened for SARS-CoV-2 on admission in labour between 19th March and 4th May were positive. Two reported symptoms (click here). From author affiliations the hospital was Centro Hospitalar Universitário de São João, Porto, Portugal Citation: Figueiredo R, Tavares S, Moucho M, Ramalho C. Systematic screening for SARS-CoV-2 in pregnant women admitted for delivery in a Portuguese maternity. J Perinat Med. 2020 Oct 21:/j/jpme.ahead-of-print/jpm-2020-0387/jpm-2020-0387.xml. doi: 10.1515/jpm-2020-0387. Epub ahead of print. PMID: 33085639.
Study 324 – A case of neonatal SARS in Lisbon, Portugal
Full text not yet available (click here). From author affililations this was Hospital de São Francisco Xavier, Centro Hospitalar Lisboa Ocidental, Lisbon. Citation: Correia, Cátia R. MD*; Marçal, Mónica MD*; Vieira, Filipa MD*; Santos, Edmundo MD*; Novais, Cristina MD*; Maria, Ana Teresa MD*; Malveiro, Duarte MD*; Prior, Ana Rita MD*; Aguiar, Marta MD*; Salazar, Anabela MD*; Gouvêa Pinto, Constança MD*; Carvalho Rodrigues, Luís MD†; Pessanha, Maria Ana PhD†; Borges, Vítor PhD‡; Isidro, Joana MSc‡; Gomes, João Paulo PhD‡; Duarte, Sílvia MSc§; Vieira, Luís MSc§; Costa, Inês MSc¶; Alves, Maria João PhD‖; Calhau, Conceição PhD**; Guiomar, Raquel MSc¶; Tuna, Madalena Lopo MD* Congenital SARS-CoV-2 Infection in a Neonate With Severe Acute Respiratory Syndrome, The Pediatric Infectious Disease Journal: October 22, 2020 – Volume Online First – Issue –
Study 323 – Two mothers treated with ECMO in Los Angeles, California
Two women with Covid-19 required treatment with ECMO (click here or s-0040-1718694). Both mothers and babies survived. From author affiliations they were cared for in the University of California, Los Angeles. The hospital is not named. Citation: K. Marie Douglass, Katie M. Strobel, Michael Richley, Thalia Mok , Annabelle de St Maurice, Viviana Fajardo, Andrew T. Young, Rashmi Rao, Lydia Lee, Peyman Benharash, Alison Chu, Yalda Afshar. Maternal-Neonatal Dyad Outcomes of Maternal COVID-19 Requiring Extracorporeal Membrane Support: A Case Series Am J Perinatol. DOI: 10.1055/s-0040-1718694
Study 322 – 60 cases from Oman
Sixty women with Covid-19 were cared for at The Royal Hospital, Muscat, Oman from March 24 to July 31, 2020 (click here or ijgo.13427). Seven required ITU care of whom one was critically ill. No mothers died. There were four miscarriages, one stillbirth and eight pregnancies ongoing. The remainder of the babies survived. All four tested neonates were negative. Citation: Santhosh, J., Al Salmani, M., Khamis, F., Al Ubaidani, S.A. and Al‐Zakwani, I. (2020), Clinical characteristics of COVID‐19 in pregnant women: A retrospective descriptive single‐center study from a tertiary hospital in Muscat, Oman. International Journal of Gynecology & Obstetrics. Accepted Author Manuscript.
Study 321 – Four cases from Iran
Four pregnant women contracted Covid -19 (click here or Iran case series). All four recovered. One was postnatal, one delivered vaginally and two remained undelivered. They were cared for in Shahid Mostafa Khomeini Hospital in Ilam which has not previously reported cases. Citation: Gheysarzadeh A, Sadeghifard N, Safari M, Rashidian T, Mohammadyari E, Tavan H, Report of four pregnant women getting COVID-19 in Ilam, Iran: Case Series, New Microbes and New Infections
Study 320 – Case report from Philadelphia
A woman with Covid-19 at 36 weeks required 6 days ventilation and delivery by Caesarean (click here or 8889487). She survived, but at the time of the report remained in an inpatient rehabilitation facility. The baby tested negative. From author affiliations she was likely cared for in the Einstein Medical Center, Philadelphia which has not previously reported cases. Citation: Jerald Pelayo ,Gabriella Pugliese, Grace Salacup, Eduardo Quintero, Adeeb Khalifeh, David Jaspan, and Bhavna Sharma. Severe COVID-19 in Third Trimester Pregnancy: Multidisciplinary Approach. Case reports in Critical Care. Volume 2020 |Article ID 8889487
Study 319 – No cases in Melbourne, Australia
No positive test results among 350 pregnant women from three hospitals in Melbourne over the two-week period 6th to 19th May 2020 (click here or Rolnik 1-s2.0-S1871519220303553-main). This period was after the first wave had subsided in Australia. Citation: D.L. Rolnik, T.M. Korman, A. Rindt et al., Coronavirus testing in women attending antenatal care, Women Birth
Study 318 added
Study 318 – Case report from Chizhou, Anhui Province, China
A woman contracted Covid-19 on Jan 6th, six months after delivery while still breastfeeding ((click here or 15010 2020 Article 1532). Breastfeeding was stopped and the infant artificially fed at home. The infant’s infection status and outcome were not reported. The mother recovered. Citation: Liu X, Zhou L, Zhu Y. Report on a lactating patient with COVID-19 [published online ahead of print, 2020 Oct 9]. Infection. 2020;1-5. doi:10.1007/s15010-020-01532-2
Study 317 added.
Study 317 – 101 neonates from New York
Of 101 neonates born to 100 mothers positive for SARS-CoV-2 from March 13 to April 24, 2020, two had borderline results and the rest tested negative. No baby had clinical disease (click here). Fourteen babies were reported in study 27. Citation: Dumitriu D, Emeruwa UN, Hanft E, et al. Outcomes of Neonates Born to Mothers With Severe Acute Respiratory Syndrome Coronavirus 2 Infection at a Large Medical Center in New York City. JAMA Pediatr. Published online October 12, 2020. doi:10.1001/jamapediatrics.2020.4298
Studies 315 and 316 added.
Study 316 – Case report from Japan
A woman with Covid-19 was delivered by caesarean section on April 2nd (click here or jog.14393). This was the first birth to a woman with Covid-19 in Japan. Mother and baby survived. The baby was not infected. They were cared for in the Center for Perinatal, Pediatric and Developmental Medicine, Kitasato University Hospital which has not previously reported cases. Citation: Mochizuki, J., Nakamura, M., Iwahata, S., Nishijima, J., Ito, T., Wada, T., Takayama, Y. and Unno, N. (2020), First report in Japan of a delivery of a woman with the 2019 novel coronavirus disease. J. Obstet. Gynaecol. Res.. doi:10.1111/jog.14393
Study 315 – 31 severe cases from New York
Of 31 pregnant women with severe or critical disease, four had abnormal cardiac biomarkers, of whom two died (click here or PIIS0002937820311881). The women were cared for in the Northwell health system so may have been included in studies 162, 179 and 289. Citation: PACHTMAN SHETTY SL, MEIROWITZ N, BLITZ MJ, GADOMSKI T, WEINBERG CR, Myocardial injury associated with coronavirus disease 2019 in pregnancy, American Journal of Obstetrics and Gynecology (2020).
Studies 311 to 314 added.
Study 314 – 141 cases from Yale, New Haven, USA
Of 141 women with Covid-19 in pregnancy, one died (click here or PIIS2589933320302147 (1)). Of 76 live births, no babies were affected. They were cared for in Yale New Haven, Bridgeport, and Greenwich hospitals. One woman, who had a 22 week termination for severe pre-eclampsia, was reported in study 155. Some may also have been included in study 132. Citation: GRECHUKHINA O, GREENBERG V, LUNDSBERG LS, DESHMUKH U, CATE J, LIPKIND HS, CAMPBELL KH, PETTKER CM, KOHARI KS, REDDY UM, Coronavirus Disease 2019 (COVID-19) pregnancy outcomes in a racially and ethnically diverse population, American Journal of Obstetrics & Gynecology MFM (2020).
Study 313 – Case report from Mumbai, India
In this MedRxiv preprint, an asymptomatic woman tested positive for SARS-CoV-2 at 8 weeks gestation. At 13 weeks the fetus had died (click here or 2020.08.18.20177121v1.full). The authors detected virus in the placenta and argue the fetal demise was due to congenital transmission of SARS-CoV-2. Citation: Prajakta Shende, Pradip Gaikwad, Manisha Gandhewar, Pawankumar Ukey, Anshul Bhide, Vainav Patel, Sharad Bhagat, Vikrant Bhor, Smita Mahale, Rahul Gajbhiye, Deepak Modi Persistence of SARS-CoV-2 in the first trimester placenta leading to vertical transmission and fetal demise from an asymptomatic mother. medRxiv 2020.08.18.20177121
Study 312 – analysis of a range of specimens from 31 affected pregnancies in Milan, Italy
31 pregnancies with SARS-CoV-2 (click here or s41467-020-18933-4). From author affiliations the patients were probably cared for in Milan. Citation: Fenizia, C., Biasin, M., Cetin, I. et al. Analysis of SARS-CoV-2 vertical transmission during pregnancy. Nat Commun 11, 5128 (2020).
Study 311 – 21 placentas from St Louis, USA
No differences were seen between 21 placentas from SARS-CoV-2 positive pregnancies and 20 control ones (click here or Histopathology of Third Trimester Placenta from SARSCoV 2 Positive Women). The hospitals are not reported. Citation: Mai He, Priya Skaria, Kasey Kreutz, Ling Chen, Ian S. Hagemann, Ebony B. Carter, Indira U. Mysorekar, D. Michael Nelson, John Pfeifer & Louis P. Dehner (2020) Histopathology of Third Trimester Placenta from SARS-CoV-2-Positive Women, Fetal and Pediatric Pathology, DOI: 10.1080/15513815.2020.1828517
Studies 309 and 310 added.
Study 310 – 86 pregnant women treated with remdesivir
Of the first 86 pregnant, or recently pregnant, women with severe Covid-19 (O2 satuation <=94%), treated with compassionate use remdesivir (all outside a trial) between March 21, & April 22nd 2020, 63 were admitted to ICU, 45 required ventilation and one ECMO (click here or ciaa1466). One woman died. At 28-day follow-up seven women were still being ventilated (appendix Fig 2 ciaa1466 suppl supplementary materials 1 (1)). Among 45 deliveries there was one 17 weeks miscarriage but otherwise no babies died. Four women were treated in Spain, two in Switzerland and one each in Italy and the UK. The rest were from the United States. Many have presumably been included in other reports. Citation: Richard M Burwick, Sigal Yawetz, Kathryn E Stephenson, Ai-Ris Y Collier, Pritha Sen, Brian G Blackburn, E Milunka Kojic, Adi Hirshberg, Jose F Suarez, Magdalena E Sobieszczyk, Kristen M Marks, Shawn Mazur, Cecilia Big, Oriol Manuel, Gregory Morlin, Suzanne J Rose, Mariam Naqvi, Ilona T Goldfarb, Adam DeZure, Laura Telep, Susanna K Tan, Yang Zhao, Tom Hahambis, Jason Hindman, Anand P Chokkalingam, Christoph Carter, Moupali Das, Anu O Osinusi, Diana M Brainard, Tilly A Varughese, Olga Kovalenko, Matthew D Sims, Samit Desai, Geeta Swamy, Jeanne S Sheffield, Rebecca Zash, William R Short, Compassionate Use of Remdesivir in Pregnant Women with Severe Covid-19, Clinical Infectious Diseases, , ciaa1466
Study 309 – 2475 pregnant women with Covid-19 from Brazil
Among 2475 women identified through an acute respiratory distress register, 494 were admitted to ITU, 242 underwent invasive ventilation and 204 died (click here or ijgo.13407). Among the women who died, 8 (6%) had not reached hospital, 81 (40%) had not been admitted to intensive care, and 52 (26%) had no access to any respiratory support before dying. These are updated figures from studies 182, 248 & 249. Citation: Menezes, M.O., Takemoto, M.L., Nakamura‐Pereira, M., Katz, L., Amorim, M.M., Salgado, H.O., Melo, A., Diniz, C.S., de Sousa, L.A., Magalhaes, C.G., Knobel, R., Andreucci, C.B. and (2020), Risk factors for adverse outcomes among pregnant and postpartum women with acute respiratory distress syndrome due to COVID‐19 in Brazil. Int J Gynecol Obstet. Accepted Author Manuscript. doi: 10.1002/ijgo.13407
Studies 303 to 308 added. Study 167 publication updated.
Study 308 – Case report from Daegu, Korea
One case report of Covid-19 in pregnancy plus 12 further cases mentioned in the final pragraph (click here or ogs-20106). All cared for at Daegu Fatima Hospital or Daegu Dongsan Hospital and likely overlap with those in studies 22 & 143. Citation: Jin-Gon Bae , Jin-Kyeong Ha, Myoung Kwon, Hak-Youle Park, Won-Joon Seong, Seong-Yeon Hong. A case of delivery of a pregnant woman with COVID-19 infection in Daegu, Korea. Obstet Gynecol Sci > Epub ahead of print Case Report DOI: https://doi.org/10.5468/ogs.20106 [Epub ahead of print] Published online October 5, 2020.
Study 307 – 257 cases from Europe and other continents
These cases (click here or PIIS0301211520306400) probably overlap considerably with those reported in study 278. Citation: Di Mascio D, D’Antonio F, Perinatal mortality and morbidity of SARS-COV-2 infection during pregnancy in European countries: findings from an international study, European Journal of Obstetrics and amp; Gynecology and Reproductive Biology (2020).
Study 306 – Neonatal death in Ivan city, Ilam province, Iran
The mother had Covid-19 (click 13256_2020_Article_2519). The baby, delivered by elective caesarean at 39 weeks, had normal Apgar scores but collapsed soon after birth and died. Maternal SARS-CoV-2 swabs were positive, and baby swabs negative. The birth was at Zagros Hospital and the baby was later transferred to Ayatollah Taleghani Hospital, both in Ivan City, and neither of which have previously reported caes. Citation: Rashidian, T., Sharifi, N., Fathnezhad-Kazemi, A. et al. Death of a neonate with suspected coronavirus disease 2019 born to a mother with coronavirus disease 2019 in Iran: a case report. J Med Case Reports 14, 186 (2020).
Study 305 – Two cases from Wuhan
These two women with Covid-19 in pregnancy have probably been reported already (click s12884-020-03281-4). Citation: Cao, D., Chen, M., Peng, M. et al. Vaginal delivery in women with COVID-19: report of two cases. BMC Pregnancy Childbirth 20, 580 (2020)
Study 304 – 32 pregnant women admitted to ITU in the United States
Thirty two pregnant women with Covid-19 were admitted to ITU in multiple US hospitals (click here or rccm.202006-2182le). Citation: Sarah Rae Easter, Shruti Gupta, Samantha K. Brenner, David E. Leaf Outcomes of Critically Ill Pregnant Women with COVID-19 in the United States. American Journal of Respiratory and Critical Care Medicine Published Online: October 07, 2020
Study 303 – Case report from Turkey
This case report from (judging by author affiliations) Recep Tayyip Erdoğan University School of Medicine, Rize, Turkey (click here or 354-356) may have been reported in studies 244 and 277. Citation: Özçelik N, Özdemir S, Gürlek B, Yıldız İE. COVID-19 Pregnant Patient Management with a Case of COVID-19 Patient with An Uncomplicated Delivery. Turk Thorac J. 2020 Sep;21(5):354-356. doi: 10.5152/TurkThoracJ.2020.20135. Epub 2020 Sep 1. PMID: 33031729.
Study 302 added.
Study 302 – Two cases of repeat SARS-CoV-2 positivity in pregnancy from Brescia in Italy
A pregnant women who had recovered from mild Covid-19 in March 2020 at 24 weeks, retested positive when she gave birth in July at 41 weeks. Another asymptomatic women with SARS-CoV-2 in April at 32 weeks gestation, who had later tested negative, tested positive again at birth in June (click here or 1471-0528.16362). From author affiliations both cases were probably cared for in Brescia which means they were likely included in studies 32, 64 & 252. Citation: Zanardini, C., Saccani, B., Franceschetti, l., Zatti, S., Sartori, E. and Prefumo, F. (2020), Retest positive for SARS‐CoV‐2 RNA of recovered pregnant women with COVID‐19. Ultrasound Obstet Gynecol. Accepted Author Manuscript. doi:10.1002/uog.23144
Study 301 added.
Study 301 – 736 women in the US PRORITY study
The clinical features of 736 pregnant women with Covid-19 (594 SARS-CoV-2 positive), recruited through social media in the PRIORITY study, are reported (click here or 1471-0528.16362). They will overlap with study 281 and many other US reports. Citation: Afshar, Yalda MD, PhD; Gaw, Stephanie L. MD, PhD; Flaherman, Valerie J. MD; Chambers, Brittany D. PhD, MPH; Krakow, Deborah MD; Berghella, Vincenzo MD; Shamshirsaz, Alireza A. MD; Boatin, Adeline A. MD, MPH; Aldrovandi, Grace MD; Greiner, Andrea MD; Riley, Laura MD; Boscardin, W. John PhD; Jamieson, Denise J. MD; Jacoby, Vanessa L. MD, MAS, on behalf of the Pregnancy CoRonavIrus Outcomes RegIsTrY (PRIORITY) Study Clinical Presentation of Coronavirus Disease 2019 (COVID-19) in Pregnant and Recently Pregnant People, Obstetrics & Gynecology: October 07, 2020 – Volume Latest Articles – Issue – 10.1097/AOG.0000000000004178 doi: 10.1097/AOG.0000000000004178
Study 300 added.
Study 300 – 26 cases from Dublin, Ireland
26 women had SARS-CoV-2 detected during pregnancy by PCR in the Rotunda Hospital between 1st March & 1st July 2020 (click here or Infants Born to Mothers with COVID-19 During Pregnancy The First Four Months of the Pandemic). Maternal survival was not reported but, by implication, was good. All infants survived and none were infected. These case are probably included in study 284. Citation: C. Murphy, D. O’Reilly, N. McCallion, R. Drew, W. Ferguson. Infants Born to Mothers with COVID-19 During Pregnancy: The First Four Months of the Pandemic Ir Med J; Vol 113; No. 9; P193
Study 299 added.
Study 299 – 29 women with anti SARS-CoV-2 antibodies from Copenhagen, Denmark
Of the 29 women reported in this Medxiv preprint, 15 had previously had Covid-19 symptoms, but none had a positive swab (click here or 2020.09.14.20191106v1.full). They were cared for at Copenhagen University Hospital, Hvidovre, which has not previously reported cases. Citation; Pia Egerup, Line Fich Olsen, Ann-Marie Hellerung Christiansen, David Westergaard, Elin Rosenbek Severinsen, Kathrine Vauvert Roemmelmayer Hviid, Astrid Marie Kolte, Amalie Dyhrberg Boje, Marie-Louise Mathilde Friis Bertelsen, Lisbeth Praetorius, Anne Zedeler, Josefine Reinhardt Nielsen, Didi Bang, Sine Berntsen, Jeppe Ethelberg-Findsen, Ditte Marie Storm, Judith Bello-Rodriguez, Andreas Ingham, Joaquim Olle-Lopez, Eva Hoffmann, Charlotte Wilken-Jensen, Lone Krebs, Finn Stener Joergensen, Henrik Torkil Westh, Henrik Lovendahl Jorgensen, Nina la Cour Freiesleben, Henriette Svarre Nielsen medRxiv 2020.09.14.20191106.
Studies 292 to 298 added.
Study 298 – 67 cases from Stockholm, Sweden
The authors claim that these 67 pregnant women with SARS-CoV-2 comprise all those cared for in the Stockholm region between March 19 & April 26, 2020 (click here or aogs.14006). Four women were admitted to intensive care but none died. Three babies were infected. Two babies died. From author affliliations the unnamed hospitals probably include Karolinska, Södersjukhuset (Southern), Danderyd, and Södertälje hospitals. The series likely includes some women reported in studies 20, 88, and 282. Study 282 reported 156 women with SARS-Cov-2 admitted in labour to the Karolinska alone, albeit over a longer time period March 25 to July 24 (study 282). Citation: Remaeus, K., Savchenko, J., Brismar Wendel, S., Gidlöf, S.B., Graner, S., Jones, E., Molin, J., Saltvedt, S., Wallström, T. and Pettersson, K. (2020), Characteristics and short‐term obstetric outcomes in a case series of 67 women tested positive for SARS‐CoV‐2 in Stockholm, Sweden. Acta Obstet Gynecol Scand. Accepted Author Manuscript. doi:10.1111/aogs.14006
Study 297 – anti SARS-CoV-2 IgA in breastmilk within 72 hr of birth
A woman with a clinical diagnosis of Covid-19, but with negative PCR tests, delivered by Caesarean at 37 weeks (click here or 0890334420960433). Anti SARS-CoV-2 IgA was detected in breast milk soon after birth. The baby was not infected. From author affiliations the hospital was probably Municipal Universitário de São Bernardo do Campo, Brazil, which has not previously reported cases. Citation: Lebrão CW, Cruz MN, Silva MH da, et al. Early Identification of IgA Anti-SARSCoV-2 in Milk of Mother With COVID-19 Infection. Journal of Human Lactation. September 2020. doi:10.1177/0890334420960433
Study 296 – Case report from Portland, Maine, USA
A woman wih Covid-19 developed pre-eclampsia at 34 weeks (click here or main). Both her and the baby recovered. From author affiliations the hospital was probably Maine Medical Center, Portland, Maine, which has not previously reported cases. Citation: J.N. Hansen, J. Hine and T.D. Strout, COVID-19 and preeclampsia with severe features at 34-weeks gestation, American Journal of Emergency Medicine
Study 295 – Takotsubo cardiomyopathy in pregnancy & SARS-CoV-2
The first report of Takotsubo cardiomyopathy in pregnancy in association with SARS-CoV-2 infection (click here or e239104.full). The mother was delivered by caesarean and recovered. Baby outcomes were not reported. The hospital was probably Gauhati Medical College and Hospital, Guwahati, India, which has not previously reported cases. Citation: Bhattacharyya PJ, Attri PK, Farooqui W. Takotsubo cardiomyopathy in early term pregnancy: a rare cardiac complication of SARS-CoV-2 infection. BMJ Case Reports CP 2020;13:e239104.
Study 294 – 16 women with SARS-CoV-2 infection from Wuhan
16 pregnant women with SARS-CoV-2 infection (click here or Zhou2020 Article The Metabolic And Immunological Ch). From author affiliations and ethics committee review the hospital was probably Renmin Hospital of Wuhan University grid.412632.0, which means the cases probably overlap with those in studies 6a, 10, 12, 36, 37, and 40. Citation: Zhou, J., Wang, Y., Zhao, J. et al. The metabolic and immunological characteristics of pregnant women with COVID-19 and their neonates. Eur J Clin Microbiol Infect Dis (2020).
Study 293 – Infected triplets from Muscat, Oman
All three triplets born by Caesarean at 32 weeks to a woman with Covid-19 were infected (click here or IS VERTICAL TRANSMISSION OF SARS CoV 2 INFECTION.96038). They all thrived. The woman was cared for at Khoula Hospital, Muscat, Oman, which has not previously reported cases. Citation: Alwardi, Talal Hamood; Ramdas, Vidya; Al Yahmadi, Mohammed; Al Aisari, Salima; Bhandari, Satish; Saif Al Hashami, Hilal; Al Jabri, Amal; Manikoth, Prakash; Malviya, Manoj. IS VERTICAL TRANSMISSION OF SARS-CoV-2 INFECTION POSSIBLE IN PRETERM TRIPLET PREGNANCY? A CASE SERIES, The Pediatric Infectious Disease Journal: September 25, 2020 – Volume Online First – Issue – doi: 10.1097/INF.0000000000002926
Study 292 – Blood loss at birth among 53 women in Boston, Mass, USA
The blood loss at birth among 53 women with Covid 19 was no different from women without the disease (click here or s 0040 1718403). Women were cared for in Boston Medical Center which has not previously reported cases. Citation: Wang MJ, Schapero M, Iverson R, Yarrington CD. Obstetric Hemorrhage Risk Associated with Novel COVID-19 Diagnosis from a Single-Institution Cohort in the United States. Am J Perinatol. 2020 Sep 29. doi: 10.1055/s-0040-1718403. Epub ahead of print. PMID: 32992351.
Study 291 added.
Study 291 – Spanish registry of Covid-19 screening in asymptomatic pregnant women
By May 31st 2020, of 16,308 pregnant women screened, 338 (2.1%) had tested positive (click here or RS94C_202009092). Testing was done in 100 maternity hospitals listed in Table 2. This is a different registry from study 264b, which only covered 45 hospitals. However the hospitals, time period and presumably cases overlap. Spanish with English abstract. Citation: Encinas Pardilla MB, Caño Aguilar Á, Marcos Puig B, Sanz Lorenzana A, Rodríguez de la Torre I, Hernando López de la Manzanara P, Fernández Bernardo A, Martínez Pérez Ó. Registro español de cribado de Covid-19 en gestantes asintomáticas. Rev Esp Salud Pública. 2020; 94: 18 de septiembre e202009092
Studies 284-290 added. I’ve also noticed ten duplicate numbers, studies 257 to 266 & renumbered the later ones as 257b to 266b
Study 290 – 25 symptomatic women in St Louis, Missouri
25/532 (4.7%) women admitted for an obstetric procedure were asymptomatic but positive for SARS-CoV-2 at Barnes-Jewish Hospital in St Louis, Missouri from May 28 – July 22 (click here or PIIS0002937820311029). This series will not include the severely ill woman in study 69, but probably includes some in study 259. Citation: KELLY JC, RAGHURAMAN N, PALANISAMY A, STOUT MJ, CARTER EB, Pre-procedural asymptomatic COVID-19 in obstetric and surgical units, American Journal of Obstetrics and Gynecology (2020).
Study 289 – Seroprevalence during labour at 7 hospitals in New York State
269/1671 (16%) women were seropositive in labour (click here or Haizler-Cohen PIIS0002937820311017). They delivered in the Northwell Health system so probably were included in studies 162 and 179. Citation: HAIZLER-COHEN L, DAVIDOV A, BLITZ MJ, FRUHMAN G, SARS-CoV-2 Antibodies in Pregnant Women Admitted to Labor and Delivery, American Journal of Obstetrics and Gynecology (2020).
Study 288 – Serological testing among pregnant women in Estonia
The SARS-CoV-2 seroprevalemce was reported to be nearly five time higher than the rate of PCR positivity, and also 10 times lower than the rate of seropositivity in the general population of Spain (click here or aogs.13995) Citation: Veerus, P., Salumets, A., Naaber, P., Krjutškov, K., Tilk, K., Laanpere, M. and Uusküla, A. (2020), Seroprevalence of SARS‐CoV‐2 antibodies among pregnant women in Estonia: a call for epidemiological studies. Acta Obstetricia et Gynecologica Scandinavica. Accepted Author Manuscript.
Study 287 – 2 cases from Tehran, Iran
A woman with severe Covid-19 at 31 weeks was delivered by Caesarean and died in Shariati hospital, Tehran. Her baby was seriously ill with complications of prematurity and neonatal Covid-19. He recovered, albeit with hydrocephalus (click here or s13052-020-00897-2). A second women had milder disease diagnosed clinically. Her baby also had complications of prematurity and neonatal Covid-19 and recoverd. The mothers may have been included in studies 66, 67 and 218. The babies may have been reported in study 250. Citation: Sagheb, S., Lamsehchi, A., Jafary, M. et al. Two seriously ill neonates born to mothers with COVID-19 pneumonia- a case report. Ital J Pediatr 46, 137 (2020).
Study 286 – 52 cases from Turkey
27 women with Covid-99 in pregnancy confirmed on PCR, and 25 diagnosed clinically (click here or Alay jog.14493 (1)). From author affiliations the unnamed tertiary referral hospital is probably Dr. Sadi Konuk Education and Training Hospital, Istanbul, which has not previously reported cases on its own behalf. They may be included in other Istanbul series such as study 244. It also appears to be a different hospital from Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital which is nearby, and reported cases in studies 144 and 210. Citation: Alay, I., Yildiz, S., Kaya, C., Yasar, K.K., Aydin, O.A., Karaosmanoglu, H.K., Aydeniz, B., Salihoglu, O., Yaşar, L. and Ekin, M. (2020), The clinical findings and outcomes of symptomatic pregnant women diagnosed with or suspected of having coronavirus disease 2019 in a tertiary pandemic hospital in Istanbul, Turkey. J. Obstet. Gynaecol. Res.
Study 285 – 61 cases from New Jersey, USA
A case control study including 61 women with confirmed COVID-19 in pregnancy (click here or Brandt PIIS0002937820311340). The women were cared for at the Robert Wood Johnson University Hospital, in New Brunswick, which also reported cases in study 86. Citation: BRANDT JS, HILL J, REDDY A, SCHUSTER M, PATRICK HS, ROSEN T, SAUER MV, BOYLE C, ANANTH CV, Epidemiology of COVID-19 in Pregnancy: Risk Factors and Associations with Adverse Maternal and Neonatal Outcomes, American Journal of Obstetrics and Gynecology (2020).
Study 284 – 70 cases from the Republic of Ireland’s Covid-19 register
70 women tested positive for SARS-CoV-2 during pregnancy in March and April 2020 (click here). There were no maternal deaths (pers comm Keelin O’Donoghue). The first report from the Republic of Ireland. Citation: ROI COVID-19 Study. Accessed 27 Sept 2020
Study 283 added.
Study 283 – 321 cases from Maharashtra state, India
This first report from the Indian PregCOVID registry reports 141 pregnant women testing positive for SARS-CoV-2 in 15 hospitals in Maharashtra state (click here or PIIS0301211520306084). To these are added a further 180 cases from Topiwala National Medical College & BYL Nair Charitable Hospital, grid.413161.0, a dedicated Covid-19 hospital in Mumbai. The registry hospitals are listed and appear to have not previously reported cases. Note Lokmanya Tilak Municipal General Hospital and Lokmanya Tilak Municipal Medical College, in Mumbai grid.415652.1, study 245, does not appear to be part of the registry.The Nair hospital cases may overlap with those in study 225. Citation: Waghmare R, Gajbhiye R, Mahajan N, Modi D, Mukherjee S, Mahale S, Universal screening identifies asymptomatic carriers of SARS-CoV-2 among pregnant women in India, European Journal of Obstetrics and amp; Gynecology and Reproductive Biology (2020)
Study 282 added.
Study 282 – 156 cases from Stockholm, Sweden
Of 156 pregant women seen at the Karolinska Hospital in Stockoholm who tested positive for SARS-CoV-2, 65% were asymptomatic (click here). There was one stillbirth. Maternal deaths were not reported. Compared with a control group matched on various factors there was an increase in pre-eclampsia but no increase in preterm birth. This is the first report from this hospital. The cases don’t overlap with those reported in studies 20 or 259, but likely overlap with some in study 88. Citation: Ahlberg M, Neovius M, Saltvedt S, et al. Association of SARS-CoV-2 Test Status and Pregnancy Outcomes. JAMA. Published online September 23, 2020. doi:10.1001/jama.2020.19124
Study 281 added.
