Tamoxifen, a well known SERM, is used to treat breast cancer (hormone receptor positive) because of well-documented benefits including improved disease-free survival (5-year was 38% higher than placebo) and overall survival, regardless of menopausal status. It also is used as a chemoprophylactic agent for women at high risk for breast cancer. ACOG reaffirmed their guidance on tamoxifen monitoring (2019), which includes a statement that tamoxifen use may be extended to 10 years.
Uterine Cancer Risk (NSABBP)
Uterine Cancer Risk (IBIS-I trial) – 96 month follow-up
…there may be a role for pretreatment screening of postmenopausal women with transvaginal ultrasonography, and sonohysterography when needed, or office hysteroscopy
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