FDA Flouroquinolone Warning Including Use for UTI Management
The FDA has issued warnings and updated drug safety information for oral and injectable fluoroquinolone antibiotics. ACOG has likewise released a practice advisory (November 2019) to help reinforce awareness regarding the use of these medications due to their role in the treatment of UTIs. The FDA recommends
Health care professionals should not prescribe systemic fluoroquinolones to patients who have other treatment options for acute bacterial sinusitis (ABS), acute bacterial exacerbation of chronic bronchitis (ABECB), and uncomplicated urinary tract infections (UTI) because the risks outweigh the benefits in these patients. Stop fluoroquinolone treatment immediately if a patient reports serious side effects, and switch to a non-fluoroquinolone antibacterial drug to complete the patient’s treatment course
Serious Fluoroquinolone Side Effects
Musculoskeletal and Peripheral Nervous System
Numbness or tingling or pricking sensation “pins
and needles” in arms or legs
Other Body Systems
Worsening of myasthenia gravis
Abnormal, rapid or strong heart beat
Central Nervous System
Additional FDA information for healthcare
Reserve use of fluoroquinolones for patients
with acute bacterial sinusitis (ABS), acute bacterial exacerbation of chronic
bronchitis (ABECB), and UTI, but no alternative therapies
Boxed Warning, Warnings and Precautions sections
of the labels and revised patient Medication Guide now describe serious risk of
multiple disabling and potentially irreversible adverse reactions that can
Discontinue the fluoroquinolone medicine
immediately at the first signs or symptoms of any serious adverse reaction (see
Note: The FDA
released a safety announcement (December 2018) regarding increased rare event
related to increased risk for aortic rupture or tears
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