Study 281 – First report from the US PRIORITY Study
The PRIORITY study collected self-reported cases of Covid-19 in pregnancy. In this report they describe the outcomes of 179 infants born to mothers who had tested positive and 84 who tested negative. 82% of the former group and 63% of the latter had symptoms (click here or ciaa1411). 44 babies were admitted to NICU, and two were infected. Although not explicitly stated there appear to have been no stillbirths or neonatal deaths. Births occurred at over 100 hospitals across the US so it is likely that many will have been included in other US reports. Citation: Valerie J Flaherman, MD, MPH, Yalda Afshar, MD, PHD, John Boscardin, PHD, Roberta L Keller, MD, Anne Mardy, MD, Mary K Prahl, MD, Carolyn Phillips, MD, Ifeyinwa V Asiodu, RN, PHD, W Vincenzo Berghella, MD, Brittany D Chambers, PHD, Joia Crear-Perry, MD, Denise J Jamieson, MD, MPH, Vanessa L Jacoby, MD, MAS, Stephanie L Gaw, MD, PHD, Infant Outcomes Following Maternal Infection with SARS-CoV-2: First Report from the PRIORITY Study, Clinical Infectious Diseases, ciaa1411.
Study 274 belatedly added (we’d missed it on 8 June). Studies 275 to 280 also added.
Study 280 – Case report from Wuhan, China
A woman with Covid-19 gave birth on March 6th. The baby was not infected (click here or 5f3fc192e7305c00087df995). The hospital was Wuhan Central Hospital grid.440160.7 which presumably reported this case in study 39. Citation: Gao W, Deng Z, Zeng L, Yang Y, Gong H, Liu J, Xiao H. A newborn with normal IgM and elevated IgG antibodies born to an asymptomatic infection mother with COVID-19. Aging (Albany NY). 2020; 12:16672-16674. https://doi.org/10.18632/aging.103346
Study 279 – The first case of Covid-19 in pregnancy in the United States
A woman with Covid-19 presented to New York City Health and Hospitals/Lincoln in New York City on March 12, 2020 (click here or 9795 IN PRESS 52450 5 10 20200908). She had mild disease, was treated as an outpatient and recovered. She was delivered by Caesarean at 37 weeks and the baby was not infected. The authors claim this was the first case of Covid-19 in pregnancy in the US. They may be correct. However the paper title is misleading because it was not a case of intrauterine transmission. Citation: Elkafrawi D, Joseph J, Schiattarella A, Rodriguez B, Sisti G. Intrauterine transmission of COVID-19 in Pregnancy: case report and review of literature. Acta Bio Med [Internet]. 2020Sep.7 [cited 2020Sep.20];91(3):e2020041.
Study 278 – 388 mothers testing positive for SARS-COV-2 from 22 countries
The World Association of Perinatal Medicine Covid-19 working group has collected 388 women, pregnant with singletons, and diagnosed with SARS-CoV-19 between February 1 and April 30, 2020, from 73 centers in 22 countries (Argentina, Australia, Belgium, Brazil, Colombia, Czech Republic, Finland, Germany, Greece, Israel, Italy, North Macedonia, Peru, Portugal, Republic of
Kosovo, Romania, Russia, Serbia, Slovenia, Spain, Turkey, and United States (click here or uog.23107). Three mothers died. Of 266 completed pregnancies there were 6 miscarriages, 3 pregnancy terminations, and 6 stillbirths. Of 251 livebirths, 5 neonates died. The centres are listed in the supplement here uog23107 sup 0001 supinfo and many appear to have not previously reported cases. However the number of cases per centre is not reported and there is no explicit statement about previous reports. Citation: Di Mascio, D. and the WAPM (The World Association of Perinatal Medicine) working group on COVID‐19 (2020), Maternal and Perinatal Outcomes of Pregnant Women with SARS‐COV‐2 infection. Ultrasound Obstet Gynecol. Accepted Author Manuscript.
Study 277 – 37 Neonates with community acquired Covid-19 in Turkey
This series of 37 neonates with Covid-91 acquired in the community were collected from 24 neonatal intensive care units around Turkey (click here or A Multicentered Study on Epidemiologic and.2). Those born to mothers with SARS-CoV-2 during pregnancy were excluded. One with Down’s syndrome died. Citation: Kanburoglu, Mehmet Kenan; Tayman, Cuneyt; Oncel, Mehmet Yekta; Akin, Ilke Mungan; Can, Emrah; Demir, Nihat; Arayici, Sema; Baser, Demet Orhan; Caner, Ibrahim; Memisoglu, Asli; Uygun, Saime Sundus; Akar, Selahattin; Akin, Mustafa Ali; Ataoglu, Emel; Bezirganoglu, Handan; Bilgin, Leyla; Bozdag, Senol; Comert, Serdar; Gurpinar, Resat; Imamoglu, Ebru Yalin; Imdadoglu, Timucin; Narter, Fatma; Ozdemir, Ramazan; Toptan, Handan Hakyemez; Yalinbas, Emine Esin; Yaman, Akan; Erdeve, Omer; Koc, Esin. A Multicentered Study on Epidemiologic and Clinical Characteristics of 37 Neonates With Community-acquired COVID-19, The Pediatric Infectious Disease Journal: October 2020 – Volume 39 – Issue 10 – p e297-e302
Study 276 – a case treated with Remdesivir from New York Presbyterian
A woman with severe Covid-19 requiring supplemental oxygen but not invasive ventilation was treated with hydroxychloroquine and remdesivir (click here or ofaa345). She recovered and later gave birth vaginally. She was a health care worker caring for COVID-19 patients. From author affiliations this was NewYork-Presbyterian Hospital, Weill Cornell Medical Center, so she may have been included in studies 99, 230, 234 and 270 and possibly other New York series. Citation: Grace A Maldarelli, MD, PhD, Megan Savage, MD, Shawn Mazur, PharmD, Corrina Oxford-Horrey, MD, Mirella Salvatore, MD, Kristen M Marks, MD, Remdesivir treatment for severe COVID-19 in third-trimester pregnancy: Case report and management discussion, Open Forum Infectious Diseases.
Study 275 – 20 women infected with SARS-CoV-2 and pre-eclampsia from Peru
20 women with SARS-CoV-2 also developed pre-eclampsia (click here or PIIS0301211520305959). Two babies died. One baby tested positive. One woman require hysterectomy for placenta accreata. Patients were cared for at Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru and, as acknowledged by the authors, they overlap with those reported in study 274. Citation: Coronado-Arroyo JC, Concepcion-Zavaleta MJ, Zavaleta-Gutierrez FE, Concepcion-Urteaga LA, Is COVID-19 a risk factor for severe preeclampsia? Hospital experience in a developing country, European Journal of Obstetrics and amp; Gynecology and Reproductive Biology (2020).
Study 274 – 41 patients from Peru
Of 41 women with Covid-19 in pregnancy, treated between March 24 & May 7, 2020, none died although two required non invasive ventilation. Report in Spanish (click here). English translation (available here or 2245-6876-2-PB). From author affiliations the patients were cared for in Edgardo Rebagliati Martins National Hospital, Lima, Peru. One baby was infected. This is a different hospital from the case in study 51. Citation: Huerta Saenz IH, Elías Estrada JC, Campos Del Castillo K, Muñoz Taya R, Cristina Coronado J. Maternal and perinatal characteristics of pregnant women with COVID-19 in a national hospital in Lima, Peru. Rev Peru Ginecol Obstet. 2020;66(2).
Studies 272 & 273 added.
Study 273 – 598 cases from US COVID-NET hospitals
598 hospitalized women with COVID-19, cared for in the COVID-19-Associated Hospitalization Surveillance Network (COVID-NET) were pregnant (click here or mm6938e1-H). 44 mothers were admitted to ICU, 23 required invasive mechanical ventilation, and two died. COVID-NET covers 99 counties in 14 US states, which amounts to about 10% of the US population. The cases likely overlap with those in previous COVID-NET reports, studies 171 and 173. Citation: Delahoy MJ, Whitaker M, O’Halloran A, et al. Characteristics and Maternal and Birth Outcomes of Hospitalized Pregnant Women with Laboratory-Confirmed COVID-19 — COVID-NET, 13 States, March 1–August 22, 2020. MMWR Morb Mortal Wkly Rep. ePub: 16 September 2020.
Study 272 – 105 cases from eight US hospitals participating in vaccine surveillance
Among 105 pregnant women admitted with SARS-CoV-2 infection to eight hospitals participating in a Vaccine Safety Datalink (VSD) surveillance project, over half were admitted for obstetric reasons (click here or mm6938e2-H). The participating hospitals are listed here. Citation: Panagiotakopoulos L, Myers TR, Gee J, et al. SARS-CoV-2 Infection Among Hospitalized Pregnant Women: Reasons for Admission and Pregnancy Characteristics — Eight U.S. Health Care Centers, March 1–May 30, 2020. MMWR Morb Mortal Wkly Rep. ePub: 16 September 2020
Study 271 added.
Study 271 – 86 “extra” maternal deaths during pandemic in Mexico
These authors used publicly available goverment statisitics (click here) to estimate the excess maternal deaths from Covid-19 in Mexico in 2020 (click here or Excess Maternal Deaths Associated With Coronavirus.97254). The predicted maternal mortality ratio was 29.5 per 100,000 live births, and so far in 2020 the actual ratio is 42.4. The excess was entirely confined to respiratory disease. Overall 86 “extra” deaths have ocurred. In comparison the 168 deaths officially reported as due to respiratory disease are made up of 109 deaths due to confirmed COVID-19, 34 for which COVID-19 needs to be confirmed, and 25 due to other respiratory diseases. Citation: Lumbreras-Marquez, Mario I. MBBS, MMSc; Campos-Zamora, Melissa MBBS, MMSc; Seifert, Sara M. MD; Kim, Jimin MD, MSc; Lumbreras-Marquez, Jesus MBBS; Vazquez-Alaniz, Fernando PhD; Fields, Kara G. MS; Farber, Michaela K. MD, MS Excess Maternal Deaths Associated With Coronavirus Disease 2019 (COVID-19) in Mexico, Obstetrics & Gynecology: September 09, 2020 – Volume Publish Ahead of Print – Issue – doi: 10.1097/AOG.0000000000004140
Studies 267-270 added.
Study 270 – more from New York Presbyterian
Not clear from abstract if this includes original data (click here). Citation: Dayal, A. K., Razavi, A. S., Jaffer, A. K., Prasad, N., & Skupski, D. W. (2020). COVID-19 in obstetrics 2020: the experience at a New York City medical center, Journal of Perinatal Medicine (published online ahead of print 2020), 000010151520200365.
Study 269 – Case report from Baltimore
A woman with Covid-19 ruptured her membranes at 19 weeks, and delivered vaginally at 29 weeks (click here or Haiti 8847859 (1)). The baby tested negative but suffered complications of prematurity and remains on ICU. From author affiliations the hospital was probably University of Maryland Medical Center, which has not previously repoted cases. Citation: Mary E. Burgoyne, Emad A. Elsamadicy, Liviu Cojocaru, Andrea Desai, “COVID-19 Barriers to Care for Pregnant Patients in Prolonged Isolation”, Case Reports in Obstetrics and Gynecology, vol. 2020, Article ID 8847859, 4 pages, 2020. https://doi.org/10.1155/2020/8847859
Study 268 – 14 cases from Tongi, Wuhan
Further details on 14 cases which have probably been described before (click here or 1-s2.0-S2052297520301049-main). Citation: Gao X, Wang S, Zeng W, Chen S, Wu J, Lin X, Liu Y, Sun Z, Feng L, Clinical and immunological features among COVID-19 affected mother-infant pairs: antibodies to SARS- CoV- 2 detected in breast milk, New Microbes and New Infections
Study 267 – Case from Izmir, Turkey
Mild Covid-19 delivered by Caesarean, both well (click here or ozer pdf_TPD_1941). From Dokuz Eylul University Hospital, Izmir, which has not previously reported cases. Citation: Ozer E, Cagliyan E, Yuzuguldu RI, Cevizci MC, Duman N. Villitis of Unknown Etiology in the Placenta of a Pregnancy Complicated by COVID-19 [published online ahead of print, 2020 Sep 8]. Villitis of Unknown Etiology in the Placenta of a Pregnancy Complicated by COVID-19 [published online ahead of print, 2020 Sep 8]. Turk Patoloji Derg. 2020;10.5146/tjpath.2020.01506. doi:10.5146/tjpath.2020.01506
Study 266 added.
Study 266 – United States, Centres for Disease Control update
The latest CDC tracking data, updated 10th September, shows 20,798 pregnant women with Covid-19 in the United States, of whom 44 (0.21%) have died (click here). Among those for which data were available 205/5,339 (4.7%) were admitted to ICU, and 77/4,674 (1.6%) required mechanical ventialtion. Citation: Centres for Disease Control. Weekly COVID-19 Pregnancy Data updated September 10, 2020, Accessed 11 Sept 2020.
Studies 264 & 265 added.
Study 265 – 71 cases from Houston, Texas
The authors report 71 women who tested positive for SARS-CoV-2 at delivery, four who had tested positive earlier in the pregnancy and two postnatally (click here or PIIS0301211520305807). One mother with severe disease recovered. Another required ECMO and remains on ventilatory support at a tertiary centre three months following delivery at 30 weeks. All neonates were isolated, and one tested positive but was asymptomatic. No babies died. All authors were affiliated with McGovern Medical School at The University of Texas. Houston but the acknowledgment suggests that the unnamed community hospital was Memorial Hermann Southwest Hospital. There have been no previous reports from Houston. Citation: Pineles BL, Alamo IC, Farooq N, Green J, Blackwell SC, Sibai BM, Parchem JG, Racial-Ethnic Disparities and Pregnancy Outcomes in SARS-CoV-2 Infection in a Universally-Tested Cohort in Houston, Texas, European Journal of Obstetrics & Gynecology & Reproductive Biology (2020)
Study 264 – 246 cases from Spain
246 women with SARS-CoV-2 and 763 control women are reported in this Medxiv preprint (click here or 2020.09.05.20188458v1.full). Five women were admitted to ICU, but none died. Three babies were stillborn. This is the first report from the Spanish “Obs Covid registry” which includes 77 hospitals in Spain. The patients are therefore likely to include some from previous Spanish series, namely studies 53, 125, 151, 158, 165, 185, 191, 196, 235, and 266. Note that study 196, authored by the Neo-COVID-19 Research Group, which includes 14 hospitals in Spain, reported 42 cases and included one maternal death, so presumably does not completely overlap. Citation: SPANISH OBSTETRIC EMERGENCY GROUP, Oscar Martinez Perez, et al. The association between COVID-19 and preterm delivery: A cohort study with a multivariate analysis. medRxiv 2020.09.05.20188458
Studies 261-263 added.
Study 263 – 66 cases (plus one maternal death) from Tehran, Iran
Of 66 women with Covid-19 treated between March 1 to Sep 1, 2020, four were admitted to ICU but none required ventilation (click here or taaa158). Two women aborted, 43 delivered, and 21 pregnancies are ongoing. No baby outcomes are reported directly, although one baby tested positive. No women in the series died. However in the discusssion section it is mentioned that in February 2020, a 22-year-old pregnant woman with COVID-19 at 37 weeks had died in the same hospital. It is not clear if she had been included in studies 23, 66 or 67. The women were cared for in Arash Women’s Hospital, which has also reported a set of triplets of which one was infected with SARS-CoV-2 and survived, and the other two who were negative died, (case 5 in study 250). Those triplets seem not to be included in the present series although it is not clear why. Citation: Pirjani R, Hosseini R, Soori T, et al. Maternal and neonatal outcomes in COVID-19 infected pregnancies: a prospective cohort study [published online ahead of print, 2020 Sep 5]. J Travel Med. 2020;taaa158. doi:10.1093/jtm/taaa158
Study 262 – case report from Wuhan
A woman with Covid-19 gave birth normally on Feb 22nd at 38 weeks gestation (click here or Antibodies in the breast milk of a maternal woman with COVID 19). Her baby was isolated and tested negative. IgG and IgA were both detected in breast milk, but no virus. The hospital of birth is unnamed but the mother was later transferred Guanggu Branch of Hubei Maternal and Child Health Hospital, a designated hospital for COVID-19 treatment in Wuhan city. This is not listed on GRID.ac but has reported cases many times. The case has probably been included in studies 8, 17, 30, 38, 54, and 55, and perhaps others. Citation: Yunzhu Dong, Xiangyang Chi, Huang Hai, Liangliang Sun, Mengyao Zhang, Wei-Fen Xie & Wei Chen (2020) Antibodies in the breast milk of a maternal woman with COVID-19, Emerging Microbes & Infections, 9:1, 1467-1469, DOI: 10.1080/22221751.2020.1780952
Study 261 – Case report from Al Ahssa, Saudi Arabia
A woman with mild Covid-19 was delivered by Caesarean at 38 weeks and the baby isolated from the mother (click here or cureus-0012-00000010035). The baby did not become infected although 1/29 health care workers involved contracted SARS-CoV-2. This is the first reported case from Saudi Arabia. Citation: AlOmran A, Almatawah Y, Al Sharit B, Alsadah Z, Mousa O. Infection Prevention and Control Challenges With First Pregnant Woman Diagnosed With COVID-19: A Case Report in Al Ahssa, Saudi Arabia. Cureus. 2020;12(8):e10035. Published 2020 Aug 26. doi:10.7759/cureus.10035
Studies 258-260 added.
Study 260 – Case report from Leicester, UK
A woman with Covid-19 at 28 weeks recovered and delivered at term (click here or e237007.full). The baby was unaffected. From author affiliations the hospital was part of University Hospitals of Leicester NHS Trust, which runs two maternity hospitals, Leicester Royal Infirmary and Leicester General Hospital. Neither has previously reported cases, although the patient was probably included in the UKOSS report, Study 92. Citation: Anness A, Siddiqui F. COVID-19 complicated by hepatic dysfunction in a 28-week pregnant woman. BMJ Case Reports CP 2020;13:e237007.
Study 259 – Case report from Malmo, Sweden
A woman with severe Covid-19 and coagulopathy at 32 weeks required Caesarean delivery (click here or 1-s2.0-S1876034120304391-main). Mother and baby recovered. The baby tested negative. The hospital was Skåne University Hospital in Malmö which has not previously reported cases. Citation: Ronnje, L., Länsberg, J., Vikhareva, O. et al. Complicated COVID-19 in pregnancy: a case report with severe liver and coagulation dysfunction promptly improved by delivery. BMC Pregnancy Childbirth 20, 511 (2020)
Study 258 – Case of successful ECMO from France
A woman with Covid 19 required ventilation and Caesarean at 31 weeks. Following delivery her condition worsened and she was treated with ECMO for 7 days (click here or PIIS105307702030793X (002)). She recovered with moderate residual shortness of breath. The baby tested negtive and also recovered. From author affiliations the unnamed ECMO hospital was probably Hôpital Henri-Mondor in Creteil, a southeastern suburb of Paris. The patient may have been previously included in studies 150 & 184. Citation: Fiore A, Piscitelli M, Adodo DK, et al. Successful use of Extracorporeal Membrane Oxygenation (ECMO) in postpartum as rescue therapy in a woman with Covid-19: ECMO postpartum in COVID-19 patient [published online ahead of print, 2020 Aug 6]. J Cardiothorac Vasc Anesth. 2020;doi:10.1053/j.jvca.2020.07.088
Studies 266-267 added.
Study 257 – Case report from Suzhou, China
A woman with Covid-19 was delivered by Caesarean on February 6, 2020 (click here or main (1)). The baby and other placental/amniotic samples tested negative. Both mother and baby survived. She was cared for in the 5th People’s Hospital of Suzhou grid.490559.4 (click here) which has not previously reported cases. Citation: Lv Y, Gu B, Chen Y, et al. No intrauterine vertical transmission in pregnancy with COVID-19: A case report [published online ahead of print, 2020 Aug 5]. J Infect Chemother. 2020;S1341-321X(20)30266-X. doi:10.1016/j.jiac.2020.07.015
Study 256 – Two cases from Alcazar de San Juan, Spain
Two pregnant woman with Covid-19 at 12 and 20 weeks respectively had amniocenteis negative for SARS-CoV-2 (click here or email@example.com). From author affiliations the unnamed hospital was probably Hospital La Mancha Centro, in Alcazar de San Juan, Spain which has not previously reported cases. Citation: Ana M. Rubio Lorente, Maria Pola Guillén, Nuria López Jimenez, Maria Moreno-Cid Garcia-Suelto, Eduardo Rodriguez Rodriguez & Ana Pascual Pedreño (2020) Study of amniotic fluid in pregnant women infected with SARS-CoV-2 in first and second trimester. Is there evidence of vertical transmission?, The Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2020.1811669
Study 265 added.
Study 265 – PreStudygnant v non-pregnant disease severity using smartphone apps
The authors of this Medxiv preprint (click here or 2020.08.17.20161760v1.full) used a smartphone app (400K women – click here) and the Facebook/Carnegie Mellon COVID-19 survey (1.8M women – click here) to record Covid-19 symptoms and outcomes prospectively. Pregnant women with SARS-CoV-2 infection had the same disease severity as the non-pregnant. Citation: Erika Molteni, Christina M Astley, Wenjie Ma, Carole Helene Sudre, Laura A Magee, Benjamin Murray, Tove Fall, Maria F Gomez, Neli Tsereteli, Paul W Franks, John S Brownstein, Richard Davies, Jonathan Wolf, Timothy Spector, Sebastien Ourselin, Claire Steves, Andrew T Chan, Marc Modat SARS-CoV-2 (COVID-19) infection in pregnant women: characterization of symptoms and syndromes predictive of disease and severity through real-time, remote participatory epidemiology. medRxiv 2020.08.17.20161760
Studies 257 to 264 added.
Study 264 – SARS-CoV-2 cell entry gene expression in placenta
Placental expression of the SARS-CoV-2 cell entry genes, ACE2 and TMPRSS2 in pre-pandemic stored samples from the Research Centre for Women’s and Infants’ Health BioBank, and the Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, both in Toronto, Ontario (click here or Bloise AJOG 1-s2.0-S000293782030884X-main). Citation: Bloise E, Zhang J, Nakpu J, Hamada H, Dunk CE, Li S, Imperio GE, Nadeem L, Kibschull M, Lye P, Matthews SG, Lye SJ, Expression of SARS-CoV-2 cell entry genes, ACE2 and TMPRSS2, in the placenta across gestation and at the maternal-fetal interface in pregnancies complicated by preterm birth or preeclampsia, American Journal of Obstetrics and Gynecology (2020).
Study 263 – Case report from The Netherlands
A pregnant woman with Covid-19 developed coagulopathy at 31 weeks, and CTG abnormalities at 32 weeks, necessitating Caesarean birth (click here or Mongula uog.22189). From author affiliations the unnamed hospital was probably Máxima Medical Centre, in Einthoven. Apart from NethOSS reports, the case has not been previously reported. Citation: Mongula, J.E., Frenken, M.W.E., van Lijnschoten, G., Arents, N.L.A., de Wit‐Zuurendonk, L.D., Schimmel‐de Kok, A.P.A., van Runnard Heimel, P.J., Porath, M.M. and Goossens, S.M.T.A. (2020), COVID‐19 during pregnancy: non‐reassuring fetal heart rate, placental pathology and coagulopathy. Ultrasound Obstet Gynecol. Accepted Author Manuscript. doi:10.1002/uog.22189
Study 262 – COVID-19 perinatal biorepository in Massachussetts
100 women and 78 newborns enrolled in the Massachussets General Hospital COVID-19 biorepository (click here or s12874-020-01102-y). No clinical outcomes reported. Citation: Shook, L.L., Shui, J.E., Boatin, A.A. et al. Rapid establishment of a COVID-19 perinatal biorepository: early lessons from the first 100 women enrolled. BMC Med Res Methodol 20, 215 (2020).
Study 261- Cardiac abnomalities with, but not caused by, SARS-CoV-2. New York
Six babies with congenital heart disease and one with congenital diaphragmatic hernia born to women with SARS-CoV-2, and cared for in the cardiac unit of New York Presbyterian’s Morgan Stanley Children’s Hospital and Columbia University Irving Medical Center (click here or Goldshtrom 2150135120950256). No babies had symptoms and none tested positive. Four babies were inborn, & two transferred in. Some of the pregnancies and births have probably been described elsewhere. Citation: Goldshtrom, N., Vargas, D., Vasquez, A., Kim, F., Desai, K., Turner, M. E., … Krishnamurthy, G. (2020). Neonates With Complex Cardiac Malformation and Congenital Diaphragmatic Hernia Born to SARS-CoV-2 Positive Women—A Single Center Experience. World Journal for Pediatric and Congenital Heart Surgery.
Study 260 – 2 patients from Vercelli in Italy
Two women with positive SARS-CoV-2 serology also had anti SARS-CoV-2 IgG antibodies in their baby’s cord blood (click here or vendola EJOG PIIS0301211520305352). One birth was vaginal and one by Caesarean. From author affilitations the unnamed hospital was probably Ospedale Sant’Andrea in Vercelli in Piedmont, which has not previously reported caes. Both mothers and babies were healthy. Citation: Vendola Nicoletta, Stampini Viviana, Amadori, Roberta, Gerbino Martina, Curatolo Annalisa, Surico Daniela, et al. Vertical transmission of antibodies in infants born from mothers with positive serology to COVID-19 pneumonia’ European Journal of Obstetrics & Gynecology & Reproductive Biology, Accepted article online.
Study 259 – Test uptake druing hospital birth in St Louis, Missouri
Of 270 women offered SARS-CoV-2 testing on admission in labour, 13 had symptomatic disease, 3 had tested positive earlier in the pregnancy, and 223 accepted testing. Uptake rose after a range of methods to encourage testing (click here or Kernberg Universal SARS.97256). No clinical details or test results reported. Barnes Jewish Hospital in St. Louis, Missouri has not previously reported cases. However the case reported in study 69 may have been cared for in the same hospital. Citation: Kernberg A, Kelly J, Nazeer S, et al. Universal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) Testing Uptake in the Labor and Delivery Unit: Implications for Health Equity [published online ahead of print, 2020 Aug 26]. Obstet Gynecol. 2020;10.1097/AOG.0000000000004127
Study 258 – Environmental sampling during 4 births in Oregon
A range of samples were collected from the room during two vaginal and two Ceasarean births of asymptomatic women with SARS-CoV-2 (click here or Hermesch SARSCoronavirus_2.97258). No other clinical details. The unnamed university hospital is difficult to identify from author affiliations. Citation: Hermesch, Amy C. MD, PhD; Horve, Patrick F. BS; Edelman, Alison MD, MPH; Dietz, Leslie PhD; Constant, David PhD; Fretz, Mark DDS, MArch; Messer, William B. MD, PhD; Martindale, Robert MD; Van Den Wymelenberg, Kevin PhD Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Environmental Contamination and Childbirth, Obstetrics & Gynecology: August 19, 2020 – Volume Publish Ahead of Print – Issue – doi: 10.1097/AOG.0000000000004112
Study 257 – 6 cases treated with nitric oxide from Massachusetts
Six pregnant women with severe Covid-19 were treated with nitric oxide (click here or FAKHR High Concentrations of Nitric Oxide Inhalation.97257). Three women delivered four babies, and three pregnancies are ongoing. No mothers or babies died. The patients were treated at Massachusetts General Hospital from April to June 2020, and probably overlap with those reported in studies 142 & 231. Citation: Safaee Fakhr B, Wiegand SB, Pinciroli R, et al. High Concentrations of Nitric Oxide Inhalation Therapy in Pregnant Patients With Severe Coronavirus Disease 2019 (COVID-19) [published online ahead of print, 2020 Aug 26]. Obstet Gynecol. 2020; 10.1097/AOG.0000000000004128.
Studies 255 & 256 added.
Study 256 – Case report from Norway
In Norweigan. Following from Google translate. A woman with twins developed mild Covid-19 during the process of labour induction at 38 weeks (click here or 59551 fødende risikopasient med covid-19). Both babies were delivered vaginally. She recovered and the twins were healthy. Baby test results not reported. 14 hospital employees were quarantined due to patient contact, but none diagnosed with infection. From author affiliations the unnamed hospital was Sørlandet Hospital, Kristiansand, which has not previously reported cases. Citation: Ane Cecilie Munk, Linda Reme Sagedal, Turid Stavseth Krogedal, Ida McFadzean, Hanna Oommen. Fødende risikopasient med covid-19 (Maternity risk patient with covid-19) Tidsskrift for Den norske legeforening. Published: July 16, 2020 Issue 11, August 18, 2020 Tidsskr Nor Legeforen 2020 doi: 10.4045 / tidsskr.20.0425
Study 255 – 16 maternal deaths in the UK
Ten women died with SARS-CoV-2 between 01/03/2020 and 31/05/2020, seven directly due to Covid-19, one cause not determined, and two due to unrelated causes (click here or Ref. 201 MBRRACE UK maternal COVID-19 Report FINAL (002)). Six further women died by suicide or domestic violence, conceivably related to lockdown, over the same period. They overlap with those in studies 29, 52, 68, 92, 107, 126 & 200. Citation: Knight M, Bunch K, Cairns A, Cantwell R, Cox P, Kenyon S, Kotnis R, Lucas DN, Lucas S, Marshall L, Nelson-Piercy C, Page L, Rodger A, Shakespeare J, Tuffnell D, Kurinczuk JJ on behalf of MBRRACE-UK. Saving Lives, Improving Mothers’ Care Rapid Report: Learning from SARS-CoV-2-related and associated maternal deaths in the UK March – May 2020 Oxford: National Perinatal Epidemiology Unit, University of Oxford 2020.
Study 254 added.
Study 254 – Breast milk testing in 18 affected women from the United States
Eighteen women with SARS-CoV-2, 17 symptomatic, had multiple breast milk samples tested (click here or jama chambers 2020 ld 200087 1597789061.40481). One sample had detectable SARS-CoV-2 RNA, but no replication-competent virus was detectable in any sample, including the sample that tested positive for viral RNA. The samples were collected from woman anywhere in the United States so may include cases previously reported. Citation: Chambers C, Krogstad P, Bertrand K, et al. Evaluation for SARS-CoV-2 in Breast Milk From 18 Infected Women. JAMA. Published online August 19, 2020. doi:10.1001/jama.2020.15580
Studies 251 and 252 added.
Study 252 – 49 new cases from Lombardy, Italy
These 49 women with SARS-CoV-2 in pregnancy were collected between 10–26 April (click here or firstname.lastname@example.org). No outcomes reported. The unnamed hospitals in Milan and the six provinces of Lombardy (Brescia, Como, Lecco, Monza, Pavia, and Sondrio) were probably Sacco (Milan), Mangiagalli (Milan), S. Gerardo MBBM Foundation (Monza), Papa Giovanni XXIII (Bergamo), and San Matteo (Pavia) and the hospitals of Padua, Florence, Lecco, Trento, Modena, Seriate and Piacenza. However the recruitment period was later than that in studies 33, 64 & 117, so these patients have not been previously reported. Citation: Enrico Ferrazzi, Paolo Beretta, Stefano Bianchi, Irene Cetin, Paolo Guarnerio, Anna Locatelli, Anna Maria Marconi, Mario Giuseppe Meroni, Giulia Pavone, Armando Pintucci, Federico Prefumo, Valeria Savasi, Arsenio Spinillo, Beatrice Tassis, Patrizia Vergani, Michele Vignali, Fabio Parazzini & Carlo La Vecchia. (2020): SARS-CoV-2 infection testing at delivery: a clinical and epidemiological priority. Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2020.1788532
Study 251 – 101 cases from Chicago
Risk factors for 101 pregnant women testing positive for SARS-CoV-2 were compared with 1,317 controls (click here or 1-s2.0-S2589933320301543-main). No outcome data. The women were cared for at Northwestern Memorial Hospital March 19 to May 31 2020. They likely include cases in studies 116 & 124. Citation: SAKOWICZ A, AYALA AE, UKEJE CC, WITTING CS, GROBMAN WA, MILLER ES, Risk Factors for SARS-CoV2 Infection in Pregnant Women, American Journal of Obstetrics & Gynecology MFM (2020).
Belated addition of study 246, ItOSS registry, (HT Aris Papageorghiou), & studies 247 to 250.
Study 250 – 19 infected babies from Iran
19 newborns (incl. one set of triplets) infected with SARS-CoV-2 (click here or email@example.com). One mother and four babies died. Dates of birth preceded paper receptin 20 June. The hospitals were Imam Khomeini Hospital, Orumiyeh, West Azerbaijan Province; Shariati Hospital, Tehran (the mother of this case died); Torbat-e Jām Hospital in Torbat-e Jām, Razavi Khorasan Province; Taleghani Hospital in Tehran, Arash Women’s Hospital in Tehran (triplets – 2 died, 1 survived); Boo-Ali Sina Hospital in Sari, Mazandaran Province; Qods Hospital in Qazvin; Ayatollah Mousavi Hospital in Zanjan; Mustafa Khomeini Hospital in Ilam; Allameh Bohluli Hospital in Gonabad, Razavi Khorasan Province; Imam Reza Hospital in Mashhad, Khorasan-e Razavi Province; Imam Sajad Hospital in Shahriar, Tehran Province; Day General Hospital in Tehran; Taleghani Hospital in Gorgan, Golestan Province (baby died); Hakim Jorjani Hospital in Gorgan, Golestan Province (baby died); and Hamedan Besat Hospital in Hamedan. The cases may overlap with those in studies 66, 67 & 218. They probably differ from those reported in studies 23 & 70. Citation: David A. Schwartz, Parisa Mohagheghi, Babak Beigi, Nazanin Zafaranloo, Fereshteh Moshfegh, Anita Yazdani. Spectrum of neonatal COVID-19 in Iran: 19 infants with SARS-CoV-2 perinatal infections with varying test results, clinical findings and outcomes. J Mat Fetal & Neonatal Med 2020, AHEAD-OF-PRINT, 1-10
Study 249 – 669 cases with respiratory problems from Brazil
Another report of women with Covid-19 in pregnancy identified through the Brazilian Acute Respiratory Distress Syndrome Surveillance System (click here or oup accepted manuscript 2020). Overlap with studies 66, 138, 282, 194, 201, 203 & 248. Citation: Debora de Souza Santos, RN, PhD, Mariane de Oliveira Menezes, CM, MSc, Carla Betina Andreucci, MD, PhD, Marcos Nakamura-Pereira, MD, PhD, Roxana Knobel, MD, PhD, Leila Katz, MD, PhD, Heloisa de Oliveira Salgado, MSc, PhD, Melania Maria Ramos de Amorim, MD, PhD, Maira L S Takemoto, CNM, PhD, Disproportionate impact of COVID-19 among pregnant and postpartum Black Women in Brazil through structural racism lens, Clinical Infectious Diseases, ciaa1066.
Study 248 – 978 cases with respiratory problems from Brazil
Of 978 pregnant or postpartum women with COVID-19 and Acute Respiratory Distress Syndrome (ARDS), 124 died (click here or 1471-0528.16470). These appear to be the same cases as reported in study 182, albeit in more detail. They probably also overlap with studies 66, 138, 194, 201, & 203. Citation: Takemoto, M.L., Menezes, M.O., Andreucci, C.B., Knobel, R., Sousa, L.A., Katz, L., Fonseca, E.B., Nakamura‐Pereira, M., Magalhães, C.G., Diniz, C.S., Melo, A.S., Amorim, M.M. and Menezes, M.O. (2020), Clinical characteristics and risk factors for mortality in obstetric patients with severe COVID‐19 in Brazil: a surveillance database analysis. BJOG: Int J Obstet Gy. Accepted Author Manuscript. doi:10.1111/1471-0528.16470
Study 247 – 6 placentas from 5 women, Turin, Italy
This preprint reports the histology of 6 placentas from 5 pregnancies (one set of twins) complicated by Covid-19 (click here or Placenta in SARS CoV-2 Bertero). All mothers and babies survived and all babies tested negative. They were cared for in S. Anna Hospital, Turin from March 22, to April 23, 2020, so are probably included in study 246. Citation: Luca Bertero, Fulvio Borella, Giovanni Botta, Andrea Carosso, Stefano Cosma, Marialuisa Bovetti, Marco Carosso, Giancarlo Abbona, Mauro Papotti, Paola Cassoni. Placenta in SARS-CoV-2 infection: a new target for inflammatory and thrombotic events. Research Square. Maternal Fetal Medicine. 2020. DOI: 10.21203/rs.3.rs-30412/v1
Study 246 – 146 cases from Italy (ItOSS)
This Medxiv preprint (not yet published as a peer reviewed paper) reports 146 women with Covid-19 in pregnancy up to April 22nd and collected by the Italian Obstetric Surveillance System, ItOSS (click here or 2020.06.11.20128652v1.full). 142 were positive for SARS-CoV-2 and 4 diagnosed clinically via CXR. Seven mothers were admitted to ITU, and 2 intubated, but none died. Two babies were stillborn and five tested positive. There were no neonatal deaths. These patients likely overlap with those in studies 32, 64, 76, 79, 109, 114, 188 and 197. They probably do not overlap with those in study 195. Citation: Alice Maraschini, Edoardo Corsi, Michele Antonio Salvatore, Serena Donati. Coronavirus and birth in Italy: results of a national population-based cohort study. medRxiv 2020.06.11.20128652.
Studies 238 to 245 added.
Study 245 – 141 cases from Mumbai, India
Out of 141 women with Covid-19 in pregnancy there were 3 abortions, one ectopic pregnancy and 3 maternal deaths (click here or Nayak 13224 2020 Article 1335). There were 3 stillbirths and 3 babies tested positive. From the description and author affiliations, the unnamed hospital is almost certainly Lokmanya Tilak Municipal General Hospital which has not previously reported cases. Citation: Nayak, A.H., Kapote, D.S., Fonseca, M. et al. Impact of the Coronavirus Infection in Pregnancy: A Preliminary Study of 141 Patients. J Obstet Gynecol India 70, 256–261 (2020).
Study 244 – 125 cases from Turkey
Of 125 pregnant women with Covid-19 (click here or Oncel2020 Article), 7 mothers required ventilation and 5 died. Four babies tested positive and one (who tested negative) died. The babies were cared for in 34 unnamed neonatal intensive care units. From author affiliations these probably include İzmir (3 centres), İstanbul (6 centres), Rize (1 centre), Ankara (4 centres) and Kocaeli (1 centre). Some of these cases probably overlap with those reported in studies 31, 145, 146, 203, 210 & 223. Citation: Oncel, M.Y., Akın, I.M., Kanburoglu, M.K. et al. A multicenter study on epidemiological and clinical characteristics of 125 newborns born to women infected with COVID-19 by Turkish Neonatal Society. Eur J Pediatr (2020).
Studies 238 to 243 – 6 case reports, from Portugal, France, US, India, UK & Nigeria
S 240 (serial cord antibody levels) from Mount Sinai, New York (click here or Toner). Citation: Toner et al. Passive Immunity in COVID Positive Pregnant Patient. Am J Perinatol. 21 July 2020.
S 241 (mild case) from New Delhi, India (click here or Chhabra Indian J Anaesth 6414141-6060246 165002). Citation: Chhabra A, Rao TN, Kumar M, Singh Y, Subramaniam R. Anaesthetic management of a COVID‑19 parturient for caesarean section ‑ Case report and lessons learnt. Indian J Anaesth 2020;64:S141-3.
S 242 (HELLP) from Birmingham, UK (click here or Ahmed e237521.full) Citation: Ahmed I, Eltaweel N, Antoun L, et al. BMJ Case Rep 2020;13:e237521. doi:10.1136/bcr-2020-237521. S 243 (Caesarean) from Lagos, Nigeria (click here or Makwe). Citation: Christian Chigozie Makwe et al. Caesarean delivery of first prediagnosed COVID-19 pregnancy in Nigeria. Pan African Medical Journal. 2020;36:100. [doi: 10.11604/pamj.2020.36.100.23892]
Studies 236 & 237 added.
Study 237 – Effect of lockdown on hospital births in Nepal
Birth numbers halved, stillbirths increased by 50% and neonatal mortality nearly fourfold, during lockdown in nine Nepal hospitals (click here or PIIS2214109X20303454). No women or babies were tested for Covid-19. Citation: Ashish KC, Rejina Gurung, Mary V Kinney, Avinash K Sunny, Md Moinuddin, Omkar Basnet, Prajwal Paudel, Pratiksha Bhattarai, Kalpana Subedi, Mahendra Prasad Shrestha, Joy E Lawn, Mats Målqvist. Effect of the COVID-19 pandemic response on intrapartum care, stillbirth, and neonatal mortality outcomes in Nepal: a prospective observational study. Lancet Global Health. August 10, 2020
Study 236 – 45 cases from New York
45 babies were born to SARS-CoV-2 positive mothers, 30 were vaginal births, 33 co-located with their mothers and 31 were breast fed (click here or s41372-020-0765-30). 27 of the mothers were asymptomatic. No other maternal details were reported. All 45 new borns were tested & 3 were positive. The patients were cared for at Elmhurst Hospital Center in New York which has not previously reported cases. Citation: Patil, U.P., Maru, S., Krishnan, P. et al. Newborns of COVID-19 mothers: short-term outcomes of colocating and breastfeeding from the pandemic’s epicenter. J Perinatol (2020).
Study 235 added.
Study 235 – 125 anti-SARS-CoV-2 sero-positive women from Barcelona, Spain
Of 874 pregnant women attending first trimester screening (n=372) or delivery (n=502) from April 14 to May 5, 2020, 125 were positive for anti-SARS-CoV-2 IgG, IgM, or IgA. 54/372 in first trimester, and 71/502 in 3rd trimester (click here or PIIS0140673620317141 & supplementary material mmc1). Three women required oxygen therapy, but none critical care. No baby outcomes reported. Women were cared for in Hospital Sant Joan de Déu, Hospital Clínic, and Sant Pau all in Barcelona. They probably overlap with cases reported in studies 185 and 191, but probably not with those in studies 53, 125, 151, 158, 165, or 196. Citation: Francesca Crovetto, Fàtima Crispi, Elisa Llurba, Francesc Figueras, María Dolores Gómez-Roig, Eduard Gratacós. Seroprevalence and presentation of SARS-CoV-2 in pregnancy. Lancet. Published Online August 6, 2020.
Study 234 added.
Study 234 – 70 cases from New York
Of 675 pregnant women admitted for delivery and tested for SARS-CoV-2, 70 were positive, of whom 55 were asymptomatic on presentation (click here or 1471-0528.16403). Three mothers were hypoxic, one was admitted to ITU but none required ventilation. No mothers died. There was one stillbirth to a mother with asymptomatic Covid-19 and other pathology. 73 babies were born, 71 were tested and all were negative. The three hospitals, all affiliated with New York Presbyterian were Weill Cornell Medical Center, Queens, and Lower Manhattan Hospital. The cases may therefore also have been included in studies 160, 216 and 230. However, they were probably not included in the other NY Presbyterian series namely studies 14, 27, 41, 95, 96 and 136. Citation: Prabhu, M., Cagino, K., Matthews, K.C., Friedlander, R.L., Glynn, S.M., Kubiak, J.M., Yang, Y.J., Zhao, Z., Baergen, R.N., DiPace, J.I., Razavi, A.S., Skupski, D.W., Snyder, J.R., Singh, H.K., Kalish, R.B., Oxford, C.M. and Riley, L.E. (2020), Pregnancy and postpartum outcomes in a universally tested population for SARS‐CoV‐2 in New York City: A prospective cohort study. BJOG: Int J Obstet Gy. Accepted Author Manuscript.
Studies 230 to 233 added.
Study 233 – case report from Marrakech, Morocco
A woman contracted Covid-19 at 31 weeks gestation, required oxygen therapy and went into premature labour. A Caesarean was performed for fetal distress (click here or 8852816). The mother recovered. The baby tested negative but had severe birth asphyxia and died age 5 days. The mother was cared for at University Hospital of Mohammed VI, Marrakech, which has not previously reported cases. This is the first report from Morocco. Citation: Yassamine Abourida, Houssam Rebahi, Imane Oussayeh, Hajar Chichou, Bouchra Fakhir, Abderraouf Soummani, Hicham Jalal, Fatiha Bennaoui, Nadia El Idrissi Slitine, Fadl Mrabih Rabou Maoulainine, Ahmed Rhassane El Adib, and Mohamed Abdenacer Samkaoui. Management of Severe COVID-19 in Pregnancy. Case Reports in Obstetrics and Gynecology Volume 2020, Article ID 8852816, 5 pages.
Study 232 – 44 cases from Boston, Massachusetts
Of 44 pregnant or recently postpartum women with COVID-19, 5 had severe disease and 2 required ventilation (click here or ijgo.13333). All mothers survived. Of 11 babies born, 9 tested negative and 2 declined testing. All survived. 31 pregnancies are ongoing. The majority of patients belonged to racial [sic] or ethnic minority groups. From author affiliations the unnamed hospital was probably Brigham and Women’s Hospital, Boston. Some cases may therefore have been reported in study 231, but probably differ from those in studies 129 & 142. Citation: Onwuzurike, C., Diouf, K., Meadows, A.R. and Nour, N.M. (2020), Racial and ethnic disparities in severity of COVID‐19 disease in pregnancy in the United States. Int J Gynecol Obstet. Accepted Author Manuscript.
Study 231 – 19 placentas from Boston, Massachusetts
2/19 placentas of affected pregnancies tested positive for SARS-CoV-2 by in-situ hybrization (click here or s41379-020-0639-4). There were no specific pathologic features compared with 262 control placentas. One fetus was stillborn at 22 weeks and not tested. There were two sets of twins. All liveborn babies survived, and only one tested positive. From the case codes in Table 2 it appears that 10 pregnancies had been cared for at Massachusetts General Hospital, 4 at Brigham and Women’s Hospital & 5 at Beth Israel Deaconess Medical Center. Some have therefore probably been reported in studies 129 & 142. Citation: Hecht, J.L., Quade, B., Deshpande, V. et al. SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers. Mod Pathol (2020).
Study 230 – Placental features of 74 cases from New York
2/53 placentas from affected pregnancies contained a SARS-CoV-2 viral signal by in-situ hybridization (click here or Zhang, Placenta, AJOGMFM). One baby tested positive, the other negative. Both were asymptomatic. There were no specific histological differences between 74 placentas from SARS-CoV-2 positive pregnancies and 290 controls. The authors are affiliated with the New York Presbyterian, Brooklyn Methodist, Weill Cornell group of hospitals so the clinical aspects of the cases have probably been reported before. Citation: Zhang P, Heyman T, Salafia C, Dygulska B, Lederman S, Detection of SARS-CoV-2 in placentas with pathology and vertical transmission, American Journal of Obstetrics & Gynecology MFM (2020).
Studies 225 to 229 added.
Study 229 – Some assisted reproduction pregnancies during the pandemic in France
The authors report 88, or possibly 104, women (numbers are unclear) who conceived by assisted reproduction between December 2019 & March 2020, and were still pregnant after the first reported case of Covid-19 in France on 12th February. Ten had symptoms related to Covid-19, none severe or requiring intensive care (click here or PIIS0301211520304929). Five of the ten were tested and two were positive. 15 women miscarried although their Covid-19 status was not reported. From author affiliations the unnamed centre was probably the Reproductive Biology Unit, Antoine Béclère Hospital, Clamart, France. These cases may therefore feature in studies 150, 157, 184 & 217. The pregnancies were unlikely to have been sufficiently far advanced to have featured in studies 48 & 187. Citation: Mayeur A, Binois O, Gallot V, Hesters L, Benoit A, Oppenheimer A, Presse M, Zeghari F, Benguigi J, Grynberg M, Frydman N, Sonigo C, First follow-up of art pregnancies in the context of the COVID-19 outbreak, European Journal of Obstetrics & Gynecology and Reproductive Biology (2020).
Study 228 – Case report from Stockton, California
A pregnant woman contracted severe Covid-19 requiring ventilation at 32 weeks (click here or Ching Case Rep RespMed). She was delivered by Caesarean section for suspected placenta praevia and recovered. The baby required intubation and ventilation for 48 hours but tested negative. The ultimate baby outcome is not reported. The hospital is unnamed but the authors’ affiliation with San Joaquin Critical Care Medical Group, suggests that it was San Joaquin General Hospital in Stockton, California which has not previously reported cases. Citation: Josebelo Chong, Siraj Ahmed, Kyle Hill. Acute Respiratory Distress Syndrome in a pregnant patient with COVID-19 improved after delivery: A case report and brief review. Respiratory Medicine Case Reports. Volume 31, 2020, 101171, ISSN 2213-0071.
Study 227 – Case report from Columbia, Missouri, USA
A woman with mild Covid-19 gave birth to a male infant vaginally at term (click here or HSU jmv.26386). She recovered. The baby breast fed, tested negative and was fine. The virus was demonstrated in the placenta by immuno-histochemistry using a SARS-CoV-2 nucleocapsid-specific monoclonal antibody. Mother and baby were cared for at University of Missouri Women and Children’s Hospital which has not previously reported cases. The clinical details of case 69 differ. Citation: Hsu, A.L., Guan, M., Johannesen, E., Stephens, A.J., Khaleel, N., Kagan, N., Tuhlei, B.C. and Wan, X.‐F. (2020), Placental SARS‐CoV‐2 in a Pregnant Woman with Mild COVID‐19 Disease. J Med Virol. Accepted Author Manuscript.
Study 226 – 3 cases treated with remdesivir from Stanford
Three pregnant women with Covid-19 were treated with remdesivir outside a clinical trial (click here or PIIS0002937820308292). One developed “transaminitis” – I think the authors mean raised liver transaminase. The pre-print is missing a table – which the authors attributed to the remdesivir. That woman later developed intrahepatic cholestasis of pregnancy and delivered normally. The other pregnancies are ongoing. The acknowledgements suggest that the unnamed hospital is Lucile Packard Children’s Hospital at Stanford. Although one author is shared with study 115 from another unnamed Stanford hospital, the clinical details differ. These cases have probably not previously been reported. Citation: Igbinosa I, Miller S, Bianco K, Nelson J, Kappagoda S, Blackburn BG, Grant P, Subramanian A, Lyell D, El-Sayed Y, Aziz N, Use of Remdesivir for Pregnant Patients with Severe Novel 2019 Coronavirus Disease, American Journal of Obstetrics and Gynecology (2020).
Study 225 – over 600 cases (412 births) in Nair Hospital, Mumbai
Nair hospital, Mumbai, India, a dedicated Covid-19 facility, has cared for over 600 pregnant women with the disease (click here or ijgo.13338). There have been 412 births including seven pairs of twins and one set of triplets. No mothers died of Covid-19 directly, although four died of other causes. No baby outcomes reported. The first two cases had originally been cared for elsewhere, and also previously denied admission at four private hospitals, the latter a feature of news reports from India (click here). Two health care workers contracted COVID-19. Nair Hospital has not previously reported cases. The case reported in study 58 was from New Delhi. Citation: Mahajan, N.N., Pednekar, R., Patil, S.R., Subramanyam, A.A., Rathi, S., Malik, S., Mohite, S.C., Shinde, G., Joshi, M., Kumbhar, P., Tilve, A., Lokhande, P.D. and Srivastava, S.A. (2020), Preparedness, administrative challenges for establishing obstetric services, and experience of delivering over 400 women at a tertiary care COVID‐19 hospital in India. Int J Gynecol Obstet. Accepted Author Manuscript.
Studies 221 to 224 added.
Study 224 – 6 cases from Sri Lanka
This paper primarily reports the mental health of pregnant women without Covid-19 during the pandemic in Sri Lanka (click here or ijgo.13335). The authors mention six cases of COVID-19 positive pregnant women in the country. Although no further details are given, and the link given (ref 8) to the Live Situational Analysis Dashboard of Sri Lanka (click here) does not cite pregnancy cases, this is the first scientific report of Covid-19 in pregnancy from Sri Lanka. Citation: Patabendige, M., Gamage, M.M., Weerasinghe, M. and Jayawardane, A. (2020), Psychological impact of the COVID‐19 pandemic among pregnant women in Sri Lanka. Int J Gynecol Obstet. Accepted Author Manuscript.
Study 223 – 3 cases from Ankara
Three pregnant women tested postive for SARS-CoV-2 in Ankara City Hospital (click here or PIIS0301211520304930). All three had co-morbidities but mild disease and were delivered by Caesarean. Baby outcomes not reported. Citation: Tanacan A, Erol SA, Turgay B, Anuk AT, Secen EI, Yegin GF, Ozyer S, Kirca F, Dinc B, Unlu S, Yapar Eyi EG, Keskin HL, Sahin D, Surel AA, Tekin OM, The Rate of SARS-CoV-2 Positivity in Asymptomatic Pregnant Women Admitted to Hospital for Delivery: Experience of A Pandemic Center in Turkey, European Journal of Obstetrics and amp; Gynecology and Reproductive Biology (2020).
Study 222 – Case report from California
A 22-year-old woman with placenta previa and a past medical history of tuberous sclerosis and multiple associated comorbidities contracted Covid-19 at 23 weeks + 6 days gestation (click here or 2324709620946621). She required intubation and ventilation and was delivered by caesarean at 25+5. The baby tested negative. Both mother and baby survived. The hospital is unnamed but from author affiliations is probably Los Angeles County+USC Medical Center, which has not previously reported cases. Citation: Easterlin, M. C., De Beritto, T., Yeh, A. M., Wertheimer, F. B., & Ramanathan, R. (2020). Extremely Preterm Infant Born to a Mother With Severe COVID-19 Pneumonia. Journal of Investigative Medicine High Impact Case Reports.
Study 221 – SARS-CoV-2 serological testing of 1,293 parturient women
1,293 parturient women tested fro SARS-CoV-2 antbodies in two hospitals in Philadelphia, 80 were positive (click here or eabd5709.full), Percentages in results table 1 are given by row rather than column making comparisons difficult. The hospitals are unnamed. A preprint of this paper in MedXiv was study 202. Citation: D. D. Flannery et al., Sci. Immunol. (2020)
Study 220 added.
Study 220 – 29 cases from Wuhan
29 women with Covid-19 between January 30 and March 10, 2020, gave birth to 30 neonates (1 set of twins) (click here or journal.pmed.1003195). The hospitals were Renmin Hospital, Wuhan University, and Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology. These cases have surely been published before. Citation: Wu Y-T, Liu J, Xu J-J, Chen Y-F, Yang W, Chen Y, et al. (2020) Neonatal outcome in 29 pregnant women with COVID-19: A retrospective study in Wuhan, China. PLoS Med 17(7): e1003195.
Studies 217 to 219 added.
Study 219 – 3 cases from New Jersey, USA
Three women with Covid-19 in pregnancy required ventilation and delivery by Caesarean (click here or Douedi AM J Cas Rep NJ). All three mothers and babies survived, and all babies tested negative. The hospital is unnamed, but from author affiliations is probably Jersey Shore University Medical Center. The cases were probably therefore also reported in study 149. Citation: Steven Douedi, Asseel Albayati, Nasam Alfraji, Usman Mazahir, Eric Costanzo Steven Douedi, Asseel Albayati, Nasam Alfraji, Usman Mazahir, Eric Costanzo. Am J Case Rep 2020; 21:e925513 DOI: 10.12659/AJCR.925513
Study 218 – Case report from Tehran, Iran
A 30 year old woman contracted Covid-19 at 21 weeks gestion (click here or Soleimani JMFM). She received methyprednisolone, Lopinivir, Azithromycin, Hydrocortisone and immune plasma and survived. The pregnancy is ongoing. The hospital is unnamed and only identifiable as being in Tehran from author affiliations. The case in study 101 was from a different city, and the details differ from those of the two survivors is study 67. Citation: Zahra Soleimani & Azam Soleimani (2020): ADRS due to COVID-19 in midterm pregnancy: successful management with plasma transfusion and corticosteroids, The Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2020.1797669
Study 217 – 83 cases from France & Belgium
83 pregnant women with Covid-19 were compared with a group of non-pregnant affected control women (click here or Badr AJOG PIIS0002937820307766). No raw data and no pregnancy outcomes provided. The hospitals were Antoine Béclère, Clamart, Paris, Bicêtre Hospital, Le Kremlin-Bicêtre, Centre Hospitalier Sud Francilien, Corbeil-Essones, and University Hospital Brugmann, Brussels. These cases have probably been already reported. Citation: Badr DA, Mattern J, Carlin A, Cordier A-G, Maillart E, El Hachem L, El Kenz H, Andronikof M, De Bels D, Damoisel C, Preseau T, Vignes D, Cannie MM, Vauloup-Fellous C, Fils J-F, Benachi A, Jani JC, Vivanti AJ, Are clinical outcomes worse for pregnant women ≥ 20 weeks’ gestation infected with COVID-19? A multicenter case-control study with propensity score matching, American Journal of Obstetrics and Gynecology (2020).
Study 216 added.
Study 216 – 120 babies born to SARS-CoV-2 positive mothers from New York
120 neonates born to 116 mothers who had tested positive for SARS-CoV-2 in pregnancy, were were tested at 24 hours of life. Of them, 79 were also tested at 5-7 days, and 72 at 14 days. All tested negative at all time points and none had symptoms of COVID-19 (click here or 1-s2.0-S2352464220302352-main). The mothers and babies were cared for at three unnamed New York Presbyterian Hospitals. From author affiations these were probably Weill Cornell Presbyterian Komansky, Presbyterian Queens, and Presbyterian Lower Manhattan hospitals. These hospital names are not found among previous reports from New York despite many previous reports from the New York Presbyterian network. Citation: Christine M Salvatore, Jin-Young Han, Karen P Acker, Priyanka Tiwari, Jenny Jin, Michael Brandler, Carla Cangemi, Laurie Gordon, Aimee Parow, Jennifer DiPace, Patricia DeLaMora. Neonatal management and outcomes during the COVID-19 pandemic: an observation cohort study, The Lancet Child & Adolescent Health, 2020, ISSN 2352-4642.
Studies 212 to 215 added.
Study 215 – Case report from Tacoma, Washington State, USA
A woman with Covid-19 in pregnancy continued to test positive for SARS-CoV-2 for 100 days (click here or Prolonged Detection of Severe Acute Respiratory.97292). Mother and baby survived. All viral tests on baby, placenta and breast milk were negative. The cord blood was positive for IgG antibodies to SARS-CoV-2. From author affiliations the hospital was MultiCare Tacoma General Hospital, which has not previously reported cases. Citation: Molina, Loren P. MD; Chow, Siu-Kei PhD; Nickel, Adam DO; Love, Jason E. MD Prolonged Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA in an Obstetric Patient With Antibody Seroconversion, Obstetrics & Gynecology: July 21, 2020 – Volume Publish Ahead of Print – Issue – doi: 10.1097/AOG.0000000000004086
Study 214 – 100 cases from New York
The authors report the Race [sic] and Ethnicity of 100 cases of Covid-19 in pregnancy from New York (click here or Influence of Race and Ethnicity on Severe Acute.97290). These cases have likely been reported before. Citation: Emeruwa, Ukachi N. MD, MPH; Spiegelman, Jessica MD; Ona, Samsiya MD; Kahe, Ka MD, ScD; Miller, Russell S. MD; Fuchs, Karin M. MD, MHA; Aubey, Janice J. MD, MPH; Booker, Whitney MD; D’Alton, Mary E. MD; Friedman, Alexander M. MD, MPH; Aziz, Aleha MD, MPH; Sutton, Desmond MD; Purisch, Stephanie E. MD; Goffman, Dena MD; Melamed, Alexander MD, MPH; Gyamfi-Bannerman, Cynthia MD, MSc Influence of Race and Ethnicity on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Rates and Clinical Outcomes in Pregnancy, Obstetrics & Gynecology: July 21, 2020 – Volume Publish Ahead of Print – Issue – doi: 10.1097/AOG.0000000000004088
Study 213 – 89 cases from Sao Paolo, Brazil
Of 89 women with Covid-19 cared for in a single institution between March 12 & May 25, 2020, the details of five who experienced a fetal death are reported (click here or 1-s2.0-S2214911220300734-main). No details of the other cases, and no explicit maternal outcomes are reported, but enough details are given for it to be implied that the mothers survived. From author affiliations the unnamed hospital is probably Hospital e Maternidade Santa Joana, São Paulo. Apart from study 194 which was from a different city, all previous reports of Covid-19 in pregnancy from Brazil (studies 66, 138, 182 & 201) have been of maternal deaths. These cases have therefore probably not previously been reported. Citation: Rosana Richtmann, Maria Regina Torloni, Andre Ricardo Oyamada Otani, Jose Eduardo Levi, Mariana Crema Tobara, Camila de Almeida Silva, Lívio Dias, Lisia Miglioli-Galvão, Pollyanna Martins Silva, Mario Macoto Kondo, Fetal deaths in pregnancies with SARS-CoV-2 infection in Brazil: A case series, Case Reports in Women’s Health, Volume 27, 2020, e00243, ISSN 2214-9112,
Study 212 – 2 cases from Yichang city, in Hubei province, China
There were only two pregnant women with Covid-19 in Yichang city between January 20 & April 9, 2020 (click here or Coronavirus disease 2019 COVID19 in pregnancy.126). Both mothers and both babies survived. Neither baby was infected. The hospital was Yichang Central People’s Hospital. On GRID.ac this disambiguates as Peking University People’s Hospital grid.411634.5 which is probably an error. Yichang city is in Western Hubei province about 200 km west of Wuhan, and about 1000 km south of Peking/Beijing. Yichang city was a centre in study 57, so these two cases were probably included in that series, Citation: Zheng, Tingting; Guo, Jianqiang; He, Wencong; Wang, Hao; Yu, Huiling; Ye, Hong. Coronavirus disease 2019 (COVID-19) in pregnancy: 2 case reports on maternal and neonatal outcomes in Yichang city, Hubei Province, China, Medicine: July 17, 2020 – Volume 99 – Issue 29 – p e21334 doi: 10.1097/MD.0000000000021334
Studies 208 to 211 added.
Study 211 – 21 cases from Wuhan, China
21 term pregnancies with Covid-19 (click here or Chen-Bai2020 Article Maternal And Infant Outcomes Of Ful). No mothers or babies died. All babies tested negative. The patients were cared for in Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology. They probably overlap with those in studies 2, 8, 11, 15, 39, 55, 57, 59, 73, and 108. Citation: Chen, Y., Bai, J. Maternal and infant outcomes of full-term pregnancy combined with COVID-2019 in Wuhan, China: retrospective case series. Arch Gynecol Obstet (2020). https://doi.org/10.1007/s00404-020-05573-8
Study 210 – 23 cases from Istanbul, Turkey
23/296 pregnant women tested positive for SARS-CoV-2 infection during one month’s screening from 27 April, in a “Coronavirus Pandemic Hospital” in Istanbul (click here or firstname.lastname@example.org). Another 15 referral cases were treated over the same period. No pregnancy outcomes were reported. From author affiliations the unnamed hospital is probably Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital. If so, these cases probably include those reported in study 146. Citation: Murat Yassa, Cihangir Yirmibes, Gul Cavusoglu, Hazal Eksi, Cevdet Dogu, Canberk Usta, Memis Ali Mutlu, Pinar Birol, Cagri Gulumser & Niyazi Tug. (2020). Outcomes of universal SARS-CoV-2 testing program in pregnant women admitted to hospital and the adjuvant role of lung ultrasound in screening: A prospective cohort study. The Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2020.1798398
Study 209 – 51 placentas from infected pregnancies in New York
All 51 placentas from SARS-CoV-2 affected pregnancies were negative for SARS-Cov-2 by in situ hybridization and immunohistochemistry (click here or his.14215), Citation: Smithgall, M.C., Liu‐Jarin, X., Hamele‐Bena, D., Cimic, A., Mourad, M., Debelenko, L. and Chen, X. (2020), Third Trimester Placentas of SARS‐CoV‐2‐Positive Women: Histomorphology, including Viral Immunohistochemistry and in Situ Hybridization. Histopathology. Accepted Author Manuscript. doi:10.1111/his.14215
Study 208 – Ten cases from Porto, Portugal
Ten pregnant women with Covid-19 were cared for at Centro Hospitalar Universitario, Sao Joao, Porto, Portugal (click here or Perinatal management of SARS CoV 2 infection in a level III University Hospital). One women was admitted to intensive care but all mothers and babies survived. No babies tested positive. This hospital has not previously reported cases. Citation: Susana Pissarra, Marta Rosário, Marina Moucho & Henrique Soares (2020) Perinatal management of SARS-CoV-2 infection in a level III University Hospital, The Journal of Maternal-Fetal & Neonatal Medicine. DOI: 10.1080/14767058.2020.1786526
Studies 205 to 207 added.
Study 207 – Mental health of 14 cases from London
Fourteen women with Covid-19 in pregnancy recorded their levels of anxiety & depression (click here or PIIS0301211520304796). No clinical outcomes reported. The hospital is not named but the authors note that this is an extension of the series in study 206 so must be North Middlesex. The patients are therefore also included in study 93. Citation: Kotabagi P, Nauta M, Fortune L, Yoong W, COVID-19 positive mothers are not more anxious or depressed than non COVID pregnant women during the pandemic: a pilot case-control comparison. European Journal of Obstetrics and Gynecology and Reproductive Biology (2020). doi: https://doi.org/10.1016/j.ejogrb.2020.07.037
Study 206 – Mental health of 11 cases from London
Eleven women with Covid-19 in pregnancy recorded their levels of anxiety & depression (click here or aogs.13928). No clinical outcomes reported. The authors note that these patients were treated at North Middlesex Hospital and included those in study 93. Citation: Kotabagi, P., Fortune, L., Essien, S., Nauta, M. and Yoong, W. (2020), Anxiety and depression levels among pregnant women with COVID‐19. Acta Obstet Gynecol Scand, 99: 953-954. doi:10.1111/aogs.13928
Study 205 – 91 cases from Madrid
Of 91 pregnant women with Covid-19 treated in Hospital Universitario “12 de Octubre”, 4 required ventilation, but none died (click here or email@example.com). 38 babies delivered, all testing negative immediately after birth, although one developed mild Covid-19 and tested positive at 6 days. These cases likely overlap with those in studies 151, 165 & 196. Citation: Patricia Barbero, Laura Mugüerza, Ignacio Herraiz, Antonio García Burguillo, Rafael San Juan, Laura Forcén, Inmaculada Mejía, Emma Batllori, María Dolores Montañez, Paloma Vallejo, Olga Villar, Diana García Alcazar & Alberto Galindo (2020) SARS-CoV-2 in pregnancy: characteristics and outcomes of hospitalized and non-hospitalized women due to COVID-19. The Journal of Maternal-Fetal & Neonatal Medicine. DOI: 10.1080/14767058.2020.1793320
Study 204 added.
Study 204 – 7 screen positives from Newham, London
Seven pregnant women tested positive for SARS-CoV-2 out of 189 screened over a two week period 22nd April to 5th May, 2020 at Newham University Hospital in East London (click here or PIIS0301211520304772). Only one was symptomatic. No outcomes reported. Citation: Abeysuriya S, Wasif S, Counihan C, Shah N, Iliodromiti S, Cutino-Moguel M-Teresa, Saeed F, Velauthar L, Universal Screening for SARS-CoV-2 in Pregnant Women at Term Admitted to an East London Maternity Unit, European Journal of Obstetrics & Gynecology and Reproductive Biology (2020), doi: https://doi.org/10.1016/j.ejogrb.2020.07.035
Study 203 added.
Study 203 – 37 cases from Turkey
Of 100 pregnant women with possible Covid-19, 29 had the diagnosis confirmed by RT‐PCR, and a further eight were clinically high suspicious (click here or ijgo.13318). None died or were admitted to ITU. No babies died or tested positive. Patients were cared for at the Ministry of Health Ankara City Hospital which has not previously reported cases. The only previous Ankara case (study 31) was from a different hospital and the clinical details differ. Citation: Sahin, D., Tanacan, A., Erol, S.A., Anuk, A.T., Eyi, E.G., Ozgu‐ Erdinc, A.S., Yucel, A., Keskin, H.L., Tayman, C., Unlu, S., Kirca, F., Dinc, B., San, I., Parpucu, Ü.M., Surel, A.A. and Moraloglu, O.T. (2020). A pandemic center’s experience of managing pregnant women with COVID‐19 infection in Turkey: A prospective cohort study. Int J Gynecol Obstet. Accepted Author Manuscript.
Studies 198 to 202 added.
Study 202 – 80 cases from Pennsylvania
This preprint from medRxiv reports 80 pregnant women who tested positive for IgG and/or IgM SARS-CoV-2-specific antibodies in two centers in Philadelphia (click here or Flannery 2020.07.08.20149179v1.full). 46 of the 72 who were tested also had a SARS-CoV-2 positive PCR result. 79 women delivered a liveborn infant. The outcome of the 80th woman was not reported. The hospitals are not named. The cases may overlap with studies 65 & 175 and possibly also with study 86.Citation:Dustin D. Flannery, Sigrid Gouma, Miren B. Dhudasia, Sagori Mukhopadhyay, Madeline R. Pfeifer, Emily C. Woodford, Jeffrey S. Gerber, Claudia P. Arevalo, Marcus J. Bolton, Madison E. Weirick, Eileen C. Goodwin, Elizabeth M. Anderson, Allison R. Greenplate, Justin Kim, Nicholas Han, Ajinkya Pattekar, Jeanette Dougherty, Olivia Kuthuru, Divij Mathew, Amy. Baxter, Laura. Vella, JoEllen Weaver, Anurag Verma, Rita Leite, Jeffrey S. Morris, Daniel J. Rader, Michal A. Elovitz, E. John Wherry, Karen M. Puopolo, Scott E. Hensley. SARS-CoV-2 Seroprevalence Among Parturient Women medRxiv 2020.07.08.20149179.
Study 201 – 20 maternal deaths from Brazil
Twenty COVID-19 related maternal deaths were identified from the Brazilian Ministry of Health surveillance system (click here or Takemoto Maternal mortality and COVID 19). Ten were in the Northeast region, and nine in the Southeast (5 in São Paulo). They probably overlap with those in studies 138, 182 & 194. Citation: Maira L. S. Takemoto , Mariane O. Menezes , Carla B. Andreucci , Roxana Knobel , Liduína A. R. Sousa , Leila Katz , Eduardo B. Fonseca , Claudia G. Magalhães, Wanderson K. Oliveira , Jorge Rezende-Filho , Adriana S. O. Melo & Melania M. R. Amorim (2020): Maternal mortality and COVID-19, The Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2020.1786056
Study 200 – 23 cases from Birmingham, UK
Of 23 pregnant women with COVID-19, four were admitted to ITU and one died from basilar artery thrombosis, pulmonary embolism, and diabetic ketoacidosis (click here or Antoun EJOG 1-s2.0-S0301211520304486-main). 20 babies were delivered, incl. one set of twins. All survived. Seven babies were tested for SARS-CoV-2 and all were negative. The hospital is unnamed but from its size and author affiliations is likely to be Birmingham Women’s Hospital which has not previously reported cases. However, they will have been included in the UKOSS report study 92. The clinical details of the maternal death suggest this is the same patient as reported in study 107 as having been delivered at Birmingham Heartlands Hospital. Citation: Antoun L, Taweel NE, Ahmed I, Patni S, Honest H, Maternal COVID-19 infection, clinical characteristics, pregnancy, and neonatal outcome A prospective cohort study, European Journal of Obstetrics and amp; Gynecology and Reproductive Biology (2020), doi: https://doi.org/10.1016/j.ejogrb.2020.07.008
Study 199 – case report of a miscarriage from France
A woman with Covid-19 miscarried at 20 weeks (click here or Hachem EJOG 1-s2.0-S0301211520304668-main). The hospital is unnamed but from author affiliation is René Dubos Hospital, Cergy-Pontoise, a northern suburb of Paris. No authors with this affiliation were included in the GROG series, study 150, so this case has probably not been reported before. Citation: Hachem R, Markou G, Veluppillai C, Poncelet C, Late miscarriage as a presenting manifestation of COVID-19, European Journal of Obstetrics and Gynecology and Reproductive Biology (2020).
Study 198 – 10 cases from Cleveland, Ohio
Ten pregnant women tested positive for SARS-CoV-2, of whom three were symptomatic (click here or Berkowitz AJOG PIIS0002937820307298). None required medical treatment beyond standard obstetric care. They were cared for at various hospitals managed by the Cleveland Clinic Foundation in Ohio, which appear to be all based around the town of Cleveland itself. If so they have not previously been reported. Citation: Berkowitz KM, Goje O, Eaton J. Implementation of universal testing for SARS-CoV-2 in pregnant women with intended admission for delivery. American Journal of Obstetrics and Gynecology (2020).
Studies 192 to 196 added.
Study 197 – A case report from Mantova, Italy
A pregnant woman with Covid-19 at 24 weeks gestation was treated with convalescent plasma (click here or Grisolia AJOG MFM 1-s2.0-S258993332030118X-main). The following day her condition worsened, and she was transferred to ICU where she received non-invasive ventilation. After a 2nd dose of convalescent plasma she recovered. The pregnancy is ongoing. The hospital is not named but from author affiliations was Carlo Poma Hospital, Mantova. Mantova is in Lombardy so this case was probably included in studies 32 & 64. Citation: Grisolia G, Franchini M, Glingani C, Inglese F, Garuti M, Beccaria M, Capuzzo M, Pinto A, Pavan G, Righetto L, Perotti C, Zampriolo P, De Donno G, Convalescent plasma for COVID-19 in pregnancy: a case report and review, American Journal of Obstetrics & Gynecology MFM (2020).
Study 196 – 42 cases from Spain
42 women with COVID-19 in the third trimester of pregnancy from 14 hosptials in Spain delivered 42 babies (click here or Gabriel apa.15474). One mother died. 3/37 babies tested positive. No babies died. The authors wrote on behalf of the Neo-COVID-19 Research Group. The hospitals were, 12 de Octubre, Clínico San Carlos, Fuenlabrada, Fundación Jiménez Díaz, Getafe, Josep Trueta, La Paz, Hospitales-Madrid Group, Príncipe de Asturias, Puerta de Hierro-Majadahonda, Rey Juan Carlos, Río Hortega, Santiago de Compostela, Sant Joan, Severo Ochoa Leganés, Vall d’Hebrón and the European Institute of Perinatal Mental Health. The cases probably overlap with those in studies 151, 158, 165, 185 & 191. Citation: Marín Gabriel, M.A., Cuadrado, I., Álvarez Fernández, B., González Carrasco, E., Alonso Díaz, C., Llana Martín, I., Sánchez, L., Olivas, C., de las Heras, S., Criado, E. and (2020), Multi‐centre Spanish study found no incidences of viral transmission in infants born to mothers with COVID‐19. Acta Paediatr. Accepted Author Manuscript. doi:10.1111/apa.15474
Study 195 – 14 first trimester cases from Turin
14 women tested positive for SARS-CoV-2 in the first trimester (click here or cosma turin jmv.26267). No outcomes reported. They were cared for at Sant’ Anna Hospital, Turin, Italy, so are likely included in the 23 first trimester cases in study 167. Citation: Cosma, S., Borella, F., Carosso, A., Sciarrone, A., Cusato, J., Corcione, S., Mengozzi, G., Preti, M., Katsaros, D., Di Perri, G. and Benedetto, C. (2020), The “scar” of a pandemic: cumulative incidence of COVID‐19 during the first trimester of pregnancy. J Med Virol. Accepted Author Manuscript. doi:10.1002/jmv.26267
Study 194 – Three cases from Vitoria, Espirito Santo State. Brazil
Two women with severe Covid-19 in pregnancy, and one with severe disease postnatally, required prologed ICU admission and ventilation (click here or dos Reis Case Rep Brazil). One mother died. All three babies tested negative and survived. This is the first scientific report from this city. However, the woman who died may be included in studies 66, 138 & 182. Citation: Reis Helena Lucia Barroso dos, Boldrini Neide Aparecida Tosato, Caldas João Victor Jacomele, Paz Ana Paula Calazans da, Ferrugini Carolina Loyola Prest, Miranda Angelica Espinosa. Severe coronavirus infection in pregnancy: challenging cases report. Rev. Inst. Med. trop. S. Paulo [Internet]. 2020 [cited 2020 July 17] ; 62: e49. Available here. Epub July 13, 2020.
Study 193 – Case report from Belgium
A pregnant woman with twins developed mild Covid-19 at 22 weeks gestion (click here or Pulinx 10096_2020_Article_3964). She was nursed at home, but at 24 weeks went into spontanous labour. One twin was stillborn and the other died soon after birth. Amniotic fluid and placental tissue tested positive for SARS-CoV-2. From author affiliations this was probably Sint-Trudo Hospital in Sint-Truiden, which has not previous reported cases. Citation: Pulinx, B., Kieffer, D., Michiels, I. et al. Vertical transmission of SARS-CoV-2 infection and preterm birth. Eur J Clin Microbiol Infect Dis (2020).
Study 192 – Case report from Zhongshan, in Guangdong Province, China
A mother with Covid-19 at 35 weeks gestation suffered from a cytokine storm, and required both ventilation and ECMO (click here or Wang 1-s2.0-S0002937820307286-main). She survived, but the baby died. As the authors note this case was included in Study 3. The hospital, mother’s age, gestational age and baby outcome all suggest she is also the same woman as in studies 57 and 81. Citation: Wang X, Wang D, He S, The role of a cytokine storm in severe COVID-19 disease in pregnancy, American Journal of Obstetrics and Gynecology (2020).
Studies 188 – 191 added.
Study 191 – 27 cases from Barcelona, Spain
This preprint reports 27 pregnant women with COVID-19 of whom seven developed some features of HELLP syndrome (click 2020.07.10.20133801v1.full). The details are difficult to interpret but I think 12 delivered, 5 by Caesarean, and no mothers or babies died. The patients were cared for in two unnamed hospitals which from author afiliations were probably Hospital de la Santa Creu i Sant Pau and Hospital Sant Joan de Deu, both in Barcelona. These hospitals have not previously reported cases under their own names. However, the patients may have been included in the Spanish Covi-Preg registry study 151. Citation: Francesc Figueras, Elisa LLurba, Raigam Martinez-Portilla, Josefina Mora, Fatima Crispi, Eduard Gratacos. COVID-19 causing HELLP-like syndrome in pregnancy and role of angiogenic factors for differential diagnosis. medRxiv 2020.07.10.20133801.
Study 190 – Two cases from Bergamo, Italy
Two pregant women with diabetes contracted Covid -19. Clinical details are given for only one who recovered (click here or ijgo.13306). Both were cared for in Papa Giovanni XXIII Hospital in Bergamo between Feb 22 & May 17, 2020 so have probably been reported in studies 32, 64, 114 & 117. Citation: Dodesini, A.R., Galliani, S., Ciriello, E., Bellante, R. and Trevisan, R. (2020), Pre‐gestational diabetes during the COVID‐19 pandemic in Bergamo, Italy. Int J Gynecol Obstet. Accepted Author Manuscript.
Study 189 – 185 cases from Kuwait
This preprint reports 185 pregnant women with Covid-19 treated in New-Jahra Hospital, where all pregnant women with Covid-19 in Kuwait are treated, between March 15th & May 31st 2020 (click here or firstname.lastname@example.org). No mothers died or required ECMO, although two required ventilation. Three women miscarried, and 41 babies delivered. Two babies tested positive but none died. Citation: Amal Ayed, Alia Embaireeg, Asmaa Benawadth, Wadha Al-Fouzan, Majeda Hammoud, Monif Alhathal, Abeer Alzaydai, Mariam Ayed. Maternal and perinatal characteristics and outcomes of pregnancies complicated with COVID-19 in Kuwait. medRxiv 2020.07.10.20150623.
Study 188 – Four, possibly five, cases from Bergamo, Italy
Four pregnant women with Covid-19 and a further woman who had possible pneumonia one day after delivering twins and two months later had SARS-CoV-2 IgG antbodies, are reported (click here or 1-s2.0-S0014256520301120-main (002)) All mothers and babies survived although one of the four definite Covid-19 mothers developed Guillain-Barré syndrome and remains in hospital. All patients were cared for Bolognini Hospital which is a “spoke center” for COVID 19 in pregnancy in Seriate, Bergamo in Lombardy. It is thus likely that they were included in studies 32, 64 & 117. Citation: Paola Algeri, Valentina Stagnati, Maria Donata Spazzini, Cristina Bellan, Alessandro Montanelli, Gianluigi Patelli & Massimo Ciammella (2020) Considerations on COVID-19 pregnancy: a cases series during outbreak in Bergamo Province, North Italy, The Journal of Maternal-Fetal & Neonatal Medicine.
Study 187 added.
Study 187 – Case report of neonatal infection from Paris
A woman contracted Covid-19 at 35 weeks, required Caesarean for fetal distress, and recovered with supportive treatment (click here or s41467-020-17436-6). The baby was initially well but developed neurological symptoms on day 3. Maternal nasopharynx (NP), blood, placental, vaginal and amniotic samples were all positive for SARS-CoV-2. Baby blood and rectal samples, as well as NP samples on days 1, 3 and 18, were also positive. The baby recovered with supportive treatment. From author affiliations the hospital was Antoine Béclère, Paris. Although not cited, this is case two in study 48. The papers share two authors, Alexandra J Vivanti & Alexandra Benachi, from the same hospital, and all reported maternal and baby characteristics, as well as all the mother’s blood values on the day of birth, are identical. Citation: Vivanti, A.J., Vauloup-Fellous, C., Prevot, S. et al. Transplacental transmission of SARS-CoV-2 infection. Nat Commun 11, 3572 (2020).
Study 186 added.
Study 186 – Case report from Dallas, Texas
A woman with Covid-19 gave birth vaginally at 34 weeks (click here or INTRAUTERINE TRANSMISSION OF SARS COV 2 INFECTION.96099). Despite isolation from the mother, the baby was infected SARS-CoV-2. Mother and baby were cared for at Parkland Health & Hospital System, Dallas, Texas which has not previously reported cases. Citation: Sisman, Julide; Jaleel, Mambarambath A; Moreno, Wilmer; Rajaram, Veena; Collins, Rebecca R.J; Savani, Rashmin; Rakheja, Dinesh; Evans, Amanda S. INTRAUTERINE TRANSMISSION OF SARS-COV-2 INFECTION IN A PRETERM INFANT, The Pediatric Infectious Disease Journal: July 10, 2020 – Volume Online First – Issue – doi: 10.1097/INF.0000000000002815
Studies 183 and 184 added.
Study 184 – 100 cases from Paris
One hundred pregnant women with Covid-19 were treated in four Paris hospitals between March 12 & April 13, 2020 (click here). Ten were admitted to ICU of whom 9 required intubation. There were no stillbirths or miscarriages, but one neonatal death due to prematurity. All neonates were tested for SARS-CoV-2. One was positive but did not show signs of respiratory illness. The hospitals were Antoine Béclère, Clamart; Bicêtre Hospital, Le Kremlin Bicêtre; Louis-Mourier, Colombes; and Centre Hospitalier Sud Francilien, Evry. They therefore include one of the cases in study 48, are included in study 150 and probably also overlap with those in study 157. Citation: Vivanti AJ, Mattern J, Vauloup-Fellous C, Jani J, Rigonnot L, El Hachem L, Le Gouez A, Desconclois C, Ben M’Barek I, Sibiude J, Benachi A, Picone O, Cordier AG. Retrospective Description of Pregnant Women Infected with Severe Acute Respiratory Syndrome Coronavirus 2, France. Emerg Infect Dis. 2020 Jul 6;26(9). doi: 10.3201/eid2609.202144. Online ahead of print.
Study 183 – 18 cases from Renmin hospital in Wuhan
Between Jan 30, & Mar 1, 2020, 10 clinically diagnosed and 8 swab positive pregnant women with COVID-19 were treated at Renmin Hospital of Wuhan University (click here or s12884 020 03026-3). These cases probably overlap with studies 10, 36, 37, 40, and 80. They are also likely to be included in studies 55 & 57. Citation: Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) infection during late pregnancy: a report of 18 patients from Wuhan, China. Zhang L, Dong L, Ming L, Wei M, Li J, Hu R, Yang J. BMC Pregnancy Childbirth. 2020 Jul 8;20(1):394. doi: 10.1186/s12884-020-03026-3.
Study 181 & 182 added. Latter HT Fred Peret.
Study 182 – 124 maternal deaths from Covid-19 in Brazil
Between Feb 26 & June 18, 978 pregnant and postpartum women with COVID-19 were registered with the Brazilian Ministry of Health’s Acute Respiratory Distress Syndrome (ARDS) Surveillance System, of whom 124 died (click here or IJOGfinal (1)). They probably include five cases from study 66. Citation: Takemoto, M.L.S., Menezes, M.O., Andreucci, C.B., Nakamura‐Pereira, M., Amorim, M.M.R., Katz, L. and Knobel, R. (2020), The tragedy of COVID‐19 in Brazil: 124 maternal deaths and counting. Int J Gynecol Obstet. Accepted Author Manuscript.
Study 181 – Rise in stillbirths during pandemic in London
Nineteen women with Covid-19 were cared for at St Georges Hospital in London during the period February 1 to June 14, 2020. None experienced stillbirth. However the overall stillbirth rate in the hospital was significantly higher than in the pre-pandemic period (click here or jama khalil 2020 ld 200076). Included in study 92. Citation: Khalil A, von Dadelszen P, Draycott T, Ugwumadu A, O’Brien P, Magee L. Change in the Incidence of Stillbirth and Preterm Delivery During the COVID-19 Pandemic. JAMA. Published online July 10, 2020. doi:10.1001/jama.2020.12746
Studies 178 -180 added.
Study 180 – case report of postnatal Covid-19 from Monza
A mother developed pyrexia on day two after a normal birth, and both her and her baby tested positive (click here or e20201121.full). The baby was cared for in Fondazione Monza e Brianza per il Bambino e la sua Mamma and Azienda Socio Sanitaria Territoriale-Monza. Monza is in Lombardy so this case may be included in studies 32, 64, 109 & 114. However as a postnatal case it may not. We’re keeping an open mind. Citation: Sinelli M, Paterlini G, Citterio M, et al. Early Neonatal SARS-CoV-2 Infection Manifesting With Hypoxemia Requiring Respiratory Support. Pediatrics. 2020;146(1):e20201121
Study 179 – 67 cases from New York
67 women with SARS-CoV-2 infection from March 13 to April 24, (click here or s-0040-1713851). Patients cared for in seven hospitals within the Northwell Health system in New York: North Shore University Hospital, Long Island Jewish Medical Center, Long Island Jewish Forest Hills, Huntington Hospital, Southside Hospital, Lenox Hill Hospital, and Staten Island University Hospital. The patients probably overlap with those reported in studies 49, 83, 113,118,134 & 162. Citation: Moti Gulersen, Matthew J. Blitz, Burton Rochelson, Michael Nimaroff, Weiwei Shan, Eran Bornstein Clinical Implications of SARS-CoV-2 Infection in the Viable Preterm Period. Am J Perinatol DOI: 10.1055/s-0040-1713851
Study 178 – Ten cases from Wuhan
Ten pregnant women with COVID-19, treated in the Zhongnan Hospital of Wuhan University (grid.413247.7) from Jan 20 to Feb 6 (click here or email@example.com). These women are probably also included in studies 1, 13, 55 & 57, and may also overlap with study 75. Citation: Gong X, Song L, Li H, Li L, Jin W, Yu K, et al. (2020) CT characteristics and diagnostic value of COVID-19 in pregnancy. PLoS ONE 15(7): e0235134.
Study 177 added. Study 176 removed. Duplicate of study 89. Jim’s mistake. HT Keelin.
Study 177 – CTG changes in 12 Covid-19 pregnancies
Intrapartum electronic fetal cardiotocograms (CTGs) from 11 women with Covid-19 and one antepartum CTG at 28 weeks, were evaluated using a physiological system (click here or PIIS0301211520304243). All eleven delivered babies had normal Apgar scores and cord pH. No details of maternal severity, mode of delivery or other baby details were given. Some patients had been cared for in Puerta de Hierro hospital, Madrid, which also included cases in studies 125 and 151. Others came from Germans Trias i Pujol Hospital, Badalona, a northern suberb of Barcelona, which has not previously reported cases. Citation: Gracia-Perez-Bonfils A, Martinez-Perez O, Llurba E, Chandraharan E, Fetal heart rate changes on the cardiotocograph trace secondary to maternal COVID-19 infection, European Journal of Obstetrics and amp; Gynecology and Reproductive Biology (2020).
Study 176 added.
Study 176 – Case report from San Francisco
A 34 year old woman contracted Covid-19 at 28 weeks gestation (click here or Acute Respiratory Distress Syndrome in a Preterm.11). She required ventilation and was delivered by Caesarean section. The baby tested negative. Both recovered. The hospital is not named but authors are all affiliated with University of California, San Francisco. Citation: Blauvelt, Christine A. MD; Chiu, Catherine MD; Donovan, Anne L. MD; Prahl, Mary MD; Shimotake, Thomas K. MD; George, Ronald B. MD, FRCPC; Schwartz, Brian S. MD; Farooqi, Naghma A. MD; Ali, Syed S. MD; Cassidy, Arianna MD; Gonzalez, Juan M. MD, PhD; Gaw, Stephanie L. MD, PhD Acute Respiratory Distress Syndrome in a Preterm Pregnant Patient With Coronavirus Disease 2019 (COVID-19), Obstetrics & Gynecology: July 2020 – Volume 136 – Issue 1 – p 46-51 doi: 10.1097/AOG.0000000000003949
Study 175 added.
Study 175 – 5 cases from Philadelphia, Pennsylvania, US
Five pregnant women with Covid-19 were treated with remdesivir (click here or mccoy remdesevir ajogmfm). Three were ventilated, four delivered and all recovered. One pregnancy is ongoing. All neonates tested negative. From author affiliations these cases may overlap with studies 65 and 86. Citation: Mccoy JA, Short WR, Srinivas SK, Levine LD, Hirshberg A, Compassionate use remdesivir for treatment of severe COVID-19 in pregnant women at a United States academic center, American Journal of Obstetrics & Gynecology MFM (2020).
Study 174 added.
Study 174 – US CDC Covid-19 & pregnancy weekly tracking data
The US Centers for Disease Control (CDC) are now publishing weekly COVID-19 in pregnancy tracking data. The June 25th update (click here) duplicates that in study 172. Citation: US CDC Weekly COVID-19 Pregnancy Data; Pregnant women with COVID-19, United States [January 22-June 23, 2020]. Accessed 26 June 2020.
Studies 171 to 173 added (Study 173 belatedly).
Study 173 – 33 cases from Covid-Net
An April 6th MMWR, which we had previously missed, of SARS-CoV-2 hospitalisations reported to COVID-NET, a network of hospitals representing about 10% of the United States, included 33 pregnant women of whom 3 (9%) had been hospitalised (click here or mm6915e3-H). These cases overlap with studies 171 and 172. Citation: Garg S, Kim L, Whitaker M, et al. Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 — COVID-NET, 14 States, March 1–30, 2020. MMWR Morb Mortal Wkly Rep 2020;69:458–464. DOI: http://dx.doi.org/10.15585/mmwr.mm6915e3
Study 172 – 8,207 pregnant woman with SARS-CoV-2 from CDC
Of 8,207 pregnant women who tested positive for SARS-CoV-2 and were reported to the US Centers For Disease Control by 7th June, 2,587 (31.5%) were hospitalised, 120 (1.5%) admitted to ICU, 42 (0.5%) ventilated, and 16 (0.2%) died. Comparative figures for 83,205 non-pregnant women in the same age group were; 4,840 (5.8) hospitalised, 757 (0.9%) admitted to ICU, 225 (0.3%) ventilated, 208 (0.2%) died (click here or mm6925a1-H). Citation: Ellington S, Strid P, Tong VT, et al. Characteristics of Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status — United States, January 22–June 7, 2020. MMWR Morb Mortal Wkly Rep 2020;69:769–775.
Study 171 – 36 cases from Covid-Net
In this MedRxiv preprint, of 2,491 adults hospitalised with Covid-19, in the US Covid-Net database (154 acute hospitals in 13 states), 26 were pregnant. This represent 12.9% of the 279 women of childbearing age (15–49 years) in the cohort (click here or 2020.05.18.20103390v1.full). [Comment – see table 1. The percentage seems to be wrong.] Citation: Lindsay Kim, Shikha Garg, Alissa O’Halloran, Michael Whitaker, Huong Pham, Evan J. Anderson, Isaac Armistead, Nancy M. Bennett, Laurie Billing, Kathryn Como-Sabetti, Mary Hill, Sue Kim, Maya L. Monroe, Alison Muse, Arthur Reingold, William Schaffner, Melissa Sutton, H. Keipp Talbot, Salina M. Torres, Kimberly Yousey-Hindes, Rachel A Holstein, Charisse Cummings, Lynette Brammer, Aron Hall, Alicia Fry, Gayle E. Langley. Interim Analysis of Risk Factors for Severe Outcomes among a Cohort of Hospitalized Adults Identified through the U.S. Coronavirus Disease 2019 (COVID-19)-Associated Hospitalization Surveillance Network (COVID-NET) medRxiv 2020.05.18.20103390
Studies 165 to 170 added.
Study 170 – 241 cases from the Netherlands
The 19th June update of NethOSS (click here), accessed 24 June 2020, contains the following. 6/224 women with brief additional details were admitted to intensive care. One mother died. 69 women have given birth, 26 by Caesarean. 152 pregnancies are ongoing. No baby has died. No babies were infected. Citation: See Studies 42, 46, 120, 141, & 147. Available here. Accessed 24 June 2020.
Study 169 – 19 June ICNARC report
The 19th June ICNARC update (click here or ICNARC COVID-19 report 2020-06-19.pdf) contains 26 currently, and 37 recently, pregnant women critically ill with Covid-19. Of these 10 are currently, and 24 have in the past, received advanced respiratory support. NOTE – ICNARC has recently started reporting pregnancy data subdivided by white/non white ethnicity.
Study 168 – The PRIORITY study 24 June 2020
The PRIORITY (Pregnancy Coronavirus Outcomes Registry) study (click here) has issued no formal reports yet. However the dashboard (click here accessed 24 June 2020) shows 882 participants, by age group, gestational age band, ethnic group and US state of residence. Citation: University of California San Francisco. PRIORITY Study dashboard. Accessed 24 June 2020.
Study 167 – 23 women in the first trimester from Turin
Of 23 women in this preprint from Medxiv, testing positive for SARS-Cov2 in the first trimester, 11 miscarried and 12 had ongoing prgnancies (click here or 2020.06.19.20135749v1.full). This was a case control study comparing SARS-Cov2 rates between women experiencing miscarriage and matched women with ongoing pregnancy. The rates did not differ significantly. The patients were cared for at S. Anna Hospital, Turin, which has not previously reported cases in the first trimester. Citation: Stefano Cosma, Andrea Carosso, Jessica Cusato, Fulvio Borella, Marco Carosso, Marialuisa Bovetti, Claudia Filippini, Antonio D’Avolio, Valeria Ghisetti, Giovanni Di Perri, Chiara Benedetto. COVID-19 and first trimester spontaneous abortion: a case-control study of 225 pregnant patients. medRxiv 2020.06.19.20135749
Study 166 – 3 cases from Hubei, China
Three pregnant woman with Covid-19 were all delivered by Caesarean (click here or E603.full). The babies all tested negative. The mothers came from a cohort of 166 pregnant women testing positive for SARS-Cov19 in a predefined administrative region containing 12 hospitals, including the Xiangyang First People’s Hospital in Hubei, China. This hospital is not found on GRID.ac. Citation: Peng An, Bradford J. Wood, Wei Li, Min Zhang, Yingjian Ye. Postpartum exacerbation of antenatal COVID-19 pneumonia in 3 women. CMAJ Jun 2020, 192 (22) E603-E606; DOI: 10.1503/cmaj.200553
Study 165 – 65 cases from Madrid
Of 65 women with Covid-19, 13 were diagnosed postnatally. Of the 52 antenatal cases, 32 developed pneumonia and two required ICU admission (click here or PIIS2589537020301516. No mother died. 6/32 women with pneumonia had delivered and no babies were infected. Patients were cared for at University Hospital “12 de Octubre”. They therefore probably overlap with those reported in study 151 but differ from those in study 125. Citation: R. San-Juan et al., Incidence and clinical profiles of COVID-19 pneumonia in pregnant women: A single-centre cohort study from Spain, EClinicalMedicine (2020)
Studies 163 & 164 added.
Study 164 – Two cases from New York
One woman with severe Covid-19 miscarried at 22 weeks. At the time of writing she remained ventilated. Another woman required Caesarean birth at 29 weeks and recovered. Her baby required intubation and tested positive for SARS-Cov2 at 6 days (click here or Futterman NY s-0040-1712978). The hospital is not named. Author affiliations are Dept. OBGYN, New York Medical College, Valhalla, New York, which is affiliated with multiple clinical sites. These cases may therefor have been previously reported. Citation: Itamar Futterman, Miriam Toaff, Liel Navi, Camille A. Clare. COVID-19 and HELLP: Overlapping Clinical Pictures in Two Gravid Patients. Am J Perinatol Rep 2020;10:e179–e182.
Study 163 – 9 cases with placental histology from Milan
Of 9 women with SARS-CoV2 infection delivered between March and April 2020 at Fondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico (Milan), all mothers recovered and all babies tested negative (click here or Cribiu Eur JOG IIS0301211520304164). Placental histology is reported. Although the hospital name differs these cases are probably included in studies 32 & 64. Citation: Cribi `u FM, Croci GA, Gobbo AD, Rizzuti T, Iurlaro E, Tondo M, Viscardi A, Bosari S, Ferrero S, HISTOLOGICAL CHARACTERIZATION OF PLACENTA IN COVID19 PREGNANT WOMEN, European Journal of Obstetrics and amp; Gynecology and Reproductive Biology (2020).
Studies 161 & 162 added.
Study 162 – 462 cases (70 severe) from New York
Of 462 pregnant women with Covid-19, 70 had severe disease, 14 were admitted to ICU, and two died (click here or PIIS0002937820306360). The patients were cared for in the Norwell Hospital network which includes Maimonides Medical Centre. The paper includes a statement about severe case overlap with studies 113, 118 & 134. Shared authorship suggests overlap with studies 49 and 83 as well. Citation: Blitz MJ, Rochelson B, Minkoff H, Meirowitz N, Prasannan L, London V, Rafael TJ, Chakravarthy S, Bracero LA, Wasden SW, Pachtman Shetty SL, Santandreu O, Chervenak FA, Schwartz BM, Nimaroff M, Maternal Mortality Among Women with COVID-19 Admitted to the Intensive Care Unit, American Journal of Obstetrics and Gynecology (2020).
Study 161 – 54 cases from Strasbourg
Of 54 pregnant women with confirmed (n=38) or suspected (n=16) COVID-19 in pregnancy treated at Strasbourg University Hospital (France) from March 1 to April 3, there was one miscarriage, 21 live births (12 vaginal, 9 cesarean), and 32 ongoing pregnancies (click here or PIIS0002937820306396). Five women were admitted to ICU, three required mechanical ventilation and one ECMO. No mothers died, although at the time of writing the woman on ECMO remained on it. All babies tested negative & none died. Strasbourg doctors co-authored the GROG report, so these cases are probably included in study 150. Citation: Sentilhes L, De Marcillac F, Jouffrieau C, Kuhn P, Thuet V, Hansmann Y, Ruch Y, Fafi-Kremer S, Deruelle P, COVID-19 in pregnancy was associated with maternal morbidity and preterm birth, American Journal of Obstetrics and Gynecology (2020).
Studies 157-160 added.
Study 160 – 241 cases from New York
Of 241 pregnant women with laboratory-confirmed SARSCoV-2 infection who gave birth between March 13 & April 12, there were 245 live births to 241 women (6 sets of twins), & 2 stillbirths (click here or Characteristics and_Outcomes of 241 Births to.97310). 17 women were admitted to ITU and 9 intubated. No mothers died, although one woman remained intubated at time of writing. 27% of neonates were admitted to NICU. Of liveborns with SARS-CoV-2 test results 236/230 tested negative. No further neonatal outcomes reported. The five hospitals were “Montefiore Medical Center; Mount Sinai Health System, including Mount Sinai Hospital and Mount Sinai West; its affiliate, NYC Health and Hospitals- Elmhurst Hospital; NewYork-Presbyterian Hospital- Columbia University; and New York University Langone Health, including NYU Langone Hospitals, Manhattan campus, and NYU Langone Hospitals-Brooklyn”. These cases therefore likely overlap with studies 14, 27, 41, 49, 83, 85, 86, 95, 95, 119, 135, 136, & 152. They probably do not overlap with women in studies 61, 113, 118, 122 & 134, which included women cared for in different New York centres. Women in Study 99 are unclear. Citation: Khoury, Rasha MD, MPH; Bernstein, Peter S. MD; Debolt, Chelsea MD; Stone, Joanne MD; Sutton, Desmond M. MD; Simpson, Lynn L. MD; Limaye, Meghana A. MD; Roman, Ashley S. MD; Fazzari, Melissa PhD; Penfield, Christina A. MD; Ferrara, Lauren MD; Lambert, Calvin MD; Nathan, Lisa MD; Wright, Rodney MD; Bianco, Angela MD; Wagner, Brian MD; Goffman, Dena MD; Gyamfi-Bannerman, Cynthia MD; Schweizer, William E. MD; Avila, Karina MPH; Khaksari, Bijan MPH; Proehl, Meghan MPH; Heitor, Fabiano MD; Monro, Johanna BS; Keefe, David L. MD; D’Alton, Mary E. MD; Brodman, Michael MD; Makhija, Sharmila K. MD; Dolan, Siobhan M. MD Characteristics and Outcomes of 241 Births to Women With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection at Five New York City Medical Centers, Obstetrics & Gynecology: June 16, 2020 – Volume Publish Ahead of Print – Issue – doi: 10.1097/AOG.0000000000004025
Study 159 – Three severe cases from New Jersey
Three pregnant women with Covid-19 required ventilation (click here or s-0040-1713664). All three recovered and their pregnancies are ongoing. They were cared for in Morristown Medical Center and St. Peter’s University Medical Center in central New Jersey, neither of which have previously reported cases. Citation: Lucarelli E, Behn C, Lashley S, Smok D, Benito C, Oyelese Y. Mechanical Ventilation in Pregnancy Due to COVID-19: A Cohort of Three Cases [published online ahead of print, 2020 Jun 16]. Am J Perinatol. 2020;10.1055/s-0040-1713664. doi:10.1055/s-0040-1713664
Study 158 – Four patients undergoing amniocentesis from Spain
Four pregnant women with Covid-19 underwent midtrimester amniocentesis for prenatal diangosis of other conditions (click here or 1-s2.0-S0014256520301569-main). No amniotic samples tested postive. The hospital is not named but from author affiliations is probably Hospital Universitario Maternal-Infantil de Jaén, Jaén. This hospital has not previously reported cases, but these cases may be included in study 151 which included registry cases from Spain. Citation: Hijona Elósegui JJ, et al. ¿Existe transmisión materno-fetal del SARS-CoV-2 durante la gestación? Rev Clin Esp. 2020
Study 157 – 88 cases from France
Eighty eight pregnant women with Covid-19 responded to an anonymous internet survey hosted by the French television pregnancy show “la Maison des Maternelles” (click here). 6 had been sufficiently severe to require oxygen. 14 had delivered, 5 by Caesarean. Many are probably included in study 150. Citation: J. Cohen, et al., Covid-19 in pregnant women: General data from a French National Survey, Eur J Obstet Gynecol (2020)
Study 156 added.
Study 156 – Case report of Covid-19, pregnancy & pancreatitis
A 36-year-old woman contracted Covid-19 at 33 weeks (click here or 1 s2.0 S2214911220300588 main). Pancreatitis was diagnosed on the basis of raised lipase, despite normal amylase. She recovered and was later delivered by Caesarean. Both mother & baby discharged in stable condition. Author affiliations Saint Joseph Hospital, Denver, Colorado. Citation: Sarah R. Rabice, Paulina C. Altshuler, Claire Bovet, Cathlyn Sullivan, Amy J. Gagnon. COVID-19 infection presenting as pancreatitis in a pregnant woman: A case report. Case Reports in Women’s Health. Volume 27, 2020, e00228, ISSN 2214-9112
Study 155 added.
Study 155 – Case report of placental infection from Yale
This MedRxiv preprint (click here or SARS CoV-2 infection of the placenta (002)) reports a 35-year-old woman who contracted Covid-19 at 22 weeks gestation. She had coagulopathy and hypertension, and was offered and accepted pregnancy termination, which was performed under GA with extubation on day 1. SARS-CoV-2 RNA was present at high levels in the placenta, and virions were visible on electron microscopy. The hospital is not named but author affiliations are Yale School of Medicine. The case is therefore probably included in study 132. Citation: Hillary Hosier, Shelli Farhadian, Raffaella Morotti, Uma Deshmukh, Alice Lu-Culligan, Katherine Campbell, Yuki Yasumoto, Chantal Vogels, Arnau Casanovas-Massana, Pavithra Vijayakumar, Bertie Geng, Camila Odio, John Fournier, Anderson Brito, Joseph Fauver, Feimei Liu, Tara Alpert, Reshef Tal, Klara Szigeti-Buck, Sudhir Perincheri, Christopher Larsen, Aileen Gariepy, Gabriela Aguilar, Kristen Fardelmann, Malini Harigopal, Hugh Taylor, Christian Pettker, Anne Wyllie, Charles Dela Cruz, Aaron Ring, Nathan Grubaugh, Albert Ko, Tamas Horvath, Akiko Iwasaki, Uma Reddy, Heather Lipkind. SARS-CoV-2 Infection of the Placenta. medRxiv 2020.04.30.20083907
Studies 153 & 154 added.
Study 154 – Case report from Northwick Park Hospital, London
A 34-year woman with immunologic thrombocytopaenia developed a cough, fever, petechiae and gum bleeding at 20 weeks gestation (click here or Nesr BJH case bjh.16928). She had a low platelet count, swabbed positive for SARS-CoV-2 and recovered. Pregnancy outcome not reported, but by implication ongoing. Case presumably included in study 92. Citation: Nesr, G., Garnett, C., Bailey, C. and Arami, S. (2020), ITP flare with mild COVID‐19 infection in pregnancy: A case report. Br J Haematol. Accepted Author Manuscript. doi:10.1111/bjh.16928
Study 153 – Case report from Jordan
A 30-year-old woman, contracted mild Covid-19 at 36 weeks gestation (click here or Al Zaghal Case Rep Jordan 1-s2.0-S2214911220300424-main). She delivered by Caesarean. The baby tested negative. Both recovered. The first report from Jordan. Citation: Laila A. AlZaghal, Najwa AlZaghal, Safwan O. Alomari, Nail Obeidat, Basil Obeidat, Wail A. Hayajneh. Multidisciplinary team management and cesarean delivery for a Jordanian woman infected with SARS-COV-2: A case report. Case Reports in Women’s Health 27 (2020)
Studies 151 & 152 added.
Study 152 – 2 severe cases from New York
Two women with Covid-19 required ventilation and caesarean delivery (click here or Silverstein AmJPerinatol Rep s-0040-1712925). Both neonates tested negative. Both mothers recovered. The hospital(s) are not named but author affiliations suggest either Langone Medical Center or Bellevue Hospital Center. The cases are therefore probably included in studies 85 & 86, and possibly also in studies 49 & 83. Citation: Jenna S. Silverstein, Meghana A. Limaye, Sara G. Brubaker, Ashley S. Roman, Judita Bautista, Judith Chervenak, Adam J. Ratner, Philip M. Sommer, Nicole M. Roselli, Charlisa D. Gibson, David Ellenberg, Christina A. Penfield. Acute Respiratory Decompensation Requiring Intubation in Pregnant Women with SARS-CoV-2 (COVID-19) Am J Perinatol Rep 2020;10:e169–e175.
Study 151 – 82 cases from Spain
Of 82 women with singleton pregnancies and Covid-19, who delivered within 14 days of disease onset, collected from from 96 level 2 or 3 maternity hospitals in Spain, 9 were admitted to ICU and 7 ventilated (click here or jama martnezperez 2020 ld 200062). Five babies tested positive. No mothers or babies died. The hospitals are not named but author affiliations include Puerta de Hierro University Hospital, 12 Octubre University Hospital, & Gregorio Marañon University Hospital, all three from Madrid. Three other authors are associated with the Covi-Preg registry in Switzerland (click here). The cases probably overlap with those in studies 53 & 125. Citation: Martínez-Perez O, Vouga M, Cruz Melguizo S, et al. Association Between Mode of Delivery Among Pregnant Women With COVID-19 and Maternal and Neonatal Outcomes in Spain. JAMA. Published online June 08, 2020. doi:10.1001/jama.2020.10125
Study 150 added.
Study 150 – 617 cases from France
Thirty three maternity units from the “Groupe de Recherche en Obstétrique et Gynécologie (GROG)” treated 617 pregnant women with COVID-19 between March 1 & April 14 (click here or GIlles France JOG HR). Eighty three women required nasal oxygen, a further 10 non-invasive ventilation, a further 29 mechanical ventilation and a further six, ECMO. One woman died. There were 5 miscarriages and 7 stillbirths among the 181 pregnancies which had ended. Among the 190 live births (7 twins & 1 set of triplets) there was one neonatal death. Two babies tested positive. The 33 maternity units (including 24 tertiary referral centers) are not named, although 19 can be guessed from the author affiliations. Citation: Kayem G, Alessandrini V, Azria E, Blanc J, Bohec C, Bornes M, Bretelle F, Ceccaldi P-Franc¸ois, Chalet Y, Chauleur C, Cordier A-Gael, Deruelle P, Desbri`ere R, Doret M, Dreyfus M, Driessen M, Fermaut M, Gallot D, Garab´edian C, Huissoud C, Lecarpentier E, Luton D, Morel O, Perrotin F, Picone O, Rozenberg P, Schmitz T, Sentilhes L, Sroussi J, Vayssi`ere C, Verspyck E, Vivanti AJ, Winer N, A snapshot of the Covid-19 pandemic among pregnant women in France, Journal of Gynecology Obstetrics and Human Reproduction (2020)
Study 149 added.
Study 149 – 73 cases, 8 severe, from New Jersey
Of 73 pregnant women with COVID-19, 31 were admitted, of whom 8 visited ICU. Of these 6 needed intubation, and 1 ECMO (click here or 1-s2.0-S2589933320300951-main). 7 of the 8 ICU cases were delivered by Caesarean and one remains undelivered. All babies were isolated and fed artificial or donor milk. All tested negative. All mothers were discharged from intensive care. No babies died but four remain in hospital. No details given of the non ICU cases. The “network’s two largest hospitals” in which the patients were treated are not named. The authors are affiliated with three large hospitals in New Jersey Hackensack University Medical Center, University Hospital (Newark, New Jersey) and Hackensack Meridian Jersey Shore University Medical Center. The patients are therefore probably different from those reported in Studies 86, and 111. Citation: Romagano MP, Guerrero K, Spillane N, Kayaalp E, Smilen SW, Alvarez M, Alvarez-Perez J, Francis Kim A, Aschner J, Al-Khan A, Perinatal outcomes in critically ill pregnant women with COVID-19, American Journal of Obstetrics & Gynecology MFM (2020)
Studies 143 to 146 added.
Study 146 – 8 cases from Turkey
Two pregnant women with Covid-19 were delivered by Caesarean at term, one miscarried at 7 weeks and five pregnancies are ongoing (click here or jum.15367). One delivered baby tested negative. No details are reported of the other. All mothers recovered. The tertiary hopsital is not named but from author affiliations is probably Sehit Prof Dr Ilhan Varank Sancaktepe Training & Research Hospital, Istanbul. These case are therefore unlikely to overlap with those in Studies 31 and 145. Citation: Yassa M, Birol P, Mutlu AM, Tekin AB, Sandal K, Tug N. Lung Ultrasound Can Influence the Clinical Treatment of Pregnant Women With COVID-19 [published online ahead of print, 2020 Jun 1]. J Ultrasound Med. 2020;10.1002/jum.15367. doi:10.1002/jum.15367
Study 145 – Case report from Turkey
A 25 year old woman with Covid-19 was delivered by Caesarean at 38 weeks (click here or 1-s2.0-S0952818020308953-main). The mother recovered and the baby tested negative. The hospital is not named but from author affiliations is likely Necmettin Erbakan University, Meram Faculty of Medicine, Konya, Turkey. The patient is different from the one in study 31. Citation: Resul Yilmaz, FatmaKiliç, Şule Arican, Gülçin Hacibeyoğlu, Halime Süslü, Mustafa Koyuncu, Sema Tuncer Uzun. Anesthetic management for cesarean birth in pregnancy with the novel coronavirus (COVID-19). Journal of Clinical Anesthesia. Available online 27 May 2020.
Study 144 – 2 (or 3) cases from Tokyo
Of 52 asymptomatic pregnant women screened for SARS-CoV-2 between April 6 and April 27, two tested positive and one, whose partner had Covid-19, was treated as if she was infected despite a negative test (click here or ijgo.13252). All three were delivered by Caesarean section, and their babies isolated. No babies were infected. Patients were cared for in Keio University Hospital, Tokyo. These are the first cases of Sars-Cov2 from Japan. Citation: Ochiai, D., Kasuga, Y., Iida, M., Ikenoue, S. and Tanaka, M. (2020), Universal screening for SARS‐CoV‐2 in asymptomatic obstetric patients in Tokyo, Japan. Int J Gynecol Obstet. Accepted Author Manuscript. doi:10.1002/ijgo.13252
Study 143 – 12 cases from Korea
Twelve women with COVID-19 were admitted for delivery between February 26th & to April 3rd 2020 (click here or kja-20204). Four birthed vaginally and 8 by Caesarean. Two babies were stillborn. All patients were cared for at Daegu Fatimal Hospital, Korea, (see Study 22 cited in paper). Although there is no explicit statement about whether the patient in Study 22 was included, the clinical details (age and gestation) differ, so it is likely that all 12 have not previously been reported. Citation: Jeongmin Oh, Eunju Kim, Hyunkyum Kim, Sang-Ah Lee, Kyeong Hee Lee, Mi Hyae Yu, Jihyun An. Infection control of operating room and anesthesia for cesarean section during pandemic Coronavirus disease-19 (COVID-19) outbreak in Daegu, the republic of Korea – 8 cases report. Korean J Anesthesiol [Epub ahead of print]. Published online June 5, 2020.
Studies 141 and 142 added.
Study 142 – 61 cases from Boston Massachusetts
Of these 61 women with Covid-19 in pregnancy, cared for at a single academic medical centre, 21 were admitted to hospital, of whom 6 went to intensive care, of whom four were intubated (click here or Prevalence and Severity of Coronavirus Disease.97338). No mothers died. The hospital is not named, but from author affiliations is likely Massachusetts General Hospital, Boston, Mass. If so, these women probably differ from those reported in Study 129, and have not previously been reported. Citation: Goldfarb, Ilona Telefus MD, MPH; Clapp, Mark A. MD, MPH; Soffer, Marti D. MD, MPH; Shook, Lydia L. MD; Rushfirth, Katherine CNM, MSN; Edlow, Andrea G. MD, MSc; Boatin, Adeline A. MD, MPH; Kaimal, Anjali J. MD, MAS; Barth, William H. Jr MD; Bryant, Allison S. MD, MPH Prevalence and Severity of Coronavirus Disease 2019 (COVID-19) Illness in Symptomatic Pregnant and Postpartum Women Stratified by Hispanic Ethnicity, Obstetrics & Gynecology: June 02, 2020 – Volume Publish Ahead of Print – Issue – doi: 10.1097/AOG.0000000000004005
Study 141 – 201 women from the Netherlands Covid in pregnancy registry
The 22nd May update of NethOSS (click here), accessed 4 June 2020, contains the following. 7/176 women with brief additional details were admitted to intensive care. One mother died after prolonged admission and intubation as a result of pulmonary infection with multiple pulmonary emboli. 49 women have given birth, 16 by Caesarean. 124 pregnancies are ongoing. No baby has died. No babies were infected. Citation: See Studies 42, 46 & 120. Available here. Accessed 4 June 2020.
Study 140 added.
Study 140 – 42 cases from Barcelona
Forty two pregnant women with Covid-19 between March 13 & April 10 (click here or 1471-0528.16339). Eight required admission to ICU of whom 6 developed some features of pre-eclampsia, 4 requiring Caesarean, one of which was due to HELLP syndrome. No maternal or baby outcomes are reported but it is implied “after recovery from severe pneumonia, hypertensive therapy was no longer required in all cases” that all women recovered. The “tertiary care” hospital is not named but from author affiliations is likely to be Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona. If so, these cases have not been previously reported. Citation: Mendoza, M., Garcia‐Ruiz, I., Maiz, N., Rodo, C., Garcia‐Manau, P., Serrano, B., Lopez‐Martinez, R.M., Balcells, J., Fernandez‐Hidalgo, N., Carreras, E. and Suy, A. (2020). Preeclampsia‐like syndrome induced by severe COVID‐19: a prospective observational study. BJOG. doi:10.1111/1471-0528.16339
Studies 138 (HT Frederico Amedee Peret) & 139 added. Study 137 removed.
Study 139 – 13 cases in Washington state
Twelve women with Covid-19 were detected through targeted testing, and one by universal screening (click here or ciaa675). No separate clinical details given for the SARS-Cov2 positive women. Patients were treated at the University of Washington Montlake Labor and Delivery Unit and Northwest Birth Center. They therefore likely overlap with Study 102. Citation: Sylvia M LaCourse, Alisa Kachikis, Michela Blain, LaVone E Simmons, James A Mays, Amber D Pattison, Carol C Salerno, Stephen A McCartney, Nicole M Kretzer, Rebecca Resnick, Rosemary L Shay, Leah M Savitsky, Anna C Curtin, Emily M Huebner, Kimberly K Ma, Shani Delaney, Carlos Delgado, Adrienne Schippers, Jeff Munson, Paul S Pottinger, Seth Cohen, Santiago Neme, Lori Bourassa, Andrew Bryan, Alex Greninger, Keith R Jerome, Alison C Roxby, Erica Lokken, Edith Cheng, Kristina M Adams Waldorf, Jane Hitti. Low prevalence of SARS-CoV-2 among pregnant and postpartum patients with universal screening in Seattle, Washington. Clinical Infectious Diseases ciaa675
Study 138 – 36 deaths among 484 pregnant women with Covid-19 in Brazil
Bulletin no 17 from the Brazilian Ministry of Health contains a special section on pregnant women with Covid-19 (click here or 2020-05-25—BEE17—Boletim-do-COE). The report is in Portugese. I’ve prepared an English translation of the pregnancy section using google translate Brazil MoH Covid 19 Bulletin 17 translation of pregnancy section. Citation: Ministério da Saúde, Secretaria de Vigilância em Saúde. Boletim Epidemiológico Especial da COVID-19 no Brasil. Número do boletim 17. 25 May 2020
Study 137 added.
Study 137 – A patient with Covid-19 & an ectopic pregnancy
A 37-year-old woman tested positive for SARS-Cov2 and presented two days later with an ectopic pregnancy (click here or Ectopic Pregnancy During Coronavirus Disease 2019). The authors discuss treatment options but give no further clinical details. Although the report is ambiguous, it is conventional in educational medical reports to present real cases unless stated otherwise. From author affiliations the patient was likely cared for in South Dakota or Texas. Citation: Hansen, Keith A; Stovall, Dale W. Ectopic Pregnancy During Coronavirus Disease 2019 (COVID-19), Obstet Gynecol: May 27, 2020 doi: 10.1097/AOG.0000000000003995
Study 136 added.
Study 136 – 158 cases from New York
Of 158 pregnant women with Covid-19, 34 had moderate or severe disease, 9 received ICU or step down care and 1 required intubation. There were no deaths (click here or Andrikopoulou Green Symptoms and Critical Illness Among Obstetric Patients With Coronavirus Disease 2019 (COVID-19) Infection). No baby outcomes reported. Patients were cared for at New York Presbyterian/Columbia University Irving Medical Center, and at
New York-Presbyterian/Allen Hospital. Cases presumably overlap with those in studies 14, 27, 41 & 95. Citation: Andrikopoulou, Maria; Madden, Nigel; Wen, Timothy; Aubey, Janice J; Aziz, Aleha; Baptiste, Caitlin D; Breslin, Noelle; D’Alton, Mary E; Fuchs, Karin; Goffman Dena; Gyamfi-Bannerman, Cynthia; Matseoane-Peterssen, Dara N; Miller, Russell S; Sheen, Jean-Ju; Simpson, Lynn L; Sutton, Desmond; Zork, Noelia; Friedman, Alexander M. Symptoms and Critical Illness Among Obstetric Patients With Coronavirus Disease 2019 (COVID-19) Infection, Obstet Gynecol May 27, 2020 – doi: 10.1097/AOG.0000000000003996
Studies 133 to 135 added.
Study 135 – 50 cases from New York
Among 307 asymptomatic women tested on admission in labour, 50 were SARS CoV-2 positive (click here or Buckley Mount Sinai AJOGMFM). The women were tested between April 4 & 15, 2020, at two institutions within Mount Sinai Health System in New York. They therefore probably overlap with those in Study 119. Citation: Buckley A, Bianco A, Stone J, Universal testing of patients and their support persons for COVID-19 when presenting for admission to Labor and Delivery within the Mount Sinai Health System, Am J Obstet Gynecol MFM (2020).
Study 134 – 125 cases from New York
These authors report further details on 12 pregnant women with severe Covid 19, out of 125 in total (click here or McLaren AJOG PIIS0002937820305676). 7 were delivered by Caesarean, 2 vaginally, and 3 remain undelivered. No mothers died, although one remains in hospital. This is an update on study 113, and again the hospital is presumably Maimonides Medical Center, Brooklyn, NY. Citation: MCLAREN Jr. RA, LONDON V, ATALLAH F, MCCALLA S, HABERMAN S, FISHER N, STEIN JL, MINKOFF HL, Delivery For Respiratory Compromise Among Pregnant Women With COVID-19, Am J Obstet Gynecol (2020).
Study 133 – 3 cases identified by screening in North Tuscany
By screening 533 women admitted for delivery for SARS-CoV2 between March 26th & April 1st in North Tuscany and Liguria, these authors identified 3 positives, who all gave birth without clinical problems (click here or PIIS0002937820305421). The women birthed in all the 6 hospitals of Azienda USL “Toscana Nord Ovest” (Tuscany), and Gaslini Children’s Hospital (Genoa, Liguria). They have therefore probably not previously been reported. Citation: Gagliardi L, Danieli R, Suriano G, Vaccaro A, Tripodi G, Rusconi F, Ramenghi LA, Universal SARS-CoV-2 testing of pregnant women admitted for delivery in two Italian regions. Am J Obstet Gynecol (2020).
Study 132 added (HT @janevandis).
Study 132 – 42 cases from Connecticut
Of 782 women presenting for childbirth between April 2nd & 29th, 2020, 12 had already been diagnosed with Covid-19. Of the remainder 30/770 screened positive, 22 of whom were asymptomatic (click here or jama_campbell_2020_ld_200052). No clinical outcomes reported. No health care workers infected. Patients were cared for in 3 Yale New Haven Health hospitals in southern Connecticut. Citation: Katherine H. Campbell, Jean M. Tornatore, Kirsten E. Lawrence, Jessica L. Illuzzi, L. Scott Sussman, Heather S. Lipkind, Christian M. Pettker. Prevalence of SARS-CoV-2 Among Patients Admitted for Childbirth in Southern Connecticut. JAMA. Published online May 26, 2020. doi:10.1001/jama.2020.8904
Studies 129 to 131 added.
Study 131 – Anti-SARS-Cov2 IgA antibodies in breast milk of recovering women
The authors of this not yet peer-reviewed preprint report anti SARS-Cov2 IgA antibodies in breast milk samples from 15 women previously infected with SARS-Cov2 (click here or 2020.05.04.20089995v1.full). No clinical details. The authors, mainly from Icahn School of Medicine at Mount Sinai, New York, report that they have recruited over 350 lactating women who have recovered from COVID-19. Citation: Alisa Fox, Jessica Marino, Fatima Amanat, Florian Krammer, Jennifer Hahn-Holbrook, Susan Zolla-Pazner, Rebecca L Powell. Evidence of a significant secretory-IgA-dominant SARS-CoV-2 immune response in human milk following recovery from COVID-19
Study 130 – Case report from Amsterdam Medical Centre
A woman developed Covid-19 at 41 weeks gestation (Click here or ajh.25877). She also developed autoimmune throbocytopaenia. The baby was delivered by Caesarean. Citation: Man Wai Tang, Erfan Nur, Bart J. Biemond. Immune Thrombocytopenia during Pregnancy due to COVID-19. Am J Haematol. First published:23 May 2020
Study 129 – 15 patients from Boston, Massachusetts
Of 213 admitted pregnant women screened by differential white blood count, 15 had Sars-Cov2 (click here or Duffy Green Lymphopenia and Severe Acute Respiratory Syndrome). Three required critical care for hypoxia. No other clinical details. From author affiliations patients were probably cared for in Beth Israel Deaconess Med Center, Harvard Med School, Boston, Mass. Citation: Duffy, Cassandra R. MD, MPH; Hart, Jessica M. MD; Modest, Anna M. PhD; Hacker, Michele R. ScD; Golen, Toni MD; Li, Yunping MD, MSc; Zera, Chloe MD, MPH; Shainker, Scott A. DO, MS; Mehrotra, Preeti MD, MPH; Zash, Rebecca MD; Wylie, Blair J. MD, MPH Lymphopenia and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Among Hospitalized Obstetric Patients, Obstetrics & Gynecology: May 19, 2020 – Volume Publish Ahead of Print – Issue – doi: 10.1097/AOG.0000000000003984
Studies 127-8 added.
Study 128 – 13 patients from North East Flanders
Of 470 pregnant women screened, 13 tested positive for SARS-Cov2, 8 were asymptomatic 4 had mild upper airway symptoms, and one respiratory symptoms. None developed severe disease (click here or Ceulemans Flanders uog.22099 (1)) The hospitals caring for the four patients are unnamed but shown on a map. Citation: D. Ceulemans, I. Thijs, A. Schreurs, J. Vercammen, L. Lannoo, J. Deprest, J. Richter, L. De Catte, R. Devlieger. Screening for COVID-19 at childbirth: does it deliver? Ultrasound Obstet Gynecol. In press.
Study 127 – SARS-CoV-2 in human breastmilk
Breast milk from two nursing mothers infected with SARS-CoV-2 was tested. Samples from one woman were positive (click here or PIIS0140673620311818). Where the patients were cared for, was not reported. The authors came from Ulm in Germany. Citation: Rüdiger Groß, Carina Conzelmann, Janis A Müller, Steffen Stenger, Karin Steinhart, Frank Kirchhoff, Jan Münch. Detection of SARS-CoV-2 in human breastmilk. Lancet. Published online May 21, 2020
Study 126 – The ISARIC report in the BMJ
Among 20,133 patients admitted to hospital with covid-19 in the UK, 100/1033 (10%) women of childbearing age, were reported as being pregnant (click here or bmj.m1985.full). This is similar to the estimated proportion of pregnant women in the community. Pregnancy was not associated with mortality. This is an update of study 68. Citation: Docherty Annemarie B, Harrison Ewen M, Green Christopher A, Hardwick Hayley E, Pius Riinu, Norman Lisa et al. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. BMJ 2020; 369 :m1985
Studies 121-125 added.
Study 125 – 60 cases from Madrid
Of 60 pregnant women with COVID-19 (click here or aogs.13921), 18 had pneumonia, 2 severely. One woman was admitted to ICU. No mothers died. Of 23 women delivered, 5 were by cesarean and 18 vaginally. Two delivered preterm. All 23 babies tested negative, and 21 were breast fed. Two babies were admitted to NICU for other reasons. No babies died. The patients were all were treated at Puerta de Hierro University Hospital Madrid, Spain from March 14th to April 14th, 2020. Citation: Pereira, A., Cruz‐Melguizo, S., Adrien, M., Fuentes, L., Marin, E. and Perez‐Medina, T. (2020), Clinical course of Coronavirus Disease‐2019 (COVID‐19) in pregnancy. Acta Obstet Gynecol Scand. Accepted Author Manuscript. doi:10.1111/aogs.13921
Study 124 – 16 cases from Chicago
Fourteen patients delivered at term, 1 at 34 weeks, & 1 at 16-weeks (click here or aqaa089). No mothers admitted to ITU. No mother or baby deaths. No baby infections. The cases were identified via a search of placental pathology records. Where the women were cared for is not recorded, but from author affiliation and a footnote probably includes Prentice Women’s Hospital, Northwestern Memorial Hospital and Feinberg School of Medicine, Northwestern University, Chicago. Citation: Elisheva D Shanes, Leena B Mithal, Sebastian Otero, Hooman A Azad, Emily S Miller, Jeffery A Goldstein. Placental Pathology in COVID-19, Am J Clin Pathol. aqaa089, Published: 22 May 2020
Study 123 – 16 cases from Michigan
Two patients received oxygen via nasal cannula, none were admitted to ITU. There were 8 vaginal births (one preterm) and 2 Caesareans. No babies were infected. Six women remain undelivered (click here or Qadri Michigan Pregnancy affected by SARS CoV 2 infection a flash report…). Citation: Farnoosh Qadri & Federico Mariona (2020) Pregnancy affected by SARS-CoV-2 infection: a flash report from Michigan. J Mat-Fetal & Neonatal Med. DOI: 10.1080/14767058.2020.1765334
Study 122 – Response of Northwell Health to Covid-19 in pregnancy
A detailed description of how a large multi-hospital network in the centre of the New York pandemic organised itself to care for women with Covid-19 in pregnancy (click here or Rochelson [16193997 – Journal of Perinatal Medicine] New York). No patient numbers or details. Citation: Burton Rochelson, Michael Nimaroff, Adriann Combs, Benjamin Schwartz, Natalie Meirowitz, Nidhi Vohra, Victor R. Klein, Orlando Santandreu, Mitchell Kramer, Navid Mootabar, Eli Serur, Lisa Spiryda, Scott Berlin. Frank Chervenak. The Care of Pregnant Women During the COVID-19 Pandemic – Response of a Large Health System in Metropolitan New York. J Perinat Med. 2020 May 20;/j/jpme.ahead-of-print/jpm-2020-0175/jpm-2020-0175.xml. doi: 10.1515/jpm-2020-0175. Online ahead of print.
Study 121 – One week’s screening in Los Angeles
The Cedars-Sinai Medical Center, Los Angeles, California screened 82 pregnant women over a one week period (Bianco Green – Testing of Patients and Support Persons for Coronavirus Disease 2019 (COVID-19) – Infection Before Scheduled Deliveries). None of the 80 asymptomatic women tested positive but one of two symptomatic ones did. No further details reported. Citation: Mariam Naqvi, Richard M Burwick, John A Ozimek, Naomi H Greene, Sarah J Kilpatrick, Melissa S Wong. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Universal Testing Experience on a Los Angeles Labor and Delivery Unit. Obstet Gynecol. In press.
Studies 116-120 added.
Study 120 – 191 women from the Netherlands Covid-19 registry
This 14 May update of NethOSS (click here), accessed 21 May 2020, contains the following. 6/156 women with brief additional details were admitted to intensive care; one remains there. One mother had a molar pregnancy and one a miscarriage. 47 women have given birth, 16 by Caesarean. 109 pregnancies are ongoing. No mother or baby has died. No babies were infected. Citation: See Studies 42 and 46. Available here. Accessed 21 May. Note: we probably missed some intermediate updates from this registry.
Study 119 – 24 cases identified by screening in New York
24/155 asymptomatic women screened for SARS-COV-2 prior to a planned delivery, tested positive (click here or Bianco Green – Testing of Patients and Support Persons for Coronavirus Disease 2019 (COVID-19) – Infection Before Scheduled Deliveries). All their newborns were tested and none were positive. No maternal outcomes were reported. The patients were all cared for in the Mount Sinai Health system between April 4th and 15th. From author affiliations this was Icahn School of Medicine at Mount Sinai Hospital. These cases may therefore overlap with some in study 64. Citation: Bianco, Angela; Buckley, Ayisha B; Overbey, Jessica; Smilen, Scott; Wagner, Brian; Dinglas, Cheryl; Loudon, Holly; Garely, Alan; Brodman, Michael; Stone, Joanne. Testing of Patients and Support Persons for Coronavirus Disease 2019 (COVID-19) Infection Before Scheduled Deliveries, Obstetrics & Gynecology: May 19, 2020 – Volume Publish Ahead of Print – Issue – doi: 10.1097/AOG.0000000000003985
Study 118 – a maternal death from New York
A 36-year-old woman developed Covid-19 at 37 weeks gestation (click here or Vallejo Green A Postpartum Death Due to Coronavirus Disease 2019 (COVID-19) in the United States). Within three hours of admission she required intubation and Caesarean, and she died within 36 hours. The baby tested negative and survived. The hospital is not named, and she was not transferred. From the author affiliations it was either Dept OBGYN, Urban Health Plan, Inc., Bronx, or Division of Maternal-Fetal Med, Dept OBGYN, Weill Cornell Medicine, New York. Citation: Victoria Vallejo, John G. Ilagan. A Postpartum Death Due to Coronavirus Disease 2019 (COVID-19) in the United States. Obstet Gynecol 2020;00:1–4 DOI: 10.1097/AOG.0000000000003950
Study 117 – 77 cases from 12 Italian hospitals
From Feb 23 to March 28th, 14/77 women with Covid-19 were severely affected, and one required ECMO (click here or Savasi Green Clinical Findings and Disease Severity in Hospitalized Pregnant Women With Coronavirus Disease 2019 (COVID-19)). 57 gave birth, 22 by Caesarean. Four newborns tested positive for SARS-COV-2, but none had symptoms. 20 pregnancies are ongoing. No mothers or babies died. The 12 hospitals L. Sacco (Milan), Mangiagalli (Milan), S. Gerardo MBBM Foundation (Monza), Papa Giovanni XXIII (Bergamo), and San Matteo (Pavia) and the hospitals of Padua, Florence, Lecco, Trento, Modena, Seriate and Piacenza. These are the same hospitals as studies 33 & 64. The patients probably overlap. Citation: Valeria M. Savasi, Francesca Parisi, Luisa Patanè, Enrico Ferrazzi, Luigi Frigerio, Antonio Pellegrino, Arsenio Spinillo, Saverio Tateo, Mariacristina Ottoboni, Paola Veronese, Felice Petraglia, Patrizia Vergani, Fabio Facchinetti, Donata Spazzini, Irene Cetin. Clinical Findings and Disease Severity in Hospitalized Pregnant Women With Coronavirus Disease 2019 (COVID-19). Obstet Gynecol in press.
Study 116 – A “universal testing in pregnancy” series from Chicago
Northwestern Memorial Hospital, tested a consecutive series of 635 pregnant women admitted between April 8th & 28th, 2020. Of these 23 (3.6%) tested positive for SARS-CoV-2, of whom 10 (44%) were asymptomatic on presentation (click here or Miller NorthWestern Clinical Implications of Universal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Testing in Pregnancy). No maternal or baby outcomes were reported. Citation: Emily S. Miller, William A. Grobman, Allie Sakowicz, Jessica Rosati, Alan M. Peaceman. Clinical Implications of Universal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Testing in Pregnancy. Obstet Gynecol. In press.
Studies 113 (HT Fred Peret. We’d missed it!) to 115 added.
Study 115 – Case report of Covid-19 & severe pre-eclampsia
A 26-year-old with Covid-19 at 37 weeks gestation also had severe pre-eclampsia (click here or AJOGMFM-20-1073 ). She was treated with magnesium sulphate and delivered vaginally. The baby tested negative. Both recovered. From author affiliations likely cared for at Stanford University Hospital. Citation: Noor Joudi, Andrea Henkel, W. Scott Lock, Dierdre Lyell, Preeclampsia Treatment in SARS-CoV-2. Am J Obstet Gynecol. In press.
Study 114 – 22 women from Bergamo, Italy
Of 22 women with Covid-19 in pregnancy two neonates tested positive, one born vaginally and one by caesarean. Both did well. Their placental histology is described (click here or AJOGMF-20-1112). No other mother or baby details are given. The women were cared for between March 5, & April 21, 2020 at Papa Giovanni XXIII Hospital, Bergamo, in the Lombardy region of Italy, so the women were probably also reported in study 32 & study 64.
Study 113 – 68 SARS-Cov-2 positive pregnant women from New York
46 had Covid-19 and a further 22 asymptomatic women tested positive for SARS-Cov-2 (click here or s-0040-1712164). 12 women had severe disease, one requiring ventilation. There was one intrauterine death at 17 weeks but otherwise no mothers or babies died. All babies tested negative. 12 pregnancies are ongoing. Women were cared for at a tertiary care hospital in Brooklyn, from March 15 to April 15, 2020. From author affiliations probably Maimonides Medical Center, Brooklyn, NY. If so, they have not been previously reported. Citation: Viktoriya London, Rodney McLaren Jr., Fouad Atallah, Catherine Cepeda, Sandra McCalla, Nelli Fisher, Janet L. Stein, Shoshana Haberman, Howard Minkoff. The Relationship between Status at Presentation and Outcomes among Pregnant Women with COVID-19. Am J Perinatol. ISSN 0735-1631. Online April 27, 2020
Studies 108 to 112 added.
Study 112 – Case report from Nashville, Tennessee
A 35-year-old developed Covid-19 at 22 weeks gestation requiring intubation & ventilation (click here or 1-s2.0-S2214911220300515-main). She recovered and the pregnancy is ongoing. U Tennessee Health Science Center has not previously reported cases. Citation: J. Anderson, J. Schauer, S. Bryant, et al., The use of convalescent plasma therapy and remdesivir in the successful management of a critically ill obstetric patient with novel coronavirus 2019 infection: A case report. Case Rep Women’s Health (2020)
Study 111 – Case report from Livingstone, New Jersey
A 39-year-old woman, with IVF twins developed Covid-19 at 27 weeks of gestation (click here or 1-s2.0-S2214911220300503-main). She required ventilation and then an emergency classical Cesarean section a the bedside due to rapid deterioration. She recovered. One twin was infected, but both survived. She was cared for in Saint Barnabas Medical Center, Livingston, New Jersey, which has not previously reported a case. Citation: H. Mehta, S. Ivanovic, A. Cronin, et al., Novel coronavirus related acute respiratory distress syndrome in a patient with twin pregnancy: A case report. Case Rep Women’s Health (2020)
Study 110 – Case report from Thailand
A 43-year-old with mild Covid-19 at 18 weeks gestation (click here or Panichaya Thailand PIIS0301211520303134). Amniocentesis done a week earlier showed trisomy 21, & the pregnancy was terminated. Placental & fetal swabs were negative. Citation: Panichaya P, Thaweerat W, Uthaisan J. Prolonged viral persistence in COVID-19 second trimester pregnant patient, Eur J Obstet & Gynecology & Reprod Biol (2020)
Study 109 – 4 women from Parma, Italy
Four women with Covid-19 recovered and later delivered healthy term neonates (click here or Acta BioMed Parma 9743-Article Text-49126-2-10-20200514). They were cared for in Parma Hospital, in the Emilia-Romagna (not Lombardy) region of Italy. Citation: Serafina Perrone, Michela Deolmi, Maurizio Giordano, Tiziana D’Alvano, Lucia Gambini, Mara Corradi, Tiziana Frusca, Tullio Ghi, Susanna Esposito. Report of a series of healthy term newborns from convalescent mothers with COVID-19. Acta Biomed 2020; Vol. 91, N. 2: 251-255 DOI: 10.23750/abm.v91i2.9743
Study 108 – 27 cases from Central Hospital of Wuhan
These 27 women with Covid-19 in pregnancy included 4 early pregnancies. They delivered 24 babies (1 set of twins) (click here or Yang Wuhan arpa.2020-0232-sa). They were cared for at “Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology in Wuhan” between Jan 20 & Mar 19, 2020. Assuming this is Central Hospital of Wuhan, grid.440160.7 these cases likely overlap with studies 39 and 73. They are probably also included in studies 55 & 57. Citation: Hui Yang, Bin Hu, Sudong Zhan, Li-ye Yang, Guoping Xiong. Effects of SARS-CoV-2 infection on pregnant women and their infants: A retrospective study in Wuhan, China. Arch Pathol Lab Med. In press. doi: 10.5858/arpa.2020-0232-SA
Studies 105 to 107 added.
Study 107 – Maternal death in Birmingham, UK
A 29-year-old woman with severe Covid-19 was delievered by Caesareran section at Birmingham Heartlands Hospital at 31 weeks gestation (click here or Mat Death Bham BrJH bjh.16849). The baby tested negative and is doing well. The mother intially improved and was extubated on day 2 post natal. However on day 6 she developed basilar artery thrombosis, and she died on day 7. Case presumably included in study 92 UKOSS. Citation: Irshad Ahmed, Ahamed Azhar, Nashwa Eltaweel, Bee K Tan. First Covid-19 maternal mortality in the UK associated with thrombotic complications. In press. doi: 10.1111/bjh.16849
Study 106 – 2 cases from Reading, UK
Two women with severe Covid-19 were treated at the Royal Berkshire Hospital (click here or Cooke Reading PIIS0301211520302761 (002). Both were preterm (28+4, 28+6 days) and required Caesarean for deteriorating maternal condition. Both mothers recovered. One baby had a perforated bowel but both eventually recovered. Presumably both cases were included in study 92 UKOSS. Citation: Cooke WR, Billett A, Gleeson S, Jacques A, Place K, Siddall J, Walden A, Soulsby K. SARS-CoV-2 infection in very preterm pregnancy: experiences from two cases, Eur J Obstet Gynecol & Reprod Biol (2020)
Study 105 – 12 cases from from Hospital Pedro Hispano, Portugal
All 123 pregnant women admitted to Hospital Pedro Hispano in Porto between March 25 & April 15 were tested for SARS-CoV-2. 12 were positive, of whom 11 were asymptomatic, 10 have delivered, 6 by
cesarean section and 4 vaginally. There was one set of twins. There were no maternal complications and all the newborns tested negative (click here or Doria N Portugal PIIS0301211520303122 (002) This series may include the cases in study 74 & study 94. Citation: D´oria M, Peixinho C, Laranjo M, Varejao AM, Silva PT. Covid-19 during pregnancy: a case series from an universally tested population from the north of Portugal. Eur J Obstet Gynecol & Reprod Biol (2020)
Study 104 added.
Study 104 – ICNARC 15th May update
The 15th May ICNARC update (click here or ICNARC COVID-19 report 2020-05-15.pdf) contains 23 currently, and 32 recently, pregnant women critically ill with Covid-19. Of these 9 and 16 respectively had received advanced respiratory support.
Study 103 – Case report from Toronto, Ontario
A 40-year-old woman developed Covid-19 at 35 weeks gestation and was delivered by Caesarean (click here or cmaj.200821.full). The baby tested positive on the day of birth, breast fed and had some minor feeding difficulties, but eventually thrived. Citation: Maksim Kirtsman, Yenge Diambomba, Susan M. Poutanen, Ann K. Malinowski, Evangelia Vlachodimitropoulou, W. Tony Parks, Laura Erdman, Shaun K. Morris, Prakesh S. Shah. Probable congenital SARS-CoV-2 infection in a neonate born to a woman with active SARS-CoV-2 infection CMAJ 2020. doi: 10.1503/cmaj.200821; early-released May 14, 2020 (HT Jon Dorling & Don Sharkey).
Study 102 – 46 patients from Washington State, USA
Of 46 pregnant women with SARS-CoV-2, 43 were symptomatic, 7 hospitalized, 6 categorised as severe, and 1 admitted to ICU (click here or Lokken-AJOG). Eight women delivered, 5 vaginal, 3 Caesarean. All mothers survived. There were 7 livebirths & one stillbirth at 38 weeks. That fetus tested negative. One baby was preterm. No further baby details were given. 38 pregnancies are ongoing. The women were cared for in 16 hospitals: University of Washington Hospital system (Montlake, Northwest, & Harborview campuses), Swedish Medical Center (First Hill, Ballard, Issaquah and Edmonds campuses), University of Washington Valley Medical Center, MultiCare Health System (Auburn Medical Center, Covington Medical Center, Tacoma General Hospital, Good Samaritan Hospital, Valley Hospital and Deaconess Hospital), Evergreen Health Medical Center, and PeaceHealth-St. Joseph’s Medical Center. Citation: Erica M. LOKKEN et al. Clinical Characteristics of 46 Pregnant Women with a SARS-CoV-2 Infection in Washington State. Am J Obstet Gynecol. in press.
Study 101 – Case report from Tabriz, Iran
A 33-year-old woman with severe Covid-19 at 34 weeks gestation was treated at Imam Reza hospital of Tabriz (click here or Taghizadieh Iran 1-s2.0-S2213007120302306-main). She required intubation, ventilation, renal dialysis & delivery by Caesarean. The baby tested negative & was in good health. The mother remains intubated but is recovering. The clinical details differ sufficiently from the two women who survived in study 67 to make it likely that this is a previously unreported case. Citation: Taghizadieh A, Mikaeili H, Ahmadi M, Valizadeh H, Acute kidney injury in pregnant women following SARS-CoV-2 infection: A case report from Iran, Respiratory Medicine Case Reports (2020).
Study 100 added.
Study 100 – Case report at 26 weeks (& 5 other cases) from Belgium
A woman was diagnosed with Covid-19 six days after giving birth at 26 weeks by Caesarean because of pre-eclampsia & HELLP syndrome at Cliniques Universitaires Saint Luc, in Brussels, Belgium, (click here or Lancet Piersigilli PIIS2352464220301401). The baby tested positive for SARS-CoV-2 but but otherwise behaved as expected for her gestational age. Subsequently five further women with Covid-19 delivered in the same hopsital. All babies were negative. Only one required NICU for unrelated reasons. Citation: Fiammetta Piersigilli, Katherine Carkeek, Catheline Hocq, Bénédicte van Grambezen, Corinne Hubinont, Olga Chatzis, Dimitri Van der Linden, Olivier Danhaive COVID-19 in a 26-week preterm neonate. Lancet Child Adolesc Health 2020 Published Online May 7, 2020
Studies 97-99 added.
Study 99 – Placental pathology of 20 cases from Weill Cornell Medical Center
Of 20 women with Covid-19, five delivered by Caesarean and 15 vaginally (click here or Baergen Ped Pathol 1093526620925569). Three gave birth preterm and there was one set of twins. No baby outcomes are reported. These may overlap with other New York cases. Citation: Baergen, R. N., & Heller, D. S. (2020), Placental Pathology in Covid-19 Positive Mothers: Preliminary Findings. Pediatric and Developmental Pathology, 23(3), 177–180.
Study 98 – Ulcerative Colitis & COVID-19 in pregancy
A 26-year-old woman with known ulcerative colitis developed Covid-19 very early in pregnancy (fetal heartbeat & yolk sac on scan). She did not require admission to ITU or ventilation, and recovered, but the pregnancy miscarried (click here or UC and COVID pregnancy IBD izaa109 (1). She was treated at NY Langone so may also be included in studies 85 & 86. Citation: Melissa H Rosen, MD, Jordan Axelrad, MD, MPH, David Hudesman, MD, David T Rubin, MD, Shannon Chang, MD, Management of Acute Severe Ulcerative Colitis in a Pregnant Woman With COVID-19 Infection: A Case Report and Review of the Literature, Inflammatory Bowel Diseases
Study 97 – Case report from Stasbourg
A 21 year old with severe Covid-19 at 23 weeks gestation (click here or Case rep Strasbourg PIIS0301211520302736) was admitted to ICU, treated with noninvasive ventilation and positional therapy and recovered. The pregnancy is ongoing. Citation: Vibert F, Kretz M, Thuet V, Barthel F, De Marcillac F, Deruelle P, Lecointre L, Prone positioning and high-flow oxygen improved respiratory function in a 25-week pregnant woman with COVID-19. European Journal of Obstetrics & Gynecology and Reproductive Biology (2020).
Studies 95 & 96 added (HT Shakila Thangaratinam).
Study 96 – another report of 5 cases from NY Presbyterian, Cornell
The same 5 cases as study 95 (click here). Citation: J. Justin Mulveya, Cynthia M.Magro, Lucy X Ma, Gerard J Nuovo, Rebecca N Baergen. Analysis of complement deposition and viral RNA in placentas of COVID-19 patients. Annals of Diagnostic Pathology Volume 46, June 2020
Study 95 – placental pathology of the first 5 cases from NY Presbyterian, Cornell
Five patients with Covid-19, one delivered by Caesarean, & four vaginally (click here). All resulted in healthy, term deliveries, but no further baby details reported. All mothers recovered. Discussion, “at the time of writing these patients represent 100% of the confirmed COVID-19 deliveries at New York Presbyterian Hospital, Cornell Campus“. A different hospital from NY Presbyterian Allen (studies 27 & 41). Citation: Justin Mulveya, Cynthia M.Magro, Lucy X Ma, Gerard J Nuovo, Rebecca N Baergen. A mechanistic analysis placental intravascular thrombus formation in COVID-19 patients. Annals of Diagnostic Pathology Volume 46, June 2020
Studies 93 & 94 added.
Study 94 – Case report from Portugal
A 31-year-old woman with Covid-19 at 38 weeks had a vaginal birth in a level 3 hospital in Porto (click here or PIIS030121152030258X). The baby was isolated and not infected. Not the same case as study 74 because delivered vaginally. Citation: Polonia-Valente R, Moucho M, Tavares M, Vilan A, Montenegro N, Rodrigues T. Vaginal delivery in a woman infected with SARS-CoV-2 – the first case reported in Portugal. European Journal of Obstetrics & Gynecology & Reproductive Biology (2020)
Study 93 – 9 cases from North Middlesex Hospital, London
Out of 9 hospital cases, 1 was preterm, 1 had a vaginal birth, and 1 baby was infected (click here or Govind EJOG London PIIS0301211520302578). Presumably all 9 included in study 92. Citation: A. Govind, et al., Re: Novel Coronavirus COVID-19 in late pregnancy: Outcomes of first nine cases in an inner city London hospital, Eur J Obstet Gynecol (2020)
Keelin’s found study 91’s figures. And study 92, the first report from UKOSS, added.
Study 92 – UKOSS
The first report from the UK Obstetric Surveillance System (UKOSS) Covid-19 registry of 427 pregnant women admitted to hospital with confirmed Sars-CoV-2 from all 194 UK obstetric units (click here). Twice the size of all previous studies combined. No overlaps. Too important to summarise. Read it. Citation: Marian Knight, Kathryn Bunch, Nicola Vousden, Eddie Morris, Nigel Simpson, Chris Gale, Patrick O’Brien, Maria Quigley, Peter Brocklehurst, Jennifer J Kurinczuk. Characteristics and outcomes of pregnant women hospitalised with confirmed SARS-CoV-2 infection in the UK: a national cohort study using the UK Obstetric Surveillance System (UKOSS) in press.
Studies 88 to 91 added.
Study 91 – Alleged visualisation of the SARS-Cov-2 virus invading the placenta
Case report of a woman, aged 40, with severe Covid-19 requiring ventilation, and later delivery at 28 weeks gestion by Caesarean section (click here or ALGARROBA). The mother recovered and was discharged on day 10. The baby tested negative. The paper is missing its figures, but there’s a video clip (click here). Author affiliations suggest she was cared for at NYU Langone Health, Winthrop Hospital. Citation: Gabriela N. ALGARROBA,, Patricia REKAWEK, Sevan A. VAHANIAN, Poonam KHULLAR, Thomas PALAIA, Morgan R. PELTIER, Martin R. CHAVEZ, Anthony M. VINTZILEOS. Visualization of SARS-CoV-2 virus invading the human placenta using electron microscopy. Am J Obstet Gynecol. in press.
Study 90 – ICNARC 8th May update
The 8th May update (click here or ICNARC COVID-19 report 2020-05-08.pdf) contains 21 currently, and 30 recently, pregnant women critically ill with Covid-19. Of these 9 and 16 respectively had received advanced respiratory support. Excluded from running totals.
Study 89 – Case report from San Francisco
A 34-year-old woman developed Covid-19 at at 28 weeks of gestation (click here or Acute_Respiratory_Distress_Syndrome_in_a_Preterm.97348). Her deteriorating condition necessitated delivery by Caesarean section. She required 10 days mechanical ventilation. Neonatal swabs for SARS-CoV-2 and COVID-19 immunoglobulin (Ig) G and IgM were negative. Citation: Blauvelt CA, Chiu C, Donovan AL, Prahl M, Shimotake TK, George RB, Schwartz BS, Farooqi NA, Ali SS, Cassidy A, Gonzalez JM, Gaw SL. Acute Respiratory Distress Syndrome in a Preterm Pregnant Patient With Coronavirus Disease 2019 (COVID-19). Obstet Gynecol. 2020 May 8. doi: 10.1097/AOG.0000000000003949. [Epub ahead of print]
Study 88 – 13 pregnant women with Covid-19 in intensive care in Sweden
Of 53 women aged 20-45 years with SARS-CoV-2 reported to the Swedish Intensive Care Registry, 13 were either pregnant or <1 week postpartum (click here or ). Citation: Collin J, Byström E, Carnahan A, Ahrne M. Pregnant and postpartum women with SARS-CoV-2 infection in intensive care in Sweden. Acta Obstet Gynecol Scand. 2020 May 9. doi: 10.1111/aogs.13901. [Epub ahead of print]
Study 87 added.
Study 87 – Case report from Detroit
A 36-year-old developed severe Covid-19 at 23 weeks gestion, and required 7 days ventilation (click here or 1-s2.0-S2214911220300473-main DETROIT). She survived, and the pregnancy is ongoing. She was treated at the Henry Ford Hospital, Detroit. Citation: L. Hong, N. Smith, M. Keerthy, et al., Severe COVID-19 infection in pregnancy requiring intubation without preterm delivery: A case report. Case Reports in Women’s Health (2020)
Studies 84-86 added.
Study 86 – 64 pregnant women with severe Covid-19 in 12 US hospitals
Of 64 pregnant women with severe (n=44) or critical (n=20) Covid-19, one had a cardiac arrest, 19 were intubated, none had ECMO, and 13 remain hospitalized, but none have died (click here or COVID_CC_post_review_04302020). Of the 32 who have given birth 24 were delivered by Caesarean. One baby was infected, but no babies died. The women had been admitted to 12 unnamed hospitals between March 5 & April 20. From the author affiliations the hospitals probably include Pennsylvania, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia; Perelman School of Medicine, University of Pennsylvania; St. Luke’s University Health Network, Bethlehem; Crozer Chester Medical Center, Chester; Einstein Healthcare Network, Philadelphia. New York Montefiore Medical Center/Albert Einstein College of Medicine, Bronx; New York University Langone Medical Center; Icahn School of Medicine at Mount Sinai; New Jersey Rutgers Robert Wood Johnson Medical School, New Brunswick; Saint Barnabas Medical Center, Livingston; Ohio TriHealth-Good Samaritan Hospital, Cincinnati. Citation: Rebecca A.M. Pierce-Williams, Julia Burd, Laura Felder, Rasha Khoury, Peter S. Bernstein, Karina Avila, Christina A. Penfield, Ashley S. Roman, Chelsea A. DeBolt, Joanne L. Stone, Angela Bianco, Adina R. Kern-Goldberger, Adi Hirshberg, Sindhu K. Srinivas,, Jenani S. Jayakumaran, Justin S. Brandt, Hannah Anastasio, Meredith Birsner, Devon S. O’Brien, Harish M. Sedev, Cara D. Dolin, William T. Schnettler, Anju Suhag, Shabani Ahluwalia, Reshama S. Navathe, Adeeb Khalifeh, Kathryn Anderson, Vincenzo Berghella. Clinical course of severe and critical COVID-19 in hospitalized pregnancies: a US cohort study. Am J Obstet Gynecol. In press.
Study 85 – 32 women from New York University, Langone Health
Between March 1 & April 20, 32 women with Covid-19 gave birth at NYU Langone Health. Eleven had placental or membrane swabs tested of which 3 were positive. Of the 11 women 3 women with critical, and one with severe disease, were delivered by caesarean. All the rest, one severe disease, the remainder mild, gave birth vaginally. None of the infants tested positive or demonstrated symptoms of COVID-19 infection. Citation: Christina A. Penfield, Sara G. Brubaker, Meghana A. Limaye, Jennifer Lighter, Adam J. Ratner Kristen M. Thomas, Jessica Meyer, Ashley S. Roman. Detection of SARS-COV-2 in Placental and Fetal Membrane Samples. Am J Obstet Gynecol. In press.
Study 84 – Twins from St Thomas’s, London
A woman with twins developed Covid-19 at 32 weeks (click here or Twins abruption STH london AJOGMFM-20-1053). She was delivered by Caesarean section due to suspected abruption. Both babies tested negative for COVID-19. Citation: Katy Kuhrt, Jess McMicking, Surabhi Nanda, Catherine Nelson Piercy, Andrew Shennan. Placental abruption in a twin pregnancy at 32 weeks’ gestation complicated by COVID-19, without vertical transmission to the babies. Am J Obstet Gynecol in press.
Studies 82 & 83 added. Study 81 comment revised; this is probably the same ECMO case as previously reported in studies 3 and 57.
Study 83 – 82 women in New York
Of 82 pregnant women with Covid-19, admitted to seven hospitals within an unnamed large hospital group in New York State, eight (9.8%) were admitted to intensive care (click here or L20-081), a similar proportion to non-pregnant women of reproductive age. No clinical outcomes are reported. Study 49 by the same group, reporting Covid-19 admissions in an unnamed 14 hospital group, is cited. Although not explicitly stated, it seems likely that the cases overlap. Citation: Matthew J. Blitz, Amos Grünebaum, Asma Tekbali, Eran Bornstein, Burton Rochelson, Michael Nimaroff, Frank A. Chervenak. Intensive Care Unit Admissions for Pregnant and Non-Pregnant Women with COVID-19. Am J Obstet Gynecol in press.
Study 82 – 9 screen-positive women at The Portland, London
Between March 27 & April 20th, The Portland, a private hospital in London, performed planned Caesareans for 129 NHS patients. All were screened for SARS-CoV2, and 9 (7%) were positive, of whom only one was symptomatic (click here or SARS-CoV-2_and_pregnancy_letter_line_nbrs). None of the positive asymptomatic women developed COVID-19 symptoms. The outcome of the symptomatic woman was not reported. All babies were well at birth and at discharge. Citation: Asma KHALIL, Robert HILL, Shamez LADHANI, Katherine PATTISSON, Pat O’BRIEN. SARS-CoV-2 in pregnancy: symptomatic pregnant women are only the tip of the iceberg. Am J Obstet Gynecol. in press.
Studies 79 (HT Shakila Thangaratinam) & studies 80, 81 added.
Study 81 – Case report from Xiaolan People’s Hospital of Zhongshan
A 31 year old woman developed Covid-19 at 31 weeks gestation (click here, full text not yet available). The baby died. Zhongshan People’s Hospital disambiguates as grid.476868.3 Citation: Li J, Wang Y, Zeng Y, Song T, Pan X, Jia M, He F, Hou L, Li B, He S, Chen D. Critically ill pregnant patient with COVID-19 and neonatal death within two hours of birth. Int J Gynaecol Obstet. 2020 May 5. doi: 10.1002/ijgo.13189.
Study 80 – 13 women from Renmin Hospital, Wuhan
These 13 women were cared for in Renmin Hospital of Wuhan University, Wuhan (click here for abstract. Full text not yet available). Citation: Wu Y, Liu C, Dong L, Zhang C, Chen Y, Liu J, Zhang C, Duan C, Zhang H, Mol BW, Dennis CL, Yin T, Yang J, Huang H. Coronavirus disease 2019 among pregnant Chinese women: Case series data on the safety of vaginal birth and breastfeeding. BJOG. 2020 May 5. doi: 10.1111/1471-0528.16276. [Epub ahead of print]
Study 79 – Case report from Turin
A 28-year-old woman with Covid-19 gave birth vaginally at 37 weeks (click here or PIIS0301211520302025). The baby tested positive but was otherwise well. The baby was born at Sant’Anna Hospital, Turin, Italy. Turin is outside Lombardy; this case was not included in studies 32 and 64. Citation: A. Carosso, et al., Pre-labor anorectal swab for SARS-CoV-2 in COVID-19 pregnant patients: is it time to think about it? Eur J Obstet Gynecol (2020)
Study 78 added.
Study 78 – Case report from Fondazione Policlinico Universitario Agostino Gemelli
A 23 weeks pregnant woman with Covid-19 admitted on 10th March to Fondazione Policlinico Universitario Agostino Gemelli (click here or PIIS0002937820304683). Obstetric ultrasound revealed a normally grown fetus with normal amniotic fluid and Doppler parameters. No further pregnancy details. Likely to be one of the women with ongoing pregnancy in study 76. Citation: Inchingolo R, Smargiassi A, Moro F, Buonsenso D, Salvi S, Del Giacomo P, Scoppettuolo G, Demi L, Soldati G, Testa AC, The Diagnosis of Pneumonia in a Pregnant Woman with COVID-19 Using Maternal Lung Ultrasound. American Journal of Obstetrics and Gynecology (2020).
Studies 76 & 77 added.
Study 77 – ICNARC 1st May update
The 1st May update (click here or ICNARC COVID-19 report 2020-05-01) contains 20 currently, and 27 recently, pregnant women critically ill with Covid-19. Of these 7 and 14 respectively had received advanced respiratory support. Excluded from running totals.
Study 76 – 7 cases from Fondazione Policlinico Universitario Agostino Gemelli Rome, Italy
Of seven pregnant women with Covid-19, one miscarried at 7 weeks, 4 pregnancies are ongoing, and 2 were delivered, both by Caessarean (click here or buonsenso Rome AJP s-0040-1710541). Both babies had many swabs tested but were well. Citation: Danilo Buonsenso, Simonetta Costa, Maurizio Sanguinetti, Paola Cattani, Brunella Posteraro, Simona Marchetti, Brigida Carducci, Antonio Lanzone, Enrica Tamburrini, Giovanni Vento, Piero Valentini. Neonatal Late Onset Infection with Severe Acute Respiratory Syndrome Coronavirus 2. Am J Perinatol.
Studies 73 to 75 added.
Study 75 – 10 vaginal births in Zhongnan Hospital
Among 88 pregnant women with confirmed or suspected COVID-19 admitted to the obstetric isolation ward of Zhongnan Hospital of Wuhan University between January 20 and March 2, ten delivered vaginally (click here or LIAO ijgo.13188). All 7 tested neonates were negative. Three babies were not tested. These ten cases don’t overlap with those in studies 1, 13 & 56, who had all delivered by Caesarean, but probably overlap with studies 55 and 57. Not added to running totals. Citation: Jing Liao, Xiaoyan He, Qing Gong, Lingyun Yang, Chunhua Zhou, Jiafu Li. Analysis of vaginal delivery outcomes among pregnant women in Wuhan, China during the COVID‐19 pandemic. First published: 29 April 2020
Study 74 – Case report from Portugal
A healthy woman with “occasional dry cough” tested positive at term and was delivered by Caesarean (click here or Lyra Portugal case13883-54440-1-PB. The baby was uninfected and both did well. Citation: Joana LYRA, Rita VALENTE, Marta ROSÁRIO, Mariana GUIMARÃES. Cesarean Section in a Pregnant Woman with COVID-19: First Case in Portugal. Acta Med Port 2020
Study 73 – 28 women from The Central Hospital of Wuhan
Among pregnant women cared for in the Central Hospital of Wuhan between 15 January to 15 March 2020. (click here or Quancheng IJID 1-s2.0-S1201971220302800-main) there were 17 Caesareans, 5 vaginal births, 4 medical abortions and 2 ongoing pregnancies. Total 30 [sic]. They include one set of twins. No babies were infected, and no mothers or babies died. The authors admit that these data are included in Study 55. They are probably also included in study 57, & overlap with Study 39. Not added to running totals. Citation: Qiancheng X, Jian S, Lingling P, Lei H, Xiaogan J, Weihua L, Gang Y, Shirong L, Zhen W, GuoPing X, Lei Z, The sixth batch of Anhui medical team aiding Wuhan for COVID-19, Coronavirus disease 2019 in pregnancy, International Journal of Infectious Diseases (2020)
Study 72 added.
Study 72- Miscarriage in Switzerland
A 28-year-old with Covid-19 miscarried at 19 weeks gestation at Lausanne University Hospital (click here or second trimester miss jama_baud_2020_ld_200040 ). Placental swabs were positive for SARS-CoV-2. The mother’s outcome was not reported. Citation: David Baud, Gilbert Greub, Guillaume Favre, Carole Gengler, Katia Jaton, Estelle Dubruc, Léo Pomar. Second-Trimester Miscarriage in a Pregnant Woman With SARS-CoV-2 Infection. JAMA. Published online April 30, 2020. doi:10.1001/jama.2020.7233
Studies 68 to 71 added.
Study 71 – Follow-up of 4 women from Study 6
Patients 12-15 in Study 6 from Tongji were still in hospital at the time of the report. This (click here or YANG L_Tongji_AJR) describes follow-up till March 30th. All four had been discharged and were still pregnant. Citation: Lin Li, Dehan Liu, Lian Yang. Follow-Up Information About the Four Pregnant Patients With Coronavirus Disease (COVID-19) Pneumonia Who Were Still in the Hospital at the End of Our Study American Journal of Roentgenology: W1-W2. 10.2214/AJR.20.23247
Study 70 – Maternal death from Iran
A 22-year-old developed Covid-19 at 32 (or possibly 30) weeks gestation, and was treated at Imam Khomeini Hospital of Mazandaran University, Sari, Iran (click here or ZAMANIYAN M_Iran_Prenatal diagnosis). She was delivered by Caesarean section, but on day 10 required ventilation, and died on day 15. The first baby swabs were negative, but amniotic fluid and later baby swabs were positive. Apart from developing a fever the baby did well. The clinical details suggest that she was not included in Study 67. Citation: Marzieh Zamaniyan, Aghdas Ebadi, Samaneh Aghajanpoor Mir, Zahra Rahmani, Mohammadreza Haghshenas, Setareh Azizi. Preterm delivery in pregnant woman with critical COVID‐19 pneumonia and vertical transmission. Prenatal diagnosis. First published:17 April 2020
Study 69 – Case report from Missouri
A patient with Covid-19 at 33 weeks gestation required intubation and ventilation for 11 days (click here or Kelly false negative SARSCOV2 AJOGMFM). The baby was delivered by Caesarean. The mother has been extubated, and is recovering. The baby tested negative and is well. Citation: Jeannie C Kelly, Michael Dombrowksi, Micaela O’neil-Callahan, Annessa S Kernberg, Antonina I Frolova, Molly J Stout. False-Negative COVID-19 Testing: Considerations in Obstetrical Care. American Journal of Obstetrics & Gynecology MFM Available online 28 April 2020
Study 68 – 55 pregnant women in the UK ISARIC report
This preprint from the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) (click here or ISARIC UK 2020.04.23.20076042v1.full) includes 16,749 hospitalised UK patients with COVID-19. This represents 14.7% of people who have tested positive for COVID-19 in the UK, most of whom have not required hospital admission, and 28% of admissions with COVID-19. 55/963 (6%) of the women of reproductive age were pregnant. This is similar to the estimated proportion of pregnant women in the community. Pregnancy was not associated with mortality. Citation: Annemarie B Docherty, Ewen M Harrison, Christopher A Green, Hayley E Hardwick, Riinu Pius, Lisa Norman, Karl A Holden, Jonathan M Read, Frank Dondelinger, Gail Carson, Laura Merson, James Lee, Daniel Plotkin, Louise Sigfrid, Sophie Halpin, Clare Jackson, Carrol Gamble, Peter W Horby, Jonathan S Nguyen-Van-Tam, Jake Dunning, Peter JM Openshaw, J Kenneth Baillie, Malcolm Gracie Semple. Features of 16,749 hospitalised UK patients with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol. medRxiv 2020.04.23.20076042
Study 67 – 7/9 maternal deaths with severe disease in Iran
This preprint from Am J Obstet Gynecol (click here or Aagaard_W20-2021) reports 9 pregnant women with severe Covid-19 treated between mid-February & mid-March 2020 in Iran. The hospitals, exact ages and exact dates of admission and death were concealed to protect anonymity. Seven mothers died, one recovered and one remains seriously ill. Of the babies 6 died (incl one set of twins) and 5 survived (incl one set of twins). These cases may overlap with those in studies 23 & 43. Citation: Sedigheh Hantoushzadeh, Alireza A. Shamshirsaz, Ashraf Aleyasin, Maxim D Seferovic, Soudabeh Kazemi Aski, Sara E. Arian, Parichehr Pooransari, Fahimeh Ghotbizadeh, Soroush Aalipour, ,Zahra Soleimani, Mahsa Naemi, Behnaz Molaei, Roghaye Ahangari, Mohammadreza Salehi, Atousa Dabiri Oskoei, Parisa Pirozan, Roya Faraji Darkhaneh, Mahboobeh Gharib Laki, Ali Karimi Farani, Shahla Atrak, Mir Mohammad Miri, Mehran Kouchek, Seyedpouzhia Shojaei, Fahimeh Hadavand, Fatemeh Keikha, Maryam Sadat Hosseini, Sedigheh Borna, Shideh Ariana, Mamak Shariat, Alireza Fatemi, Behnaz Nouri, Seyed Mojtaba Nekooghadam, Kjersti Aagaard. Maternal Death Due to COVID-19 Disease. Am J Obstet Gynecol. In press.
Studies 64-66 added.
Study 66 – A review from Brazil of 9 maternal deaths due to Covid-19
This preprint from AJOG refers to nine maternal deaths (click here or Maternal deaths AJOG L20-082. Two from Iran had been reported in Study 23 below. Of the five from Brazil, two post-partum deaths in women delivered by Caesarean section, are referenced to the Brazilian Ministry of Health. No further details are given. The other three are sourced to Brazilian newspapers. The first link provided (click here) goes to the newspaper Folha de Londrina, but not to the report of the maternal death. The 2nd link (click here) describes the death of Viviane Albuquerque, age 33 from Pernambuco, at 32 weeks gestation (added here). The third link (click here) is broken. The final two deaths occurred in Mexico. The first is attributed to the Mexican Ministry of Health. The second to a newspaper report. The link provided (click here) goes to a report of two maternal deaths from Covid-19. Added it to the news reports here. Citation: Amorim MMR, Takemoto MLS, Fonseca EB. Maternal Deaths with Covid19: a different outcome from mid to low resource countries? Am J Obstet Gynnecol. In press.
Study 65 – 5 patients with severe disease from Philadelphia
This preprint from AJOG (click here or Hirshberg AJOG L20-083) describes five women in Phaladelphia, who required ventilation. Three were delivered by Caesarean, and two remain undelivered. No mothers or babies died, but one woman remains severely ill. Citation: Adi HIRSHBERG,, Adina R. KERN-GOLDBERGER, Lisa D. LEVINE,, Rebecca PIERCE-WILLIAMS, William R. SHORT, Samuel PARRY, Vincenzo BERGHELLA, Jourdan E. TRIEBWASSER, Sindhu K. SRINIVAS. Care of critically ill pregnant patients with COVID-19: a case series. Am J Obstet Gynecol. In press.
Study 64 – 42 cases from Lombardy
This pre-print in BJOG (click here or 1471-0528.16278) describes the 42 cases in study 32 in much more detail. Citation: Enrico Ferrazzi, Luigi Frigerio, Valeria Savasi, Patrizia Vergani, Federico Prefumo, Santa Barresi, Stefano Bianchi, Elena Ciriello, Fabio Facchinetti, Maria Teresa Gervasi, Enrico Iurlaro, Alessandra Kustermann, Giovanna Mangili, Fabio Mosca, Luisa Patanè, Donata Spazzini, Arsenio Spinillo, Giuseppe Trojano, Michele Vignali, Antonella Villa, GianVincenzo Zuccott,i Fabio Parazzini, Irene Cetin. Vaginal delivery in SARS‐CoV‐2 infected pregnant women in Northern Italy: a retrospective analysis. BJOG 27 April 2020
Studies 58-63 added.
Study 63. ICNARC 24 April update
The 24 April update (click here or ICNARC COVID-19 report 2020-04-24) contains 20 currently, and 25 recently, pregnant women critically ill with Covid-19. Of these 5 and 7 respectively had received advanced respiratory support. Excluded from running totals.
Study 62. Case report from Hefei city
A 22 year old woman with asymptomatic COVID-19 was delivered by Caesarean on Feb 11, 2020 at the No 2 People’s Hospital of Hefei City (click here). The baby tested negative and both did well. Although this hospital does not appear on www.grid.ac this is the first report from Hefei City, which is 373 km from Wuhan. Citation: Lu D, Sang L, Du S, Li T, Chang Y, Yang XA. Asymptomatic COVID-19 infection in late pregnancy indicated no vertical transmission. J Med Virol. 2020 Apr 24. doi: 10.1002/jmv.25927. [Epub ahead of print]
Study 61. 32 Covid-19 screen positive women from New York Winthrop Hospital
Out of 161 pregnant women admitted in labour to New York University Winthrop Hospital between March 30 & April 12, and screened for Covid-19, 32 were positive, of whom 11 were symptomatic (click here or AJOG_Screening_all_pregnant_women vintzileos). Of 29 neonates tested all were negative with three results pending. No clinical outcomes reported. Citation: William S VINTZILEOS, Jolene MUSCAT, Eva HOFFMANN, Duc VO, Nicole S JOHN, Rosanne VERTICHIO, Anthony M VINTZILEOS, Screening all pregnant women admitted to Labor and Delivery for the virus responsible for 2 COVID-19 American Journal of Obstetrics & Gynecology. in press.
Study 60. Preterm labour in a patient with Covid-19
A woman from South Carolina developed Covid-19 at 23 weeks, was treated for suspected preterm labour at 24 weeks, and recovered. The pregnancy is ongoing at 27 weeks (click here or Browne Aj Peri preterm labour). Citation: Paul C. Browne, Jennifer B. Linfert, Emilio Perez-Jorge. Successful Treatment of Preterm Labor in Association with Acute COVID-19 Infection. Am J Perinatol. Published Online 24 April 2020. DOI: 10.1055/s-0040-1709993
Study 59. Two patients with Covid-19 & negative amniocentesis
Two women from Tongji Hospital, Wuhan developed Covid-19 in the first trimester and underwent amniocentesis in the second (click here or Yu SARS COV2 in AF Lancet Infect Dis 20). Both specimens were negative. Both cases may overlap with those in Studies 55 and 57. Not added to running totals. Citation: Nan Yu, Wei Li, Qingling Kang, Wanjiang Zeng, Ling Feng, Jianli Wu. No SARS-CoV-2 detected in amniotic fluid in mid-pregnancy. Lancet Infect Dis 2020 Published Online April 22, 2020
Study 58. First case report from India
An asymptomatic woman at 38+6 weeks gestation tested positive for COVID-19 (click here or Sharma India ijgo.13179). She delivered by Caesarean section, and her breast-fed baby tested negative on day 7. Both recovered. Citation: K. Aparna Sharma, Rajesh Kumari, Garima Kachhawa, Anjolie Chhabra, Ramesh Agarwal, Akash Sharma, Neerja Bhatla. Management of the first patient with confirmed COVID‐19 in pregnancy in India: From guidelines to frontlines. Int J Gynecol Obstet. In press. doi:10.1002/ijgo.13179
Studies 56 & 57 added.
Study 57. 116 cases from 25 hospitals in China
This preprint from Am J Obstet Gynecol (click here) includes 116 mothers with Covid-19 (65 lab confirmed, 51 clinically diagnosed), of whom 8 had severe disease. None died. 99 mothers had delivered 100 babies (one set of twins) of whom one died. This paper claims to be an “an expanded series that have included 33 published cases.16,18-20”. Their reference 16 is our Study 1, ref 18 is our Study 38 and ref 19 is our Study 6a. Their reference 20 is as follows: “Lei D, Wang C, Li C, et al. Clinical characteristics of COVID-19 in pregnancy: analysis of nine cases. Chin J Perinat Med 2020,23:doi: 10.3760/cma.j.cn113903-20200216-00117.” Although cited in a number of reviews we have so far been unable to find the original source.
The patients were collected from 25 hospitals within and outside Hubei province, between January 20 and March 24, 2020. Three recruiting hospitals, all from Wuhan, listed in the supplementary material, overlap with those in study 55 (appendix table s1). These are Zhongnan Hospital of Wuhan univerisity, the Central Hospital of Wuhan, and Tongi Hospital, all multiple reporters of Covid-19 in pregnancy. Thus it is likely that, in addition to the studies cited, this series overlaps considerably with Study 55. Not added to running totals. Citation: Yan J, Guo J, Fan C, Juan J, Yu X, Li J, Feng L, Li C, Chen H, Qiao Y, Lei D, Wang C, Xiong G, Xiao F, He W, Pang Q, Hu X, Wang S, Chen D, Zhang Y, Poon LC, Yang H, Coronavirus disease 2019 (COVID-19) in pregnant women: A report based on 116 cases, American Journal of Obstetrics and Gynecology (2020)
Study 56. Seven mothers and babies from Zhongnan Hospital
All mothers had Covid-19 and were delivered by Caesarean. No mothers or babies died (click here). 6/7 babies had a range of swabs taken, all of which were negative. Due to probability of duplication with Studies 1 and 55, not included in running totals. Citation. Pu Yang, Xia Wang, Pin Liu, Cong Wei, Bingyan He, Junwen Zheng, Dongchi Zhao. Clinical characteristics and risk assessment of newborns born to mothers with COVID-19 Journal of Clinical Virology Volume 127, June 2020, 104356.
Studies 53-55 added.
Study 55. 118 cases with Covid-19 from Wuhan collected by the National Health Commission of China
This regional series of women treated between December 8, 2019, & March 20, 2020, was extracted by the National Health Commission of China, which stores the medical records of all 50 designated hospitals in Wuhan city (click here). Nineteen of the 50 hospitals had reported cases (Appendix table S1, click here). No mothers died, and apart from 3 spontaneous abortions, 2 ectopic pregnancies, & 4 induced abortions, no babies died. At the next running total update we will replace all other cases from hospitals in Wuhan with these data. Citation: Lian Chen, Qin Li, Danni Zheng, Hai Jiang, Yuan Wei, Li Zou, Ling Feng, Guoping Xiong, Guoqiang Sun, Haibo Wang, Yangyu Zhao, Jie Qiao, Clinical Characteristics of Pregnant Women with Covid-19 in Wuhan, China. New Engl J Med. April 17, 2020 DOI: 10.1056/NEJMc2009226
Study 54. Six confirmed, & two suspected cases from the Maternal & Child Health Hospital, Wuhan
The eight patients from the Maternal and Child Health Hospital of Hubei Province, Wuhan, between January 23 and February 10, 2020 (click here) probably overlap with other reports from the same hospital. They are not included in the running totals. Citation: Wu, C., Yang, W., Wu, X. et al. Clinical Manifestation and Laboratory Characteristics of SARS-CoV-2 Infection in Pregnant Women. Virol. Sin. (2020).
Study 53. Case report from Las Palmas de Gran Canaria, Spain
A 44-year-old woman developed Covid-19 at 29+2 weeks gestation (click here or 1-s2.0-S0014256520301120-main (002)). She was treated at Hospitalario Universitario Insular Materno Infantil, and required mechanical ventilation and delivery by caesarean. Both mother and baby recovered. [Spanish. Google translate] Citation: González Romero D, Ocampo Pérez J, González Bautista L, Santana-Cabrera L. Pronóstico perinatal y de la paciente embarazada con infección por COVID-19. Revista Clínica Española Available online 17 April 2020.
Studies 48 – 52 added.
Study 52. ICNARC update 17 April
This update of the UK Intensive Care National Audit & Research Centre (ICNARC) database (click here or ICNARC COVID-19 report 2020-04-17.pdf (1) mentions 16 currently, and 21 recently, pregnant women with Covid-19 who are or had been critically ill. Three & six respectively had received advanced respiratory support. Excluded from running totals.
Study 51. Case report from the British American Hospital, Lima, Peru
A 41 year old women with severe Covid-19 requiring ventilation was delivered by caesarean section at 33 weeks gestation (click here or Alzamora Am J Perintal Apr 18 . The baby was isolated but a nasopharyngeal swab taken at 16 hours was positive for SARS-COV-2. The baby was ventilated for 12 hours, and later, at age 6 days, developed mild respiratory symptoms. The mother’s serology is reported on day 4, but otherwise the maternal outcome is not reported. It is presumed that she recovered. Citation: Maria Claudia Alzamora, Tania Paredes, David Caceres, Camille M. Webb, Luis M. Valdez, Mauricio La Rosa. Severe COVID-19 during Pregnancy and Possible Vertical Transmission. Am J Perinatal. Online April 18.
Study 50. A severe case of Covid-19 from the Good Samaritan Hospital. Cincinnati, Ohio
A 39 year old woman presented at 31 weeks gestation with severe Covid-19. She required ventilation. After 8 days on ITU she was delivered by Caesarean section for fetal bradycardia. The baby was intubated on NICU for three days, and isolated for 14. Amniotic fluid and nasopharyngeal swabs were negative. The mother remains on synchronized intermittent mandatory ventilation. The clinical details and patient age indicate that this is not patient no. 42 (click here) reported in the Ohio newspapers. Citation: Schnettler WT, Al Ahwel Y, Suhag A, Severe ARDS in COVID-19-infected pregnancy: obstetric and intensive care considerations American Journal of Obstetrics & Gynecology MFM (2020).
Study 49. 62 pregnant women from a 14 hospital group in New York State
Over four weeks to March 29th, 62 out of 3064 pregnant women attending an unnamed 14 hospital group in New York State tested positive for SARS-COV2 (click here). No further details given, & since they may overlap with other New York Cases, not included in running totals. Citiation: Tekbali A, Grünebaum A, Saraya A, McCullough L, Bornstein E, Chervenak FA. Pregnant versus non-pregnant SARS-CoV-2 and COVID-19 Hospital Admissions: The first 4 weeks in New York, American Journal of Obstetrics and Gynecology (2020).
Study 48. One case from Toronto & one from Clamart, France.
Two cases (click here or COVID coagulopathy Canada jth.14856) One delivered in Mount Sinai Hospital, Toronto, Canada, and one in Antoine Béclère hospital in Clamart, France. Citation: Evangelia Vlachodimitropoulou Koumoutsea, Alexandre J. Vivanti, Nadine Shehata, Alexandra Benachi, Agnes Le Gouez, Celine Desconclois, Wendy Whittle, John Snelgrove, Kinga Ann Malinowski. COVID19 and acute coagulopathy in pregnancy. J Thrombosis Haemostasis. 17 April 2020.
Study 47 added.
Study 47. Report of 13 pregnant women in ITU from Santé Publique France
Thirteen pregnant women have been admitted to intensive care in France (click here or COVID19_PE_20200418 Report in French). None have died. Citation: COVID-19: epidemiological update of April 16, 2020 Santé Publique France.
Study 46 (16 April update of NethOSS) added, & study 42 (prev NethOSS data) removed from running totals
Study 46. 107 women from the Netherlands Covid-19 registry
This 16 April update of NethOSS (click here), accessed 18 April 2020, contains the following. 5/91 women with brief additional details were admitted to intensive care. 25 have given birth, eight by Caesarean. No mother or baby has died. Citation: See Study 42. Available here. Accessed 18 April.
Studies 44 & 45 added. HT @Belinda_J_Lowe for study 45. We’ve also done some housekeeping today. Study 13 probably overlaps with study 1, so 13 has been removed from running totals. Study 3 includes 13 patients from multiple centres, both in and outside Hubei province, who may overlap with other studies. 12 mothers (3 undelivered) and 9 babies therefore removed from the running total. Only case 6, where the woman was reported to be on ECMO and the baby stillborn and preterm, does not appear to have been reported elsewhere, so remains in the running totals.
Study 45. Case report from Bond University, Australia
This case report from Bond University Hospital, Southport, Queensland, is the first from Australia (click here). Full text to follow. Citation: Lowe B, Bopp B. COVID‐19 vaginal delivery – a case report. ANZOG 15 April 2020.
Study 44. 42 suspected & 13 confirmed cases from Tongji Hospital
Thirteen pregnant women all seen at Tongji Hospital grid.412793.a between Jan 20 & Mar 5, 2020 (click here). Four delivered vaginally and nine by Caesarean. All mothers had mild disease and none died. The baby details for the Covid and non-Covid mothers are reported together. These cases probably overlap with previous reports from Tongji hospital so not included in running totals. Citation: Hui yang, Guoqiang Sun, Fei Tang, Min Peng, Ying Gao, Jing Peng, Hui Xie, Yun Zhao, Zhichun Jin, Clinical Features and Outcomes of Pregnant Women Suspected of Coronavirus Disease 2019, Journal of Infection (2020).
Studies 41 – 43 added.
Study 43. A maternal death from Covid-19 in Iran
A 27 year old woman was transferred to Vali-e-asr Hospital at 30 weeks gestation (click here or Karami Travel med Apr 11 2020) with severe respiratory failure. She required intubation and ventilation. A few hours later she delivered a stillborn baby vaginally, and a few hours after that she died. Post-mortem on the mother confirmed SARS-Cov-2 in the lungs. No further details are given about the baby. Vali-e-asr Hospital does not appear on Grid.ac but is part of Zanjan University of Medical Sciences. grid.469309.1. This is the first academic report (as opposed to unconfirmed news reports) of a maternal death due to Covid-19. Citation: Parisa Karami, Maliheh Naghavib, Abdolamir Feyzib, Mehdi Aghamohammadic, Mohammad Sadegh Novinc, Ahmadreza Mobaiend, Mohamad Qorbanisania, Aida Karamia, Amir Hossein Norooznezhad. Travel Medicine and Infectious Disease, in press. https://doi.org/10.1016/j.tmaid.2020.101665
Study 42. 89 women from the Netherlands Covid-19 registry
This is the first Covid-19 in pregnancy registry report of which we are aware. It has not been formally published, but is available here and regularly updated. Using Google translate, the 9 April version, accessed 14 April 2020 contains the following. 5/89 pregnant women with Covid-19 have been admitted to intensive care. 19 women have given birth, four by Caesarean. No mother or baby has died. Citation: The Nederlandse Vereniging voor Obstetrie en Gynaecologie (Dutch Association for Obstetrics and Gynecology) (NVOG). Registratie COVID-19 positieve zwangeren in NethOSS (Update registration COVID-19 positive pregnant women in NethOSS). Accessed 14 April.
Study 41. 33 women from NY Presbyterian & Columbia
These 33 women with Covid-19 delivered infants at the New York–Presbyterian Allen Hospital and Columbia University Irving Medical Center between March 22 & April 4, 2020 (click here). They presumably include the 18 women with Covid-19 previously reported as having delivered in the same two hospitals (Studies 14 & 27), as well as some of the women who were at the time undelivered in those two series. Since no birth details are given, these cases have not been included in running totals. Citation: Sutton, D, Fuchs, K, D’Alton M, Goffman D. Universal Screening for SARS-CoV-2 in Women Admitted for Delivery. New Engl J Med April 13, 2020. DOI: 10.1056/NEJMc2009316
Studies 39 and 40 added.
Study 40. 17 pregnant women from Renmin
These 17 women with Covid-19, all delivered by Caesarean section in Remnin hospital (click here or Khan Clin Micro Infect 27 Mar), almost certainly are the same women as in studies 6a & 12. They have not been added to the running totals. Citation: Khan S, Jun L, Nawsherwan Siddique R, Li Y, Han G, Xue M, Nabi G, Liu J, Association of COVID-19 infection with pregnancy outcomes in healthcare workers and general women, Clinical Microbiology and Infection,
Study 39. 23 pregnant women from the Central Hospital Wuhan
23 pregnant women with COVID-19 from the Central Hospital of Wuhan. Wu ijgo.13165 Three patients terminated the pregnancy in the first trimester. Of the other 20, 18 delivered by Caesarean and two vaginally. There was one set of twins. No neonates were infected. This is the first report from this hospital which has a unique GRID reference. We have therefore added these to the running totals. Citation: Xiaoqing Wu, Ruihong Sun, Jianpu Chen, Yuanliang Xie, Shutong Zhang, Xiang Wang. Radiological findings and clinical characteristics of pregnant women with
COVID-19 pneumonia In J Gynecol Obstet. In press doi: 10.1002/ijgo.13165
Studies 34 – 38 added
Study 38. 41 women from the Maternal & Child Health Hospital of Hubei Province
Out of 41 pregnant women from the Maternal and Child Health Hospital of Hubei Province, with typical Covid-19 infection on lung CT, 16 were SARS-CoV-2 positive, 17 negative and 8 not tested. Nineteen were inpatients for delivery, and the rest outpatients from 22 weeks onwards. No birth details were given and in view of the probability of overlap with other cases in the same hospital none have been added to the running totals. Citation: H. Liu, F. Liu and J. Li et al., Clinical and CT imaging features of the COVID-19 pneumonia: Focus on pregnant women and children, Journal of Infection
Study 37. Three vaginal births in Renmin
Three babies were born vaginally to women with Covid-19, one preterm, two term. None were infected. Khan 3 vaginal births renmin. All previous reports from Renmin (Studies 6a, 10, 12 & 36) were of Caesarean births, so these have been included as non-duplicates in the summary totals. Citation: Suliman Khan, Liangyu Peng, Rabeea Siddique, Ghulam Nabi, Nawsherwan, Mengzhou Xue, Jianbo Liu, Guang Han. Infection Control & Hospital Epidemiology as part of the Cambridge Coronavirus Collection. March 2020. DOI: 10.1017/ice.2020.84
Study 36. Caesarean birth in 17 women in Remnin
This case series includes details of the Caesarean births of 17 women with Covid-18 in Renmin Hospital of Wuhan University Chen 17 renmin cs. All mothers and babies survived. However the series probably includes the 16 cases also reported from Remnin in Chinese (study 6a), which included the same number, three, preterm patients, all also delivered by Caesarean. They may also overlap with study 10; both studies mention two doctors delivered by Caesarean in Renmin. The obstetrican on study 36, Bi-heng Cheng, is shared with study 6a. We have therefore not included these cases in the running total. Citation: Rong Chen, Yuan Zhang, Lei Huang, Bi-heng Cheng, Zhong-yuan Xia, Qing-tao Meng, Safety and efficacy of different anesthetic regimens for parturients with COVID-19 undergoing Cesarean delivery: a case series of 17 patients. Can J Anesth
Study 35. Four neonates with Covid-19 from China
Four infected neonates (age less than 1 month) all born by Caesarean section (click here). They were identified by searching China’s national database of 81,026 laboratory-confirmed cases up to March 13 using the same methods as in a study of infants age 1 month to one year reported in JAMA (click herebut not listed in this blog post). It seems likely that they overlap with the three infected neonates reported earlier in JAMA (study 12), the case report in Clinical Infectious Diseases (study 11) or the infected neonate reported in Lancet Inf Dis (study 15). We have therefore not included them in the running totals. Citation: Zhi-Jiang Zhang, Xue-Jie Yu, Tao Fu, Yu Liu, Yan Jiang, Bing Xiang Yang, Yongyi Bi. Novel Coronavirus Infection in Newborn Babies Under 28 Days in China. European Respiratory Journal 2020; DOI: 10.1183/13993003.00697-2020
Study 34. Case report of uninfected baby from Beijing
Abstract (click here). Full text (here). A 25 year old woman with Covid-19 at 35 weeks recovered and had a normal vaginal birth of a 3070g boy at 38w + 4d. The baby had no signs of past or present infection with SARS-COV-2. The birth occurred at YouAn Hospital, Capital Medical University, Beijing, which has not previously reported cases in pregnancy, but the mother had been transferred from an unnamed hospital in Wuhan. Nevertheless we have included this as a non-duplicated case in summary totals. Citation: Xiali Xiong, Hong Wei, Zhihong Zhang, Jing Chang, Xiaopeng Ma, Xiang Gao, Qiang Chen, Qiumei Pang. Vaginal Delivery Report of a Healthy Neonate Born to a Convalescent Mother with COVID-19 J Med Virol. 2020 Apr 10. doi: 10.1002/jmv.25857.
Study 33 added
Study 33. US Centres for Disease Control reports 143 pregnant women
Preliminary data on lab-confirmed COVID-19 reported to CDC Feb 12–March 28, 2020. Of 7,162 cases, 143 were pregnant. Of these 72 stayed home, 31 hospitalised (non ICU), 4 entered ICU, and 36 had unknown hospitalisation status. “[…] for […] pregnancy, few severe outcomes were reported […].” Many probably reported elsewhere, so not added to running totals. Citation: Preliminary Estimates of the Prevalence of Selected Underlying Health Conditions Among Patients with Coronavirus Disease 2019 — United States, February 12–March 28, 2020. MMWR Morb Mortal Wkly Rep 2020;69:382–386. DOI: http://dx.doi.org/10.15585/mmwr.mm6913e2external icon.
Study 31 & 32 added. Keelin O’Donoghue & Kate Walker have joined the team. Thank you also to Nicola Vousden for alerting us to 31.
Study 32. 42 women from Lombardy
This pre-print Ferrazzi Lombardy ijgo.13162 cites a paper in press describing 42 pregnant women from Lombardy, Italy who had Covid-19 and delivered, 18 by Caesarean, and 24 vaginally. Two were spontaneously preterm. Seven women required CPAP or were admitted to ICU, but all “eventually did well”. No baby details are given. This is the first scientific report from Italy. Citation: Ferrazzi EM, Frigerio L, Cetin I, Vergani P, Spinillo A, Prefumo F, Pellegrini E, Gargantini G.COVID-19 Obstetrics Task Force, Lombardy, Italy: executive management summary and short report of outcome. Int J Gynecol Obstet in press.
Study 31. Case report from Ankara, Turkey
Report from Dept OBGYN, Ankara University, Faculty of Medicine. Woman age 32, with Covid-19 at 35 weeks gestation, delivered by Caesarean section prior to admission to intensive care (click here). Birthweight 2790g. Three days after birth mother required intubation and ventilation, and she remains in intensive care. Baby not infected. Citation: E. Kalafat E. Yaprak G. Cinar B. Varli S. Ozisik C. Uzun A. Azap A. Koc Lung ultrasound and computed tomographic findings in pregnant woman with COVID‐19 Ultrasound Obstet Gynecol. First published: 06 April 2020 https://doi.org/10.1002/uog.22034
Study 30. 16 women with Covid-19 pneumonia from Hubei province
Sixteen pregnant women with confirmed COVID-19 pneumonia, and 18 with pneumonia on chest imaging who tested negative, were compared with two groups of control pregnancies (click here or ciaa352). The comparative design is similar to study 6a which, apart from an English abstract, has only been published in Chinese. However the hospital and authors differ, so I’m confident there is no overlap. Citation: Li N, Han L, Peng M, Lv Y, Ouyang Y, Liu K, Yue L, Li Q, Sun G, Chen L, Yang L. Maternal and neonatal outcomes of pregnant women with COVID-19 pneumonia: a case-control study. Clin Infect Dis. 2020 Mar 30. pii: ciaa352. doi: 10.1093/cid/ciaa352. [Epub ahead of print]
Study 29. ICNARC report 4 April 2020
This report from the UK Intensive Care National Audit & Research Centre (ICNARC) mentions two currently, and six recently (<6 weeks) pregnant women with Covid-19 who were also critically ill. One of the currently pregnant, and two of the recently pregnant women, were receiving advanced respiratory support. Excluded from running totals.
Study 28. Seven cases from Newark Beth Israel Medical Center. Newark, NJ
Pre-print from Am J Obstet Gynecol MFM (click here ) of two pregnant women with Covid-19 who developed cardiomyopathy. Report also mentions five other pregnant women with Covid-19 in Newark Beth Israel Medical Center. Details are only given for the two women with cardiomyopathy, and no baby details are given. For consistency of numbers I’ve assumed the other five pregnancies are ongoing in running totals.
Study 27. Expanded series from New York Presbyterian
This pre-print reports 43 pregnant women with COVID-19. It includes 36 new cases, identified during a period of universal testing, and 7 previously reported (Study 14) 43_COVID_040320. Click here.
No new scientific reports today. But obstetricians & midwives will enjoy reading the first newspaper report of a Covid-19 pregnancy and birth in France. Case 10 here. Better written and more detailed than many scientific reports.
Study 26 added. The first report of puerperal Covid-19. Not added to running totals.
Study 26. The first case report of puerperal COVID-19
This baby developed COVID-19 symptoms at age 10 days and was admitted to Wuhan Children’s Hospital age 17 days on February 5, 2020. Click here for the article in Chinese. What follows is based on Google translate. Both parents are reported to have had Covid-19 symptoms from three days before admission, i. e. day 14 after birth. This is therefore not a case of COVID infection in pregnancy or at birth, and therefore excluded from the running totals. However, the mother had puerperal Covid-19 and is, I believe, the first such case reported. The baby recovered and by implication, albeit not stated explicitly, so did the parents. The first author Zeng Lingkong shares a name with the first author of the series of 33 neonatal cases reported in JAMA Paediatrics, Study 8., but this is clearly not one of the three infected babies reported in that paper. Citation: Zeng Lingkong, Tao Xuwei, Yuan Wenhao, et al. The first neonatal coronavirus pneumonia in China [J]. Chinese Journal of Pediatrics, 2020,58 (04): 279-280. DOI: 10.3760 / cma.j.cn112140 -20200212-00081
Study 25 added belatedly.
Study 25. Report of the WHO-China Joint Mission on Coronavirus Disease 2019, 16-24 February 2020
Click here or who-china-joint-mission-on-covid-19-final-report for full text including annexes. (For Chinese version click here or who-china-joint-mission-on-covid-19-final-report chinese version. Annexe 6, page 32 of English version: “As opposed to Influenza A(H1N1)pdm09, pregnant women do not appear to be at higher risk of severe disease. In an investigation of 147 pregnant women (64 confirmed, 82 suspected and 1 asymptomatic), 8% had severe disease and 1% were critical.” Neither raw numbers, a citation, nor any further details are given. Assuming the percentages are of all 147, this would imply 12 women with severe disease, and one or two who were critical. In view of the high possibility of double counting – cases notified to the WHO team are likely to have also got reported elsewhere – I’ve left these out of the running total. Citation: Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19) 16-24 February 2020. Report submitted 28 February 2020
Study 23 added. Not yet added to running totals.
Study 23 Three cases from Iran
This review article (click here, full text here) from researchers from both Tehran and Shiraz in Iran, reports the births of three infants from infected mothers. The authors’ source was this Iranian ministry website (click here). All three babies were uninfected and survived, but two of the three mothers developed acute respiratory distress syndrome (ARDS) after delivery and died. Presumably this was related to their Covid-19 infection. Citation: Mojgan Karimi-Zarchia, Hossein Neamatzadeh, Seyed Alireza Dastgheib, Hajar Abbasi, Seyed Reza Mirjalili, thena Behforouz, Farzad Ferdosian, Reza Bahrami. Vertical Transmission of Coronavirus Disease 19 (COVID-19) from Infected Pregnant Mothers to Neonates: A Review. Fetal & Paed Pathol.
Thank you to Keelin O’Donoghue, Cork, for pointing me to Studies 18 & 19, which I had missed, and to Ganesh Acharya, Editor-in-Chief AOGS, for permission to upload a pre-publication version of Study 20.
Study 22. Case report from Korea
Delivered by Caesarean section at 37 weeks at Daegu Fatimal Hospital, Korea (click here). The baby was not infected. Mother and baby did well. Citation: Dong Hwan Lee, Jihyang Lee, Eunju Kim, Kyeongyoon Woo, Hak Youle Park, Jihyun An. Emergency cesarean section on severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) confirmed patient. Korean J Anesthesiol. [Epub ahead of print]
Study 21. Case report from Washington DC
The patient had a normal vaginal delivery at 39 weeks at MedStar Washington Hospital Center (click here). Baby not infected. Both fine. Citation: Iqbal SN Rachael Overcash R, Neggin Mokhtari N,.
Haleema Saeed H, Gold S, Auguste T, Mirza M-U, Ruiz M-E, Chahine JJ, Waga M, Wortmann G. An Uncomplicated Delivery in a Patient with Covid-19 in the United States New Engl J Med April 1, 2020 DOI: 10.1056/NEJMc2007605
Study 20. Case report of twins from Stockholm
Twins born by Caesarean at 36 weeks in Southern General Hospital, Stockholm. Twins, breast milk & maternal vaginal secretions all Covid-19 negative. Pre-publication version here AOGS-20-0296_Proof_hi with permission of the editor, Ganesh Acharya. Link will follow. Citation: Gidlof S, Savchenko J, Brune, T, Josefsson H. COVID-19 in pregnancy with comorbidities: More liberal testing strategy is needed. Acta Obstetricia et Gynecologica Scandinavica
Study 19. Case report from Souzhou, China
Woman delivered by Caesarean at 30 weeks in the Affiliated Infectious Hospital of Soochow University, Souzhou, China. Although “no improvement was made on maximal ventilator support for four hours”, later “informed consent was obtained, an emergency cesarean section under combined spinal-epidural anesthesia was performed” and “uneventful perinatal course”. Baby isolated and not infected. Both survived. Citation: Xiaotong Wang, Zhiqiang Zhou, Jianping Zhang, Fengfeng Zhu, Yongyan Tang, Xinghua Shen. A case of 2019 Novel Coronavirus in a pregnant woman with preterm delivery. Clinical Infectious Diseases, ciaa200
Study 18. Case report from Honduras, Central America
The woman went into preterm labour and delivered vaginally at 32 weeks. Baby not infected. Both doing well at time of report. Citation. Zambrano LI, Fuentes-Barahona IC, Bejarano-Torres DA, Bustillo C, Gonzales G, Vallecillo-Chinchilla G, Sanchez-Martínez FE, Valle-Reconco JA, Sierra M, Bonilla-Aldana DK, Cardona-Ospina JA, Rodríguez-Morales AJ. A pregnant woman with COVID-19 in Central America. Travel Medicine and Infectious Disease. Online 25 March 2020.
Study 6a added (details below).
Study 17. Five from Maternal & Child Hospital of Hubei Province, Tongji Medical College
Two Caesarean and three vaginal births delivered in the Maternal and Child Hospital of Hubei Province, Tongji Medical College (click here). Or siyu chen. All mothers recovered. All babies well. According to Wikipaedia the MCH of HP is the 10th clinical college/hospital associated with Tongji Medical College. It is distinct from both Union hospital and Tongji hospital. These five births are therefore additional to those in the various Union Hospital reports, and to those in study 15. Citation: Chen S, Liao E, Shao Y. Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia. J Med Virol. 2020 Mar 28. doi: 10.1002/jmv.25789. [Epub ahead of print]
Study 16. Three non-cases from Shenzhen 2nd People’s Hospital
Shenzen, a city of 13 million had had 420 confirmed cases of Covid-19, the second highest number outside Hubei, up to March 11th. Despite an annual birth rate in the city of 188,000, the 2nd People’s Hospital saw no COVID-19 infected pregnant women. Instead they report three suspected cases who, after barrier nursing, and in one case surgery for an ectopic pregnancy, were later confirmed negative. Citation: Yu Chen, Zhe Li, Yuan-Yuan Zhang, Wei-Hua Zhao, Zhi-Ying Yu. Maternal health care management during the outbreak of coronavirus disease 2019 (COVID-19) J Med Virol. 2020 Mar 26. doi: 10.1002/jmv.25787. [Epub ahead of print]
Study 15. Seven cases from Tongji in Lancet Respiratory Med
These seven cases (click here) delivered at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (Wuhan, China) between Jan 1 and Feb 8, 2020. All mothers had mild Covid-19 disease and all were delivered around term by Caesarean section. One baby (Patient 1) tested positive for Covid-19 by throat PCR at 36 hours and was transferred to Wuhan Children’s hospital. His mother’s age, gravidity, parity, lack of direct contact with Hunan seafood market and history of hypothyroidism all suggest this is the same mother/infant dyad as in report 11. Note however the reported birthweights differ 3250g v 3205g. No babies had any clinical symptoms and all (including the transferred one) were discharged home well. Wikipedia lists ten different hospitals/clinical colleges affiliated with Tongji Medical College in Wuhan. The 1st clinical college is called Wuhan Union Hospital. The 2nd clinical college is called Wuhan Tongji Hospital. This series is therefore unlikely to overlap with the various case series from Union Hospital Tongji. Citation: Nan Yu, Wei Li, Qingling Kang, Zhi Xiong, Shaoshuai Wang, Xingguang Lin, Yanyan Liu, Juan Xiao, Haiyi Liu, Dongrui Deng, Suhua Chen, Wanjiang Zeng, Ling Feng, Jianli Wu. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. Lancet Infect Dis 2020 Published Online March 24, 2020
Study 14. Seven pregnant women from New York Presbyterian
AJOG MFM Preprint (click here) or COVID_Early_Lessons_032620 NY presbyterian. via @neel_shah. The first reported cases outside China. Citation; Breslin N, Baptiste C, Miller R, Fuchs K, Goffman D, Gyamfi-Bannerman C, D’Alton M. COVID-19 in pregnancy: early lessons. Am J Obstet Gynecol. Available online 27 March 2020.
Four more primary reports including ten more cases. All previously unreported.
Study 13. Cord blood serology from six babies in Zhongnan Hospital, Wuhan
Six cases reported in JAMA (click here). All births by Caesarean. All mothers mild disease. All babies asymptomatic. Since they were born in a different hospital these are probably additional to the other 33 Wuhan neonates reported in JAMA. Citation: Hui Zeng, Chen Xu, Junli Fan, Yueting Tang, Qiaoling Deng, Wei Zhang, Xinghua Long. Antibodies in Infants Born to Mothers With COVID-19 Pneumonia. JAMA. Published online March 26, 2020.
Study 12. Case report from Renmin Hospital Wuhan
Case report in JAMA of baby, born at Renmin Hospital, Wuhan, by Caesarean, 23 days after mother developed Covid-19, had IgM antibodies detected in cord blood (click here). This is additional to the two Remnin cases below, because the clinical details differ substantially. Citation: Lan Dong, Jinhua Tian, Songming He, Chuchao Zhu, Jian Wang, Chen Liu, Jing Yang. Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn. JAMA. Published online March 26, 2020.
Study 11. Caesarean birth & neonatal infection, Wuhan
Case report (click here) of a baby born by Caesarean to an infected mother at Wuhan Tongji Hospital. The baby was separated from the mother at birth but became infected (pharyngeal PCR at 36 hours). Both mother and baby recovered. I believe this case report is additional to the 33 Wuhan neonatal cases reported in JAMA, because the details (e.g. birth weight) do not align. This is therefore the fourth infected baby born by Caesarean. Citation: Shaoshuai Wang, Lili Guo, Ling Chen, Weiyong Liu, Yong Cao, Jingyi Zhang, Ling Feng A Case Report of Neonatal 2019 Coronavirus Disease in China. Clinical Infectious Diseases, ciaa225.
Study 10. Two cases from Renmin Hospital, Wuhan
Two pregnant doctors with Covid-19 both delivered by Caesarean at term (click here). Also remnin two cases. Babies separated and not infected. Probably additional to the 33 JAMA Wuhan neonates because neither neonate was transferred to Wuhan Children’s Hospital. Citation: Cuifang Fan, Di Lei, Congcong Fang, Chunyan Li, Ming Wang, Yuling Liu, Yan Bao, Yanmei Sun, Jinfa Huang, Yuping Guo, Ying Yu, Suqing Wang Perinatal Transmission of COVID-19 Associated SARS-CoV-2: Should We Worry? Clinical Infectious Diseases, ciaa226
Three more more primary scientific reports.
Study 9. A Caesarean birth from Zhejiang
This case report is in Chinese but has an English abstract. Click here. It’s from the First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, Hangzhou. There appears to be no overlap of the authors with the Zhejiang Caesarean below, so this may be a new case. The Caesarean is reported as being “successful” which presumably means both mother and baby survived. Citation: Kang X, Zhang R, He H, Yao Y, Zheng Y, Wen X, Zhu S. Anesthesia management in cesarean section for a patient with coronavirus disease 2019. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020 May 25;49(1):0. Chinese. PMID: 32207592
Study 8. The 33 neonatal cases from Wuhan
A series of 33 neonates born to mothers who had Covid-19. All from Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Reported in JAMA here. It seems possible that some or all of these infants are also included in the other Union Hospital Tongji series below. Of the 26 neonates delivered by Caesarean three became infected. One born at 30 weeks and 2 days developed RDS, pneumonia and suspected sepsis, and required non-invasive ventilation. The authors speculate that some of his problems were related to prematurity rather than COVID-19. The other two neonates were healthy. All three survived. By inference, although this is not specifically stated in the paper, none of the seven infant born vaginally became infected. Citation: Lingkong Zeng, Shiwen Xia, Wenhao Yuan, Kai Yan, Feifan Xiao, Jianbo Shao, Wenhao Zhou. Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China. JAMA Pediatr. Published online March 26, 2020.
Study 7. The Quingdao case
This appears to be the first pregnancy case from that city. Click here. The mother developed Covid-19 at 30 weeks but recovered and was discharged. At the time the report was written the pregnancy was ongoing. Citation: Rong Wen, Yue Sun, Quan-Sheng Xing A patient with SARS-CoV-2 infection during pregnancy in Qingdao, China Journal of Microbiology, Immunology and Infection. Available online 10 March 2020
Assuming all the Union Hospital Tongji cases overlap, i.e. that Tongji has reported only 15 in total, there have been 38 published cases (39 babies) of Covid-19 infection in pregnancy. There have been no reports in the scientific literature of any maternal deaths, and all neonates have survived and not been infected. Four neonates remain undelivered.
David A Schwarz (click here) in a review in Arch Pathol (preprint available March 21st) also makes the total 38 published cases. However he includes a series published only in Chinese (his reference 17) Zhang I, Jiang Y, Wei M, Cheng BH, Zhou XC, Li J, et al. 湖北地区新型冠状病毒肺炎流行期间孕妇的 384 妊娠结局分析 [Analysis of the Pregnancy Outcomes in Pregnant Women With COVID-19 in Hubei Province]. Zhonghua Fu Chan Ke Za Zhi . 2020;55(0), E009. Accessed and translated 12 March 2020. He reports this as including 16 cases. For the moment I’ve not included this Hubei series, (but see Study 6a added 1 April).
Study 6a. 16 cases from Remnin
The cases included by David Schwarz on March 21 (see note above). English abstract (click here). Full text in Chinese here. Google translate used. The authors come from Remnin Hospital, but the paper reports that all 16 women were delivered by Caesarean at the Eastern Hospital of Wuhan University People’s Hospital. Therefore assume no duplicates. Citation: Zhang Lu, Jiang Yan, Wei Min, et al. Analysis of pregnancy outcomes of pregnant women during the epidemic of new coronavirus pneumonia in Hubei [J / OL]. Chinese Journal of Obstetrics and Gynecology, 2020,55 (2020-03-08). DOI: 10.3760 / cma.j.cn112141-20200218-00111.
Study 6. The 15 Union hospital Tongji cases
A series of 15 pregnant women, of whom 11 had delivered and four remained undelivered from Union Hospital, Tongji Medical College, click here. These may include the four from the same hospital below and also possibly the 9 cases from the same hospital in Translational Paediatrics. Citation: Dehan Liu, Lin Li, Xin Wu, Dandan Zheng, Jiazheng Wang, Lian Yang and Chuansheng Zheng. Pregnancy and Perinatal Outcomes of Women With Coronavirus Disease (COVID-19) Pneumonia: A Preliminary Analysis American Journal of Roentgenology: 1-6. 10.2214/AJR.20.23072
Study 5. The 9 Union Hospital Tongji cases
Published in Translational Paediatrics (click here). Nine mothers, ten neonates. Citation: Huaping Zhu, Lin Wang, Chengzhi Fang, Sicong Peng, Lianhong Zhang, Guiping Chang, Shiwen Xia, Wenhao Zhou. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Translational Pediatrics Vol 9, No 1 (February 2020)
Study 4. The Zeijang case
From the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China (click here) Caesarean for unclear indication. Baby not infected. Citation: Yang Li, Ruihong Zhao, Shufa Zheng, Xu Chen, Jinxi Wang, Xiaoli Sheng, Jianying Zhou, Hongliu Cai, Qiang Fang, Fei Yu, Jian Fan, Kaijin Xu, Yu Chen and Jifang Sheng Lack of Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2, China. Emerging Infectious Diseases. 2020 Apr [date cited].
Study 3. The Sun Yat Sen series
These 13 cases were reported from the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Province. Guangdong, P.R. China. (click here). Also pre-publication text). They included 3 patients from Zhejiang, 3 from other cities of Hubei and 1 each from Fujian, Shanxi, Beijing, Guangdong, Jiangxi, Heilongjiang and Anhui. No infected neonates but one mother seriously ill on ECMO. Citation: Yangli Liu, Haihong Chen, Kejing Tang, Yubiao Guo. Clinical manifestations and outcome of SARS-CoV-2 infection during pregnancy J Infect.
Study 2. The first Union Hospital Tongji series
From Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan. The original abstract here, described three cases and linked to an original paper in Chinese. These may overlap with four cases later published in Frontiers click here. There is also a pre-print of three cases from Tongji, (Click here) which includes some authors from the Liverpool School of Tropical Medicine & Hygiene. Again these may overlap, or even be the same cases.
Study 2a. Citations: Chen S, Huang B, Luo DJ, Li X, Yang F, Zhao Y, Nie X, Huang BX. Pregnant women with new coronavirus infection: a clinical characteristics and placental pathological analysis of three cases. Zhonghua Bing Li Xue Za Zhi. 2020 Mar 1;49(0):E005. doi: 10.3760/cma.j.cn112151-20200225-00138.
Study 2b. Liu, W.; Wang, Q.; Zhang, Q.; Chen, L.; Chen, J.; Zhang, B.; Lu, Y.; Wang, S.; Xia, L.; Huang, L.; Wang, K.; Liang, L.; Zhang, Y.; Turtle, L.; Lissauer, D.; Lan, K.; Feng, L.; Yu, H.; Liu, Y.; Sun, Z. Coronavirus Disease 2019 (COVID-19) During Pregnancy: A Case Series. Preprints 2020, 2020020373
Study 2c. Yan Chen, Hua Peng, Lin Wang, Yin Zhao, Lingkong Zeng, Hui Gao and Yalan Liu. Infants Born to Mothers With a New Coronavirus (COVID-19) Front. Pediatr., 16 March 2020
Study 1. The original Lancet nine
All from Zhongnan Hospital of Wuhan University, Wuhan, click here. Citation: Huijun Chen, Juanjuan Guo, Chen Wang, Fan Luo, Xuechen Yu, Wei Zhang, Jiafu Li, Dongchi Zhao, Dan Xu, Qing Gong, Jing Liao, Huixia Yang, Wei Hou, Yuanzhen Zhang. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. Volume 395, Issue 10226, 7–13 March 2020, Pages 809-815.
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